Captopril_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Captopril perturbation in A-172 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Captopril_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.207962
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.19777
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.150395
DLG1 discs, large homolog 1 (Drosophila) 0.133859
SLC39A11 solute carrier family 39, member 11 0.0910956
NAV2 neuron navigator 2 0.0759719
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.071089
MT2A metallothionein 2A 0.0695117
OGA O-GlcNAcase 0.0694727
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.065067
ZEB1 zinc finger E-box binding homeobox 1 0.0630282
FLNB filamin B, beta 0.0611172
ATP13A3 ATPase type 13A3 0.0604009
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0582252
DST dystonin 0.0549311
SBF2 SET binding factor 2 0.054879
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0507252
XPO1 exportin 1 0.050028
ELL2 elongation factor, RNA polymerase II, 2 0.0489571
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0487809
SPAG9 sperm associated antigen 9 0.0473961
CSTB cystatin B (stefin B) 0.0472714
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0463246
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0459411
CCND1 cyclin D1 0.0457931
CDH13 cadherin 13 0.0456448
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0454979
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0454128
SETD5 SET domain containing 5 0.0442555
RHOBTB3 Rho-related BTB domain containing 3 0.0442058
GPC6 glypican 6 0.044088
COL3A1 collagen, type III, alpha 1 0.0431164
ESYT2 extended synaptotagmin-like protein 2 0.0417776
KLF7 Kruppel-like factor 7 (ubiquitous) 0.041593
MYOF myoferlin 0.04123
VIM vimentin 0.0407832
BACE2 beta-site APP-cleaving enzyme 2 0.0387879
PLAT plasminogen activator, tissue 0.0386136
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0380691
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0374824
CD109 CD109 molecule 0.0373768
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0363238
CYLD cylindromatosis (turban tumor syndrome) 0.0361196
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0355005
USP34 ubiquitin specific peptidase 34 0.0352323
AVL9 AVL9 homolog (S. cerevisiase) 0.0347759
STC1 stanniocalcin 1 0.0346783
FNIP1 folliculin interacting protein 1 0.0344067
WDFY1 WD repeat and FYVE domain containing 1 0.0342823
ARRDC3 arrestin domain containing 3 0.0340996
NFE2L1 nuclear factor, erythroid 2-like 1 0.033649
ZNF292 zinc finger protein 292 0.033418
PBX3 pre-B-cell leukemia homeobox 3 0.0332933
SDK1 sidekick cell adhesion molecule 1 0.033116
RICTOR RPTOR independent companion of MTOR, complex 2 0.0331157
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0329516
LOXL2 lysyl oxidase-like 2 0.0329305
MXI1 MAX interactor 1, dimerization protein 0.0326534
COL1A2 collagen, type I, alpha 2 0.0325521
SQSTM1 sequestosome 1 0.0320299
NBAS neuroblastoma amplified sequence 0.0320082
KMT2E lysine (K)-specific methyltransferase 2E 0.0318701
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0317425
NAP1L1 nucleosome assembly protein 1-like 1 0.0316704
PRELID2 PRELI domain containing 2 0.0314403
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0312873
COL8A1 collagen, type VIII, alpha 1 0.0309157
MMP12 matrix metallopeptidase 12 0.030506
CAPN2 calpain 2, (m/II) large subunit 0.0303565
NCKAP1 NCK-associated protein 1 0.0301893
CDK19 cyclin-dependent kinase 19 0.0299824
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0297961
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0291512
STK10 serine/threonine kinase 10 0.0291115
BHLHE40 basic helix-loop-helix family, member e40 0.0288627
APAF1 apoptotic peptidase activating factor 1 0.0287357
C1ORF21 chromosome 1 open reading frame 21 0.0287203
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0285318
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0281988
ERRFI1 ERBB receptor feedback inhibitor 1 0.0279326
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0277893
NGLY1 N-glycanase 1 0.0277668
SPIRE1 spire-type actin nucleation factor 1 0.0275094
ITCH itchy E3 ubiquitin protein ligase 0.0273364
MARCHF6 membrane associated ring-CH-type finger 6 0.0271465
FBXL7 F-box and leucine-rich repeat protein 7 0.027138
NPEPPS aminopeptidase puromycin sensitive 0.0270177
WAC WW domain containing adaptor with coiled-coil 0.0269698
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.026938
YEATS2 YEATS domain containing 2 0.0267297
KIF13A kinesin family member 13A 0.0265417
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0260714
BRWD1 bromodomain and WD repeat domain containing 1 0.0260506
MSI2 musashi RNA-binding protein 2 0.0259693
FNBP1 formin binding protein 1 0.0259001
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0258009
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0257547
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.0257051
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0255217
HIP1 huntingtin interacting protein 1 0.0255083

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.233223
TMSB10 thymosin beta 10 -0.168768
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157617
MAP1B microtubule-associated protein 1B -0.096424
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0784634
PODXL podocalyxin-like -0.0726897
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0670853
AHNAK AHNAK nucleoprotein -0.0651026
FTH1 ferritin, heavy polypeptide 1 -0.0649088
POTEF POTE ankyrin domain family, member F -0.057406
LOC112694756 uncharaterized LOC112694756 -0.0551576
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0548242
PKM pyruvate kinase, muscle -0.0540199
GLIS3 GLIS family zinc finger 3 -0.0461648
TAPBP TAP binding protein (tapasin) -0.0417723
COL5A1 collagen, type V, alpha 1 -0.0408054
C1D C1D nuclear receptor corepressor -0.0403971
COL5A2 collagen, type V, alpha 2 -0.037024
SLC38A2 solute carrier family 38, member 2 -0.034522
ACTG1 actin gamma 1 -0.0337776
ACTN4 actinin, alpha 4 -0.033692
MX2 MX dynamin-like GTPase 2 -0.0332573
EGR1 early growth response 1 -0.0320302
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.031307
FN1 fibronectin 1 -0.0310715
VCL vinculin -0.0308013
UBC ubiquitin C -0.030392
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0299552
MCL1 myeloid cell leukemia 1 -0.02981
SEPTIN9 septin 9 -0.0296618
EIF1 eukaryotic translation initiation factor 1 -0.0293309
GOLGB1 golgin B1 -0.0291006
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0289114
SP100 SP100 nuclear antigen -0.0286027
RIGI RNA sensor RIG-I -0.028296
ENO2 enolase 2 (gamma, neuronal) -0.0281859
FBN1 fibrillin 1 -0.0277935
EXT1 exostosin glycosyltransferase 1 -0.0268328
LAMA5 laminin, alpha 5 -0.0265742
NCOR2 nuclear receptor corepressor 2 -0.02654
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0264759
PML promyelocytic leukemia -0.0261159
RAB7A RAB7A, member RAS oncogene family -0.0260782
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0258823
L1CAM L1 cell adhesion molecule -0.0256762
EPAS1 endothelial PAS domain protein 1 -0.025578
BSG basigin (Ok blood group) -0.0251091
IFITM3 interferon induced transmembrane protein 3 -0.0245222
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0241973
SRRM2 serine/arginine repetitive matrix 2 -0.0233007
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0231528
ISG15 ISG15 ubiquitin-like modifier -0.0230826
FADS2 fatty acid desaturase 2 -0.0229832
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0228685
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0226612
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0223689
TGFB1 transforming growth factor, beta 1 -0.0223496
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) -0.0220961
TXNRD1 thioredoxin reductase 1 -0.02203
PIEZO1 piezo-type mechanosensitive ion channel component 1 -0.0219156
FLNA filamin A, alpha -0.0218214
TUBB4B tubulin, beta 4B class IVb -0.0217224
WWTR1 WW domain containing transcription regulator 1 -0.0214862
RPS19 ribosomal protein S19 -0.0214723
TOR1AIP2 torsin A interacting protein 2 -0.0213611
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0212735
HSPB1 heat shock 27kDa protein 1 -0.0212685
ATP5F1B ATP synthase F1 subunit beta -0.0212209
PLEC plectin -0.021212
COL6A1 collagen, type VI, alpha 1 -0.0210588
MEF2D myocyte enhancer factor 2D -0.020962
CANX calnexin -0.0207754
TSC22D2 TSC22 domain family, member 2 -0.0207591
SORBS2 sorbin and SH3 domain containing 2 -0.0205819
EEF2 eukaryotic translation elongation factor 2 -0.0203045
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0197409
IFI44 interferon-induced protein 44 -0.0196212
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0194096
IFITM1 interferon induced transmembrane protein 1 -0.0193557
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0193486
TLE4 transducin-like enhancer of split 4 -0.0193031
LENG8 leukocyte receptor cluster (LRC) member 8 -0.0192703
FBXO11 F-box protein 11 -0.0192681
OASL 2'-5'-oligoadenylate synthetase-like -0.0191506
HLA-C major histocompatibility complex, class I, C -0.0190328
NPR2 natriuretic peptide receptor 2 -0.0187797
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0187701
EZR ezrin -0.0186706
C6ORF62 chromosome 6 open reading frame 62 -0.0185481
HLA-A major histocompatibility complex, class I, A -0.018503
IARS1 isoleucyl-tRNA synthetase 1 -0.0184684
COPA coatomer protein complex, subunit alpha -0.0184357
CUL4A cullin 4A -0.0184293
PPARD peroxisome proliferator-activated receptor delta -0.0184167
S100A11 S100 calcium binding protein A11 -0.018309
LY6E lymphocyte antigen 6 complex, locus E -0.0181437
PCDH7 protocadherin 7 -0.0180517
TAGLN2 transgelin 2 -0.0179871
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0179467
SLC38A1 solute carrier family 38, member 1 -0.0179215