| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capivasertib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.110668 |
| SDC4 | syndecan 4 | 0.0709361 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0704844 |
| MSN | moesin | 0.0685748 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0668763 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0629476 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0622742 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0605755 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0601735 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0596516 |
| RBM25 | RNA binding motif protein 25 | 0.058959 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0584901 |
| RNF145 | ring finger protein 145 | 0.0563636 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0552929 |
| FTL | ferritin, light polypeptide | 0.0542013 |
| RASA2 | RAS p21 protein activator 2 | 0.0512662 |
| TMSB10 | thymosin beta 10 | 0.0504526 |
| HMGA1 | high mobility group AT-hook 1 | 0.0493503 |
| USP3 | ubiquitin specific peptidase 3 | 0.0487364 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.046542 |
| DTNA | dystrobrevin, alpha | 0.045748 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0448438 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0447068 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.044618 |
| NPTN | neuroplastin | 0.0444097 |
| ZNF292 | zinc finger protein 292 | 0.0442615 |
| LAMB3 | laminin, beta 3 | 0.0440326 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0435705 |
| FAM13A | family with sequence similarity 13, member A | 0.0434821 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0426351 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0414446 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0413288 |
| JUP | junction plakoglobin | 0.041037 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0409868 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0408829 |
| PTK2 | protein tyrosine kinase 2 | 0.0406033 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0401264 |
| DUSP10 | dual specificity phosphatase 10 | 0.0397977 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0390914 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0388823 |
| TPD52 | tumor protein D52 | 0.0387212 |
| CCNL1 | cyclin L1 | 0.0384636 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0379966 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0375035 |
| POTEF | POTE ankyrin domain family, member F | 0.037445 |
| SNX9 | sorting nexin 9 | 0.0372101 |
| TFG | TRK-fused gene | 0.0366481 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.036613 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0359057 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0358483 |
| PCBP2 | poly(rC) binding protein 2 | 0.035705 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0354787 |
| CDC73 | cell division cycle 73 | 0.0346223 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0345606 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0345419 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0343901 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0330761 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0330096 |
| MYO5B | myosin VB | 0.0324498 |
| HELZ | helicase with zinc finger | 0.0316873 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0316697 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0316018 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0315546 |
| RNASE3 | ribonuclease, RNase A family, 3 | 0.0313862 |
| RYBP | RING1 and YY1 binding protein | 0.0313013 |
| EZR | ezrin | 0.0312514 |
| ATP11B | ATPase, class VI, type 11B | 0.0309863 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0304099 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0302032 |
| ATP13A3 | ATPase type 13A3 | 0.0300192 |
| AFDN | afadin, adherens junction formation factor | 0.0299859 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0298921 |
| MYO10 | myosin X | 0.0297959 |
| TJP2 | tight junction protein 2 | 0.0294991 |
| RLF | rearranged L-myc fusion | 0.0287468 |
| MTMR3 | myotubularin related protein 3 | 0.0284414 |
| MEF2A | myocyte enhancer factor 2A | 0.0282121 |
| TPM3 | tropomyosin 3 | 0.02815 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.027763 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0277051 |
| SLMAP | sarcolemma associated protein | 0.0275354 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0274481 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0273205 |
| CLINT1 | clathrin interactor 1 | 0.0270442 |
| FAM3C | family with sequence similarity 3, member C | 0.0270253 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0269478 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0268209 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0265611 |
| CORO1C | coronin, actin binding protein, 1C | 0.0265456 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0264819 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0263753 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0261544 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0261443 |
| SPAG9 | sperm associated antigen 9 | 0.0260894 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0260722 |
| CDK17 | cyclin-dependent kinase 17 | 0.0259679 |
| ANXA5 | annexin A5 | 0.0258506 |
| SF1 | splicing factor 1 | 0.0258337 |
| SRPK2 | SRSF protein kinase 2 | 0.0256337 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0255497 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SAMD4A | sterile alpha motif domain containing 4A | -0.165072 |
| EFNA5 | ephrin-A5 | -0.148055 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.146732 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.137552 |
| ACTG1 | actin gamma 1 | -0.12587 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0884489 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0870343 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0870093 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0770246 |
| FN1 | fibronectin 1 | -0.0670555 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0627098 |
| FNIP1 | folliculin interacting protein 1 | -0.0626069 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0602598 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0597745 |
| INTS6 | integrator complex subunit 6 | -0.057779 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0571793 |
| VCL | vinculin | -0.0563405 |
| LMO7 | LIM domain 7 | -0.0552697 |
| ARF1 | ADP-ribosylation factor 1 | -0.0518424 |
| FBXO32 | F-box protein 32 | -0.0518238 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0507506 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.04925 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.046956 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0467652 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0458958 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0458103 |
| FBXO34 | F-box protein 34 | -0.0446206 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0444495 |
| GNAS | GNAS complex locus | -0.0441752 |
| CANX | calnexin | -0.043869 |
| RAI14 | retinoic acid induced 14 | -0.043784 |
| NAV2 | neuron navigator 2 | -0.0434136 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0429197 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.042634 |
| TPM4 | tropomyosin 4 | -0.0422147 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0418631 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.041137 |
| CCND1 | cyclin D1 | -0.0402066 |
| MYO1E | myosin IE | -0.03976 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0386055 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0382451 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0380027 |
| PDLIM5 | PDZ and LIM domain 5 | -0.037793 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0377549 |
| RPS29 | ribosomal protein S29 | -0.0371768 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0365711 |
| CEP350 | centrosomal protein 350kDa | -0.0357632 |
| ATP11A | ATPase, class VI, type 11A | -0.0342291 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0339029 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0335215 |
| ARF4 | ADP-ribosylation factor 4 | -0.033054 |
| TMSB4X | thymosin beta 4, X-linked | -0.0324476 |
| RPS23 | ribosomal protein S23 | -0.0323433 |
| LDHA | lactate dehydrogenase A | -0.0322881 |
| LOXL2 | lysyl oxidase-like 2 | -0.0322468 |
| ENO1 | enolase 1, (alpha) | -0.0318759 |
| RPS27A | ribosomal protein S27a | -0.0318205 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0318026 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0317661 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0315254 |
| HDLBP | high density lipoprotein binding protein | -0.0306588 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0303953 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0303829 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0303804 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0300349 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0292324 |
| RIGI | RNA sensor RIG-I | -0.0292054 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0291268 |
| UBAP1 | ubiquitin associated protein 1 | -0.0290456 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.028776 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0286548 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0283521 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.0283057 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0282137 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.027955 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0274556 |
| CAVIN1 | caveolae associated protein 1 | -0.0271416 |
| RPS3 | ribosomal protein S3 | -0.0269384 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0266518 |
| MAP4 | microtubule-associated protein 4 | -0.0266341 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0265023 |
| EPCAM | epithelial cell adhesion molecule | -0.0264224 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0261939 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0260898 |
| AHNAK | AHNAK nucleoprotein | -0.0260523 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0259365 |
| RPS27 | ribosomal protein S27 | -0.0258795 |
| RNF213 | ring finger protein 213 | -0.025762 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0256684 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0256656 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0253644 |
| GOLGB1 | golgin B1 | -0.0251263 |
| PHF3 | PHD finger protein 3 | -0.0248963 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.0248032 |
| PTMA | prothymosin, alpha | -0.0245895 |
| CUX1 | cut-like homeobox 1 | -0.0245417 |
| PALLD | palladin, cytoskeletal associated protein | -0.0243796 |
| LAMC2 | laminin, gamma 2 | -0.0243722 |
| RPS13 | ribosomal protein S13 | -0.0243648 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0241511 |
