| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capivasertib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.120487 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.101397 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0466052 |
| FTL | ferritin, light polypeptide | 0.0412255 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0353078 |
| TMSB10 | thymosin beta 10 | 0.0339168 |
| GOLGA4 | golgin A4 | 0.0320737 |
| MYO1E | myosin IE | 0.0318391 |
| NEBL | nebulette | 0.0310506 |
| NDRG1 | N-myc downstream regulated 1 | 0.0294159 |
| TXNIP | thioredoxin interacting protein | 0.0288928 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0288518 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0277065 |
| FAM13A | family with sequence similarity 13, member A | 0.0253257 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0250189 |
| CALR | calreticulin | 0.0241457 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0241017 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.023288 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0228287 |
| RNF145 | ring finger protein 145 | 0.0218113 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0215967 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.0208724 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.020471 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0201742 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0194428 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0193842 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0186974 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.018271 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0181044 |
| LMO7 | LIM domain 7 | 0.017872 |
| HDLBP | high density lipoprotein binding protein | 0.0175168 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0173804 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0172525 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0169119 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0167103 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0165589 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0165222 |
| CANX | calnexin | 0.0164899 |
| HM13 | histocompatibility (minor) 13 | 0.0164876 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.016463 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0163871 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.016338 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0162342 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0160895 |
| RAB6A | RAB6A, member RAS oncogene family | 0.016047 |
| EREG | epiregulin | 0.0160466 |
| GDF15 | growth differentiation factor 15 | 0.0155061 |
| UBC | ubiquitin C | 0.0153197 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0152399 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0151669 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0146385 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0144337 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.014367 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0143185 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0143107 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0142159 |
| WAC | WW domain containing adaptor with coiled-coil | 0.014208 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0141238 |
| DNM2 | dynamin 2 | 0.0139909 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0139271 |
| EXT1 | exostosin glycosyltransferase 1 | 0.013868 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0137324 |
| COPA | coatomer protein complex, subunit alpha | 0.0135623 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0134958 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0134545 |
| PDZD8 | PDZ domain containing 8 | 0.0134518 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0132606 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0131753 |
| USP3 | ubiquitin specific peptidase 3 | 0.0131359 |
| SEC24D | SEC24 family member D | 0.0131018 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.013091 |
| OGA | O-GlcNAcase | 0.0130248 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0127802 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0121481 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0121355 |
| CLINT1 | clathrin interactor 1 | 0.0121078 |
| PRRC1 | proline-rich coiled-coil 1 | 0.0120633 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0119319 |
| SEC24A | SEC24 family member A | 0.011722 |
| RPL31 | ribosomal protein L31 | 0.0117073 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0117068 |
| TPD52 | tumor protein D52 | 0.0116905 |
| TES | testin LIM domain protein | 0.0116853 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0115983 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0115522 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0115505 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0115273 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0115015 |
| TMEM41B | transmembrane protein 41B | 0.0114105 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0113912 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0112884 |
| PREPL | prolyl endopeptidase-like | 0.0111752 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 0.0111085 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0110721 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0110687 |
| RBM5 | RNA binding motif protein 5 | 0.0110616 |
| HYOU1 | hypoxia up-regulated 1 | 0.0110403 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0109612 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0109542 |
| ATXN1 | ataxin 1 | 0.0109495 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.18864 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0956591 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0934757 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0745664 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0715 |
| FLNB | filamin B, beta | -0.067621 |
| ITGA6 | integrin, alpha 6 | -0.0668898 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0586284 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0562976 |
| RPS12 | ribosomal protein S12 | -0.0558481 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0493516 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0474144 |
| FAT1 | FAT atypical cadherin 1 | -0.0469112 |
| LAMA4 | laminin, alpha 4 | -0.0466279 |
| RPS6 | ribosomal protein S6 | -0.0453358 |
| RNF217 | ring finger protein 217 | -0.0443491 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0429501 |
| ACTG1 | actin gamma 1 | -0.0413614 |
| RPLP2 | ribosomal protein, large, P2 | -0.0411063 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0406373 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0404791 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0394084 |
| ANXA2 | annexin A2 | -0.0393378 |
| ASPH | aspartate beta-hydroxylase | -0.0392176 |
| RPS8 | ribosomal protein S8 | -0.0376824 |
| KRT18 | keratin 18, type I | -0.03764 |
| ACTN4 | actinin, alpha 4 | -0.0361025 |
| RPS3 | ribosomal protein S3 | -0.0350834 |
| RPL37A | ribosomal protein L37a | -0.0347069 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0342002 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0340497 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0338886 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0331267 |
| EHBP1 | EH domain binding protein 1 | -0.0319466 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0314462 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.030962 |
| CALB1 | calbindin 1, 28kDa | -0.0297844 |
| POTEF | POTE ankyrin domain family, member F | -0.0287074 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0286366 |
| RPS23 | ribosomal protein S23 | -0.0286362 |
| GPHN | gephyrin | -0.028309 |
| RPS27A | ribosomal protein S27a | -0.0275416 |
| RPL9 | ribosomal protein L9 | -0.0275196 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0273702 |
| RPL26 | ribosomal protein L26 | -0.027043 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0268318 |
| DIAPH2 | diaphanous-related formin 2 | -0.0266951 |
| RAD51B | RAD51 paralog B | -0.0266194 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0264946 |
| RPL12 | ribosomal protein L12 | -0.0259265 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0258287 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0256204 |
| EZR | ezrin | -0.0253041 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0250283 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0246077 |
| ONECUT3 | one cut homeobox 3 | -0.0241795 |
| RPS29 | ribosomal protein S29 | -0.0240753 |
| CCND1 | cyclin D1 | -0.0237339 |
| DENND1A | DENN/MADD domain containing 1A | -0.0236538 |
| RPL36 | ribosomal protein L36 | -0.0232091 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0231007 |
| S100A10 | S100 calcium binding protein A10 | -0.0227716 |
| RPL28 | ribosomal protein L28 | -0.0225833 |
| FHIT | fragile histidine triad | -0.0223782 |
| SH3D19 | SH3 domain containing 19 | -0.0223739 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0221921 |
| RPS19 | ribosomal protein S19 | -0.022058 |
| LSAMP | limbic system-associated membrane protein | -0.0216518 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.021585 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0215275 |
| RPS24 | ribosomal protein S24 | -0.0215158 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0212838 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0210982 |
| MYOF | myoferlin | -0.0210656 |
| MECOM | MDS1 and EVI1 complex locus | -0.0210006 |
| RIN2 | Ras and Rab interactor 2 | -0.0209484 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0206038 |
| S100A6 | S100 calcium binding protein A6 | -0.0205506 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0201438 |
| FERMT1 | fermitin family member 1 | -0.0201065 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0200636 |
| PRDX1 | peroxiredoxin 1 | -0.0199039 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0196468 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0194759 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0193679 |
| RPS11 | ribosomal protein S11 | -0.018811 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0186558 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.018627 |
| PERP | PERP, TP53 apoptosis effector | -0.0185248 |
| EMP1 | epithelial membrane protein 1 | -0.018467 |
| NRXN3 | neurexin 3 | -0.0184478 |
| RPL37 | ribosomal protein L37 | -0.0183407 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0181703 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0180182 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0178438 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.017767 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0177581 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0174259 |
| KRT19 | keratin 19, type I | -0.0174121 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.0174022 |
