Capmatinib_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capmatinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Capmatinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0771488
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0637103
RPS12 ribosomal protein S12 0.0491791
BIRC3 baculoviral IAP repeat containing 3 0.0391506
UBC ubiquitin C 0.0387013
RPS4X ribosomal protein S4, X-linked 0.0360377
MT1E metallothionein 1E 0.0284922
SPAG9 sperm associated antigen 9 0.0284526
SQSTM1 sequestosome 1 0.0282366
ERRFI1 ERBB receptor feedback inhibitor 1 0.0268264
ARRDC3 arrestin domain containing 3 0.0268051
HSPA8 heat shock 70kDa protein 8 0.0242918
RPL23 ribosomal protein L23 0.0236574
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0233935
SDC4 syndecan 4 0.0225805
RACK1 receptor for activated C kinase 1 0.0223416
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0219587
ZSWIM6 zinc finger, SWIM-type containing 6 0.0188443
EMP1 epithelial membrane protein 1 0.0187286
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0177624
KLF6 Kruppel-like factor 6 0.0176684
RPS27A ribosomal protein S27a 0.0173406
RPS8 ribosomal protein S8 0.0170842
B2M beta-2-microglobulin 0.0170478
JUN jun proto-oncogene 0.0166417
RPS2 ribosomal protein S2 0.0161612
MT1X metallothionein 1X 0.0161154
EZR ezrin 0.0158297
CFLAR CASP8 and FADD-like apoptosis regulator 0.0155251
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0152719
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0146999
RPS27 ribosomal protein S27 0.0142855
RPS17 ribosomal protein S17 0.0140844
SVIL supervillin 0.0138143
RPS3 ribosomal protein S3 0.0133595
DDIT4 DNA-damage-inducible transcript 4 0.0133437
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0132049
DIAPH1 diaphanous-related formin 1 0.0130755
RPL12 ribosomal protein L12 0.0129603
RPS18 ribosomal protein S18 0.0118851
HMOX1 heme oxygenase 1 0.0113788
ARL15 ADP-ribosylation factor-like 15 0.0113475
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0110987
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0110504
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0106945
ANGPTL4 angiopoietin-like 4 0.0106666
RPL5 ribosomal protein L5 0.010463
IFITM1 interferon induced transmembrane protein 1 0.0104252
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0102258
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0102112
PABPN1 poly(A) binding protein, nuclear 1 0.0100818
RPL26 ribosomal protein L26 0.0100726
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0100324
PDE4D phosphodiesterase 4D, cAMP-specific 0.00980626
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.00969496
BBS9 Bardet-Biedl syndrome 9 0.00967229
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.00946347
PMEPA1 prostate transmembrane protein, androgen induced 1 0.00926504
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.00922174
PDIA4 protein disulfide isomerase family A, member 4 0.0091782
CRY1 cryptochrome circadian clock 1 0.00908887
TPM3 tropomyosin 3 0.00907803
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.00905273
MCL1 myeloid cell leukemia 1 0.0088631
CSF3 colony stimulating factor 3 (granulocyte) 0.00869105
ARGLU1 arginine and glutamate rich 1 0.00868934
EREG epiregulin 0.00866161
EIF4A1 eukaryotic translation initiation factor 4A1 0.00861401
IRF1 interferon regulatory factor 1 0.00858018
DSCAM Down syndrome cell adhesion molecule 0.00853136
RPL36 ribosomal protein L36 0.00852224
ANKRD36 ankyrin repeat domain 36 0.00846105
PLEC plectin 0.00845287
CTNND1 catenin (cadherin-associated protein), delta 1 0.00843814
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.00829649
FAT1 FAT atypical cadherin 1 0.00820453
ARFGEF3 ARFGEF family member 3 0.00820122
NACA nascent polypeptide-associated complex alpha subunit 0.00819671
FBXL17 F-box and leucine-rich repeat protein 17 0.00813653
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.00811948
RSAD2 radical S-adenosyl methionine domain containing 2 0.00810697
SYAP1 synapse associated protein 1 0.00810403
BRD2 bromodomain containing 2 0.00808812
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.00804281
AFDN afadin, adherens junction formation factor 0.0079873
ZC3H11A zinc finger CCCH-type containing 11A 0.00785631
EXT1 exostosin glycosyltransferase 1 0.00780284
RIPK4 receptor-interacting serine-threonine kinase 4 0.00779531
NIN ninein (GSK3B interacting protein) 0.00775496
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.00772762
RPL3 ribosomal protein L3 0.00770976
CXCL3 chemokine (C-X-C motif) ligand 3 0.00766972
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.00763315
RPS15 ribosomal protein S15 0.00762894
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.00759298
UBAP2L ubiquitin associated protein 2-like 0.00757993
MINK1 misshapen-like kinase 1 0.00755998
CCL5 chemokine (C-C motif) ligand 5 0.00755428
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.00755104
DOCK5 dedicator of cytokinesis 5 0.00754625

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.235386
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.1626
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.150447
DLG1 discs, large homolog 1 (Drosophila) -0.129804
CD44 CD44 molecule (Indian blood group) -0.128601
PSD3 pleckstrin and Sec7 domain containing 3 -0.118035
PTMA prothymosin, alpha -0.109221
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.105608
EHBP1 EH domain binding protein 1 -0.0989892
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0961556
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0885443
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0880008
TMSB4X thymosin beta 4, X-linked -0.0856249
SLC38A2 solute carrier family 38, member 2 -0.0852246
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0834154
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0823055
TP63 tumor protein p63 -0.0778685
RAI1 retinoic acid induced 1 -0.0751025
CADM2 cell adhesion molecule 2 -0.0740178
FMNL2 formin-like 2 -0.0726702
EFNA5 ephrin-A5 -0.0704782
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.070215
CFAP299 cilia and flagella associated protein 299 -0.0676035
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.065495
DPYD dihydropyrimidine dehydrogenase -0.0628864
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0622561
TSC22D1 TSC22 domain family, member 1 -0.0612738
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0596482
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0588869
EPHA4 EPH receptor A4 -0.0588178
EXOC4 exocyst complex component 4 -0.0575899
CANX calnexin -0.0561678
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0544338
MACF1 microtubule-actin crosslinking factor 1 -0.0521758
CENPF centromere protein F, 350/400kDa -0.0514775
ACTG1 actin gamma 1 -0.05063
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0499172
ZMYND8 zinc finger, MYND-type containing 8 -0.049646
PDE10A phosphodiesterase 10A -0.0493804
TMSB10 thymosin beta 10 -0.0483843
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0481579
APP amyloid beta (A4) precursor protein -0.0471812
PGK1 phosphoglycerate kinase 1 -0.0471662
ARHGAP5 Rho GTPase activating protein 5 -0.0471354
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0458452
RUNX1 runt-related transcription factor 1 -0.0458131
LOXL2 lysyl oxidase-like 2 -0.045696
TMEM123 transmembrane protein 123 -0.0432285
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0424477
RAD51B RAD51 paralog B -0.0416796
COL5A2 collagen, type V, alpha 2 -0.0405679
DENND1A DENN/MADD domain containing 1A -0.0405211
RAB27B RAB27B, member RAS oncogene family -0.0403824
DOCK11 dedicator of cytokinesis 11 -0.0399842
PTPRF protein tyrosine phosphatase, receptor type, F -0.0397207
CSMD3 CUB and Sushi multiple domains 3 -0.0397129
TXNRD1 thioredoxin reductase 1 -0.0374232
PTK2 protein tyrosine kinase 2 -0.0371749
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0371287
LMAN1 lectin, mannose-binding, 1 -0.0365517
MAP4 microtubule-associated protein 4 -0.0357395
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0353925
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0353863
TTC28 tetratricopeptide repeat domain 28 -0.0353653
DNER delta/notch-like EGF repeat containing -0.0347452
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0347079
KPNB1 karyopherin (importin) beta 1 -0.03455
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0342328
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0341131
SGK1 serum/glucocorticoid regulated kinase 1 -0.0339177
SDCCAG8 serologically defined colon cancer antigen 8 -0.0338307
CDK6 cyclin-dependent kinase 6 -0.0331011
VDAC1 voltage-dependent anion channel 1 -0.0329483
WASF2 WAS protein family, member 2 -0.032568
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0324823
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0324396
ANKRD11 ankyrin repeat domain 11 -0.0322414
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0317742
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.031596
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0315633
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0313353
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0313262
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0311321
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0309161
POTEF POTE ankyrin domain family, member F -0.0307957
CMIP c-Maf inducing protein -0.0306967
BRWD1 bromodomain and WD repeat domain containing 1 -0.0306425
GSK3B glycogen synthase kinase 3 beta -0.0305836
TNS3 tensin 3 -0.0303814
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0301919
RAB7A RAB7A, member RAS oncogene family -0.029996
THSD4 thrombospondin, type I, domain containing 4 -0.0299178
PDIA3 protein disulfide isomerase family A, member 3 -0.0287929
PRRC2B proline-rich coiled-coil 2B -0.0287885
ADGRG6 adhesion G protein-coupled receptor G6 -0.0286169
ANKRD12 ankyrin repeat domain 12 -0.0285788
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0282864
LPP LIM domain containing preferred translocation partner in lipoma -0.0281965
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0281934
TRIP12 thyroid hormone receptor interactor 12 -0.0280135