Capmatinib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capmatinib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capmatinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.181611
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.115383
PTMA prothymosin, alpha 0.112013
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0737972
ARL4C ADP-ribosylation factor-like 4C 0.0718712
ANXA1 annexin A1 0.0693516
RPS8 ribosomal protein S8 0.0662621
HSPA8 heat shock 70kDa protein 8 0.0658062
RPS4X ribosomal protein S4, X-linked 0.0631671
EEF2 eukaryotic translation elongation factor 2 0.0600282
ENO1 enolase 1, (alpha) 0.0535329
PLK2 polo-like kinase 2 0.052307
EZR ezrin 0.0491983
APP amyloid beta (A4) precursor protein 0.0483537
LDHA lactate dehydrogenase A 0.0483502
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0483384
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0405328
TPT1 tumor protein, translationally-controlled 1 0.0385157
SET SET nuclear proto-oncogene 0.0374357
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0366111
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0365366
SFTPA2 surfactant protein A2 0.0355174
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0344979
DUSP6 dual specificity phosphatase 6 0.0344926
TM4SF1 transmembrane 4 L six family member 1 0.0337977
TMSB4X thymosin beta 4, X-linked 0.0335224
NACA nascent polypeptide-associated complex alpha subunit 0.0328296
TUBB tubulin, beta class I 0.0322914
TXNIP thioredoxin interacting protein 0.0318504
MXI1 MAX interactor 1, dimerization protein 0.0312964
HSPH1 heat shock 105kDa/110kDa protein 1 0.0303941
MACROD2 MACRO domain containing 2 0.029116
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0288043
MKI67 marker of proliferation Ki-67 0.0279056
RIPOR2 RHO family interacting cell polarization regulator 2 0.0277452
CREB5 cAMP responsive element binding protein 5 0.0277151
JUN jun proto-oncogene 0.0272355
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0265897
ERRFI1 ERBB receptor feedback inhibitor 1 0.0260856
JMJD1C jumonji domain containing 1C 0.0253889
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0250926
RPS6 ribosomal protein S6 0.0250089
KLF6 Kruppel-like factor 6 0.0244396
RPS2 ribosomal protein S2 0.0243173
RBM3 RNA binding motif (RNP1, RRM) protein 3 0.0235123
SEPTIN7 septin 7 0.0232177
ZNF608 zinc finger protein 608 0.02307
HDAC9 histone deacetylase 9 0.0226287
PLPP3 phospholipid phosphatase 3 0.0225919
KMT2A lysine (K)-specific methyltransferase 2A 0.0222312
ARID1A AT rich interactive domain 1A (SWI-like) 0.0221082
KAT6A K(lysine) acetyltransferase 6A 0.0218386
IL6ST interleukin 6 signal transducer 0.0217426
RACK1 receptor for activated C kinase 1 0.0217319
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 0.0214127
TRIP12 thyroid hormone receptor interactor 12 0.0209902
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0208759
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.0206093
YARS1 tyrosyl-tRNA synthetase 1 0.0202796
KPNB1 karyopherin (importin) beta 1 0.0201595
UBQLN1 ubiquilin 1 0.0201124
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0200772
CSNK1E casein kinase 1, epsilon 0.0200274
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0199276
UBC ubiquitin C 0.0198567
RSL1D1 ribosomal L1 domain containing 1 0.0198314
RPL7 ribosomal protein L7 0.0195918
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0194957
CCND1 cyclin D1 0.0191923
ANKRD36C ankyrin repeat domain 36C 0.0190458
CCNC cyclin C 0.0187652
SPRY2 sprouty homolog 2 (Drosophila) 0.0187539
SOS1 son of sevenless homolog 1 (Drosophila) 0.0186443
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0184018
ITGA6 integrin, alpha 6 0.0183777
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0183057
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0182871
RPL12 ribosomal protein L12 0.0182333
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0180236
FUS FUS RNA binding protein 0.0176051
ITPRID2 ITPR interacting domain containing 2 0.0175285
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0174616
ZNF106 zinc finger protein 106 0.0173653
FBXO11 F-box protein 11 0.0173209
ARID4A AT rich interactive domain 4A (RBP1-like) 0.0172565
STAU1 staufen double-stranded RNA binding protein 1 0.0172267
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0170725
CSDE1 cold shock domain containing E1, RNA-binding 0.0170151
RPL7A ribosomal protein L7a 0.0169668
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 0.0169117
CHSY1 chondroitin sulfate synthase 1 0.0168529
PDS5A PDS5 cohesin associated factor A 0.0167326
RAB6A RAB6A, member RAS oncogene family 0.0166867
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0166627
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0166203
GADD45B growth arrest and DNA-damage-inducible, beta 0.016517
CDC16 cell division cycle 16 0.0164844
SERINC3 serine incorporator 3 0.0164638
MTDH metadherin 0.0164542
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0164349

decreased expression

Symbol Name Standardized Value
CPED1 cadherin-like and PC-esterase domain containing 1 -0.183369
NBEA neurobeachin -0.174727
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.122632
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.110527
SOX6 SRY (sex determining region Y)-box 6 -0.084044
NAV2 neuron navigator 2 -0.0832396
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0828295
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.080984
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0809668
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0790625
ECT2 epithelial cell transforming 2 -0.0788524
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0735021
FLNB filamin B, beta -0.0728172
NPAS2 neuronal PAS domain protein 2 -0.0673268
VCL vinculin -0.0671902
GLI2 GLI family zinc finger 2 -0.0665026
FNDC3B fibronectin type III domain containing 3B -0.0633818
FOXP1 forkhead box P1 -0.0625043
DPYD dihydropyrimidine dehydrogenase -0.0602251
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.057729
BMP10 bone morphogenetic protein 10 -0.0574813
RBM39 RNA binding motif protein 39 -0.0562563
EXOC6B exocyst complex component 6B -0.054704
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0528955
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0512333
POTEF POTE ankyrin domain family, member F -0.0455217
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0454564
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0453361
TTC28 tetratricopeptide repeat domain 28 -0.0449931
PICALM phosphatidylinositol binding clathrin assembly protein -0.0447337
EGFR epidermal growth factor receptor -0.0436084
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0425367
IGF2 insulin-like growth factor 2 -0.0417923
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0403703
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0402494
PRUNE2 prune homolog 2 (Drosophila) -0.0400642
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0396662
NEBL nebulette -0.0395483
NBAS neuroblastoma amplified sequence -0.0393348
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0389007
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.038802
DIAPH2 diaphanous-related formin 2 -0.0387481
GLI3 GLI family zinc finger 3 -0.0384532
LCORL ligand dependent nuclear receptor corepressor-like -0.0382516
SMC4 structural maintenance of chromosomes 4 -0.0381123
BABAM2 BRISC and BRCA1 A complex member 2 -0.038094
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0374669
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0373764
HJURP Holliday junction recognition protein -0.0371139
TTC17 tetratricopeptide repeat domain 17 -0.0364809
MSI2 musashi RNA-binding protein 2 -0.0363355
TTC3 tetratricopeptide repeat domain 3 -0.0358921
ZBTB20 zinc finger and BTB domain containing 20 -0.0356004
DHFR dihydrofolate reductase -0.0355924
SSBP2 single-stranded DNA binding protein 2 -0.0352806
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0350201
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0344668
BTBD9 BTB (POZ) domain containing 9 -0.0340881
SFPQ splicing factor proline/glutamine-rich -0.0339365
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0332459
ANKRD11 ankyrin repeat domain 11 -0.0328227
FAM13A family with sequence similarity 13, member A -0.0326064
ZMYND8 zinc finger, MYND-type containing 8 -0.0323287
PNISR PNN-interacting serine/arginine-rich protein -0.0323002
SPRY4 sprouty homolog 4 (Drosophila) -0.0318164
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0317808
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.031708
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0313626
FER fer (fps/fes related) tyrosine kinase -0.0312591
RBM26 RNA binding motif protein 26 -0.031132
CD47 CD47 molecule -0.0311257
DENND1A DENN/MADD domain containing 1A -0.0311096
AHI1 Abelson helper integration site 1 -0.0310921
SBF2 SET binding factor 2 -0.0309627
RHBDD1 rhomboid domain containing 1 -0.0309273
RPL26 ribosomal protein L26 -0.0307794
RCOR1 REST corepressor 1 -0.0305219
RPL37A ribosomal protein L37a -0.0303396
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0300635
PDE7B phosphodiesterase 7B -0.0298405
PARD3 par-3 family cell polarity regulator -0.0296727
PTEN phosphatase and tensin homolog -0.0296544
PLXNA2 plexin A2 -0.0295584
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0295149
HEG1 heart development protein with EGF-like domains 1 -0.0294224
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0293775
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0293329
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0292938
SMYD3 SET and MYND domain containing 3 -0.0292631
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0289876
PUM2 pumilio RNA-binding family member 2 -0.0286393
SRPK2 SRSF protein kinase 2 -0.02857
TAS2R14 taste receptor, type 2, member 14 -0.0284403
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0278883
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0276846
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0276024
TMEM135 transmembrane protein 135 -0.0270558
TBCA tubulin folding cofactor A -0.0268654
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0267778
PIAS2 protein inhibitor of activated STAT, 2 -0.0267597