| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capmatinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capmatinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.296935 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.132717 |
| HSPB1 | heat shock 27kDa protein 1 | 0.131472 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.12297 |
| TENM3 | teneurin transmembrane protein 3 | 0.115569 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0837565 |
| NLGN1 | neuroligin 1 | 0.0836955 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0775586 |
| ANXA1 | annexin A1 | 0.072896 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0712027 |
| RPS3 | ribosomal protein S3 | 0.0683264 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0612125 |
| HDAC9 | histone deacetylase 9 | 0.0606592 |
| CALR | calreticulin | 0.0598997 |
| RPS8 | ribosomal protein S8 | 0.0575493 |
| RPS12 | ribosomal protein S12 | 0.0574069 |
| DST | dystonin | 0.0562189 |
| NEBL | nebulette | 0.0560058 |
| SYT1 | synaptotagmin I | 0.0503577 |
| RNF213 | ring finger protein 213 | 0.0482929 |
| FSTL5 | follistatin-like 5 | 0.0478614 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0475737 |
| CDK6 | cyclin-dependent kinase 6 | 0.0474871 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0450949 |
| MGAT4C | MGAT4 family, member C | 0.0445316 |
| TPI1 | triosephosphate isomerase 1 | 0.043718 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0437059 |
| MYPN | myopalladin | 0.0427462 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0423104 |
| CEP112 | centrosomal protein 112kDa | 0.0407322 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0401797 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.0393432 |
| NRXN3 | neurexin 3 | 0.0384347 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0374519 |
| PDGFC | platelet derived growth factor C | 0.0372322 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.0366361 |
| LDHA | lactate dehydrogenase A | 0.035637 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0355251 |
| RPL37A | ribosomal protein L37a | 0.0353578 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0348721 |
| EPHA5 | EPH receptor A5 | 0.0343808 |
| SERTAD2 | SERTA domain containing 2 | 0.0334058 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0321441 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.030624 |
| INTS6 | integrator complex subunit 6 | 0.0305153 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0302483 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0296368 |
| AXIN2 | axin 2 | 0.0295082 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0286148 |
| CANX | calnexin | 0.0283762 |
| NBEAL1 | neurobeachin-like 1 | 0.0280706 |
| ADIPOR2 | adiponectin receptor 2 | 0.0276877 |
| EPHA6 | EPH receptor A6 | 0.0273511 |
| MAP4 | microtubule-associated protein 4 | 0.0270652 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0268166 |
| VCL | vinculin | 0.0265125 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0256279 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0249749 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0243635 |
| RPS2 | ribosomal protein S2 | 0.024354 |
| MED13L | mediator complex subunit 13-like | 0.0236068 |
| HLA-B | major histocompatibility complex, class I, B | 0.0234025 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0229948 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0229547 |
| RSU1 | Ras suppressor protein 1 | 0.0228598 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.02277 |
| CLPTM1L | CLPTM1-like | 0.0220595 |
| RPL31 | ribosomal protein L31 | 0.021854 |
| FDPS | farnesyl diphosphate synthase | 0.0214215 |
| CMIP | c-Maf inducing protein | 0.0211305 |
| TOB1 | transducer of ERBB2, 1 | 0.0209337 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0208241 |
| THSD7A | thrombospondin, type I, domain containing 7A | 0.0207057 |
| S100A10 | S100 calcium binding protein A10 | 0.0205869 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0205232 |
| EXOC6B | exocyst complex component 6B | 0.0205223 |
| ACLY | ATP citrate lyase | 0.0205076 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0204348 |
| MPG | N-methylpurine-DNA glycosylase | 0.0197996 |
| ATP9A | ATPase, class II, type 9A | 0.0197695 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0196662 |
| NFIB | nuclear factor I/B | 0.0196628 |
| ANK2 | ankyrin 2, neuronal | 0.0195738 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0194936 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.019407 |
| RPL26 | ribosomal protein L26 | 0.0193875 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0193549 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0191738 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0191537 |
| PRR16 | proline rich 16 | 0.0189589 |
| PEG10 | paternally expressed 10 | 0.0189103 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0189094 |
| COL5A2 | collagen, type V, alpha 2 | 0.0187183 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0186579 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0184042 |
| JUN | jun proto-oncogene | 0.0183908 |
| CADM2 | cell adhesion molecule 2 | 0.0183601 |
| FLNA | filamin A, alpha | 0.0183351 |
| PCDH9 | protocadherin 9 | 0.0183324 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0182554 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | -0.293817 |
| TMSB10 | thymosin beta 10 | -0.130567 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.127373 |
| PCDH7 | protocadherin 7 | -0.111783 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0998802 |
| VIM | vimentin | -0.089796 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0864537 |
| PFN1 | profilin 1 | -0.0831822 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0822416 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0792338 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0784853 |
| YBX3 | Y box binding protein 3 | -0.0696578 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0668103 |
| NHSL1 | NHS-like 1 | -0.0656178 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0639017 |
| CCN2 | cellular communication network factor 2 | -0.0637893 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0603606 |
| YAP1 | Yes-associated protein 1 | -0.0601879 |
| EGR1 | early growth response 1 | -0.0562822 |
| TMEM41B | transmembrane protein 41B | -0.0556892 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0525193 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0521524 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0496226 |
| RRM2 | ribonucleotide reductase M2 | -0.0475806 |
| IPO7 | importin 7 | -0.0473475 |
| HMGA1 | high mobility group AT-hook 1 | -0.0471873 |
| ASPH | aspartate beta-hydroxylase | -0.0452202 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.043099 |
| EDN1 | endothelin 1 | -0.0415246 |
| CCNL1 | cyclin L1 | -0.0402808 |
| MKI67 | marker of proliferation Ki-67 | -0.0385372 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0380706 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0366479 |
| RPLP0 | ribosomal protein, large, P0 | -0.0364568 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0357648 |
| TUBA1B | tubulin, alpha 1b | -0.0355995 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0355733 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0353071 |
| RPS21 | ribosomal protein S21 | -0.0352374 |
| PCBP2 | poly(rC) binding protein 2 | -0.0347989 |
| RPL35A | ribosomal protein L35a | -0.0347485 |
| XPO1 | exportin 1 | -0.0339164 |
| PTMS | parathymosin | -0.033416 |
| ECT2 | epithelial cell transforming 2 | -0.0332957 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0324954 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.032437 |
| RTN4 | reticulon 4 | -0.0319782 |
| RBM25 | RNA binding motif protein 25 | -0.0318632 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.030931 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0308933 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0304919 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0303463 |
| DEK | DEK proto-oncogene | -0.0300796 |
| TMEM123 | transmembrane protein 123 | -0.0295487 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0289702 |
| CBX3 | chromobox homolog 3 | -0.0288194 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0281641 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0281415 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0277434 |
| RPLP1 | ribosomal protein, large, P1 | -0.0275115 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0274511 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0273372 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0272495 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0272421 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0270371 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0268505 |
| CDK17 | cyclin-dependent kinase 17 | -0.0266162 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0264968 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0262145 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.0262003 |
| RPS6 | ribosomal protein S6 | -0.0261582 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0261123 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0257723 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0257147 |
| POTEF | POTE ankyrin domain family, member F | -0.025649 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0254573 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0253723 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0253537 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0252416 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0249758 |
| KIF18B | kinesin family member 18B | -0.0249624 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.024939 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0248967 |
| CEP192 | centrosomal protein 192kDa | -0.0245809 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0243877 |
| TBK1 | TANK-binding kinase 1 | -0.0243239 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0242989 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0239368 |
| WDR43 | WD repeat domain 43 | -0.023715 |
| TXNRD1 | thioredoxin reductase 1 | -0.0236973 |
| ETV5 | ets variant 5 | -0.0236479 |
| CENPF | centromere protein F, 350/400kDa | -0.0236078 |
| H1-0 | H1.0 linker histone | -0.0235967 |
| ZNF207 | zinc finger protein 207 | -0.0235443 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0235016 |
| MATR3 | matrin 3 | -0.0232765 |
| ATP11A | ATPase, class VI, type 11A | -0.0230028 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0229469 |
| KIF5B | kinesin family member 5B | -0.0229455 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | -0.0227537 |
