Capmatinib_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capmatinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capmatinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.27272
PDE4D phosphodiesterase 4D, cAMP-specific 0.152732
CCL5 chemokine (C-C motif) ligand 5 0.0671645
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0546842
WWOX WW domain containing oxidoreductase 0.0533663
NTN4 netrin 4 0.0516601
RPS27A ribosomal protein S27a 0.0488048
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0448128
RPS12 ribosomal protein S12 0.0435193
IGFBP3 insulin-like growth factor binding protein 3 0.0430132
GRAMD1B GRAM domain containing 1B 0.042119
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0402032
SMOC1 SPARC related modular calcium binding 1 0.0398946
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0390921
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0388699
RPS8 ribosomal protein S8 0.0387123
FGB fibrinogen beta chain 0.0385421
KYNU kynureninase 0.0376244
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0366661
UBC ubiquitin C 0.0343395
IGF1R insulin-like growth factor 1 receptor 0.0336891
ATXN1 ataxin 1 0.0325969
BASP1 brain abundant, membrane attached signal protein 1 0.0311007
ZSWIM6 zinc finger, SWIM-type containing 6 0.0308607
ASPH aspartate beta-hydroxylase 0.0307964
EFNA1 ephrin-A1 0.0303484
AHNAK AHNAK nucleoprotein 0.0294817
RPS3 ribosomal protein S3 0.0292394
RPL37A ribosomal protein L37a 0.0283497
CFLAR CASP8 and FADD-like apoptosis regulator 0.0281153
KIAA0319 KIAA0319 0.0280048
RPS17 ribosomal protein S17 0.0277858
HLA-B major histocompatibility complex, class I, B 0.0276458
RPL23 ribosomal protein L23 0.0266475
RNF213 ring finger protein 213 0.0264684
FGG fibrinogen gamma chain 0.0260986
NNMT nicotinamide N-methyltransferase 0.0259164
HSPA8 heat shock 70kDa protein 8 0.0256527
RPL31 ribosomal protein L31 0.0256152
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0246882
ENO1 enolase 1, (alpha) 0.0246218
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0244557
ZBTB20 zinc finger and BTB domain containing 20 0.0244477
FGA fibrinogen alpha chain 0.0236698
NFE2L2 nuclear factor, erythroid 2-like 2 0.0235941
HMOX1 heme oxygenase 1 0.0229652
PDE10A phosphodiesterase 10A 0.0228821
RPS29 ribosomal protein S29 0.0222977
EXOC6B exocyst complex component 6B 0.0217676
HSPB1 heat shock 27kDa protein 1 0.0215267
AHR aryl hydrocarbon receptor 0.0214
DST dystonin 0.0213619
OSMR oncostatin M receptor 0.0209441
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0209398
EEF2 eukaryotic translation elongation factor 2 0.020879
B2M beta-2-microglobulin 0.0207348
ALCAM activated leukocyte cell adhesion molecule 0.0207179
BPTF bromodomain PHD finger transcription factor 0.0200762
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0199454
MYH9 myosin, heavy chain 9, non-muscle 0.0195404
MBD5 methyl-CpG binding domain protein 5 0.0195302
DSCAM Down syndrome cell adhesion molecule 0.0194868
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0193923
FHIT fragile histidine triad 0.019195
ZFHX3 zinc finger homeobox 3 0.0187973
PRKN parkin RBR E3 ubiquitin protein ligase 0.0186966
SFTPA2 surfactant protein A2 0.01868
RAD51B RAD51 paralog B 0.018373
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0183682
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0183586
EHBP1 EH domain binding protein 1 0.0181067
PRRC2C proline-rich coiled-coil 2C 0.0180764
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0178885
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0178125
PRELID2 PRELI domain containing 2 0.0177758
GOLGB1 golgin B1 0.0177094
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0176259
RBMS3 RNA binding motif, single stranded interacting protein 3 0.017568
KIAA1217 KIAA1217 0.0175426
INTS6 integrator complex subunit 6 0.0173683
SAMD4A sterile alpha motif domain containing 4A 0.0173332
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0173098
SPIDR scaffolding protein involved in DNA repair 0.0170765
AHNAK2 AHNAK nucleoprotein 2 0.0167438
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0166283
RPS4X ribosomal protein S4, X-linked 0.0164762
MKI67 marker of proliferation Ki-67 0.0161625
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0160375
CALR calreticulin 0.0159308
KANSL1L KAT8 regulatory NSL complex subunit 1-like 0.0159146
NFE2L1 nuclear factor, erythroid 2-like 1 0.015642
MYOF myoferlin 0.0155637
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0155077
SQSTM1 sequestosome 1 0.0154678
MYO9A myosin IXA 0.0154127
ARL15 ADP-ribosylation factor-like 15 0.0152885
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0152265
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0149383
LGALS12 lectin, galactoside-binding, soluble, 12 0.0145643
SET SET nuclear proto-oncogene 0.0143907

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.35624
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.198555
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.187726
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.160242
TMSB10 thymosin beta 10 -0.135034
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.126655
IGF2 insulin-like growth factor 2 -0.116981
FTH1 ferritin, heavy polypeptide 1 -0.114677
DOCK4 dedicator of cytokinesis 4 -0.113574
TFPI2 tissue factor pathway inhibitor 2 -0.112217
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101132
POTEF POTE ankyrin domain family, member F -0.0849778
ACTG1 actin gamma 1 -0.0825044
THSD4 thrombospondin, type I, domain containing 4 -0.0736336
FTL ferritin, light polypeptide -0.0715987
RBM25 RNA binding motif protein 25 -0.0703835
RBM39 RNA binding motif protein 39 -0.0679717
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0637636
PFN1 profilin 1 -0.0628185
PTK2 protein tyrosine kinase 2 -0.0626803
FMNL2 formin-like 2 -0.0620782
USP3 ubiquitin specific peptidase 3 -0.05979
S100A6 S100 calcium binding protein A6 -0.0585824
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0555818
ZNF207 zinc finger protein 207 -0.0541933
ZFAND3 zinc finger, AN1-type domain 3 -0.0538498
HMGA1 high mobility group AT-hook 1 -0.0534069
IER3 immediate early response 3 -0.0524887
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0523672
PARD3 par-3 family cell polarity regulator -0.0522704
SLC38A1 solute carrier family 38, member 1 -0.0516091
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0506994
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0496098
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0495162
WDR43 WD repeat domain 43 -0.0493559
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0480573
PYGL phosphorylase, glycogen, liver -0.0475486
TPD52 tumor protein D52 -0.047051
NOP58 NOP58 ribonucleoprotein -0.0467985
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0462715
TRA2A transformer 2 alpha homolog (Drosophila) -0.0456983
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0439342
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.043893
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0430433
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0424551
UBASH3B ubiquitin associated and SH3 domain containing B -0.0412556
ERBIN erbb2 interacting protein -0.0411441
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0409256
DENND4A DENN/MADD domain containing 4A -0.0408973
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0392519
TFG TRK-fused gene -0.0391854
KMT2E lysine (K)-specific methyltransferase 2E -0.0373549
MARCHF6 membrane associated ring-CH-type finger 6 -0.0372567
RTN4 reticulon 4 -0.0366514
FNBP1L formin binding protein 1-like -0.0360842
ZNF292 zinc finger protein 292 -0.0356761
PAWR PRKC, apoptosis, WT1, regulator -0.0353718
UGCG UDP-glucose ceramide glucosyltransferase -0.0353693
RPS21 ribosomal protein S21 -0.0350055
EGR1 early growth response 1 -0.03477
RPL35A ribosomal protein L35a -0.0345653
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0343324
NAV3 neuron navigator 3 -0.0340796
KDM5B lysine (K)-specific demethylase 5B -0.0340228
RPLP1 ribosomal protein, large, P1 -0.0335556
RAB7A RAB7A, member RAS oncogene family -0.0334314
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0334059
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0332359
PDIA3 protein disulfide isomerase family A, member 3 -0.0331862
CYRIB CYFIP related Rac1 interactor B -0.0331022
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0327171
RNF145 ring finger protein 145 -0.0325849
STC1 stanniocalcin 1 -0.0325836
RAB1A RAB1A, member RAS oncogene family -0.0322855
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0321988
KDM3A lysine (K)-specific demethylase 3A -0.0313764
BHLHE40 basic helix-loop-helix family, member e40 -0.0307588
ITGB5 integrin, beta 5 -0.0307279
COPA coatomer protein complex, subunit alpha -0.030526
KPNB1 karyopherin (importin) beta 1 -0.0303957
RAD21 RAD21 homolog (S. pombe) -0.0303749
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0303634
BZW2 basic leucine zipper and W2 domains 2 -0.030001
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0298729
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.029703
ADAM9 ADAM metallopeptidase domain 9 -0.0296852
LOC112694756 uncharaterized LOC112694756 -0.0294991
RPLP0 ribosomal protein, large, P0 -0.0292736
SETD5 SET domain containing 5 -0.0286961
CHN1 chimerin 1 -0.028385
TLK1 tousled-like kinase 1 -0.0280741
CCNL1 cyclin L1 -0.0280385
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0279192
AK1 adenylate kinase 1 -0.0277914
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0276993
GNAS GNAS complex locus -0.0270283
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.027003
PUM2 pumilio RNA-binding family member 2 -0.026862
PRRC1 proline-rich coiled-coil 1 -0.0268293
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0267731