| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Capivasertib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0727354 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.067131 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0584437 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.056038 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0559133 |
| KYNU | kynureninase | 0.0555079 |
| FMNL2 | formin-like 2 | 0.0532008 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0496178 |
| MCL1 | myeloid cell leukemia 1 | 0.0485264 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0476571 |
| GDA | guanine deaminase | 0.0457578 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0454329 |
| GRAMD1B | GRAM domain containing 1B | 0.0431936 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0429723 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0418959 |
| NEK7 | NIMA-related kinase 7 | 0.0418579 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0413068 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0410118 |
| EZR | ezrin | 0.0407332 |
| FLNB | filamin B, beta | 0.0403925 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0393356 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0380964 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0369953 |
| RTN4 | reticulon 4 | 0.0366525 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0361557 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0344953 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.03421 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0339099 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0332558 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0319114 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0318201 |
| OGA | O-GlcNAcase | 0.0307477 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0300242 |
| CD44 | CD44 molecule (Indian blood group) | 0.0292936 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0291343 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0279269 |
| NBEAL1 | neurobeachin-like 1 | 0.0276862 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0273088 |
| USP53 | ubiquitin specific peptidase 53 | 0.0268741 |
| GOLGA4 | golgin A4 | 0.0268596 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0268551 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0264699 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0261504 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0259485 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0256989 |
| BMERB1 | bMERB domain containing 1 | 0.0256915 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0256206 |
| MYO10 | myosin X | 0.0254079 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0253202 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0248177 |
| SPAG9 | sperm associated antigen 9 | 0.0246789 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0242004 |
| CTBP2 | C-terminal binding protein 2 | 0.0241254 |
| MSN | moesin | 0.0238692 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0238107 |
| OXSR1 | oxidative stress responsive 1 | 0.0234256 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0229061 |
| COPA | coatomer protein complex, subunit alpha | 0.022624 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0224542 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0222936 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0222005 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0220683 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0220466 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0220205 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0217151 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0216707 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0216672 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0216491 |
| ACVR1 | activin A receptor, type I | 0.0215357 |
| RASAL2 | RAS protein activator like 2 | 0.0214002 |
| BMP6 | bone morphogenetic protein 6 | 0.0212335 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0210929 |
| CD109 | CD109 molecule | 0.0210124 |
| MED13 | mediator complex subunit 13 | 0.0208188 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0207966 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0206915 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0201723 |
| JMJD1C | jumonji domain containing 1C | 0.0199378 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0199368 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0198779 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0198679 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0198533 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0194822 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0194286 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0194176 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0191895 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0191172 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0190763 |
| TNPO1 | transportin 1 | 0.0190758 |
| ACTN4 | actinin, alpha 4 | 0.0190757 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0189403 |
| ANXA1 | annexin A1 | 0.018926 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0189073 |
| HLA-A | major histocompatibility complex, class I, A | 0.0187446 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0186483 |
| ATP13A3 | ATPase type 13A3 | 0.018616 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | 0.018512 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0184857 |
| FNIP1 | folliculin interacting protein 1 | 0.0184166 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0184095 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.359394 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.173293 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.146606 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.139146 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.1163 |
| PDE10A | phosphodiesterase 10A | -0.105096 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.100796 |
| SMYD3 | SET and MYND domain containing 3 | -0.0817785 |
| FN1 | fibronectin 1 | -0.079475 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.063901 |
| CDH13 | cadherin 13 | -0.0588814 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0564902 |
| LSAMP | limbic system-associated membrane protein | -0.0509145 |
| COL5A2 | collagen, type V, alpha 2 | -0.0506063 |
| NCKAP5 | NCK-associated protein 5 | -0.046853 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0456574 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0456116 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0435268 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.043396 |
| CADM2 | cell adhesion molecule 2 | -0.0424062 |
| KIAA0825 | KIAA0825 | -0.0380311 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0380196 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0370444 |
| EFNA5 | ephrin-A5 | -0.0366586 |
| VIM | vimentin | -0.0361499 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0358641 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0358017 |
| RAD51B | RAD51 paralog B | -0.0354048 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.032382 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0320446 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0320241 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0314272 |
| PDE7B | phosphodiesterase 7B | -0.0303716 |
| PCDH15 | protocadherin-related 15 | -0.0300627 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0297078 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0285235 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0280647 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.027869 |
| RTN1 | reticulon 1 | -0.0276266 |
| PCBP3 | poly(rC) binding protein 3 | -0.0276174 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0269722 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0265254 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0263626 |
| NRCAM | neuronal cell adhesion molecule | -0.0263122 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0256143 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0250772 |
| ASPH | aspartate beta-hydroxylase | -0.0250471 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0244453 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0241958 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0229831 |
| ESM1 | endothelial cell-specific molecule 1 | -0.022868 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0227055 |
| RPS23 | ribosomal protein S23 | -0.0220378 |
| TENM3 | teneurin transmembrane protein 3 | -0.0220119 |
| DST | dystonin | -0.0210625 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0210564 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0209261 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0206661 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0205846 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0201259 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0194908 |
| RGS2 | regulator of G-protein signaling 2 | -0.019307 |
| RPS29 | ribosomal protein S29 | -0.0191761 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0191294 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0185199 |
| RPS24 | ribosomal protein S24 | -0.0180662 |
| SLCO1C1 | solute carrier organic anion transporter family, member 1C1 | -0.0179409 |
| PCDH9 | protocadherin 9 | -0.0177378 |
| EXOC4 | exocyst complex component 4 | -0.017468 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0171778 |
| TMSB10 | thymosin beta 10 | -0.0171352 |
| RPLP1 | ribosomal protein, large, P1 | -0.0166245 |
| PAPPA2 | pappalysin 2 | -0.016527 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0164721 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0163702 |
| RPL38 | ribosomal protein L38 | -0.0163619 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0161665 |
| RPLP2 | ribosomal protein, large, P2 | -0.0158686 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0158347 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0157902 |
| PRELID2 | PRELI domain containing 2 | -0.0157478 |
| AEBP2 | AE binding protein 2 | -0.0156581 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0155975 |
| GPC6 | glypican 6 | -0.015405 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | -0.0152794 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.015178 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | -0.0147243 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0144394 |
| RPS27A | ribosomal protein S27a | -0.014346 |
| RPL35A | ribosomal protein L35a | -0.0134738 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0134572 |
| RANBP17 | RAN binding protein 17 | -0.0134214 |
| IRS2 | insulin receptor substrate 2 | -0.0131945 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0131618 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0130873 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.013082 |
| THSD7A | thrombospondin, type I, domain containing 7A | -0.0128197 |
| GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 | -0.012723 |
| RPS19 | ribosomal protein S19 | -0.0126548 |
| FRMD4B | FERM domain containing 4B | -0.0124327 |
