| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capivasertib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF292 | zinc finger protein 292 | 0.0998179 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0979835 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0913847 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0850609 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0832075 |
| HDAC9 | histone deacetylase 9 | 0.0672769 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.066995 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0660637 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0555215 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0548804 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0525227 |
| PLPP1 | phospholipid phosphatase 1 | 0.0522528 |
| JMJD1C | jumonji domain containing 1C | 0.0515483 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0507032 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0502374 |
| NCKAP1 | NCK-associated protein 1 | 0.0501148 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0494755 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0490726 |
| ITGAV | integrin, alpha V | 0.0477943 |
| RCOR1 | REST corepressor 1 | 0.0471624 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0467356 |
| TRAK1 | trafficking protein, kinesin binding 1 | 0.0466556 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0456977 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0456719 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0456534 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0453792 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0452344 |
| SMYD3 | SET and MYND domain containing 3 | 0.0450037 |
| RPS12 | ribosomal protein S12 | 0.044855 |
| CDH19 | cadherin 19, type 2 | 0.0447871 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0446817 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0440114 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0426726 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0426311 |
| RIGI | RNA sensor RIG-I | 0.04261 |
| PRTG | protogenin | 0.0410867 |
| PGAP1 | post-GPI attachment to proteins 1 | 0.040879 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0400435 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0399341 |
| PCDH18 | protocadherin 18 | 0.0399172 |
| SRPK2 | SRSF protein kinase 2 | 0.0392645 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0385561 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0382686 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0374869 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0369904 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0368731 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0366155 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0364795 |
| TMEM165 | transmembrane protein 165 | 0.0362532 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.036155 |
| COL5A2 | collagen, type V, alpha 2 | 0.0359799 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0355626 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0354931 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0354212 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0353058 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0349881 |
| NFIA | nuclear factor I/A | 0.0340116 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0339468 |
| NHSL1 | NHS-like 1 | 0.0334618 |
| XPO1 | exportin 1 | 0.032756 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0327386 |
| MB21D2 | Mab-21 domain containing 2 | 0.0320285 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0314295 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.031394 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0313283 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0310847 |
| FIGN | fidgetin | 0.030615 |
| YAP1 | Yes-associated protein 1 | 0.0303933 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0303489 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0302293 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0298782 |
| OPHN1 | oligophrenin 1 | 0.0296124 |
| ACTN4 | actinin, alpha 4 | 0.0292929 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | 0.0292594 |
| NF1 | neurofibromin 1 | 0.0291896 |
| RBM20 | RNA binding motif protein 20 | 0.0291755 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0291415 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0289729 |
| RTN4 | reticulon 4 | 0.0289639 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0287936 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0286649 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0285819 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0284358 |
| ENAH | enabled homolog (Drosophila) | 0.0282887 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.028004 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0276157 |
| CUX1 | cut-like homeobox 1 | 0.0275274 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0274335 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0273847 |
| RPL37A | ribosomal protein L37a | 0.0273639 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0272926 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0272926 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0271307 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0269193 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0268808 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0268637 |
| CDC14A | cell division cycle 14A | 0.0267937 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0265886 |
| SPAG9 | sperm associated antigen 9 | 0.0265112 |
| ATXN2 | ataxin 2 | 0.0264062 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.243427 |
| COL11A1 | collagen, type XI, alpha 1 | -0.135095 |
| PTMA | prothymosin, alpha | -0.115919 |
| GPC3 | glypican 3 | -0.109411 |
| TMSB10 | thymosin beta 10 | -0.0942647 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0918529 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0832413 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0789605 |
| CADM2 | cell adhesion molecule 2 | -0.0762945 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0713866 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0624064 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0623592 |
| MAP4 | microtubule-associated protein 4 | -0.0606976 |
| EMP1 | epithelial membrane protein 1 | -0.0605663 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0596603 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0589643 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0556355 |
| RAI1 | retinoic acid induced 1 | -0.0528721 |
| HMGB1 | high mobility group box 1 | -0.0521345 |
| RPS6 | ribosomal protein S6 | -0.0517147 |
| PEG10 | paternally expressed 10 | -0.0510799 |
| TMSB4X | thymosin beta 4, X-linked | -0.0478179 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0475304 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0468607 |
| HMGA1 | high mobility group AT-hook 1 | -0.0466957 |
| COL3A1 | collagen, type III, alpha 1 | -0.0466048 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0463758 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0436709 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0425506 |
| MKI67 | marker of proliferation Ki-67 | -0.0424577 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0416236 |
| SNX6 | sorting nexin 6 | -0.0413523 |
| PCDH9 | protocadherin 9 | -0.0409157 |
| H1-0 | H1.0 linker histone | -0.0400291 |
| ZNF217 | zinc finger protein 217 | -0.0391036 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | -0.0390047 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0381428 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.038063 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0378804 |
| PCDH7 | protocadherin 7 | -0.0370933 |
| TUBA1B | tubulin, alpha 1b | -0.0369891 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0369016 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0366655 |
| CANX | calnexin | -0.0360633 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0353396 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0352609 |
| RPL31 | ribosomal protein L31 | -0.0343237 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0341664 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0337828 |
| RPL7 | ribosomal protein L7 | -0.0333507 |
| TXNRD1 | thioredoxin reductase 1 | -0.0333017 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0332982 |
| DMD | dystrophin | -0.0331868 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0331857 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0329378 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0325856 |
| TRIM2 | tripartite motif containing 2 | -0.0324863 |
| GNAS | GNAS complex locus | -0.0319113 |
| HMGA2 | high mobility group AT-hook 2 | -0.031748 |
| CBX3 | chromobox homolog 3 | -0.0315153 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0314291 |
| TPX2 | TPX2, microtubule-associated | -0.0303302 |
| TENM3 | teneurin transmembrane protein 3 | -0.0303139 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.030255 |
| AHNAK | AHNAK nucleoprotein | -0.03023 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | -0.0299362 |
| SON | SON DNA binding protein | -0.029787 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | -0.0296589 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.02936 |
| RPS24 | ribosomal protein S24 | -0.0287654 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0286395 |
| TPM4 | tropomyosin 4 | -0.0283118 |
| FRY | furry homolog (Drosophila) | -0.0279764 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0278617 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0277708 |
| CLTC | clathrin, heavy chain (Hc) | -0.0276822 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0276727 |
| ZFR | zinc finger RNA binding protein | -0.0273261 |
| RPS8 | ribosomal protein S8 | -0.027214 |
| APOE | apolipoprotein E | -0.0272089 |
| YBX1 | Y box binding protein 1 | -0.0271336 |
| LDHA | lactate dehydrogenase A | -0.0267554 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.026666 |
| RPL35A | ribosomal protein L35a | -0.0266158 |
| RPL5 | ribosomal protein L5 | -0.0265424 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0262958 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0262762 |
| CEP350 | centrosomal protein 350kDa | -0.0261668 |
| MPG | N-methylpurine-DNA glycosylase | -0.025953 |
| PKM | pyruvate kinase, muscle | -0.0257397 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0256994 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0256342 |
| FST | follistatin | -0.0254367 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0251332 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0250382 |
| FTL | ferritin, light polypeptide | -0.024851 |
| TENM2 | teneurin transmembrane protein 2 | -0.0247876 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0242291 |
| RPL34 | ribosomal protein L34 | -0.0241728 |
| TCEA1 | transcription elongation factor A (SII), 1 | -0.0240037 |
