Capivasertib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capivasertib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capivasertib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.0639667
SMAD3 SMAD family member 3 0.0433835
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0429707
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0389122
SMYD3 SET and MYND domain containing 3 0.0352988
HMGA2 high mobility group AT-hook 2 0.0345002
TMEM156 transmembrane protein 156 0.0334571
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0303041
SHB Src homology 2 domain containing adaptor protein B 0.0302346
NPAS2 neuronal PAS domain protein 2 0.0299803
SEPTIN9 septin 9 0.0296186
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0273268
PELO pelota homolog (Drosophila) 0.0273127
DOCK5 dedicator of cytokinesis 5 0.0271057
PALLD palladin, cytoskeletal associated protein 0.0262563
ZC3H12C zinc finger CCCH-type containing 12C 0.0257034
LOXL2 lysyl oxidase-like 2 0.0241519
OSMR oncostatin M receptor 0.023931
ANKRD28 ankyrin repeat domain 28 0.0238707
ZSWIM6 zinc finger, SWIM-type containing 6 0.0234985
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0234718
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0233135
SVIL supervillin 0.0229831
HSPA8 heat shock 70kDa protein 8 0.0228219
CCSER1 coiled-coil serine-rich protein 1 0.0226243
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0219726
BICD1 bicaudal D homolog 1 (Drosophila) 0.0217105
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0213988
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.02127
CAB39 calcium binding protein 39 0.0210663
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0207227
FHL2 four and a half LIM domains 2 0.020487
VCL vinculin 0.019505
SAMD4A sterile alpha motif domain containing 4A 0.0188845
PLEC plectin 0.0182675
ABR active BCR-related 0.017264
TCIM transcriptional and immune response regulator 0.0171021
RASAL2 RAS protein activator like 2 0.0170685
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0168178
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.016645
GLIS3 GLIS family zinc finger 3 0.0164453
NRIP1 nuclear receptor interacting protein 1 0.0161676
ITGB5 integrin, beta 5 0.0159598
RANBP17 RAN binding protein 17 0.0153248
VEGFC vascular endothelial growth factor C 0.0151914
TOM1L2 target of myb1-like 2 (chicken) 0.0147726
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0147126
MAML2 mastermind-like 2 (Drosophila) 0.0146205
ARHGAP42 Rho GTPase activating protein 42 0.0145465
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0144522
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0143564
RSPRY1 ring finger and SPRY domain containing 1 0.0142465
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0141954
FNDC3A fibronectin type III domain containing 3A 0.0140405
EFNA5 ephrin-A5 0.0139223
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0138319
MAP1B microtubule-associated protein 1B 0.0137917
FRY furry homolog (Drosophila) 0.0137869
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0137664
LTBP1 latent transforming growth factor beta binding protein 1 0.0136017
TSHZ2 teashirt zinc finger homeobox 2 0.0135922
LRMDA leucine rich melanocyte differentiation associated 0.0135213
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0134524
SH3KBP1 SH3-domain kinase binding protein 1 0.0134254
LIMCH1 LIM and calponin homology domains 1 0.0132852
YLPM1 YLP motif containing 1 0.0132074
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.013131
DUSP6 dual specificity phosphatase 6 0.0130923
NTN4 netrin 4 0.0128729
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.012857
ANKRD17 ankyrin repeat domain 17 0.0127521
DUSP5 dual specificity phosphatase 5 0.012714
ZNF160 zinc finger protein 160 0.0127121
N4BP2L2 NEDD4 binding protein 2-like 2 0.0127107
RASD1 RAS, dexamethasone-induced 1 0.0125747
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0125232
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0125141
CLIP2 CAP-GLY domain containing linker protein 2 0.0124025
PRKCE protein kinase C, epsilon 0.0123728
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0123427
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0123025
EREG epiregulin 0.0122103
FAT1 FAT atypical cadherin 1 0.0121937
LYST lysosomal trafficking regulator 0.0120689
MIPOL1 mirror-image polydactyly 1 0.0120531
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0120501
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 0.0120118
CAPN2 calpain 2, (m/II) large subunit 0.0119485
MAPK8 mitogen-activated protein kinase 8 0.0119438
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0119417
ATXN1 ataxin 1 0.0119393
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0118305
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0118277
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0116883
SGMS2 sphingomyelin synthase 2 0.0116868
AGO2 argonaute RISC catalytic component 2 0.0116846
AEBP2 AE binding protein 2 0.0116803
SGMS1 sphingomyelin synthase 1 0.0116281
ANTXR2 anthrax toxin receptor 2 0.0116232
TAS2R14 taste receptor, type 2, member 14 0.0115524

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.192094
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.178556
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.156655
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.131598
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.113213
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.110388
VIM vimentin -0.101187
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0966723
NAMPT nicotinamide phosphoribosyltransferase -0.0884961
NDRG1 N-myc downstream regulated 1 -0.0850539
HILPDA hypoxia inducible lipid droplet-associated -0.0843658
CXCL8 chemokine (C-X-C motif) ligand 8 -0.082138
FTL ferritin, light polypeptide -0.0814152
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0773429
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0733586
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0730323
CANX calnexin -0.0723664
TMSB10 thymosin beta 10 -0.0716744
PLIN2 perilipin 2 -0.0575519
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0574257
IFI27 interferon, alpha-inducible protein 27 -0.0568742
RPS6 ribosomal protein S6 -0.0564062
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.054499
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0541138
TPT1 tumor protein, translationally-controlled 1 -0.0529637
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0527873
SOD2 superoxide dismutase 2, mitochondrial -0.0526904
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.05037
FTH1 ferritin, heavy polypeptide 1 -0.0496185
S100A6 S100 calcium binding protein A6 -0.0483818
RBM39 RNA binding motif protein 39 -0.0477925
RNF145 ring finger protein 145 -0.0461911
SEPTIN7 septin 7 -0.0461187
SPAG9 sperm associated antigen 9 -0.0458616
RTN4 reticulon 4 -0.0458311
B2M beta-2-microglobulin -0.0456732
IGFBP3 insulin-like growth factor binding protein 3 -0.0452635
CD109 CD109 molecule -0.045065
KMT2E lysine (K)-specific methyltransferase 2E -0.0443125
PKM pyruvate kinase, muscle -0.0434225
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.041796
RPL35A ribosomal protein L35a -0.0417272
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0415524
WAC WW domain containing adaptor with coiled-coil -0.0415151
LDHA lactate dehydrogenase A -0.0415111
CENPF centromere protein F, 350/400kDa -0.0407927
FN1 fibronectin 1 -0.040515
NPEPPS aminopeptidase puromycin sensitive -0.0401747
NAP1L1 nucleosome assembly protein 1-like 1 -0.0398224
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.039295
RPS24 ribosomal protein S24 -0.0384719
ACBD3 acyl-CoA binding domain containing 3 -0.0374636
LCORL ligand dependent nuclear receptor corepressor-like -0.0373245
WDR45B WD repeat domain 45B -0.0368716
SQSTM1 sequestosome 1 -0.0366852
PDIA3 protein disulfide isomerase family A, member 3 -0.0365235
TFG TRK-fused gene -0.0363102
TMSB4X thymosin beta 4, X-linked -0.0360923
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.035942
TOP2A topoisomerase (DNA) II alpha 170kDa -0.035601
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0354032
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0353056
PGK1 phosphoglycerate kinase 1 -0.0350404
MARCHF6 membrane associated ring-CH-type finger 6 -0.034736
ZNF292 zinc finger protein 292 -0.0343939
RAB6A RAB6A, member RAS oncogene family -0.0343531
HLA-B major histocompatibility complex, class I, B -0.034301
GOLGA4 golgin A4 -0.0339625
CADM1 cell adhesion molecule 1 -0.0333549
PCBP2 poly(rC) binding protein 2 -0.033283
HMGB3 high mobility group box 3 -0.0328145
TRA2A transformer 2 alpha homolog (Drosophila) -0.0325837
HELZ helicase with zinc finger -0.0325573
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0325424
KDM5B lysine (K)-specific demethylase 5B -0.0323128
IER3 immediate early response 3 -0.0316966
CALU calumenin -0.0316504
WSB1 WD repeat and SOCS box containing 1 -0.0309324
MATR3 matrin 3 -0.0307466
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0305082
BIRC6 baculoviral IAP repeat containing 6 -0.0304547
RPS12 ribosomal protein S12 -0.0304086
DDIT4 DNA-damage-inducible transcript 4 -0.0303373
RAB1A RAB1A, member RAS oncogene family -0.0302827
RPS25 ribosomal protein S25 -0.0298114
NUP58 nucleoporin 58 -0.0296559
ANLN anillin, actin binding protein -0.0295867
OGA O-GlcNAcase -0.0294533
CALR calreticulin -0.0293338
XPO1 exportin 1 -0.0292467
RYBP RING1 and YY1 binding protein -0.0291115
UBC ubiquitin C -0.0288971
PDIA6 protein disulfide isomerase family A, member 6 -0.0288927
COPA coatomer protein complex, subunit alpha -0.0288231
KMT2C lysine (K)-specific methyltransferase 2C -0.0287888
RIOK3 RIO kinase 3 -0.0286861
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0285391
RLF rearranged L-myc fusion -0.028115
MRPS6 mitochondrial ribosomal protein S6 -0.0280926
UGCG UDP-glucose ceramide glucosyltransferase -0.0280664