Capmatinib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capmatinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capmatinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
APOB apolipoprotein B 0.0523616
SVIL supervillin 0.0316878
IGFBP1 insulin-like growth factor binding protein 1 0.0266889
AFDN afadin, adherens junction formation factor 0.0227231
PCBP2 poly(rC) binding protein 2 0.0222485
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0196371
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0183102
DDIT4 DNA-damage-inducible transcript 4 0.0179535
BCL2L1 BCL2-like 1 0.017489
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.017487
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0157762
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0152043
CFB complement factor B 0.0143779
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0142368
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0138889
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0136143
SMAD5 SMAD family member 5 0.0134396
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0133628
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0132128
SOS1 son of sevenless homolog 1 (Drosophila) 0.0129592
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0127275
SOD2 superoxide dismutase 2, mitochondrial 0.0126062
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.012284
EFNA1 ephrin-A1 0.0121167
CRY1 cryptochrome circadian clock 1 0.0119135
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0117882
EEF2 eukaryotic translation elongation factor 2 0.0117183
EIF3A eukaryotic translation initiation factor 3, subunit A 0.011634
GRK3 G protein-coupled receptor kinase 3 0.0113938
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0113901
PAPOLA poly(A) polymerase alpha 0.0111672
SPAG9 sperm associated antigen 9 0.0111366
TOP1 topoisomerase (DNA) I 0.0111128
MYO1B myosin IB 0.0110821
CEMIP2 cell migration inducing hyaluronidase 2 0.010962
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0107729
USP47 ubiquitin specific peptidase 47 0.010446
DTNA dystrobrevin, alpha 0.0103514
LRRC1 leucine rich repeat containing 1 0.0103442
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0102548
PUM1 pumilio RNA-binding family member 1 0.0101268
RREB1 ras responsive element binding protein 1 0.0100865
BHLHE40 basic helix-loop-helix family, member e40 0.010009
KDM6A lysine (K)-specific demethylase 6A 0.0098986
MRTFA myocardin related transcription factor A 0.00975616
GIGYF2 GRB10 interacting GYF protein 2 0.00974292
NUP58 nucleoporin 58 0.00967682
NPTN neuroplastin 0.00967323
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.00946394
ADAM17 ADAM metallopeptidase domain 17 0.00922579
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.00914185
CCNL1 cyclin L1 0.00912934
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.00911932
GPBP1 GC-rich promoter binding protein 1 0.00907767
ARRDC3 arrestin domain containing 3 0.00907573
SYNJ2 synaptojanin 2 0.00902772
FAM168B family with sequence similarity 168, member B 0.00899261
PAWR PRKC, apoptosis, WT1, regulator 0.00896764
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.00896457
NCOA4 nuclear receptor coactivator 4 0.00881098
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 0.00880528
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.00878912
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.00875324
ADARB1 adenosine deaminase, RNA-specific, B1 0.00868312
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.00867486
MAN1A2 mannosidase, alpha, class 1A, member 2 0.00857751
ECE1 endothelin converting enzyme 1 0.00857595
KAT6A K(lysine) acetyltransferase 6A 0.00845034
TNS1 tensin 1 0.00842253
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.00832353
LCOR ligand dependent nuclear receptor corepressor 0.00825612
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 0.00824068
PER2 period circadian clock 2 0.00822003
SRSF10 serine/arginine-rich splicing factor 10 0.00819668
TENT2 terminal nucleotidyltransferase 2 0.00802271
FOXO1 forkhead box O1 0.00800673
PUM2 pumilio RNA-binding family member 2 0.00799963
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.00799215
ZMIZ1 zinc finger, MIZ-type containing 1 0.00796106
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.00795605
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.00793272
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.00792146
MACF1 microtubule-actin crosslinking factor 1 0.00790344
SKI SKI proto-oncogene 0.00785951
DPP4 dipeptidyl-peptidase 4 0.00784489
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.00783479
ARHGAP17 Rho GTPase activating protein 17 0.00778606
RNF43 ring finger protein 43 0.00776942
PHC3 polyhomeotic homolog 3 (Drosophila) 0.00776398
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.00773404
EIF4B eukaryotic translation initiation factor 4B 0.0077135
CORO1C coronin, actin binding protein, 1C 0.00767219
RNF10 ring finger protein 10 0.00758388
ANKRD28 ankyrin repeat domain 28 0.00757096
TNRC6A trinucleotide repeat containing 6A 0.00752832
SPOPL speckle-type POZ protein-like 0.00752322
YTHDC1 YTH domain containing 1 0.00744283
ANKRD17 ankyrin repeat domain 17 0.0074215
FBXO42 F-box protein 42 0.00741658
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.00730011

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.329656
IGF2 insulin-like growth factor 2 -0.180632
EHBP1 EH domain binding protein 1 -0.123058
SLC38A2 solute carrier family 38, member 2 -0.100835
GPC6 glypican 6 -0.0998767
MAML2 mastermind-like 2 (Drosophila) -0.0835561
ASPH aspartate beta-hydroxylase -0.0828176
TPT1 tumor protein, translationally-controlled 1 -0.0723118
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0716043
FN1 fibronectin 1 -0.0713873
PEG3 paternally expressed 3 -0.0676257
GMDS GDP-mannose 4,6-dehydratase -0.0647162
CP ceruloplasmin (ferroxidase) -0.0622353
APOA2 apolipoprotein A-II -0.0610033
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0609606
NPAS2 neuronal PAS domain protein 2 -0.0598266
FRMD5 FERM domain containing 5 -0.0576765
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0573378
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0570925
GPC3 glypican 3 -0.0550071
ENO1 enolase 1, (alpha) -0.0544476
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0539176
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0527844
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0510779
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0490316
TMSB10 thymosin beta 10 -0.047896
PLIN2 perilipin 2 -0.0472695
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0469124
TM4SF1 transmembrane 4 L six family member 1 -0.0465521
PARD3 par-3 family cell polarity regulator -0.0464625
HMGA1 high mobility group AT-hook 1 -0.046069
DLC1 DLC1 Rho GTPase activating protein -0.04208
FBF1 Fas (TNFRSF6) binding factor 1 -0.041929
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0418208
ZMYND8 zinc finger, MYND-type containing 8 -0.0400516
RPS24 ribosomal protein S24 -0.039915
ATXN1 ataxin 1 -0.0391623
DSPP dentin sialophosphoprotein -0.0380781
FMNL2 formin-like 2 -0.037408
AHSG alpha-2-HS-glycoprotein -0.0373262
GNAS GNAS complex locus -0.0357951
ATP10A ATPase, class V, type 10A -0.0341694
RPS6 ribosomal protein S6 -0.0340165
TPM4 tropomyosin 4 -0.0338265
ZBTB20 zinc finger and BTB domain containing 20 -0.0334102
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0334073
RPL11 ribosomal protein L11 -0.0322153
GK glycerol kinase -0.0319927
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0318869
MT2A metallothionein 2A -0.0312609
RPL35A ribosomal protein L35a -0.0311146
VCL vinculin -0.0306309
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0303667
FNDC3B fibronectin type III domain containing 3B -0.030253
DST dystonin -0.0298708
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0298344
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0288224
C3 complement component 3 -0.0285922
TRIO trio Rho guanine nucleotide exchange factor -0.0282645
RPS8 ribosomal protein S8 -0.0273501
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0273117
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0272493
STK17A serine/threonine kinase 17a -0.0268809
TMEM123 transmembrane protein 123 -0.0268535
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.026704
H1-0 H1.0 linker histone -0.0266096
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.025708
ACTG1 actin gamma 1 -0.0256992
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0255591
SOX5 SRY (sex determining region Y)-box 5 -0.0254743
ZHX2 zinc fingers and homeoboxes 2 -0.0253008
LOC112694756 uncharaterized LOC112694756 -0.0249291
FTL ferritin, light polypeptide -0.0248454
INTS6 integrator complex subunit 6 -0.0246514
PGK1 phosphoglycerate kinase 1 -0.0246507
PRKCA protein kinase C, alpha -0.0241946
AMBP alpha-1-microglobulin/bikunin precursor -0.0238314
LPP LIM domain containing preferred translocation partner in lipoma -0.0236917
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0233306
RPLP1 ribosomal protein, large, P1 -0.0232033
ITGA1 integrin, alpha 1 -0.0228659
RPLP0 ribosomal protein, large, P0 -0.022833
NHSL1 NHS-like 1 -0.0227622
NPR2 natriuretic peptide receptor 2 -0.0227267
LYZ lysozyme -0.0220603
CTSB cathepsin B -0.0218852
RPL34 ribosomal protein L34 -0.021418
PTCHD4 patched domain containing 4 -0.0213893
RNF213 ring finger protein 213 -0.0209551
ZFHX3 zinc finger homeobox 3 -0.0206887
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.020529
RPS19 ribosomal protein S19 -0.0198009
PTPRM protein tyrosine phosphatase, receptor type, M -0.0198
RAI14 retinoic acid induced 14 -0.019705
ARHGAP5 Rho GTPase activating protein 5 -0.0196244
VCAN versican -0.0195302
MARCKS myristoylated alanine-rich protein kinase C substrate -0.019469
RIGI RNA sensor RIG-I -0.0192613
LAMA4 laminin, alpha 4 -0.019191
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0190349