Capmatinib_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capmatinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capmatinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.189828
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.110657
RNF213 ring finger protein 213 0.102235
ERRFI1 ERBB receptor feedback inhibitor 1 0.0971152
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0905693
OASL 2'-5'-oligoadenylate synthetase-like 0.089338
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0702365
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0685784
SPTBN1 spectrin, beta, non-erythrocytic 1 0.066685
INHBA inhibin, beta A 0.06575
RSAD2 radical S-adenosyl methionine domain containing 2 0.0650845
TJP1 tight junction protein 1 0.0643988
PDE4D phosphodiesterase 4D, cAMP-specific 0.0631521
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0628395
SMOC1 SPARC related modular calcium binding 1 0.0619786
MYH9 myosin, heavy chain 9, non-muscle 0.0616502
TXNRD1 thioredoxin reductase 1 0.0610285
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0594505
ABLIM1 actin binding LIM protein 1 0.058472
MTUS1 microtubule associated tumor suppressor 1 0.0583095
ARHGAP21 Rho GTPase activating protein 21 0.0569454
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0561581
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0552292
IFI6 interferon, alpha-inducible protein 6 0.0545733
SEC31A SEC31 homolog A (S. cerevisiae) 0.0538168
STK24 serine/threonine kinase 24 0.0529052
EGFR epidermal growth factor receptor 0.0525368
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0524641
SIK3 SIK family kinase 3 0.0516532
FNDC3A fibronectin type III domain containing 3A 0.0514172
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0504639
FGFR2 fibroblast growth factor receptor 2 0.0500538
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.049839
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0497213
RAP1GAP2 RAP1 GTPase activating protein 2 0.0482036
ZFAND6 zinc finger, AN1-type domain 6 0.0480055
ETV6 ets variant 6 0.0477998
ATXN1 ataxin 1 0.0474935
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0469217
NPEPPS aminopeptidase puromycin sensitive 0.0466656
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0465309
VEGFA vascular endothelial growth factor A 0.0463557
ESYT2 extended synaptotagmin-like protein 2 0.0459823
DIAPH1 diaphanous-related formin 1 0.0458347
TRIO trio Rho guanine nucleotide exchange factor 0.0447134
MTDH metadherin 0.0442914
FUS FUS RNA binding protein 0.0441752
RIGI RNA sensor RIG-I 0.0441093
HMGA2 high mobility group AT-hook 2 0.0439583
SLC38A2 solute carrier family 38, member 2 0.0436584
MAML3 mastermind-like 3 (Drosophila) 0.0433651
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0431504
GRB10 growth factor receptor-bound protein 10 0.0429946
AHI1 Abelson helper integration site 1 0.0425729
EZR ezrin 0.0424268
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0421688
ISG15 ISG15 ubiquitin-like modifier 0.0421614
AKAP13 A kinase (PRKA) anchor protein 13 0.0413769
KAT6B K(lysine) acetyltransferase 6B 0.0411432
DTNA dystrobrevin, alpha 0.0408043
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0406633
TMF1 TATA element modulatory factor 1 0.0404714
FRMD5 FERM domain containing 5 0.0403276
MSI2 musashi RNA-binding protein 2 0.0403009
KYNU kynureninase 0.0402311
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0402054
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0401284
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0401149
EXT1 exostosin glycosyltransferase 1 0.0397487
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0396972
TXNIP thioredoxin interacting protein 0.0388349
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0386349
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0386239
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0385248
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0381428
FBXL17 F-box and leucine-rich repeat protein 17 0.0379112
BIRC6 baculoviral IAP repeat containing 6 0.0377713
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0377624
PSD3 pleckstrin and Sec7 domain containing 3 0.0373649
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0373606
CSNK1A1 casein kinase 1, alpha 1 0.0368371
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0367158
CMIP c-Maf inducing protein 0.0363876
RASAL2 RAS protein activator like 2 0.0362834
IGF1R insulin-like growth factor 1 receptor 0.0362485
SQSTM1 sequestosome 1 0.0358725
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0357976
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0357621
PRELID2 PRELI domain containing 2 0.0355122
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0351659
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0348542
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0347165
TSC22D1 TSC22 domain family, member 1 0.0346748
RPL5 ribosomal protein L5 0.034554
ZNF609 zinc finger protein 609 0.0343161
TOP1 topoisomerase (DNA) I 0.0342527
MED13 mediator complex subunit 13 0.0342316
PDLIM5 PDZ and LIM domain 5 0.0342268
ABHD3 abhydrolase domain containing 3 0.0340767
LMO7 LIM domain 7 0.033871

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.184143
TMSB10 thymosin beta 10 -0.145256
PTMA prothymosin, alpha -0.137407
POTEF POTE ankyrin domain family, member F -0.133843
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103574
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0981519
JMJD1C jumonji domain containing 1C -0.0971716
NAMPT nicotinamide phosphoribosyltransferase -0.0951039
RPS6 ribosomal protein S6 -0.093423
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -0.0905302
SLC38A1 solute carrier family 38, member 1 -0.0879628
MUC16 mucin 16, cell surface associated -0.0864873
VIM vimentin -0.084715
KRT17 keratin 17, type I -0.0816693
S100A6 S100 calcium binding protein A6 -0.078745
RPS16 ribosomal protein S16 -0.0735941
RPS5 ribosomal protein S5 -0.0724587
RUNX1 runt-related transcription factor 1 -0.0722619
RPL35A ribosomal protein L35a -0.071587
RPLP0 ribosomal protein, large, P0 -0.0714136
FNDC3B fibronectin type III domain containing 3B -0.0701356
GOLGA4 golgin A4 -0.0673056
DLG1 discs, large homolog 1 (Drosophila) -0.0664409
RPL15 ribosomal protein L15 -0.0664284
STC1 stanniocalcin 1 -0.0655912
MCTP1 multiple C2 domains, transmembrane 1 -0.0635908
RPS12 ribosomal protein S12 -0.0610474
SEPTIN7 septin 7 -0.0606707
MT2A metallothionein 2A -0.0602039
RPS20 ribosomal protein S20 -0.0599248
NKD1 naked cuticle homolog 1 (Drosophila) -0.0589742
UBC ubiquitin C -0.0575999
TPM4 tropomyosin 4 -0.0571899
ENO1 enolase 1, (alpha) -0.0561526
DOCK4 dedicator of cytokinesis 4 -0.0553191
RPS19 ribosomal protein S19 -0.0534497
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0533727
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0527669
RCOR1 REST corepressor 1 -0.0513813
RPLP1 ribosomal protein, large, P1 -0.0509261
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0509082
EIF1 eukaryotic translation initiation factor 1 -0.0499539
CAPN2 calpain 2, (m/II) large subunit -0.0495947
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0494402
LDHA lactate dehydrogenase A -0.0494019
CARD16 caspase recruitment domain family, member 16 -0.0488893
EEF2 eukaryotic translation elongation factor 2 -0.0482023
RPL31 ribosomal protein L31 -0.0453942
PKM pyruvate kinase, muscle -0.0451858
HELZ helicase with zinc finger -0.0445711
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0436054
RAB7A RAB7A, member RAS oncogene family -0.0433954
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0433542
SMC5 structural maintenance of chromosomes 5 -0.0425371
RPS25 ribosomal protein S25 -0.042135
RHOA ras homolog family member A -0.0412784
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0411687
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0410269
ZNF207 zinc finger protein 207 -0.0409967
SRPK2 SRSF protein kinase 2 -0.0409878
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0407446
RPL7 ribosomal protein L7 -0.040534
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0400791
PTK2 protein tyrosine kinase 2 -0.0396198
RTN4 reticulon 4 -0.0395936
RRBP1 ribosome binding protein 1 -0.0391091
RNF145 ring finger protein 145 -0.0384143
FAM13A family with sequence similarity 13, member A -0.0384029
NKTR natural killer cell triggering receptor -0.0383857
SPAG9 sperm associated antigen 9 -0.038077
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0379643
ZFAND3 zinc finger, AN1-type domain 3 -0.0379053
SETD5 SET domain containing 5 -0.037898
KDM5B lysine (K)-specific demethylase 5B -0.0376595
SYPL1 synaptophysin-like 1 -0.0372056
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0369103
SCAF11 SR-related CTD-associated factor 11 -0.0368118
NAP1L1 nucleosome assembly protein 1-like 1 -0.0367849
RPL36 ribosomal protein L36 -0.0366266
TCF12 transcription factor 12 -0.0365219
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0363422
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0362657
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0362066
RPS27A ribosomal protein S27a -0.0361274
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0359597
SCFD1 sec1 family domain containing 1 -0.0357678
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0355481
ANKHD1 ankyrin repeat and KH domain containing 1 -0.035419
KDM2A lysine (K)-specific demethylase 2A -0.0349223
STAG2 stromal antigen 2 -0.0345063
RPL12 ribosomal protein L12 -0.033997
RPS11 ribosomal protein S11 -0.0339414
WSB1 WD repeat and SOCS box containing 1 -0.0338092
STAU1 staufen double-stranded RNA binding protein 1 -0.0337734
YAP1 Yes-associated protein 1 -0.0336831
RPLP2 ribosomal protein, large, P2 -0.0336465
CCNL1 cyclin L1 -0.0332748
ZEB1 zinc finger E-box binding homeobox 1 -0.033199
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 -0.0331345
INSIG1 insulin induced gene 1 -0.0329096