Capmatinib_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capmatinib perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

154 genes differentially expressed following the Capmatinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.1577
FN1 fibronectin 1 0.129425
INHBA inhibin, beta A 0.128132
LIMS1 LIM and senescent cell antigen-like domains 1 0.126247
THSD4 thrombospondin, type I, domain containing 4 0.122664
MACF1 microtubule-actin crosslinking factor 1 0.12053
ZFAND3 zinc finger, AN1-type domain 3 0.117126
PDE4D phosphodiesterase 4D, cAMP-specific 0.11487
HMGA2 high mobility group AT-hook 2 0.114217
ASPH aspartate beta-hydroxylase 0.113145
INTS6 integrator complex subunit 6 0.102275
EGFR epidermal growth factor receptor 0.0993079
MYO10 myosin X 0.098307
NPAS2 neuronal PAS domain protein 2 0.0982858
MYO1E myosin IE 0.0930682
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0857223
LAMA4 laminin, alpha 4 0.0826158
ALCAM activated leukocyte cell adhesion molecule 0.0823267
OXR1 oxidation resistance 1 0.0808743
RAB1A RAB1A, member RAS oncogene family 0.0771002
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0761206
FER fer (fps/fes related) tyrosine kinase 0.071527
ANKRD12 ankyrin repeat domain 12 0.0709005
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0689807
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0653778
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0638219
PDLIM5 PDZ and LIM domain 5 0.0633416
NALF1 NALCN channel auxiliary factor 1 0.0621439
CSNK1A1 casein kinase 1, alpha 1 0.0605784
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0594304
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.059337
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0572232
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0530811
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0525953
SEC31A SEC31 homolog A (S. cerevisiae) 0.0499197
TTC3 tetratricopeptide repeat domain 3 0.0481711
FNDC3B fibronectin type III domain containing 3B 0.0470851
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.045455
NF1 neurofibromin 1 0.0453952
SYAP1 synapse associated protein 1 0.0436223
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0425645
CANX calnexin 0.0423379
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0400368
ERRFI1 ERBB receptor feedback inhibitor 1 0.037993
JARID2 jumonji, AT rich interactive domain 2 0.0362989
TPM4 tropomyosin 4 0.0325783
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0315424
PUM2 pumilio RNA-binding family member 2 0.0314258
AKAP13 A kinase (PRKA) anchor protein 13 0.0304658
NAMPT nicotinamide phosphoribosyltransferase 0.0301698
ZBTB20 zinc finger and BTB domain containing 20 0.0288693
RPS19 ribosomal protein S19 0.0276026
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0272268
SBF2 SET binding factor 2 0.0264404
KMT2C lysine (K)-specific methyltransferase 2C 0.0264242
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0243422
MYOF myoferlin 0.0231549
RPS6 ribosomal protein S6 0.0223161
ARL15 ADP-ribosylation factor-like 15 0.022062
ESYT2 extended synaptotagmin-like protein 2 0.0219642
CTBP2 C-terminal binding protein 2 0.019107
SLIT2 slit homolog 2 (Drosophila) 0.0180175
NCOR1 nuclear receptor corepressor 1 0.0176213
KMT2E lysine (K)-specific methyltransferase 2E 0.0153692
SMAD3 SMAD family member 3 0.0140693
FNIP1 folliculin interacting protein 1 0.0138057
MEF2A myocyte enhancer factor 2A 0.0135911
TRIO trio Rho guanine nucleotide exchange factor 0.0120552
KTN1 kinectin 1 (kinesin receptor) 0.0120314
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0112866
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0102663
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.00977862
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.00872064
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.00800973
RORA RAR-related orphan receptor A 0.00789065
EXT1 exostosin glycosyltransferase 1 0.00617053
KANSL1 KAT8 regulatory NSL complex subunit 1 0.00552169
P4HB prolyl 4-hydroxylase, beta polypeptide 0.00545159
RAD51B RAD51 paralog B 0.00500591
RPL26 ribosomal protein L26 0.00293843
ENO1 enolase 1, (alpha) 0.0011944
AFDN afadin, adherens junction formation factor 1.59948E-4

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.285689
NDRG1 N-myc downstream regulated 1 -0.203418
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.181979
VIM vimentin -0.158765
MT2A metallothionein 2A -0.153571
PTMA prothymosin, alpha -0.150506
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.146125
ITGA6 integrin, alpha 6 -0.132851
SLC38A1 solute carrier family 38, member 1 -0.126936
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.126329
CAMTA1 calmodulin binding transcription activator 1 -0.110263
SMYD3 SET and MYND domain containing 3 -0.109457
TMSB10 thymosin beta 10 -0.0893791
TPT1 tumor protein, translationally-controlled 1 -0.0889425
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0804008
FTL ferritin, light polypeptide -0.0793532
PTK2 protein tyrosine kinase 2 -0.0780514
GCLC glutamate-cysteine ligase, catalytic subunit -0.0777273
RPL12 ribosomal protein L12 -0.0734745
PKM pyruvate kinase, muscle -0.0710684
PRRC2C proline-rich coiled-coil 2C -0.0659945
DSCAM Down syndrome cell adhesion molecule -0.0616293
MED13L mediator complex subunit 13-like -0.0587935
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.057859
USP34 ubiquitin specific peptidase 34 -0.0562968
ANXA2 annexin A2 -0.0561322
RAP1B RAP1B, member of RAS oncogene family -0.0557514
GOLGA4 golgin A4 -0.0517349
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0501365
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0490851
GPC6 glypican 6 -0.0426405
EIF1 eukaryotic translation initiation factor 1 -0.0409103
RPL9 ribosomal protein L9 -0.0403641
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0367251
JMJD1C jumonji domain containing 1C -0.0346846
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0340389
TXNRD1 thioredoxin reductase 1 -0.0338107
WSB1 WD repeat and SOCS box containing 1 -0.0337002
RPL19 ribosomal protein L19 -0.0336847
RPL37 ribosomal protein L37 -0.0322076
FBXO11 F-box protein 11 -0.031523
SRRM2 serine/arginine repetitive matrix 2 -0.0313363
NKD1 naked cuticle homolog 1 (Drosophila) -0.0312909
GARS1 glycyl-tRNA synthetase 1 -0.0308248
BPTF bromodomain PHD finger transcription factor -0.0299695
RPL23 ribosomal protein L23 -0.0253673
FLNB filamin B, beta -0.0246322
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0221279
SPAG9 sperm associated antigen 9 -0.0186853
PTPRK protein tyrosine phosphatase, receptor type, K -0.0148858
STC1 stanniocalcin 1 -0.012368
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0111662
RPS8 ribosomal protein S8 -0.0109473
EEF2 eukaryotic translation elongation factor 2 -0.0101517
RPLP1 ribosomal protein, large, P1 -0.00997078
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0099211
GOLGB1 golgin B1 -0.00740635
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.00724092
TENM3 teneurin transmembrane protein 3 -0.00700224
EZR ezrin -0.00609522
ELL2 elongation factor, RNA polymerase II, 2 -0.00560022
ANKRD11 ankyrin repeat domain 11 -0.00433744
RPL37A ribosomal protein L37a -0.00346949
PCCA propionyl CoA carboxylase, alpha polypeptide -0.00317934
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0026483
LMO7 LIM domain 7 -0.00226875
LDHA lactate dehydrogenase A -0.00177711
MYO9A myosin IXA -0.00154109
NRG1 neuregulin 1 -0.00151322
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -9.31951E-4
EFNA5 ephrin-A5 -6.62004E-4
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -2.55654E-4