| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Capivasertib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.143084 |
| CAPRIN2 | caprin family member 2 | 0.126668 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0949865 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0712225 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0602732 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0559333 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0490043 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0478407 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0465437 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0422483 |
| TMEM41B | transmembrane protein 41B | 0.0419571 |
| EZR | ezrin | 0.0410621 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0388371 |
| SEC24A | SEC24 family member A | 0.037832 |
| RPL27 | ribosomal protein L27 | 0.0377295 |
| USP12 | ubiquitin specific peptidase 12 | 0.0361643 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0351997 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.032375 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0323476 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0319003 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.031315 |
| RPS12 | ribosomal protein S12 | 0.0304185 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0298011 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0295541 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0291096 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0290742 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0289837 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0285984 |
| TXNRD1 | thioredoxin reductase 1 | 0.0284045 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0283202 |
| ANGPTL4 | angiopoietin-like 4 | 0.0282789 |
| RPL37 | ribosomal protein L37 | 0.0281998 |
| JMJD1C | jumonji domain containing 1C | 0.0279786 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0278901 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0270144 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0267482 |
| SQSTM1 | sequestosome 1 | 0.0261049 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0256079 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.02549 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0251367 |
| RTN4 | reticulon 4 | 0.0247372 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0238918 |
| EREG | epiregulin | 0.0233524 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0232303 |
| VMP1 | vacuole membrane protein 1 | 0.0227255 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0221631 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0220251 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0213626 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0213395 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0213154 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.020992 |
| TUBB6 | tubulin, beta 6 class V | 0.0208301 |
| TXNIP | thioredoxin interacting protein | 0.0207224 |
| LOXL2 | lysyl oxidase-like 2 | 0.0206795 |
| RPL19 | ribosomal protein L19 | 0.0206473 |
| AREG | amphiregulin | 0.0203312 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0203076 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0201816 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0200419 |
| RASA2 | RAS p21 protein activator 2 | 0.0199404 |
| DENND5A | DENN/MADD domain containing 5A | 0.0199303 |
| MT1E | metallothionein 1E | 0.0198597 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0197373 |
| CDK19 | cyclin-dependent kinase 19 | 0.0196836 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0194964 |
| VEGFC | vascular endothelial growth factor C | 0.019477 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0192583 |
| RPS2 | ribosomal protein S2 | 0.0192197 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0188723 |
| KIF1B | kinesin family member 1B | 0.0188441 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.018647 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0186374 |
| RPL3 | ribosomal protein L3 | 0.0184229 |
| SRP54 | signal recognition particle 54kDa | 0.0182924 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0181653 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0181479 |
| LENG8 | leukocyte receptor cluster (LRC) member 8 | 0.0179066 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0178276 |
| RPL37A | ribosomal protein L37a | 0.0176925 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | 0.0176473 |
| PRRC2A | proline-rich coiled-coil 2A | 0.0176424 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0175292 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0170747 |
| LYST | lysosomal trafficking regulator | 0.0168521 |
| EGR1 | early growth response 1 | 0.0167936 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0167863 |
| STX1A | syntaxin 1A (brain) | 0.0167362 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0166487 |
| STK40 | serine/threonine kinase 40 | 0.0165759 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0165341 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0164134 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0163211 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0162482 |
| COPA | coatomer protein complex, subunit alpha | 0.0156887 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0153753 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0152082 |
| CORO1C | coronin, actin binding protein, 1C | 0.0151637 |
| FHL2 | four and a half LIM domains 2 | 0.0150083 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.014864 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0146515 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | -0.186864 |
| VIM | vimentin | -0.136181 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.122971 |
| CD44 | CD44 molecule (Indian blood group) | -0.119646 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.119259 |
| CADM2 | cell adhesion molecule 2 | -0.100025 |
| RAD51B | RAD51 paralog B | -0.0900676 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0873057 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.078625 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0724605 |
| TMSB10 | thymosin beta 10 | -0.0717053 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0712104 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0667817 |
| TMSB4X | thymosin beta 4, X-linked | -0.0660618 |
| PTMA | prothymosin, alpha | -0.0649764 |
| CFAP299 | cilia and flagella associated protein 299 | -0.064424 |
| EXOC4 | exocyst complex component 4 | -0.0639652 |
| TNS3 | tensin 3 | -0.0631216 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0629859 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0599449 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0591196 |
| RIGI | RNA sensor RIG-I | -0.0579642 |
| RNF213 | ring finger protein 213 | -0.05786 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0574988 |
| EHBP1 | EH domain binding protein 1 | -0.0569285 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0557827 |
| DPH6 | diphthamine biosynthesis 6 | -0.0508927 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0492674 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0475908 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.045144 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0441705 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0435371 |
| CENPF | centromere protein F, 350/400kDa | -0.0423665 |
| EFNA5 | ephrin-A5 | -0.0409539 |
| DST | dystonin | -0.0403578 |
| PRELID2 | PRELI domain containing 2 | -0.0390299 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0387093 |
| EPHA4 | EPH receptor A4 | -0.0383087 |
| HDAC9 | histone deacetylase 9 | -0.0366453 |
| DIAPH3 | diaphanous-related formin 3 | -0.0365395 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0362107 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0356119 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0341022 |
| COL5A2 | collagen, type V, alpha 2 | -0.0340584 |
| TMEM123 | transmembrane protein 123 | -0.0339248 |
| CANX | calnexin | -0.0338261 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0330536 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0330498 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0320442 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0315979 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.030408 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.030381 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0299211 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0298312 |
| FUS | FUS RNA binding protein | -0.0296978 |
| FTL | ferritin, light polypeptide | -0.0296204 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.029469 |
| SP100 | SP100 nuclear antigen | -0.0290709 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0284363 |
| PTK2 | protein tyrosine kinase 2 | -0.0281806 |
| ZNF217 | zinc finger protein 217 | -0.0281767 |
| ALDH7A1 | aldehyde dehydrogenase 7 family, member A1 | -0.0281055 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0279886 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0271884 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0270746 |
| ANLN | anillin, actin binding protein | -0.0270169 |
| RAI1 | retinoic acid induced 1 | -0.0267131 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0265507 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0264263 |
| NEK10 | NIMA-related kinase 10 | -0.026248 |
| ZNF292 | zinc finger protein 292 | -0.0261882 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0260367 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0257385 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.025467 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0251688 |
| NF1 | neurofibromin 1 | -0.0251427 |
| CEP128 | centrosomal protein 128kDa | -0.0251353 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0249963 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0248231 |
| DNER | delta/notch-like EGF repeat containing | -0.0245386 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0244908 |
| XPO1 | exportin 1 | -0.0244587 |
| CALD1 | caldesmon 1 | -0.0243993 |
| BRINP3 | bone morphogenetic protein/retinoic acid inducible neural-specific 3 | -0.0243454 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0242653 |
| VCL | vinculin | -0.0237036 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0236891 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0232258 |
| LMNTD1 | lamin tail domain containing 1 | -0.0231998 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0230929 |
| ECE1 | endothelin converting enzyme 1 | -0.0230154 |
| PGK1 | phosphoglycerate kinase 1 | -0.02284 |
| HMGB1 | high mobility group box 1 | -0.0226137 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0223584 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0223227 |
| SRGN | serglycin | -0.0222943 |
| RPS24 | ribosomal protein S24 | -0.022286 |
| COMMD10 | COMM domain containing 10 | -0.0222794 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0220548 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.021929 |
