Capivasertib_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capivasertib perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capivasertib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.511451
MCL1 myeloid cell leukemia 1 0.11046
SLTM SAFB-like, transcription modulator 0.107995
THSD4 thrombospondin, type I, domain containing 4 0.0987774
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.096487
INTS6 integrator complex subunit 6 0.0959153
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.083074
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0753814
PDLIM5 PDZ and LIM domain 5 0.0749937
FNDC3B fibronectin type III domain containing 3B 0.0728217
CEMIP cell migration inducing protein, hyaluronan binding 0.0676315
PTPRM protein tyrosine phosphatase, receptor type, M 0.0665559
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0660253
SMAD3 SMAD family member 3 0.0555166
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0489242
MACF1 microtubule-actin crosslinking factor 1 0.0471192
MCTP1 multiple C2 domains, transmembrane 1 0.0462933
PDE4D phosphodiesterase 4D, cAMP-specific 0.046133
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0441759
MYO1E myosin IE 0.0439118
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0437997
SAMD4A sterile alpha motif domain containing 4A 0.0437786
GRB10 growth factor receptor-bound protein 10 0.0418128
TMSB10 thymosin beta 10 0.0392419
BCAR3 breast cancer anti-estrogen resistance 3 0.0391583
NABP1 nucleic acid binding protein 1 0.0389448
AKAP13 A kinase (PRKA) anchor protein 13 0.0369129
NPAS2 neuronal PAS domain protein 2 0.0364609
HOMER1 homer scaffolding protein 1 0.0359733
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0346269
USP53 ubiquitin specific peptidase 53 0.0345778
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0343905
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0339452
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0326388
MYH9 myosin, heavy chain 9, non-muscle 0.0323405
MSN moesin 0.0323058
ZSWIM6 zinc finger, SWIM-type containing 6 0.0314844
BMP6 bone morphogenetic protein 6 0.030643
RPL37A ribosomal protein L37a 0.0302879
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0302448
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0298725
RAD51B RAD51 paralog B 0.0297047
BACE2 beta-site APP-cleaving enzyme 2 0.0279659
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0272776
ANKRD12 ankyrin repeat domain 12 0.0268778
KIAA1217 KIAA1217 0.026783
CTBP2 C-terminal binding protein 2 0.0263141
DOCK5 dedicator of cytokinesis 5 0.026249
HSPA8 heat shock 70kDa protein 8 0.025318
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0252739
EGR1 early growth response 1 0.0251687
RCOR1 REST corepressor 1 0.0251032
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0247202
MYO5B myosin VB 0.0240501
FBXO11 F-box protein 11 0.0238212
GPHN gephyrin 0.0235395
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0234137
SRRM2 serine/arginine repetitive matrix 2 0.0231716
TUFT1 tuftelin 1 0.0227205
TRAF3 TNF receptor-associated factor 3 0.0225324
VCL vinculin 0.0223452
FNDC3A fibronectin type III domain containing 3A 0.0223183
PSD3 pleckstrin and Sec7 domain containing 3 0.021857
CMIP c-Maf inducing protein 0.0218161
DUSP5 dual specificity phosphatase 5 0.0215429
ATXN1 ataxin 1 0.0212858
SPIRE1 spire-type actin nucleation factor 1 0.021262
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0212198
ZNF638 zinc finger protein 638 0.0208987
LYST lysosomal trafficking regulator 0.0207993
GPC6 glypican 6 0.020696
ACTN1 actinin, alpha 1 0.0206842
ENSA endosulfine alpha 0.0204978
LPP LIM domain containing preferred translocation partner in lipoma 0.0204457
BAIAP2L1 BAI1-associated protein 2-like 1 0.0202044
PMM2 phosphomannomutase 2 0.0201695
SOD2 superoxide dismutase 2, mitochondrial 0.0200589
MYOF myoferlin 0.0200454
MAP7 microtubule-associated protein 7 0.0199904
ANKRD10 ankyrin repeat domain 10 0.019832
NSUN6 NOP2/Sun domain family, member 6 0.0198132
RNF213 ring finger protein 213 0.0197493
ARHGAP26 Rho GTPase activating protein 26 0.0197305
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0197202
NRIP1 nuclear receptor interacting protein 1 0.0192862
PTK2 protein tyrosine kinase 2 0.019207
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 0.0191812
MYO1D myosin ID 0.0191285
DOCK4 dedicator of cytokinesis 4 0.0191257
MPRIP myosin phosphatase Rho interacting protein 0.0191073
FNIP1 folliculin interacting protein 1 0.0190173
NTSR1 neurotensin receptor 1 (high affinity) 0.0189881
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0189796
SDC4 syndecan 4 0.0189609
CUX1 cut-like homeobox 1 0.0188269
RPS25 ribosomal protein S25 0.0187734
AGO3 argonaute RISC catalytic component 3 0.018656
VEGFC vascular endothelial growth factor C 0.0186286
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0186006
PRKCA protein kinase C, alpha 0.0185444

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.284329
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.216143
NAMPT nicotinamide phosphoribosyltransferase -0.0855371
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0656472
GCLC glutamate-cysteine ligase, catalytic subunit -0.0605332
LMO7 LIM domain 7 -0.0532142
FTH1 ferritin, heavy polypeptide 1 -0.0518602
LAMA4 laminin, alpha 4 -0.0488811
OSMR oncostatin M receptor -0.0488795
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0486389
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0443211
MKI67 marker of proliferation Ki-67 -0.0441138
MT2A metallothionein 2A -0.0400033
BRWD1 bromodomain and WD repeat domain containing 1 -0.036491
CANX calnexin -0.0346803
BRWD3 bromodomain and WD repeat domain containing 3 -0.0332005
KDM3A lysine (K)-specific demethylase 3A -0.0320077
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0316095
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0313652
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0312167
NGLY1 N-glycanase 1 -0.0293136
TES testin LIM domain protein -0.0287496
BLZF1 basic leucine zipper nuclear factor 1 -0.0280347
EIF1 eukaryotic translation initiation factor 1 -0.0279648
HDLBP high density lipoprotein binding protein -0.0275756
SON SON DNA binding protein -0.0265351
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0262121
ZBTB20 zinc finger and BTB domain containing 20 -0.0254474
AHNAK AHNAK nucleoprotein -0.0246412
WDR45B WD repeat domain 45B -0.02447
H1-0 H1.0 linker histone -0.0242898
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0241752
PGK1 phosphoglycerate kinase 1 -0.0239929
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0237677
PRRC2C proline-rich coiled-coil 2C -0.0230184
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.022939
GCLM glutamate-cysteine ligase, modifier subunit -0.0227387
ABLIM1 actin binding LIM protein 1 -0.0226523
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0223607
RAD21 RAD21 homolog (S. pombe) -0.0221685
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0220009
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0216744
SLC38A1 solute carrier family 38, member 1 -0.0216271
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0214243
LMAN1 lectin, mannose-binding, 1 -0.0210297
UBC ubiquitin C -0.0209753
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0206714
MGAT4C MGAT4 family, member C -0.0206088
AKR1C1 aldo-keto reductase family 1, member C1 -0.0205856
NIPBL Nipped-B homolog (Drosophila) -0.0205634
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0200099
MARF1 meiosis regulator and mRNA stability factor 1 -0.0193514
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0193085
ZMYND8 zinc finger, MYND-type containing 8 -0.0190133
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0184857
TKT transketolase -0.0182039
TJP1 tight junction protein 1 -0.0181186
MGST1 microsomal glutathione S-transferase 1 -0.0180567
MORF4L2 mortality factor 4 like 2 -0.0177992
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0176724
RBM39 RNA binding motif protein 39 -0.0176502
GM2A GM2 ganglioside activator -0.0175861
GOLGB1 golgin B1 -0.0174988
CES1 carboxylesterase 1 -0.0173669
SCLT1 sodium channel and clathrin linker 1 -0.0173554
ZFR zinc finger RNA binding protein -0.0173107
LAMC2 laminin, gamma 2 -0.0171072
PDIA3 protein disulfide isomerase family A, member 3 -0.0169686
REL v-rel avian reticuloendotheliosis viral oncogene homolog -0.0167483
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0167235
METTL9 methyltransferase like 9 -0.0162627
KRT18 keratin 18, type I -0.0161904
KMT2A lysine (K)-specific methyltransferase 2A -0.0161274
SAMD9 sterile alpha motif domain containing 9 -0.016063
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0159423
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0159048
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0157086
CLTC clathrin, heavy chain (Hc) -0.0155652
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0154921
ZC3H11A zinc finger CCCH-type containing 11A -0.015402
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.015315
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0150457
OGA O-GlcNAcase -0.0150294
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0150019
CENPF centromere protein F, 350/400kDa -0.0148881
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0148481
CCND1 cyclin D1 -0.0148225
FOXP1 forkhead box P1 -0.0146941
YTHDC1 YTH domain containing 1 -0.0146544
AFF4 AF4/FMR2 family, member 4 -0.0146354
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0145866
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0145438
ARL5B ADP-ribosylation factor-like 5B -0.0143711
ZC3H15 zinc finger CCCH-type containing 15 -0.0142967
PHKB phosphorylase kinase, beta -0.0142783
NCOR1 nuclear receptor corepressor 1 -0.0142
C15ORF48 chromosome 15 open reading frame 48 -0.0139537
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.013863
RPLP0 ribosomal protein, large, P0 -0.0136737
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0135831