| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Capivasertib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.118474 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.114598 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0982367 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0890606 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0852548 |
| COPA | coatomer protein complex, subunit alpha | 0.0815674 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0780135 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.076438 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0753681 |
| RBM39 | RNA binding motif protein 39 | 0.0691391 |
| FMNL2 | formin-like 2 | 0.0672757 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0655221 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0646021 |
| MT2A | metallothionein 2A | 0.063055 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0624465 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0595001 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0593536 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0579641 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0538672 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0536049 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0520808 |
| RBM25 | RNA binding motif protein 25 | 0.0515468 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.05 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0497771 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0477813 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0477297 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0470595 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0469584 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.046254 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0452097 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0451058 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0450841 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0443909 |
| PARD3 | par-3 family cell polarity regulator | 0.0439197 |
| DSCAM | Down syndrome cell adhesion molecule | 0.043344 |
| PTK2 | protein tyrosine kinase 2 | 0.0433349 |
| ZNF207 | zinc finger protein 207 | 0.0429199 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0423184 |
| CCNL1 | cyclin L1 | 0.0423021 |
| CUL3 | cullin 3 | 0.0423002 |
| RCOR1 | REST corepressor 1 | 0.0421703 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.041636 |
| USP36 | ubiquitin specific peptidase 36 | 0.0415492 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0414333 |
| FLNB | filamin B, beta | 0.041361 |
| TOP1 | topoisomerase (DNA) I | 0.0410647 |
| TFG | TRK-fused gene | 0.0407636 |
| GLG1 | golgi glycoprotein 1 | 0.0405157 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0396454 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0391887 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0391596 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0382454 |
| FBXO11 | F-box protein 11 | 0.0382027 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0381224 |
| ITGB5 | integrin, beta 5 | 0.038101 |
| WDR43 | WD repeat domain 43 | 0.0380589 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0376979 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0374991 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0374532 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0367915 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0367499 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0364449 |
| GOLGA4 | golgin A4 | 0.0364202 |
| HELZ | helicase with zinc finger | 0.0363163 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0362846 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0361681 |
| FOXO3 | forkhead box O3 | 0.0358581 |
| NOP58 | NOP58 ribonucleoprotein | 0.0356753 |
| MCL1 | myeloid cell leukemia 1 | 0.0355239 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0350487 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0348577 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0348217 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0347926 |
| CCNY | cyclin Y | 0.0347702 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0346768 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.034416 |
| NUMB | numb homolog (Drosophila) | 0.0341809 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0340136 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0339664 |
| RPL37A | ribosomal protein L37a | 0.0335636 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0333691 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0332714 |
| WDR20 | WD repeat domain 20 | 0.032915 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0329072 |
| SPAG9 | sperm associated antigen 9 | 0.0328808 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0325535 |
| SETD5 | SET domain containing 5 | 0.0324755 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.032406 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0322637 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0320689 |
| NCKAP1 | NCK-associated protein 1 | 0.0316707 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0316691 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0316068 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0314161 |
| SRP54 | signal recognition particle 54kDa | 0.0311672 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0311034 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.031034 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0308279 |
| ACTN1 | actinin, alpha 1 | 0.0307813 |
| RBM6 | RNA binding motif protein 6 | 0.030768 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.174379 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.164278 |
| GRAMD1B | GRAM domain containing 1B | -0.105482 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.087662 |
| VIM | vimentin | -0.0857492 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0778737 |
| FGB | fibrinogen beta chain | -0.0716841 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0686443 |
| BICC1 | BicC family RNA binding protein 1 | -0.0553459 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.052763 |
| FTL | ferritin, light polypeptide | -0.0510385 |
| ASPH | aspartate beta-hydroxylase | -0.0500671 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0481221 |
| IGF2 | insulin-like growth factor 2 | -0.0446614 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0445841 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0434712 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0432329 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0423686 |
| WWOX | WW domain containing oxidoreductase | -0.0419175 |
| EFNA5 | ephrin-A5 | -0.0405548 |
| HDAC9 | histone deacetylase 9 | -0.0396752 |
| LDHA | lactate dehydrogenase A | -0.0381169 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0373034 |
| DST | dystonin | -0.0371774 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0368869 |
| MKI67 | marker of proliferation Ki-67 | -0.0339408 |
| CENPF | centromere protein F, 350/400kDa | -0.0325028 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0319064 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0315586 |
| ENO1 | enolase 1, (alpha) | -0.0312955 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0311501 |
| PKM | pyruvate kinase, muscle | -0.0300471 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0297481 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.029607 |
| NEGR1 | neuronal growth regulator 1 | -0.0291759 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0288837 |
| NNMT | nicotinamide N-methyltransferase | -0.0283101 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0273522 |
| LAMB1 | laminin, beta 1 | -0.0272246 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0266354 |
| RAD51B | RAD51 paralog B | -0.0259303 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0255457 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0246702 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0238885 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.023614 |
| AHR | aryl hydrocarbon receptor | -0.0230382 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0229768 |
| FGG | fibrinogen gamma chain | -0.0227311 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0225998 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0223516 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0217223 |
| THBS1 | thrombospondin 1 | -0.0215339 |
| ACTG1 | actin gamma 1 | -0.0214404 |
| SRGN | serglycin | -0.0211785 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0201006 |
| TUBB | tubulin, beta class I | -0.0200859 |
| FOXP1 | forkhead box P1 | -0.0197301 |
| NRG1 | neuregulin 1 | -0.0196714 |
| MAP1B | microtubule-associated protein 1B | -0.0193156 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0192796 |
| SVIL | supervillin | -0.019216 |
| RPL4 | ribosomal protein L4 | -0.0191543 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0190966 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0190735 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0190047 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0189682 |
| PTMA | prothymosin, alpha | -0.0187508 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0186331 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0184717 |
| CBX5 | chromobox homolog 5 | -0.0183709 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0182784 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0182157 |
| TUBA1B | tubulin, alpha 1b | -0.0181511 |
| RPL7 | ribosomal protein L7 | -0.0180233 |
| YBX1 | Y box binding protein 1 | -0.0179692 |
| AK1 | adenylate kinase 1 | -0.0174525 |
| ZNF804A | zinc finger protein 804A | -0.0173745 |
| CLU | clusterin | -0.0172913 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0172277 |
| UTRN | utrophin | -0.0171108 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0170837 |
| NTN4 | netrin 4 | -0.0170702 |
| TPM4 | tropomyosin 4 | -0.0163265 |
| TMEM123 | transmembrane protein 123 | -0.0162801 |
| FSTL5 | follistatin-like 5 | -0.016233 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0162254 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0161646 |
| TPX2 | TPX2, microtubule-associated | -0.016138 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.016062 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0159183 |
| KNL1 | kinetochore scaffold 1 | -0.015798 |
| PRDX1 | peroxiredoxin 1 | -0.0155969 |
| LDHB | lactate dehydrogenase B | -0.0155811 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | -0.0155303 |
| EXOC4 | exocyst complex component 4 | -0.0152622 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0151367 |
| STMN1 | stathmin 1 | -0.0151304 |
| RNF213 | ring finger protein 213 | -0.014734 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0147263 |
| ANLN | anillin, actin binding protein | -0.0145956 |
