Captopril_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Captopril perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Captopril_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.108559
B2M beta-2-microglobulin 0.0849739
TXNIP thioredoxin interacting protein 0.0817012
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0773288
RNF149 ring finger protein 149 0.0716498
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0708418
ERRFI1 ERBB receptor feedback inhibitor 1 0.0655786
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0631995
N4BP2L2 NEDD4 binding protein 2-like 2 0.0599335
ZMYM2 zinc finger, MYM-type 2 0.0597874
AHI1 Abelson helper integration site 1 0.0575896
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0540018
LIMA1 LIM domain and actin binding 1 0.053748
DSCAM Down syndrome cell adhesion molecule 0.0532161
INTS6 integrator complex subunit 6 0.0523601
FNIP1 folliculin interacting protein 1 0.0498929
ANKRD17 ankyrin repeat domain 17 0.0475439
FNDC3B fibronectin type III domain containing 3B 0.0473494
PTBP3 polypyrimidine tract binding protein 3 0.0464701
KMT2E lysine (K)-specific methyltransferase 2E 0.0461238
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0454112
MAP7 microtubule-associated protein 7 0.0432956
TM9SF2 transmembrane 9 superfamily member 2 0.0426717
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0425013
ARRDC3 arrestin domain containing 3 0.0422211
COG6 component of oligomeric golgi complex 6 0.0420241
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.040453
AKAP13 A kinase (PRKA) anchor protein 13 0.0403451
PADI1 peptidyl arginine deiminase, type I 0.040281
ITCH itchy E3 ubiquitin protein ligase 0.0397851
PRRC2C proline-rich coiled-coil 2C 0.0397231
GOLGA4 golgin A4 0.0394798
TTC3 tetratricopeptide repeat domain 3 0.0383273
EFNB2 ephrin-B2 0.0380703
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0380004
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0376057
SPAG9 sperm associated antigen 9 0.0367117
TMED2 transmembrane emp24 domain trafficking protein 2 0.0362698
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.034574
MXI1 MAX interactor 1, dimerization protein 0.0343972
FNDC3A fibronectin type III domain containing 3A 0.0343373
IFNGR1 interferon gamma receptor 1 0.0341759
MED13L mediator complex subunit 13-like 0.0338859
AKAP9 A kinase (PRKA) anchor protein 9 0.0335056
SMAD3 SMAD family member 3 0.0325303
PIAS1 protein inhibitor of activated STAT, 1 0.0312783
SEC31A SEC31 homolog A (S. cerevisiae) 0.0311742
ESYT2 extended synaptotagmin-like protein 2 0.0307281
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0303944
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0302899
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0302078
SETD5 SET domain containing 5 0.0296897
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0295593
EREG epiregulin 0.0292059
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0290974
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.028568
CTNND1 catenin (cadherin-associated protein), delta 1 0.0284925
MICU2 mitochondrial calcium uptake 2 0.0281394
BAIAP2L1 BAI1-associated protein 2-like 1 0.0280914
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0280038
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0278728
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0278063
CSNK1A1 casein kinase 1, alpha 1 0.0277359
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0275991
UBE2K ubiquitin-conjugating enzyme E2K 0.0273841
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0273822
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.027185
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0271372
RAB6A RAB6A, member RAS oncogene family 0.0267477
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0259092
AFF1 AF4/FMR2 family, member 1 0.0258353
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0257159
GPBP1 GC-rich promoter binding protein 1 0.0254389
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0253873
SPRED1 sprouty-related, EVH1 domain containing 1 0.0252318
USP53 ubiquitin specific peptidase 53 0.0251351
VEGFA vascular endothelial growth factor A 0.0245946
CALU calumenin 0.0245892
MORF4L2 mortality factor 4 like 2 0.0245142
FDPS farnesyl diphosphate synthase 0.0244751
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0244277
TM4SF19 transmembrane 4 L six family member 19 0.0244219
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0242816
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0239631
NRIP1 nuclear receptor interacting protein 1 0.0239089
OGA O-GlcNAcase 0.0239062
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0239021
ZNF207 zinc finger protein 207 0.0238984
NPEPPS aminopeptidase puromycin sensitive 0.0238503
SREBF2 sterol regulatory element binding transcription factor 2 0.0237559
DCAF7 DDB1 and CUL4 associated factor 7 0.0237241
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.0235821
ARGLU1 arginine and glutamate rich 1 0.0231006
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0230809
VMP1 vacuole membrane protein 1 0.0229759
SUCO SUN domain containing ossification factor 0.0227122
NIPBL Nipped-B homolog (Drosophila) 0.0226445
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0225653
ADAM17 ADAM metallopeptidase domain 17 0.022541
USP3 ubiquitin specific peptidase 3 0.0222898

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.193173
STAT1 signal transducer and activator of transcription 1, 91kDa -0.150434
LYZ lysozyme -0.116645
MX1 MX dynamin-like GTPase 1 -0.0989943
EGR1 early growth response 1 -0.0931248
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0929946
RNF213 ring finger protein 213 -0.0884732
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0762949
PLSCR1 phospholipid scramblase 1 -0.0749924
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0735022
EPHB2 EPH receptor B2 -0.0732114
NCKAP5 NCK-associated protein 5 -0.0701874
LCN2 lipocalin 2 -0.0685404
GMDS GDP-mannose 4,6-dehydratase -0.067391
RUNX1 runt-related transcription factor 1 -0.0673058
RIGI RNA sensor RIG-I -0.0663811
H1-0 H1.0 linker histone -0.0647569
MX2 MX dynamin-like GTPase 2 -0.0638949
IRF1 interferon regulatory factor 1 -0.0636242
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0619253
LMO7 LIM domain 7 -0.0614021
IFI27 interferon, alpha-inducible protein 27 -0.0572498
EZR ezrin -0.0570246
TMSB10 thymosin beta 10 -0.0567004
SP100 SP100 nuclear antigen -0.0563669
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0561385
RABGAP1L RAB GTPase activating protein 1-like -0.055102
CCNL1 cyclin L1 -0.0522532
FTH1 ferritin, heavy polypeptide 1 -0.0518282
BTBD9 BTB (POZ) domain containing 9 -0.051327
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0507689
LAP3 leucine aminopeptidase 3 -0.0498222
MUC13 mucin 13, cell surface associated -0.0484459
JUN jun proto-oncogene -0.0475249
HLA-C major histocompatibility complex, class I, C -0.0469923
GCLC glutamate-cysteine ligase, catalytic subunit -0.0467276
LOC102724023 ES1 protein homolog, mitochondrial -0.0447916
SOD2 superoxide dismutase 2, mitochondrial -0.0445332
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0441499
ITGA6 integrin, alpha 6 -0.0439616
TPT1 tumor protein, translationally-controlled 1 -0.043015
AHNAK AHNAK nucleoprotein -0.0428013
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0426362
FOXP1 forkhead box P1 -0.0422473
HLA-B major histocompatibility complex, class I, B -0.0414096
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0403925
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0395129
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.039475
PATJ PATJ crumbs cell polarity complex component -0.0387701
LOC112694756 uncharaterized LOC112694756 -0.03859
ACTG1 actin gamma 1 -0.0384438
TRIM25 tripartite motif containing 25 -0.0381673
MECOM MDS1 and EVI1 complex locus -0.0375718
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.037429
SPATA13 spermatogenesis associated 13 -0.0373261
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0371949
PMP22 peripheral myelin protein 22 -0.036828
NPSR1 neuropeptide S receptor 1 -0.0367968
IFIH1 interferon induced with helicase C domain 1 -0.0367565
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0367518
ACTN4 actinin, alpha 4 -0.0367062
TXNRD1 thioredoxin reductase 1 -0.0352109
ZNFX1 zinc finger, NFX1-type containing 1 -0.0349201
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0349089
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0344061
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0338776
NCOA7 nuclear receptor coactivator 7 -0.033781
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0332698
PDE4D phosphodiesterase 4D, cAMP-specific -0.0332243
C6ORF132 chromosome 6 open reading frame 132 -0.0331693
PTMA prothymosin, alpha -0.0330786
IFI6 interferon, alpha-inducible protein 6 -0.0327571
IGFBP3 insulin-like growth factor binding protein 3 -0.0324564
MSI2 musashi RNA-binding protein 2 -0.0321906
RPL35A ribosomal protein L35a -0.030945
SAMHD1 SAM domain and HD domain 1 -0.0303008
RRBP1 ribosome binding protein 1 -0.0300261
APOL6 apolipoprotein L, 6 -0.0298531
MAML2 mastermind-like 2 (Drosophila) -0.0296925
OASL 2'-5'-oligoadenylate synthetase-like -0.0293465
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0292
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0291983
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.028842
NKD1 naked cuticle homolog 1 (Drosophila) -0.0287583
TRIO trio Rho guanine nucleotide exchange factor -0.0286984
CANX calnexin -0.0284791
CTSD cathepsin D -0.0284337
HDAC4 histone deacetylase 4 -0.0281946
NEBL nebulette -0.0281624
ZMYND8 zinc finger, MYND-type containing 8 -0.0274648
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0272017
CLYBL citrate lyase beta like -0.0270181
VIM vimentin -0.0267553
ATP10B ATPase, class V, type 10B -0.0265684
FMN1 formin 1 -0.0259957
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0258657
RAD51B RAD51 paralog B -0.0252468
EEF2 eukaryotic translation elongation factor 2 -0.0248231
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0242793
NAMPT nicotinamide phosphoribosyltransferase -0.0242268