Captopril_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Captopril perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Captopril_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.200042
ERRFI1 ERBB receptor feedback inhibitor 1 0.106787
YBX3 Y box binding protein 3 0.0880252
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0634136
RAD51B RAD51 paralog B 0.0627543
WSB1 WD repeat and SOCS box containing 1 0.0595047
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0579145
KDM2A lysine (K)-specific demethylase 2A 0.052666
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0524679
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0498813
NF1 neurofibromin 1 0.0494759
KTN1 kinectin 1 (kinesin receptor) 0.048181
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0457319
USP34 ubiquitin specific peptidase 34 0.0427941
CSNK1A1 casein kinase 1, alpha 1 0.0391633
MKI67 marker of proliferation Ki-67 0.0388077
RPS3 ribosomal protein S3 0.037233
BIRC6 baculoviral IAP repeat containing 6 0.0369758
ZCCHC7 zinc finger, CCHC domain containing 7 0.036685
ANXA5 annexin A5 0.035687
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0349948
VMP1 vacuole membrane protein 1 0.0347485
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0338455
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0327372
CDK13 cyclin-dependent kinase 13 0.0319278
NIPBL Nipped-B homolog (Drosophila) 0.031846
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0318033
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0317157
HDGF hepatoma-derived growth factor 0.0315701
NAP1L1 nucleosome assembly protein 1-like 1 0.0307224
EHBP1 EH domain binding protein 1 0.0305112
EML4 echinoderm microtubule associated protein like 4 0.0302527
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0298612
SETD5 SET domain containing 5 0.0294901
CTTN cortactin 0.0286467
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0285489
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0285456
AFF3 AF4/FMR2 family, member 3 0.0284995
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0278739
RBM25 RNA binding motif protein 25 0.0274801
ZFC3H1 zinc finger, C3H1-type containing 0.02742
ANKRD12 ankyrin repeat domain 12 0.02737
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0272536
XPO1 exportin 1 0.0270337
FBXO11 F-box protein 11 0.0264998
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0262746
RAB7A RAB7A, member RAS oncogene family 0.0262694
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0261599
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0255847
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0254617
PRRC2C proline-rich coiled-coil 2C 0.0251844
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0251491
SET SET nuclear proto-oncogene 0.0250003
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0249453
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0248193
COPA coatomer protein complex, subunit alpha 0.0246319
BZW1 basic leucine zipper and W2 domains 1 0.0245781
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0244744
MORF4L2 mortality factor 4 like 2 0.0244635
DCAF7 DDB1 and CUL4 associated factor 7 0.0243135
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0241807
ATP13A3 ATPase type 13A3 0.0238269
STC1 stanniocalcin 1 0.0237776
PTMA prothymosin, alpha 0.0237234
TAS2R14 taste receptor, type 2, member 14 0.023689
RPL5 ribosomal protein L5 0.0234499
HSPA8 heat shock 70kDa protein 8 0.0234209
RICTOR RPTOR independent companion of MTOR, complex 2 0.0233728
EGFR epidermal growth factor receptor 0.0233473
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0231527
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0230453
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0230281
PDLIM5 PDZ and LIM domain 5 0.0229892
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0229675
PRELID2 PRELI domain containing 2 0.0229186
TPX2 TPX2, microtubule-associated 0.0227788
ITCH itchy E3 ubiquitin protein ligase 0.0227405
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0226436
AKAP9 A kinase (PRKA) anchor protein 9 0.022525
NBEAL1 neurobeachin-like 1 0.0224575
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0224283
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0223677
NFE2L1 nuclear factor, erythroid 2-like 1 0.0223434
MBD5 methyl-CpG binding domain protein 5 0.0222815
CAPRIN2 caprin family member 2 0.0222179
CAVIN1 caveolae associated protein 1 0.0221065
SERBP1 SERPINE1 mRNA binding protein 1 0.0220723
FMNL2 formin-like 2 0.0217877
VCL vinculin 0.0217827
PTK2 protein tyrosine kinase 2 0.0216792
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0216726
VIM vimentin 0.0215354
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0214251
RPS7 ribosomal protein S7 0.0211621
EXOC4 exocyst complex component 4 0.0211037
JMJD1C jumonji domain containing 1C 0.0210739
TRIM33 tripartite motif containing 33 0.0210298
TBC1D15 TBC1 domain family, member 15 0.0209828
SPAG9 sperm associated antigen 9 0.0209428
GRAMD1B GRAM domain containing 1B 0.020929

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.30837
TMSB10 thymosin beta 10 -0.102888
TFPI2 tissue factor pathway inhibitor 2 -0.100085
EEF2 eukaryotic translation elongation factor 2 -0.0913324
EGR1 early growth response 1 -0.0625757
POTEF POTE ankyrin domain family, member F -0.0466208
ATP5F1B ATP synthase F1 subunit beta -0.0465959
RPL35A ribosomal protein L35a -0.0462112
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0443001
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0424497
LOC112694756 uncharaterized LOC112694756 -0.0397717
RPS4X ribosomal protein S4, X-linked -0.0328146
PKM pyruvate kinase, muscle -0.0327136
YBX1 Y box binding protein 1 -0.0312018
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0304976
MYL12B myosin, light chain 12B, regulatory -0.029381
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0291284
ADAR adenosine deaminase, RNA-specific -0.0283517
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0277887
RPS21 ribosomal protein S21 -0.027699
LDHB lactate dehydrogenase B -0.027661
RPS15 ribosomal protein S15 -0.0275907
SLC38A2 solute carrier family 38, member 2 -0.0269374
CANX calnexin -0.0246317
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0241404
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.0240589
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.023954
H1-0 H1.0 linker histone -0.0237209
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0234384
MATR3 matrin 3 -0.0231039
CCNL1 cyclin L1 -0.0230126
RPLP1 ribosomal protein, large, P1 -0.0228827
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0224025
ACTG1 actin gamma 1 -0.0220874
RPLP0 ribosomal protein, large, P0 -0.0210522
DEK DEK proto-oncogene -0.0209749
TAPBP TAP binding protein (tapasin) -0.0208899
GPHN gephyrin -0.0203398
PFN1 profilin 1 -0.0197484
ATP5F1E ATP synthase F1 subunit epsilon -0.0195493
RPS19 ribosomal protein S19 -0.0194775
WNK1 WNK lysine deficient protein kinase 1 -0.0194223
RPL8 ribosomal protein L8 -0.0188479
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0188459
PER1 period circadian clock 1 -0.0187755
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0187456
RPS24 ribosomal protein S24 -0.0186591
P4HB prolyl 4-hydroxylase, beta polypeptide -0.018163
KMT2D lysine (K)-specific methyltransferase 2D -0.0181176
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0173986
OLA1 Obg-like ATPase 1 -0.017008
GATAD2B GATA zinc finger domain containing 2B -0.01694
RPS23 ribosomal protein S23 -0.0167391
MSH6 mutS homolog 6 -0.0165695
DPP9 dipeptidyl-peptidase 9 -0.0165055
BSG basigin (Ok blood group) -0.0164314
AHNAK AHNAK nucleoprotein -0.0162963
CALR calreticulin -0.0162953
RTN4 reticulon 4 -0.0162162
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0161415
ACLY ATP citrate lyase -0.0161081
UBB ubiquitin B -0.0160358
FTH1 ferritin, heavy polypeptide 1 -0.0159577
BRD2 bromodomain containing 2 -0.0158765
CDV3 CDV3 homolog (mouse) -0.0156852
HCFC1 host cell factor C1 -0.0156578
SRRM2 serine/arginine repetitive matrix 2 -0.0155845
RPL27A ribosomal protein L27a -0.0153528
RLIM ring finger protein, LIM domain interacting -0.0152547
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0152409
AGRN agrin -0.0149962
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0149354
RPL28 ribosomal protein L28 -0.0147439
ATXN2L ataxin 2-like -0.0147431
PRRC2A proline-rich coiled-coil 2A -0.0144496
RPL34 ribosomal protein L34 -0.0144221
FOSL2 FOS-like antigen 2 -0.0144153
PTEN phosphatase and tensin homolog -0.0144006
SRSF3 serine/arginine-rich splicing factor 3 -0.014384
IGF1R insulin-like growth factor 1 receptor -0.0143468
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0141157
ZFAND5 zinc finger, AN1-type domain 5 -0.0138438
HELLS helicase, lymphoid-specific -0.0138155
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0137103
RB1CC1 RB1-inducible coiled-coil 1 -0.0135269
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.013511
UBC ubiquitin C -0.0135021
BRD4 bromodomain containing 4 -0.0134796
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0134024
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0132955
CAMKMT calmodulin-lysine N-methyltransferase -0.0131493
NUP155 nucleoporin 155kDa -0.0130961
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.013027
RPL27 ribosomal protein L27 -0.0130171
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) -0.0130011
MAGEA4 melanoma antigen family A4 -0.0129448
S100A11 S100 calcium binding protein A11 -0.0129243
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma -0.0128618
HSPA4 heat shock 70kDa protein 4 -0.0128302
PPIA peptidylprolyl isomerase A (cyclophilin A) -0.0128129