| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capivasertib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAV2 | neuron navigator 2 | 0.128136 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.101017 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0906155 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.076046 |
| MSN | moesin | 0.0656581 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0622527 |
| SMAD3 | SMAD family member 3 | 0.0568476 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0538769 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.050556 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0499619 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0497864 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0453525 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.044715 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0441164 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0432023 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0425219 |
| JMJD1C | jumonji domain containing 1C | 0.0402079 |
| SDC4 | syndecan 4 | 0.0380788 |
| FLNA | filamin A, alpha | 0.0380044 |
| VEGFA | vascular endothelial growth factor A | 0.0372778 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0336654 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0334439 |
| NOTCH2 | notch 2 | 0.0333484 |
| HELZ | helicase with zinc finger | 0.0325574 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0324051 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0312931 |
| FMNL2 | formin-like 2 | 0.0312449 |
| CDK19 | cyclin-dependent kinase 19 | 0.030568 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0283792 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0277921 |
| HDAC9 | histone deacetylase 9 | 0.0274271 |
| RPS2 | ribosomal protein S2 | 0.0266503 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0263148 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.026168 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0256165 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0253761 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0251589 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0250733 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0249261 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0248521 |
| BRD2 | bromodomain containing 2 | 0.0246205 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0238019 |
| FLNB | filamin B, beta | 0.0234664 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0234291 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0233003 |
| ZNF292 | zinc finger protein 292 | 0.0231851 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0230891 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0228153 |
| RPL3 | ribosomal protein L3 | 0.0226367 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.022424 |
| RPL27 | ribosomal protein L27 | 0.0221104 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0217842 |
| MYOF | myoferlin | 0.0216992 |
| NONO | non-POU domain containing, octamer-binding | 0.021549 |
| FAM219A | family with sequence similarity 219, member A | 0.0212408 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.021057 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0208511 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0208484 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0207737 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0198394 |
| SPAG9 | sperm associated antigen 9 | 0.0197215 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0196126 |
| SYNJ2 | synaptojanin 2 | 0.0195682 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0195045 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0194602 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0193819 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0193652 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0192217 |
| FOXO3 | forkhead box O3 | 0.0191319 |
| PCBP2 | poly(rC) binding protein 2 | 0.0190886 |
| OGA | O-GlcNAcase | 0.0190321 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0189254 |
| TGM2 | transglutaminase 2 | 0.0189077 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0187106 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0184659 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0182451 |
| ARRDC3 | arrestin domain containing 3 | 0.0181746 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0180411 |
| TAPBP | TAP binding protein (tapasin) | 0.0180082 |
| ANO6 | anoctamin 6 | 0.0179667 |
| APP | amyloid beta (A4) precursor protein | 0.0178701 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0175795 |
| DUSP10 | dual specificity phosphatase 10 | 0.0175457 |
| NDRG1 | N-myc downstream regulated 1 | 0.0175261 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0174947 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0173658 |
| FNIP1 | folliculin interacting protein 1 | 0.0170784 |
| CABIN1 | calcineurin binding protein 1 | 0.0170718 |
| USP47 | ubiquitin specific peptidase 47 | 0.0170313 |
| AGRN | agrin | 0.0168533 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0168502 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 0.0168289 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0168212 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0167634 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0167363 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0165917 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0165667 |
| KYNU | kynureninase | 0.0162874 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0162124 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0161451 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.229408 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.180161 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.134087 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.121577 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.118339 |
| FRMD4A | FERM domain containing 4A | -0.116448 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.115069 |
| GLIS3 | GLIS family zinc finger 3 | -0.0955653 |
| DST | dystonin | -0.0946617 |
| HMGA2 | high mobility group AT-hook 2 | -0.0877663 |
| IER3 | immediate early response 3 | -0.085843 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0817764 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0810082 |
| CANX | calnexin | -0.071587 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0657465 |
| RAI14 | retinoic acid induced 14 | -0.0645955 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0643262 |
| PGK1 | phosphoglycerate kinase 1 | -0.06369 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0629425 |
| CDH13 | cadherin 13 | -0.0617541 |
| VCL | vinculin | -0.0613176 |
| DIAPH2 | diaphanous-related formin 2 | -0.0602667 |
| TMSB4X | thymosin beta 4, X-linked | -0.0601866 |
| FN1 | fibronectin 1 | -0.0597721 |
| BICC1 | BicC family RNA binding protein 1 | -0.0584421 |
| PLIN2 | perilipin 2 | -0.0569505 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0548503 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0544644 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0526048 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0516901 |
| VCAN | versican | -0.047858 |
| LDHA | lactate dehydrogenase A | -0.0461356 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0448813 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.043504 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0429014 |
| RPS24 | ribosomal protein S24 | -0.0423649 |
| TPM4 | tropomyosin 4 | -0.042163 |
| AHNAK | AHNAK nucleoprotein | -0.0418994 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.041749 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.041723 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0406768 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0405238 |
| RRBP1 | ribosome binding protein 1 | -0.0399696 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0396485 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0394491 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0386592 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0379352 |
| NRN1 | neuritin 1 | -0.0376657 |
| TMSB10 | thymosin beta 10 | -0.03712 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0365278 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0354659 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0352973 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0352914 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0350295 |
| INHBA | inhibin, beta A | -0.0344626 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0335524 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0333858 |
| CALR | calreticulin | -0.0326683 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0325244 |
| HLA-B | major histocompatibility complex, class I, B | -0.0323008 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0321058 |
| GNAS | GNAS complex locus | -0.0316551 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0311583 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0307971 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0301877 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0292914 |
| ENO1 | enolase 1, (alpha) | -0.0289325 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0278975 |
| MORF4L2 | mortality factor 4 like 2 | -0.0276648 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0271978 |
| PHF3 | PHD finger protein 3 | -0.0271167 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0270699 |
| HLA-E | major histocompatibility complex, class I, E | -0.0267275 |
| UBC | ubiquitin C | -0.0265273 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0263756 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0261676 |
| LOX | lysyl oxidase | -0.0261185 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0259056 |
| RIGI | RNA sensor RIG-I | -0.0255 |
| CUL4B | cullin 4B | -0.0253741 |
| THBS2 | thrombospondin 2 | -0.0252055 |
| TMEM132D | transmembrane protein 132D | -0.0251186 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0249383 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0245455 |
| TCEAL9 | transcription elongation factor A like 9 | -0.024194 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0241389 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0239942 |
| CNTN6 | contactin 6 | -0.0239485 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0237533 |
| PALLD | palladin, cytoskeletal associated protein | -0.0237382 |
| EFNA5 | ephrin-A5 | -0.023688 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0234937 |
| CD164 | CD164 molecule, sialomucin | -0.0234083 |
| FAM20C | family with sequence similarity 20, member C | -0.0230443 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0226315 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0226039 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0225441 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0225429 |
| RPL34 | ribosomal protein L34 | -0.0223831 |
| CAVIN1 | caveolae associated protein 1 | -0.0223482 |
