| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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176 genes differentially expressed following the Capivasertib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.204204 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.12431 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.112985 |
| SLTM | SAFB-like, transcription modulator | 0.103785 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0995492 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0959315 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0934312 |
| SEPTIN9 | septin 9 | 0.0899213 |
| DOCK5 | dedicator of cytokinesis 5 | 0.08902 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0808431 |
| MT2A | metallothionein 2A | 0.0768578 |
| ENO1 | enolase 1, (alpha) | 0.0762093 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0758144 |
| GPHN | gephyrin | 0.0710387 |
| JMJD1C | jumonji domain containing 1C | 0.0693275 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0689332 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0687805 |
| RUNX1 | runt-related transcription factor 1 | 0.0656868 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.065493 |
| EFNA5 | ephrin-A5 | 0.0650816 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0635854 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0627036 |
| SMYD3 | SET and MYND domain containing 3 | 0.0626683 |
| DUSP5 | dual specificity phosphatase 5 | 0.0605749 |
| SBF2 | SET binding factor 2 | 0.0563911 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0563308 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0550375 |
| NDRG1 | N-myc downstream regulated 1 | 0.0548009 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0547414 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0539672 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0525166 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0502046 |
| SQSTM1 | sequestosome 1 | 0.0498026 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0458251 |
| MYOF | myoferlin | 0.0453913 |
| MCL1 | myeloid cell leukemia 1 | 0.0439147 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0438608 |
| GPC6 | glypican 6 | 0.0435563 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0432328 |
| LMO7 | LIM domain 7 | 0.0420414 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0417855 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0416492 |
| RAB10 | RAB10, member RAS oncogene family | 0.0410652 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0405693 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0403582 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0390609 |
| RPS12 | ribosomal protein S12 | 0.0388434 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0382002 |
| AFDN | afadin, adherens junction formation factor | 0.0367886 |
| RPS2 | ribosomal protein S2 | 0.0347646 |
| HDLBP | high density lipoprotein binding protein | 0.0342803 |
| RORA | RAR-related orphan receptor A | 0.0317071 |
| ACTG1 | actin gamma 1 | 0.0315785 |
| MYO1E | myosin IE | 0.0310198 |
| RPL12 | ribosomal protein L12 | 0.0306179 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0295682 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0293797 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0281424 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0276713 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0268726 |
| RPL35A | ribosomal protein L35a | 0.0259618 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0259001 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0242674 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0240459 |
| USP34 | ubiquitin specific peptidase 34 | 0.0223979 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0217752 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0210225 |
| RPLP2 | ribosomal protein, large, P2 | 0.0197171 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0173982 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0152704 |
| GRAMD1B | GRAM domain containing 1B | 0.0139919 |
| PTK2 | protein tyrosine kinase 2 | 0.0130982 |
| VCL | vinculin | 0.0127218 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0121644 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0097233 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.00956054 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.00882925 |
| RPL15 | ribosomal protein L15 | 0.00498127 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.00437842 |
| S100A6 | S100 calcium binding protein A6 | 0.00381487 |
| ANKRD12 | ankyrin repeat domain 12 | 0.00275227 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.00231203 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.244295 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.199667 |
| TMSB10 | thymosin beta 10 | -0.169573 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.156191 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.133167 |
| TXNRD1 | thioredoxin reductase 1 | -0.127559 |
| PKM | pyruvate kinase, muscle | -0.120019 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.114489 |
| NF1 | neurofibromin 1 | -0.108279 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0955212 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.092813 |
| NAV1 | neuron navigator 1 | -0.0925426 |
| AHNAK | AHNAK nucleoprotein | -0.0917233 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0894998 |
| MAP4 | microtubule-associated protein 4 | -0.0879421 |
| B2M | beta-2-microglobulin | -0.0862224 |
| LDHA | lactate dehydrogenase A | -0.084905 |
| OSMR | oncostatin M receptor | -0.083164 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0819033 |
| STC1 | stanniocalcin 1 | -0.0801937 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0756572 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0753396 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0749526 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0741465 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0737613 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.073022 |
| HLA-B | major histocompatibility complex, class I, B | -0.0689726 |
| FTL | ferritin, light polypeptide | -0.0682668 |
| ASPH | aspartate beta-hydroxylase | -0.0678087 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0596969 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0591492 |
| PRELID2 | PRELI domain containing 2 | -0.0565725 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0528428 |
| S100A9 | S100 calcium binding protein A9 | -0.0526059 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0514295 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0513739 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0501595 |
| HMGA2 | high mobility group AT-hook 2 | -0.0477829 |
| CCNI | cyclin I | -0.0465629 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0460003 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0457715 |
| UBC | ubiquitin C | -0.0453167 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.042009 |
| INTS6 | integrator complex subunit 6 | -0.0400773 |
| DST | dystonin | -0.0398133 |
| MED13L | mediator complex subunit 13-like | -0.0377985 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0371456 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0368862 |
| RPS6 | ribosomal protein S6 | -0.035991 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0356343 |
| RPL13A | ribosomal protein L13a | -0.034993 |
| FLNB | filamin B, beta | -0.0327313 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0315314 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0313414 |
| TXNIP | thioredoxin interacting protein | -0.0308986 |
| RPLP0 | ribosomal protein, large, P0 | -0.0285148 |
| FN1 | fibronectin 1 | -0.0284553 |
| RPL11 | ribosomal protein L11 | -0.0282056 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0270456 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0250897 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0236811 |
| RPL34 | ribosomal protein L34 | -0.0230299 |
| RPL26 | ribosomal protein L26 | -0.022399 |
| PTMA | prothymosin, alpha | -0.0221447 |
| FNIP1 | folliculin interacting protein 1 | -0.0212909 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0209491 |
| CD44 | CD44 molecule (Indian blood group) | -0.0205819 |
| RBM39 | RNA binding motif protein 39 | -0.0202745 |
| SETD5 | SET domain containing 5 | -0.0202098 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0190241 |
| SYAP1 | synapse associated protein 1 | -0.0187902 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0187625 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0180914 |
| NCOR1 | nuclear receptor corepressor 1 | -0.018072 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0173311 |
| FBXO11 | F-box protein 11 | -0.0172809 |
| RPS8 | ribosomal protein S8 | -0.0166218 |
| RPL31 | ribosomal protein L31 | -0.0151162 |
| RPS19 | ribosomal protein S19 | -0.0113325 |
| MORF4L2 | mortality factor 4 like 2 | -0.0109497 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.010633 |
| PGK1 | phosphoglycerate kinase 1 | -0.00726601 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00670852 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.00638247 |
| POTEF | POTE ankyrin domain family, member F | -0.00571542 |
| GOLGA4 | golgin A4 | -0.00527043 |
| ANXA2 | annexin A2 | -0.00396438 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.00241956 |
| RPLP1 | ribosomal protein, large, P1 | -0.00222722 |
| PDE10A | phosphodiesterase 10A | -0.00174765 |
| RPS3 | ribosomal protein S3 | -0.00126333 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.00120462 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -8.0373E-4 |
| RPL37A | ribosomal protein L37a | -1.20042E-4 |
