| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Capivasertib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | 0.208768 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.140616 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.113732 |
| PLAUR | plasminogen activator, urokinase receptor | 0.101092 |
| LAMA4 | laminin, alpha 4 | 0.0973424 |
| OGA | O-GlcNAcase | 0.0912624 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0909499 |
| NDRG1 | N-myc downstream regulated 1 | 0.0886871 |
| KRT17 | keratin 17, type I | 0.0808546 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0797151 |
| NAV2 | neuron navigator 2 | 0.0777093 |
| LAMB3 | laminin, beta 3 | 0.0738539 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0737349 |
| LAMC2 | laminin, gamma 2 | 0.0723786 |
| MXD1 | MAX dimerization protein 1 | 0.0698756 |
| MYO1E | myosin IE | 0.0691071 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0633623 |
| FAM13A | family with sequence similarity 13, member A | 0.0628417 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.062794 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0620961 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0580563 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0569255 |
| RPS6 | ribosomal protein S6 | 0.0548797 |
| NPTN | neuroplastin | 0.054461 |
| KYNU | kynureninase | 0.0527653 |
| NEBL | nebulette | 0.0527206 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0483551 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.048232 |
| INTS6 | integrator complex subunit 6 | 0.0478349 |
| JMJD1C | jumonji domain containing 1C | 0.0477582 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0470576 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0466491 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0465424 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.046447 |
| CYTH1 | cytohesin 1 | 0.0459792 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0457125 |
| RIC1 | RAB6A GEF complex partner 1 | 0.0456971 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0456406 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0450918 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0443856 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.044046 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0426552 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0426206 |
| H1-0 | H1.0 linker histone | 0.0423938 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0416216 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0412315 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0407339 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0399926 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.03987 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0398164 |
| YAP1 | Yes-associated protein 1 | 0.0397581 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0394554 |
| YOD1 | YOD1 deubiquitinase | 0.0388416 |
| SETD5 | SET domain containing 5 | 0.0388414 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0388309 |
| RNF149 | ring finger protein 149 | 0.037731 |
| ATOSA | atos homolog A | 0.0377093 |
| ANXA2 | annexin A2 | 0.0375936 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0375573 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.037026 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0370056 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0368281 |
| RAB10 | RAB10, member RAS oncogene family | 0.0365154 |
| SDC4 | syndecan 4 | 0.0358475 |
| TUFT1 | tuftelin 1 | 0.0355628 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0350778 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0349087 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0344801 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0343857 |
| XPO1 | exportin 1 | 0.0342285 |
| DTNA | dystrobrevin, alpha | 0.0341608 |
| MUC16 | mucin 16, cell surface associated | 0.0340902 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0340798 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0340508 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.03358 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0332899 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0328355 |
| CA12 | carbonic anhydrase XII | 0.0325354 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0322172 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0320126 |
| ABLIM1 | actin binding LIM protein 1 | 0.0317793 |
| SLK | STE20-like kinase | 0.0317666 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0314946 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0314749 |
| LDHA | lactate dehydrogenase A | 0.0312237 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0311894 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0311259 |
| ZNF638 | zinc finger protein 638 | 0.0309291 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0308795 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0308345 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0306979 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0306656 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0304338 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0300519 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0299687 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0299306 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0297598 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | 0.0293165 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0282668 |
| SEPTIN2 | septin 2 | 0.0282319 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IFIH1 | interferon induced with helicase C domain 1 | -0.117755 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.10325 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0924078 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0908915 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0859757 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.085954 |
| PRRC2C | proline-rich coiled-coil 2C | -0.085854 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0812057 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0728404 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0720791 |
| STK17A | serine/threonine kinase 17a | -0.0704868 |
| SPAG9 | sperm associated antigen 9 | -0.0692141 |
| GPC6 | glypican 6 | -0.0676159 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0668337 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0660522 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0635503 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0604412 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.060252 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0571183 |
| PDE10A | phosphodiesterase 10A | -0.0558959 |
| SMYD3 | SET and MYND domain containing 3 | -0.0555905 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0554169 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0553545 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0553241 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0553201 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0540796 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | -0.0527697 |
| FAT1 | FAT atypical cadherin 1 | -0.0521498 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0513347 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0510413 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0492101 |
| RTN4 | reticulon 4 | -0.0487225 |
| TAOK3 | TAO kinase 3 | -0.0481085 |
| SLMAP | sarcolemma associated protein | -0.047865 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0476181 |
| PAPOLA | poly(A) polymerase alpha | -0.0470624 |
| SYT1 | synaptotagmin I | -0.0470211 |
| FTO | fat mass and obesity associated | -0.046245 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0453621 |
| BPTF | bromodomain PHD finger transcription factor | -0.0452457 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0448722 |
| COPA | coatomer protein complex, subunit alpha | -0.0448384 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0444195 |
| ASPH | aspartate beta-hydroxylase | -0.0439241 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | -0.0432709 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0432408 |
| CUL3 | cullin 3 | -0.042872 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0428298 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0428153 |
| VDAC1 | voltage-dependent anion channel 1 | -0.042554 |
| B2M | beta-2-microglobulin | -0.0424944 |
| NRG1 | neuregulin 1 | -0.0423544 |
| NBAS | neuroblastoma amplified sequence | -0.0419386 |
| NF1 | neurofibromin 1 | -0.0418975 |
| MRTFA | myocardin related transcription factor A | -0.040748 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0407426 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0406828 |
| SETX | senataxin | -0.0406218 |
| FRMD5 | FERM domain containing 5 | -0.0404831 |
| PCBP3 | poly(rC) binding protein 3 | -0.0401571 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0390539 |
| RAD51B | RAD51 paralog B | -0.038704 |
| RPL35A | ribosomal protein L35a | -0.0383849 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0378411 |
| TXNRD1 | thioredoxin reductase 1 | -0.0376867 |
| EFNA5 | ephrin-A5 | -0.037411 |
| ETV6 | ets variant 6 | -0.037344 |
| ZNF148 | zinc finger protein 148 | -0.0373146 |
| NEDD1 | neural precursor cell expressed, developmentally down-regulated 1 | -0.0366337 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.035687 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0354088 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0350082 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0342261 |
| MORC3 | MORC family CW-type zinc finger 3 | -0.0342249 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0341925 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0340678 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0337203 |
| PGK1 | phosphoglycerate kinase 1 | -0.0333123 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0332007 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0331958 |
| CDYL | chromodomain protein, Y-like | -0.033021 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0329738 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.032267 |
| HMBOX1 | homeobox containing 1 | -0.0321159 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0319058 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0318008 |
| RFX7 | regulatory factor X, 7 | -0.0317286 |
| GPATCH8 | G patch domain containing 8 | -0.0316705 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0315288 |
| FN1 | fibronectin 1 | -0.0313762 |
| POTEF | POTE ankyrin domain family, member F | -0.0308577 |
| RNF145 | ring finger protein 145 | -0.0306206 |
| MYO6 | myosin VI | -0.0305378 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0304239 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0303661 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0302153 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0302074 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0297686 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0297475 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0296478 |
