Captopril_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Captopril perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Captopril_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.132375
ANXA1 annexin A1 0.0937899
VMP1 vacuole membrane protein 1 0.0835675
BIRC6 baculoviral IAP repeat containing 6 0.0749627
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0699508
USP34 ubiquitin specific peptidase 34 0.0672219
HMGA1 high mobility group AT-hook 1 0.0667998
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0643201
MED13L mediator complex subunit 13-like 0.0540722
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0520568
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.050472
MGAT4C MGAT4 family, member C 0.049805
CSNK1A1 casein kinase 1, alpha 1 0.0494943
PUM2 pumilio RNA-binding family member 2 0.049354
EHBP1 EH domain binding protein 1 0.0473837
ERRFI1 ERBB receptor feedback inhibitor 1 0.0431224
SPATS2 spermatogenesis associated, serine-rich 2 0.0430137
ZNF292 zinc finger protein 292 0.0429621
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 0.0426945
GPBP1 GC-rich promoter binding protein 1 0.040631
TMEM41B transmembrane protein 41B 0.0398011
RAB7A RAB7A, member RAS oncogene family 0.039633
NF1 neurofibromin 1 0.0384073
MBNL1 muscleblind-like splicing regulator 1 0.0364954
CLDN1 claudin 1 0.0350701
EGLN1 egl-9 family hypoxia-inducible factor 1 0.035023
ANKRD17 ankyrin repeat domain 17 0.0348855
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.033714
TENM3 teneurin transmembrane protein 3 0.0333565
SETD5 SET domain containing 5 0.0327242
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0326634
AKAP9 A kinase (PRKA) anchor protein 9 0.0318514
PA2G4 proliferation-associated 2G4, 38kDa 0.0318306
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.0316823
SPAG9 sperm associated antigen 9 0.031666
SLC38A1 solute carrier family 38, member 1 0.0312998
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.031212
DTNA dystrobrevin, alpha 0.0302504
ARRDC3 arrestin domain containing 3 0.0301292
KMT2E lysine (K)-specific methyltransferase 2E 0.03009
JMJD1C jumonji domain containing 1C 0.0300669
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0300433
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.029968
WDR43 WD repeat domain 43 0.029652
HDGF hepatoma-derived growth factor 0.0295846
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0295318
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0295285
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0292985
NUP58 nucleoporin 58 0.0292022
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0284749
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0279831
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0278126
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0276986
WAC WW domain containing adaptor with coiled-coil 0.0273382
ANKRD12 ankyrin repeat domain 12 0.0270977
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0270513
KCMF1 potassium channel modulatory factor 1 0.0266504
NEBL nebulette 0.0266316
PARD3 par-3 family cell polarity regulator 0.0266153
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0265747
PUM1 pumilio RNA-binding family member 1 0.0264132
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0264028
MBD5 methyl-CpG binding domain protein 5 0.0262947
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0260624
KDM2A lysine (K)-specific demethylase 2A 0.0259371
KPNB1 karyopherin (importin) beta 1 0.0251591
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 0.0250642
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0250094
BCHE butyrylcholinesterase 0.0250025
EPHA6 EPH receptor A6 0.0248122
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0246964
GSK3B glycogen synthase kinase 3 beta 0.0245361
FBXO11 F-box protein 11 0.024526
P3H2 prolyl 3-hydroxylase 2 0.0241742
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0239188
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0239042
CARD16 caspase recruitment domain family, member 16 0.0232799
RAB6A RAB6A, member RAS oncogene family 0.023015
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0230113
CNOT2 CCR4-NOT transcription complex, subunit 2 0.022896
ZMYM2 zinc finger, MYM-type 2 0.022697
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0225765
CAMKMT calmodulin-lysine N-methyltransferase 0.0223671
PTMA prothymosin, alpha 0.022219
USP15 ubiquitin specific peptidase 15 0.0221553
XPO1 exportin 1 0.0221396
MON2 MON2 homolog (S. cerevisiae) 0.0220938
PRKCI protein kinase C, iota 0.0218479
ANXA5 annexin A5 0.0217581
TBK1 TANK-binding kinase 1 0.0213517
BRWD3 bromodomain and WD repeat domain containing 3 0.0213315
LCORL ligand dependent nuclear receptor corepressor-like 0.0211886
ADAM17 ADAM metallopeptidase domain 17 0.0211476
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0211422
SLMAP sarcolemma associated protein 0.0211049
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0210035
FNIP1 folliculin interacting protein 1 0.02067
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0205283
TFG TRK-fused gene 0.0205062
NFE2L1 nuclear factor, erythroid 2-like 1 0.0204357

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.326375
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201356
RPS19 ribosomal protein S19 -0.0859363
AHNAK AHNAK nucleoprotein -0.0820612
ATP5F1B ATP synthase F1 subunit beta -0.0790619
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0779916
PDE4D phosphodiesterase 4D, cAMP-specific -0.0753016
BIRC3 baculoviral IAP repeat containing 3 -0.0747292
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0722529
RPL35A ribosomal protein L35a -0.0673932
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0605038
FTL ferritin, light polypeptide -0.0604647
ACTG1 actin gamma 1 -0.0574503
EEF2 eukaryotic translation elongation factor 2 -0.0549303
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0488639
PCDH7 protocadherin 7 -0.0482099
MYL12B myosin, light chain 12B, regulatory -0.0477722
EDN1 endothelin 1 -0.0470202
EIF1 eukaryotic translation initiation factor 1 -0.0460639
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0453075
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0451918
CANX calnexin -0.043059
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0422517
RPS6 ribosomal protein S6 -0.0409197
TPT1 tumor protein, translationally-controlled 1 -0.0405776
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0391826
MAP1B microtubule-associated protein 1B -0.0384173
CNRIP1 cannabinoid receptor interacting protein 1 -0.0381409
RPLP0 ribosomal protein, large, P0 -0.0377516
YBX1 Y box binding protein 1 -0.037203
ASPH aspartate beta-hydroxylase -0.0371303
RPS14 ribosomal protein S14 -0.0365884
LOC112694756 uncharaterized LOC112694756 -0.036359
RPL19 ribosomal protein L19 -0.036089
SLC38A2 solute carrier family 38, member 2 -0.035474
RPS4X ribosomal protein S4, X-linked -0.0351452
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0342992
RPS23 ribosomal protein S23 -0.0342738
VIM vimentin -0.0342093
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0334782
RPLP1 ribosomal protein, large, P1 -0.0333985
RPS20 ribosomal protein S20 -0.0332714
RPL23 ribosomal protein L23 -0.0332321
RTN4 reticulon 4 -0.0323637
RPS27 ribosomal protein S27 -0.0321768
CELF2 CUGBP, Elav-like family member 2 -0.0318735
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0314217
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.031123
CCN2 cellular communication network factor 2 -0.0303539
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0303237
CLPTM1L CLPTM1-like -0.0294458
RPS21 ribosomal protein S21 -0.0293556
RPL11 ribosomal protein L11 -0.0292848
NLGN1 neuroligin 1 -0.0288413
YAP1 Yes-associated protein 1 -0.0284779
RPS2 ribosomal protein S2 -0.0282666
RIMS2 regulating synaptic membrane exocytosis 2 -0.028126
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.027984
SRRM2 serine/arginine repetitive matrix 2 -0.0274565
RPL34 ribosomal protein L34 -0.0272574
HLA-A major histocompatibility complex, class I, A -0.0268337
RPL31 ribosomal protein L31 -0.0264833
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0262776
RRM2 ribonucleotide reductase M2 -0.0262601
RPL3 ribosomal protein L3 -0.0261776
PTMS parathymosin -0.0259679
TUBB4B tubulin, beta 4B class IVb -0.0259593
RPS5 ribosomal protein S5 -0.0257655
MARCHF4 membrane associated ring-CH-type finger 4 -0.0257077
RPS29 ribosomal protein S29 -0.0256858
RPL37A ribosomal protein L37a -0.0252818
RPL9 ribosomal protein L9 -0.0251386
EGR1 early growth response 1 -0.0251318
RPL32 ribosomal protein L32 -0.025031
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0249221
RPS15 ribosomal protein S15 -0.0247992
RPL36 ribosomal protein L36 -0.0247744
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0244915
UBXN4 UBX domain protein 4 -0.0237543
RPL28 ribosomal protein L28 -0.023631
TEAD4 TEA domain family member 4 -0.0235465
RPL38 ribosomal protein L38 -0.0231404
POTEF POTE ankyrin domain family, member F -0.0226074
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.022265
RPL27A ribosomal protein L27a -0.0220245
RPS24 ribosomal protein S24 -0.0220056
RPS11 ribosomal protein S11 -0.0219088
UBB ubiquitin B -0.0217701
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0217339
PGK1 phosphoglycerate kinase 1 -0.0216902
RPL37 ribosomal protein L37 -0.0213456
H1-0 H1.0 linker histone -0.0211604
ZNF804A zinc finger protein 804A -0.0210269
GNAS GNAS complex locus -0.0206665
RPL12 ribosomal protein L12 -0.0205298
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0204357
GANAB glucosidase, alpha; neutral AB -0.020139
RPS27A ribosomal protein S27a -0.0199406
GOLGB1 golgin B1 -0.0198507
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0195717