Capmatinib_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capmatinib perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capmatinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0719881
MAP7 microtubule-associated protein 7 0.0472161
SMAD2 SMAD family member 2 0.0411555
AUTS2 autism susceptibility candidate 2 0.0391761
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0376006
INTS6 integrator complex subunit 6 0.0374334
XYLT1 xylosyltransferase I 0.0359278
SMOC1 SPARC related modular calcium binding 1 0.0347878
AGTPBP1 ATP/GTP binding protein 1 0.0341558
FNDC3A fibronectin type III domain containing 3A 0.0329589
EXT1 exostosin glycosyltransferase 1 0.0305934
WARS1 tryptophanyl-tRNA synthetase 1 0.0290181
FNIP1 folliculin interacting protein 1 0.0281499
ZSWIM6 zinc finger, SWIM-type containing 6 0.0279061
CHL1 cell adhesion molecule L1-like 0.0270812
LSAMP limbic system-associated membrane protein 0.0260433
OXSR1 oxidative stress responsive 1 0.0259576
FMNL2 formin-like 2 0.0257842
PRELID2 PRELI domain containing 2 0.0256461
TENM2 teneurin transmembrane protein 2 0.0242353
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0235935
AEBP2 AE binding protein 2 0.0229276
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0229181
NBEAL1 neurobeachin-like 1 0.0229143
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0218204
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0217785
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0216904
DST dystonin 0.0216024
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0215885
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0215665
PM20D1 peptidase M20 domain containing 1 0.0210953
SQSTM1 sequestosome 1 0.0207053
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.020368
SVIL supervillin 0.0201711
CTBP2 C-terminal binding protein 2 0.0198956
FAM107B family with sequence similarity 107, member B 0.0194136
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0191818
PCDH15 protocadherin-related 15 0.0185341
DENND1A DENN/MADD domain containing 1A 0.0183317
RASAL2 RAS protein activator like 2 0.0182333
SEPTIN9 septin 9 0.0180884
CUX1 cut-like homeobox 1 0.0176755
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0166614
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 0.0165783
RPS4X ribosomal protein S4, X-linked 0.0159849
TOB1 transducer of ERBB2, 1 0.0159783
CLIP1 CAP-GLY domain containing linker protein 1 0.0159339
CTIF CBP80/20-dependent translation initiation factor 0.0157954
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0157914
C9ORF153 chromosome 9 open reading frame 153 0.0157447
ZMIZ1 zinc finger, MIZ-type containing 1 0.0155646
P3H2 prolyl 3-hydroxylase 2 0.0150724
HDAC4 histone deacetylase 4 0.0148797
NTN4 netrin 4 0.0147897
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.014719
ATP9B ATPase, class II, type 9B 0.0145571
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0144448
RPS12 ribosomal protein S12 0.0144197
TTC28 tetratricopeptide repeat domain 28 0.0144164
NFX1 nuclear transcription factor, X-box binding 1 0.0142651
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0142398
GPC5 glypican 5 0.0137825
TENM3 teneurin transmembrane protein 3 0.0137164
PCDH7 protocadherin 7 0.0135795
AKAP13 A kinase (PRKA) anchor protein 13 0.0133854
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0131416
MYPN myopalladin 0.0131311
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0130835
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0130773
HDAC9 histone deacetylase 9 0.0130059
OLFML2A olfactomedin-like 2A 0.0129856
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0129738
NRXN3 neurexin 3 0.0128989
BMP6 bone morphogenetic protein 6 0.0128739
CRTC3 CREB regulated transcription coactivator 3 0.0128336
ENO2 enolase 2 (gamma, neuronal) 0.0127245
MACF1 microtubule-actin crosslinking factor 1 0.0127084
GLRX glutaredoxin (thioltransferase) 0.0127034
RSAD2 radical S-adenosyl methionine domain containing 2 0.0126899
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0126019
AADAC arylacetamide deacetylase 0.0125584
RAB31 RAB31, member RAS oncogene family 0.0123785
LYST lysosomal trafficking regulator 0.0121646
PTPRM protein tyrosine phosphatase, receptor type, M 0.0121307
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0120751
CCL5 chemokine (C-C motif) ligand 5 0.012025
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0120103
KLF3 Kruppel-like factor 3 (basic) 0.0119085
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0119056
NCOR2 nuclear receptor corepressor 2 0.0118034
SFTPA2 surfactant protein A2 0.0117299
DNER delta/notch-like EGF repeat containing 0.011701
MYO10 myosin X 0.0116206
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0115196
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0115072
FOXK1 forkhead box K1 0.0114518
CAMTA1 calmodulin binding transcription activator 1 0.011405
NT5C2 5'-nucleotidase, cytosolic II 0.0113076
PDLIM5 PDZ and LIM domain 5 0.0112753
PRR5L proline rich 5 like 0.0111499

decreased expression

Symbol Name Standardized Value
EFNA5 ephrin-A5 -0.289051
NAMPT nicotinamide phosphoribosyltransferase -0.21967
ASPH aspartate beta-hydroxylase -0.184755
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.17927
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.146019
PDE4D phosphodiesterase 4D, cAMP-specific -0.132774
TXNRD1 thioredoxin reductase 1 -0.132109
GDA guanine deaminase -0.128823
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.12523
NRCAM neuronal cell adhesion molecule -0.122348
FN1 fibronectin 1 -0.0982573
TFPI2 tissue factor pathway inhibitor 2 -0.0977872
PSD3 pleckstrin and Sec7 domain containing 3 -0.0975179
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0896538
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0866778
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0824011
NALF1 NALCN channel auxiliary factor 1 -0.0804124
TM4SF1 transmembrane 4 L six family member 1 -0.0774056
TRIO trio Rho guanine nucleotide exchange factor -0.0741553
LIMCH1 LIM and calponin homology domains 1 -0.0738198
TMSB10 thymosin beta 10 -0.0726687
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0715431
NEK7 NIMA-related kinase 7 -0.0683181
PGK1 phosphoglycerate kinase 1 -0.0667465
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0663027
RTN4 reticulon 4 -0.0651301
DOCK4 dedicator of cytokinesis 4 -0.064433
GRAMD1B GRAM domain containing 1B -0.0637741
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0633576
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0632987
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0632681
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0614442
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0549783
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0535196
NPAS2 neuronal PAS domain protein 2 -0.0535102
PCBP3 poly(rC) binding protein 3 -0.0532163
SMYD3 SET and MYND domain containing 3 -0.0519289
RBM39 RNA binding motif protein 39 -0.0512689
CTSC cathepsin C -0.0511038
CENPF centromere protein F, 350/400kDa -0.0508683
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0503018
OGA O-GlcNAcase -0.0502669
TNPO1 transportin 1 -0.0498409
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0488674
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0483067
MYOF myoferlin -0.0478377
FNDC3B fibronectin type III domain containing 3B -0.0473612
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0471699
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0465671
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0462746
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0462105
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0438964
MFF mitochondrial fission factor -0.0430739
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.043048
ELL2 elongation factor, RNA polymerase II, 2 -0.0411616
COL5A2 collagen, type V, alpha 2 -0.0408475
PTMA prothymosin, alpha -0.0400734
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0391924
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0389733
FTL ferritin, light polypeptide -0.0389299
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0388205
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0376805
TGFBI transforming growth factor, beta-induced, 68kDa -0.0371208
SRGN serglycin -0.036799
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0365117
PDE10A phosphodiesterase 10A -0.03649
AKR1C1 aldo-keto reductase family 1, member C1 -0.0363458
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0358661
EIF1 eukaryotic translation initiation factor 1 -0.035825
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.035377
NAP1L1 nucleosome assembly protein 1-like 1 -0.0353458
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0352157
MAML3 mastermind-like 3 (Drosophila) -0.0347276
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0345627
PTGR1 prostaglandin reductase 1 -0.0345584
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0344054
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0339712
GNAS GNAS complex locus -0.0331431
AGFG1 ArfGAP with FG repeats 1 -0.032478
GLIS3 GLIS family zinc finger 3 -0.0321883
RTN1 reticulon 1 -0.0321576
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0320608
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0316195
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0308996
TMX4 thioredoxin-related transmembrane protein 4 -0.0308677
CD109 CD109 molecule -0.0308258
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0305443
RGS2 regulator of G-protein signaling 2 -0.0305249
BRWD3 bromodomain and WD repeat domain containing 3 -0.0304826
NCOA7 nuclear receptor coactivator 7 -0.0301643
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.029733
ANKRD28 ankyrin repeat domain 28 -0.0295308
COL4A5 collagen, type IV, alpha 5 -0.0291964
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0290737
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.028959
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0283806
MKI67 marker of proliferation Ki-67 -0.0282678
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.02823
ATP5F1B ATP synthase F1 subunit beta -0.0281661
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.0281092