Capmatinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capmatinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capmatinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.206102
RPS12 ribosomal protein S12 0.085145
B2M beta-2-microglobulin 0.0691552
EXT1 exostosin glycosyltransferase 1 0.0578507
MUC13 mucin 13, cell surface associated 0.0530487
ISG15 ISG15 ubiquitin-like modifier 0.0441023
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0427077
RPS3 ribosomal protein S3 0.0414416
RPS4X ribosomal protein S4, X-linked 0.0405538
LOC102724023 ES1 protein homolog, mitochondrial 0.0391572
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0382619
FTL ferritin, light polypeptide 0.0381317
RPL37A ribosomal protein L37a 0.0370011
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0359773
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0340849
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0334489
NEBL nebulette 0.0334471
RPS8 ribosomal protein S8 0.0321242
FTH1 ferritin, heavy polypeptide 1 0.0320842
RPS29 ribosomal protein S29 0.0320395
TSC22D1 TSC22 domain family, member 1 0.0319849
RPS2 ribosomal protein S2 0.0307379
RPL36 ribosomal protein L36 0.0295165
SOX9 SRY (sex determining region Y)-box 9 0.0266218
CXCL3 chemokine (C-X-C motif) ligand 3 0.0245477
RPS27 ribosomal protein S27 0.0243911
ZFP36L2 ZFP36 ring finger protein-like 2 0.0240011
RPS17 ribosomal protein S17 0.0239983
TGFBR3 transforming growth factor, beta receptor III 0.0238783
AFF1 AF4/FMR2 family, member 1 0.0238127
HSPA8 heat shock 70kDa protein 8 0.0233449
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0233001
RPL26 ribosomal protein L26 0.0232879
LDHA lactate dehydrogenase A 0.0229415
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.022656
CALR calreticulin 0.0223108
NCOA7 nuclear receptor coactivator 7 0.021999
PDZD8 PDZ domain containing 8 0.0216174
FOXP1 forkhead box P1 0.0210027
RPL31 ribosomal protein L31 0.0209755
PARD3B par-3 family cell polarity regulator beta 0.0209439
OASL 2'-5'-oligoadenylate synthetase-like 0.0206582
LURAP1L leucine rich adaptor protein 1-like 0.0206389
RPL23 ribosomal protein L23 0.0198623
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0198369
IFIH1 interferon induced with helicase C domain 1 0.0196311
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0194159
RNF213 ring finger protein 213 0.0192857
SFTPA2 surfactant protein A2 0.0192394
RIGI RNA sensor RIG-I 0.019205
RACK1 receptor for activated C kinase 1 0.0189821
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0186983
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.01863
ARL15 ADP-ribosylation factor-like 15 0.0183932
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0182546
NACA nascent polypeptide-associated complex alpha subunit 0.0179824
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.017409
PRRC2C proline-rich coiled-coil 2C 0.0173223
TRIM2 tripartite motif containing 2 0.0165311
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0164931
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0162821
ADGRV1 adhesion G protein-coupled receptor V1 0.0162158
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0161361
BRD2 bromodomain containing 2 0.0158119
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0157611
DUSP16 dual specificity phosphatase 16 0.0156958
EFNA1 ephrin-A1 0.0155273
JUN jun proto-oncogene 0.0154638
TMC5 transmembrane channel-like 5 0.0154327
USP54 ubiquitin specific peptidase 54 0.0153112
PCM1 pericentriolar material 1 0.0152644
CRY1 cryptochrome circadian clock 1 0.0152635
SET SET nuclear proto-oncogene 0.0149981
SQSTM1 sequestosome 1 0.0148334
DYNLL1 dynein, light chain, LC8-type 1 0.0147147
SP100 SP100 nuclear antigen 0.0146659
GOLIM4 golgi integral membrane protein 4 0.0145786
TRPS1 trichorhinophalangeal syndrome I 0.0143764
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0143695
IFI27 interferon, alpha-inducible protein 27 0.0143208
CEMIP2 cell migration inducing hyaluronidase 2 0.0143167
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0142543
MBNL1 muscleblind-like splicing regulator 1 0.0142013
WNK1 WNK lysine deficient protein kinase 1 0.0141841
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.014161
CXCL10 chemokine (C-X-C motif) ligand 10 0.0139991
TOB1 transducer of ERBB2, 1 0.0139106
BIRC3 baculoviral IAP repeat containing 3 0.013875
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0138155
BBS9 Bardet-Biedl syndrome 9 0.0137673
RPL18 ribosomal protein L18 0.0137052
CCL5 chemokine (C-C motif) ligand 5 0.0136667
CXCL8 chemokine (C-X-C motif) ligand 8 0.013639
POF1B premature ovarian failure, 1B 0.0136222
ATP10B ATPase, class V, type 10B 0.0134682
HNF4G hepatocyte nuclear factor 4, gamma 0.0134601
APP amyloid beta (A4) precursor protein 0.0133906
RPS19 ribosomal protein S19 0.0133341
ACTN1 actinin, alpha 1 0.0132167
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0132066

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.232204
PTMA prothymosin, alpha -0.196621
TMSB10 thymosin beta 10 -0.187271
ANXA2 annexin A2 -0.156558
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.15081
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.12681
FAT1 FAT atypical cadherin 1 -0.115704
FLNB filamin B, beta -0.114275
GREB1L growth regulation by estrogen in breast cancer-like -0.108717
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.108401
ITGA6 integrin, alpha 6 -0.10684
ANTXR2 anthrax toxin receptor 2 -0.0984728
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0975821
TPM4 tropomyosin 4 -0.0946031
AHNAK AHNAK nucleoprotein -0.0894832
S100A6 S100 calcium binding protein A6 -0.0861733
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0849371
CEMIP cell migration inducing protein, hyaluronan binding -0.0832753
ASPH aspartate beta-hydroxylase -0.0823697
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0802473
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0791619
KRT8 keratin 8, type II -0.0778588
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0742768
H1-0 H1.0 linker histone -0.0718962
ESYT2 extended synaptotagmin-like protein 2 -0.0681219
TNS4 tensin 4 -0.0664134
NALF1 NALCN channel auxiliary factor 1 -0.0649404
PPARG peroxisome proliferator-activated receptor gamma -0.0646298
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0644997
ACTG1 actin gamma 1 -0.0636317
PSD3 pleckstrin and Sec7 domain containing 3 -0.0620136
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0616846
KRT18 keratin 18, type I -0.0611211
FERMT1 fermitin family member 1 -0.0604996
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0590736
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0563013
ACTN4 actinin, alpha 4 -0.0543655
GMDS GDP-mannose 4,6-dehydratase -0.0542783
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0536747
SLC35F3 solute carrier family 35, member F3 -0.0536349
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.053301
HMGA1 high mobility group AT-hook 1 -0.0532446
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0516802
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0516049
NDRG1 N-myc downstream regulated 1 -0.0515738
ONECUT3 one cut homeobox 3 -0.0503725
LAMA4 laminin, alpha 4 -0.0498121
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.049697
PGK1 phosphoglycerate kinase 1 -0.0490709
LOC112694756 uncharaterized LOC112694756 -0.0488918
GOLGA4 golgin A4 -0.0479413
RNF217 ring finger protein 217 -0.0478257
POTEF POTE ankyrin domain family, member F -0.0476842
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0468007
CALB1 calbindin 1, 28kDa -0.0466594
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.046091
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0449921
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0443785
MAML2 mastermind-like 2 (Drosophila) -0.0435659
RAP1B RAP1B, member of RAS oncogene family -0.0430259
MACF1 microtubule-actin crosslinking factor 1 -0.0429003
LMO7 LIM domain 7 -0.042806
TFF1 trefoil factor 1 -0.0422829
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.041629
EZR ezrin -0.0410467
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0404634
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0403323
EHBP1 EH domain binding protein 1 -0.0398353
FAM13A family with sequence similarity 13, member A -0.0398189
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0396923
BACE2 beta-site APP-cleaving enzyme 2 -0.0393015
ITGB4 integrin, beta 4 -0.0391509
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0388401
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0380983
CCNY cyclin Y -0.0380169
MED13L mediator complex subunit 13-like -0.0379911
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0377883
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0374679
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0370435
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0369926
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0360652
SH3D19 SH3 domain containing 19 -0.0354908
F3 coagulation factor III (thromboplastin, tissue factor) -0.0352619
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0346926
RAB1A RAB1A, member RAS oncogene family -0.0345175
GCC2 GRIP and coiled-coil domain containing 2 -0.0338716
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0335774
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0334482
IER3 immediate early response 3 -0.0334459
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0333065
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0331545
DENND1A DENN/MADD domain containing 1A -0.0331333
SETD5 SET domain containing 5 -0.0330583
NFIA nuclear factor I/A -0.0329661
MPRIP myosin phosphatase Rho interacting protein -0.0328792
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0325318
AGR2 anterior gradient 2 -0.0320803
FOSL1 FOS-like antigen 1 -0.032011
SBF2 SET binding factor 2 -0.0318666
KIF5B kinesin family member 5B -0.0313163