Capmatinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capmatinib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capmatinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0499866
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0425724
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0406459
ANKRD28 ankyrin repeat domain 28 0.0350978
PRRC2C proline-rich coiled-coil 2C 0.0312067
ELL2 elongation factor, RNA polymerase II, 2 0.0295423
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0247628
RNF145 ring finger protein 145 0.023394
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.023291
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0230165
NEK7 NIMA-related kinase 7 0.022733
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0225676
PELI1 pellino E3 ubiquitin protein ligase 1 0.0200288
ARRDC3 arrestin domain containing 3 0.0197327
OGA O-GlcNAcase 0.0190644
PCBP2 poly(rC) binding protein 2 0.018963
HELZ helicase with zinc finger 0.0187428
SVIL supervillin 0.017795
WAC WW domain containing adaptor with coiled-coil 0.0176284
SIRT1 sirtuin 1 0.0175325
RAB8B RAB8B, member RAS oncogene family 0.0174312
MT2A metallothionein 2A 0.0171866
XPO1 exportin 1 0.0165192
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0164286
RBM25 RNA binding motif protein 25 0.0161394
APP amyloid beta (A4) precursor protein 0.0158648
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0158257
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0149595
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0148922
NUP58 nucleoporin 58 0.0148858
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0148202
CAB39 calcium binding protein 39 0.0146565
UBAP2L ubiquitin associated protein 2-like 0.0142719
WDR26 WD repeat domain 26 0.0137213
CTNND1 catenin (cadherin-associated protein), delta 1 0.0136959
SIK3 SIK family kinase 3 0.0136524
YBX3 Y box binding protein 3 0.0136317
TM9SF3 transmembrane 9 superfamily member 3 0.0133723
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0133508
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0132036
CHD1 chromodomain helicase DNA binding protein 1 0.0130048
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0128107
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0127513
NCKAP1 NCK-associated protein 1 0.0127252
UGCG UDP-glucose ceramide glucosyltransferase 0.0125194
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0124937
CUL3 cullin 3 0.0124004
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0119401
PLPP3 phospholipid phosphatase 3 0.0118785
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0118474
STRN3 striatin, calmodulin binding protein 3 0.011793
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0116991
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0116704
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0116638
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0115834
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0115306
GPHN gephyrin 0.0114982
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0113568
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0112996
NOP58 NOP58 ribonucleoprotein 0.0112564
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0111998
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0111539
RBM33 RNA binding motif protein 33 0.011144
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0111174
FAM168B family with sequence similarity 168, member B 0.0110436
SUCO SUN domain containing ossification factor 0.0110052
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0109901
SPRED2 sprouty-related, EVH1 domain containing 2 0.010774
VIRMA vir like m6A methyltransferase associated 0.0107569
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0107426
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0106558
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0105485
RAB18 RAB18, member RAS oncogene family 0.010469
CORO1C coronin, actin binding protein, 1C 0.0104478
TNRC6A trinucleotide repeat containing 6A 0.0103381
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0103169
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0102288
XPR1 xenotropic and polytropic retrovirus receptor 1 0.0102286
FNDC3A fibronectin type III domain containing 3A 0.0101234
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0101013
ARGLU1 arginine and glutamate rich 1 0.0100382
TENT2 terminal nucleotidyltransferase 2 0.00997036
EIF3A eukaryotic translation initiation factor 3, subunit A 0.00996108
WDR43 WD repeat domain 43 0.00989261
PTBP2 polypyrimidine tract binding protein 2 0.0097641
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0097585
ORC4 origin recognition complex, subunit 4 0.00975738
YY1AP1 YY1 associated protein 1 0.00973397
AHR aryl hydrocarbon receptor 0.00972896
SERINC1 serine incorporator 1 0.00972394
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 0.00965828
GIGYF2 GRB10 interacting GYF protein 2 0.00962118
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0095923
ANKRD17 ankyrin repeat domain 17 0.00947745
ENAH enabled homolog (Drosophila) 0.00946744
PPME1 protein phosphatase methylesterase 1 0.00946657
AGFG1 ArfGAP with FG repeats 1 0.00941202
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.00933537
ZNF292 zinc finger protein 292 0.00927622
HOMER2 homer scaffolding protein 2 0.00927219

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.33977
FN1 fibronectin 1 -0.326972
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.230234
HMGA2 high mobility group AT-hook 2 -0.211305
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.178608
SQSTM1 sequestosome 1 -0.124716
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123608
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.115308
ITGA1 integrin, alpha 1 -0.0988361
ASPH aspartate beta-hydroxylase -0.0874833
PTMA prothymosin, alpha -0.0854873
TMSB10 thymosin beta 10 -0.0804316
GLIS3 GLIS family zinc finger 3 -0.0780414
PLIN2 perilipin 2 -0.0753817
EFNA5 ephrin-A5 -0.0749609
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0747907
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0742658
RAI14 retinoic acid induced 14 -0.0730885
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0707699
IFI27 interferon, alpha-inducible protein 27 -0.0707337
SYT1 synaptotagmin I -0.0706258
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.068055
MRPS6 mitochondrial ribosomal protein S6 -0.0673829
FTL ferritin, light polypeptide -0.0671331
HLA-B major histocompatibility complex, class I, B -0.0667676
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0666194
S100A6 S100 calcium binding protein A6 -0.0625854
FTH1 ferritin, heavy polypeptide 1 -0.0611153
GRB10 growth factor receptor-bound protein 10 -0.0608412
TMSB4X thymosin beta 4, X-linked -0.0602766
CANX calnexin -0.0585474
STC2 stanniocalcin 2 -0.0572518
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0554156
NDRG1 N-myc downstream regulated 1 -0.055133
TRIO trio Rho guanine nucleotide exchange factor -0.0549779
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0548853
VCL vinculin -0.0528013
LIMCH1 LIM and calponin homology domains 1 -0.0507481
VIM vimentin -0.0504736
ACTG1 actin gamma 1 -0.0492594
HIPK2 homeodomain interacting protein kinase 2 -0.0488209
AEBP2 AE binding protein 2 -0.0457164
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0440934
ENO2 enolase 2 (gamma, neuronal) -0.0422969
AKAP12 A kinase (PRKA) anchor protein 12 -0.0422022
INTS6 integrator complex subunit 6 -0.0414477
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0413025
CADM1 cell adhesion molecule 1 -0.0410623
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0402726
MAML2 mastermind-like 2 (Drosophila) -0.038494
HMGA1 high mobility group AT-hook 1 -0.0372901
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0371437
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0370548
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0360495
B2M beta-2-microglobulin -0.034899
TPT1 tumor protein, translationally-controlled 1 -0.0342998
TAS2R14 taste receptor, type 2, member 14 -0.034115
IGFBP3 insulin-like growth factor binding protein 3 -0.034055
SLC35F3 solute carrier family 35, member F3 -0.0337635
MAP1B microtubule-associated protein 1B -0.0334866
MBD5 methyl-CpG binding domain protein 5 -0.0332298
LRRC23 leucine rich repeat containing 23 -0.0331914
TFPI2 tissue factor pathway inhibitor 2 -0.0330948
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.033044
ERRFI1 ERBB receptor feedback inhibitor 1 -0.033028
ZBTB20 zinc finger and BTB domain containing 20 -0.0328265
LOC102724023 ES1 protein homolog, mitochondrial -0.031783
TENM4 teneurin transmembrane protein 4 -0.0316792
GLUL glutamate-ammonia ligase -0.0314864
PDE4D phosphodiesterase 4D, cAMP-specific -0.0312198
SOX4 SRY (sex determining region Y)-box 4 -0.0308854
RPL35A ribosomal protein L35a -0.0307468
TNS3 tensin 3 -0.030522
LOX lysyl oxidase -0.0304824
PRKCA protein kinase C, alpha -0.0302495
SPDYA speedy/RINGO cell cycle regulator family member A -0.0296123
PGK1 phosphoglycerate kinase 1 -0.0294735
TPI1 triosephosphate isomerase 1 -0.0293309
SOX5 SRY (sex determining region Y)-box 5 -0.0292355
SFRP1 secreted frizzled-related protein 1 -0.0292063
DNAH5 dynein, axonemal, heavy chain 5 -0.0291338
PKM pyruvate kinase, muscle -0.0289977
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0288301
LOXL2 lysyl oxidase-like 2 -0.0279358
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0270934
FBN1 fibrillin 1 -0.0269398
PDIA3 protein disulfide isomerase family A, member 3 -0.0267212
ENO1 enolase 1, (alpha) -0.026492
EGR1 early growth response 1 -0.0264914
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0263199
TMEM165 transmembrane protein 165 -0.0261323
RPS6 ribosomal protein S6 -0.0260952
FNDC3B fibronectin type III domain containing 3B -0.0258452
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0256901
GNAS GNAS complex locus -0.0256501
CTSD cathepsin D -0.0254903
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0251025
TBC1D22A TBC1 domain family, member 22A -0.0249361
RPL31 ribosomal protein L31 -0.0248181
GPC6 glypican 6 -0.0247004