| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capivasertib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COPA | coatomer protein complex, subunit alpha | 0.071989 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0716371 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.07089 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0671035 |
| INTS6 | integrator complex subunit 6 | 0.0667235 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0658336 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0627583 |
| PRELID2 | PRELI domain containing 2 | 0.0617429 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0581424 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.057417 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0531465 |
| PRKCE | protein kinase C, epsilon | 0.0516545 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0503888 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0477955 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0462099 |
| AEBP2 | AE binding protein 2 | 0.0460157 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.04526 |
| RAD51B | RAD51 paralog B | 0.0448744 |
| FBXO11 | F-box protein 11 | 0.0448326 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0424604 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.041925 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0415401 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0414294 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0403187 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0402712 |
| MCL1 | myeloid cell leukemia 1 | 0.0400696 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0393188 |
| WWOX | WW domain containing oxidoreductase | 0.0391857 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0385352 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0383003 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0372298 |
| ATXN1 | ataxin 1 | 0.0361603 |
| CANX | calnexin | 0.0358809 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0354005 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0353711 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0346167 |
| ATXN2 | ataxin 2 | 0.0343601 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0342409 |
| LRRC23 | leucine rich repeat containing 23 | 0.0342341 |
| GON4L | gon-4-like (C. elegans) | 0.0338198 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0332011 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0330854 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0322846 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0322184 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.031803 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0314055 |
| NF1 | neurofibromin 1 | 0.0313167 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0310259 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0310126 |
| SETD5 | SET domain containing 5 | 0.0308399 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0304922 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0302891 |
| TMEM14B | transmembrane protein 14B | 0.030263 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0302486 |
| HOMER1 | homer scaffolding protein 1 | 0.0301006 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0300059 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.029972 |
| ZNF638 | zinc finger protein 638 | 0.0298356 |
| GOLGB1 | golgin B1 | 0.0297523 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0294864 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0294106 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0294012 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0293761 |
| FMNL2 | formin-like 2 | 0.0289756 |
| FNIP1 | folliculin interacting protein 1 | 0.0288853 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0288277 |
| PYGL | phosphorylase, glycogen, liver | 0.0286121 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0276336 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0274658 |
| RSF1 | remodeling and spacing factor 1 | 0.0273701 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0271476 |
| HELZ | helicase with zinc finger | 0.0271116 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0270425 |
| SEPTIN2 | septin 2 | 0.0265599 |
| PMM2 | phosphomannomutase 2 | 0.0265219 |
| R3HDM2 | R3H domain containing 2 | 0.0262092 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0261479 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0256959 |
| RLF | rearranged L-myc fusion | 0.0251336 |
| DCAF8 | DDB1 and CUL4 associated factor 8 | 0.0249628 |
| DIDO1 | death inducer-obliterator 1 | 0.024932 |
| PATJ | PATJ crumbs cell polarity complex component | 0.024625 |
| CUX1 | cut-like homeobox 1 | 0.024586 |
| COG6 | component of oligomeric golgi complex 6 | 0.0242483 |
| ANO6 | anoctamin 6 | 0.0242138 |
| RSU1 | Ras suppressor protein 1 | 0.0240556 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | 0.0239481 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0239279 |
| CALU | calumenin | 0.0237287 |
| RPL37A | ribosomal protein L37a | 0.0236388 |
| ATF6 | activating transcription factor 6 | 0.0233519 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.0231351 |
| YBX3 | Y box binding protein 3 | 0.0229983 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | 0.0229843 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0228225 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.02282 |
| GPATCH2L | G patch domain containing 2-like | 0.0227963 |
| HMGA2 | high mobility group AT-hook 2 | 0.0227674 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0226658 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0225269 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.191506 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.139375 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0730309 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0614585 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0593441 |
| UBC | ubiquitin C | -0.0497456 |
| VIM | vimentin | -0.0491594 |
| GRAMD1B | GRAM domain containing 1B | -0.0491195 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0447947 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0444337 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0438235 |
| POTEF | POTE ankyrin domain family, member F | -0.0410502 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0405394 |
| TMSB10 | thymosin beta 10 | -0.0402714 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0383693 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0380059 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0376274 |
| TPI1 | triosephosphate isomerase 1 | -0.036728 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0341187 |
| RPS27A | ribosomal protein S27a | -0.0332645 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0332623 |
| CCDC91 | coiled-coil domain containing 91 | -0.0319341 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0302935 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0298649 |
| CENPF | centromere protein F, 350/400kDa | -0.0298191 |
| OSMR | oncostatin M receptor | -0.0295213 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0282176 |
| EGR1 | early growth response 1 | -0.0276181 |
| MKI67 | marker of proliferation Ki-67 | -0.0274404 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.0263403 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0257831 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0253609 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0244286 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0242909 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0240544 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0237881 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.02326 |
| LDHB | lactate dehydrogenase B | -0.0224573 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0220958 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0219308 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0217768 |
| CCND1 | cyclin D1 | -0.0214128 |
| SFPQ | splicing factor proline/glutamine-rich | -0.021195 |
| ACTG1 | actin gamma 1 | -0.0211429 |
| CENPE | centromere protein E, 312kDa | -0.0210803 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0209 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0207484 |
| MYPN | myopalladin | -0.0206506 |
| PKM | pyruvate kinase, muscle | -0.0205671 |
| STC1 | stanniocalcin 1 | -0.0205207 |
| YBX1 | Y box binding protein 1 | -0.020473 |
| PLSCR1 | phospholipid scramblase 1 | -0.0204627 |
| TUBA1B | tubulin, alpha 1b | -0.0201093 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0201003 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0197469 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.0197232 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0194234 |
| RPL12 | ribosomal protein L12 | -0.0189185 |
| RPL5 | ribosomal protein L5 | -0.0187609 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0187426 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | -0.0186957 |
| RTN4 | reticulon 4 | -0.0185681 |
| MT2A | metallothionein 2A | -0.0185127 |
| TPX2 | TPX2, microtubule-associated | -0.0182918 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0182651 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0181814 |
| RAI1 | retinoic acid induced 1 | -0.017983 |
| KIF18B | kinesin family member 18B | -0.0178193 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0176258 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0175504 |
| SET | SET nuclear proto-oncogene | -0.0175272 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0175221 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.017193 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0170217 |
| AHNAK | AHNAK nucleoprotein | -0.0169803 |
| SON | SON DNA binding protein | -0.0169689 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | -0.0167675 |
| RIGI | RNA sensor RIG-I | -0.0165942 |
| TMPO | thymopoietin | -0.0165082 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0165059 |
| LATS2 | large tumor suppressor kinase 2 | -0.0164961 |
| CD44 | CD44 molecule (Indian blood group) | -0.0163182 |
| KLHL5 | kelch-like family member 5 | -0.0163152 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0161385 |
| RRM2 | ribonucleotide reductase M2 | -0.0161014 |
| PHIP | pleckstrin homology domain interacting protein | -0.0160885 |
| PTMA | prothymosin, alpha | -0.0158353 |
| RPL23 | ribosomal protein L23 | -0.0157599 |
| RPLP1 | ribosomal protein, large, P1 | -0.0156926 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0156734 |
| PLCB4 | phospholipase C, beta 4 | -0.0156324 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0155512 |
| SNX9 | sorting nexin 9 | -0.0152822 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0152475 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.0152228 |
| EZR | ezrin | -0.0151645 |
| SBF2 | SET binding factor 2 | -0.0151199 |
| SYT1 | synaptotagmin I | -0.0150968 |
| GPSM2 | G-protein signaling modulator 2 | -0.0150254 |
| KRT18 | keratin 18, type I | -0.0149335 |
