Captopril_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Captopril perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Captopril_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.0868267
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0771348
BZW1 basic leucine zipper and W2 domains 1 0.07455
PTMA prothymosin, alpha 0.073366
ELL2 elongation factor, RNA polymerase II, 2 0.0662923
STC1 stanniocalcin 1 0.0647091
ERRFI1 ERBB receptor feedback inhibitor 1 0.0646976
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0604562
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0584362
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0557162
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0551096
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0537302
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0535151
NAP1L1 nucleosome assembly protein 1-like 1 0.052375
FNDC3A fibronectin type III domain containing 3A 0.0513537
VIM vimentin 0.0510602
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0507314
EFNA5 ephrin-A5 0.0498209
ESYT2 extended synaptotagmin-like protein 2 0.0479857
DNER delta/notch-like EGF repeat containing 0.0445863
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0434822
LIMCH1 LIM and calponin homology domains 1 0.0421657
PDGFA platelet-derived growth factor alpha polypeptide 0.0415693
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0414738
WSB1 WD repeat and SOCS box containing 1 0.041287
PCBP3 poly(rC) binding protein 3 0.0406428
BIRC6 baculoviral IAP repeat containing 6 0.038237
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0382176
PM20D1 peptidase M20 domain containing 1 0.0381462
SPAG9 sperm associated antigen 9 0.038036
ITPRID2 ITPR interacting domain containing 2 0.037961
NPAS2 neuronal PAS domain protein 2 0.0375791
OGA O-GlcNAcase 0.0375736
BMERB1 bMERB domain containing 1 0.0374205
CTSC cathepsin C 0.0362664
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0357288
TGFBR1 transforming growth factor, beta receptor 1 0.0346344
RPL23 ribosomal protein L23 0.0340804
ATP13A3 ATPase type 13A3 0.0340355
FLNB filamin B, beta 0.0339252
MXI1 MAX interactor 1, dimerization protein 0.0329185
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0324306
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0324215
AKAP12 A kinase (PRKA) anchor protein 12 0.0319463
PRRC2C proline-rich coiled-coil 2C 0.0314962
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.031071
S100A6 S100 calcium binding protein A6 0.030505
RGS2 regulator of G-protein signaling 2 0.0301579
FAM13A family with sequence similarity 13, member A 0.0300282
CEP350 centrosomal protein 350kDa 0.0299618
PDLIM5 PDZ and LIM domain 5 0.0293588
RPS12 ribosomal protein S12 0.0291374
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0291167
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0289642
SET SET nuclear proto-oncogene 0.0284222
DST dystonin 0.0282104
MAP7 microtubule-associated protein 7 0.0280975
USP34 ubiquitin specific peptidase 34 0.0278784
ARRDC3 arrestin domain containing 3 0.0277858
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0271858
SH3KBP1 SH3-domain kinase binding protein 1 0.026842
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0267581
NGLY1 N-glycanase 1 0.0264799
NFE2L1 nuclear factor, erythroid 2-like 1 0.0259832
SDK1 sidekick cell adhesion molecule 1 0.0258771
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0255729
ARHGAP5 Rho GTPase activating protein 5 0.0253085
KTN1 kinectin 1 (kinesin receptor) 0.0251752
NBEAL1 neurobeachin-like 1 0.0250479
PYGL phosphorylase, glycogen, liver 0.0248228
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0247863
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0241487
RAI1 retinoic acid induced 1 0.0240337
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0237977
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0234531
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0229319
UBA6 ubiquitin-like modifier activating enzyme 6 0.0228791
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0228632
RPS7 ribosomal protein S7 0.0227947
PGK1 phosphoglycerate kinase 1 0.0227202
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0226578
EPHA4 EPH receptor A4 0.0226229
KMT2C lysine (K)-specific methyltransferase 2C 0.0224974
GPC6 glypican 6 0.0224963
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0224862
PGM2L1 phosphoglucomutase 2-like 1 0.0224564
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0223789
USP9X ubiquitin specific peptidase 9, X-linked 0.0218314
ZMYM2 zinc finger, MYM-type 2 0.0214637
RAB1A RAB1A, member RAS oncogene family 0.021387
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0213108
SLC16A6 solute carrier family 16, member 6 0.0212364
ZNF292 zinc finger protein 292 0.0211613
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0211063
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0210893
CSNK1A1 casein kinase 1, alpha 1 0.0210743
BDNF brain-derived neurotrophic factor 0.0209797
TOP1 topoisomerase (DNA) I 0.020925
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0207501
BRWD3 bromodomain and WD repeat domain containing 3 0.0207198

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.364021
FN1 fibronectin 1 -0.206657
TXNRD1 thioredoxin reductase 1 -0.128473
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.106018
PDE4D phosphodiesterase 4D, cAMP-specific -0.100374
FTH1 ferritin, heavy polypeptide 1 -0.0943562
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0889377
EEF2 eukaryotic translation elongation factor 2 -0.0885264
PDE10A phosphodiesterase 10A -0.0861175
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0814997
NALF1 NALCN channel auxiliary factor 1 -0.0813991
SMYD3 SET and MYND domain containing 3 -0.080644
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0802789
TMSB10 thymosin beta 10 -0.0774386
ACTG1 actin gamma 1 -0.073813
COL5A2 collagen, type V, alpha 2 -0.072392
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0721684
ATP5F1B ATP synthase F1 subunit beta -0.0602493
POTEF POTE ankyrin domain family, member F -0.0587803
PSD3 pleckstrin and Sec7 domain containing 3 -0.0567367
LOC112694756 uncharaterized LOC112694756 -0.0566206
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0562595
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0539803
RPLP1 ribosomal protein, large, P1 -0.0530392
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0510647
PKM pyruvate kinase, muscle -0.0481257
FTL ferritin, light polypeptide -0.0476952
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0451293
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0423248
EGR1 early growth response 1 -0.0411273
TBXT T-box transcription factor T -0.0396823
ANTXR1 anthrax toxin receptor 1 -0.0389605
LAMA5 laminin, alpha 5 -0.0387772
MAP1B microtubule-associated protein 1B -0.0371882
CDH13 cadherin 13 -0.0362212
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0361909
PCBP2 poly(rC) binding protein 2 -0.0361774
AKR1C1 aldo-keto reductase family 1, member C1 -0.0348975
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0346302
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0342328
CSRP1 cysteine and glycine-rich protein 1 -0.0337209
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0333298
NDRG1 N-myc downstream regulated 1 -0.0313304
UBC ubiquitin C -0.0300984
COL8A1 collagen, type VIII, alpha 1 -0.0299036
RPS23 ribosomal protein S23 -0.0297367
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0296843
PRRC2B proline-rich coiled-coil 2B -0.0292432
EZR ezrin -0.0287821
EEF1G eukaryotic translation elongation factor 1 gamma -0.0287416
PRKN parkin RBR E3 ubiquitin protein ligase -0.0282985
HLA-A major histocompatibility complex, class I, A -0.0281119
FLNA filamin A, alpha -0.0279738
PALLD palladin, cytoskeletal associated protein -0.0272334
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0268146
ADGRD1 adhesion G protein-coupled receptor D1 -0.026292
CTIF CBP80/20-dependent translation initiation factor -0.0256691
RPS19 ribosomal protein S19 -0.0254745
CADM2 cell adhesion molecule 2 -0.0251557
RTN4 reticulon 4 -0.025116
YBX1 Y box binding protein 1 -0.0245122
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0244601
RPLP0 ribosomal protein, large, P0 -0.0244081
BSG basigin (Ok blood group) -0.0243622
TUSC3 tumor suppressor candidate 3 -0.0242588
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0241566
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0240983
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0240852
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0238974
PFN1 profilin 1 -0.0238769
RPS14 ribosomal protein S14 -0.023529
RPS4X ribosomal protein S4, X-linked -0.0235237
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.023519
RPS6 ribosomal protein S6 -0.0232594
FUS FUS RNA binding protein -0.0231617
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0229127
CCNL1 cyclin L1 -0.0228255
KIAA0825 KIAA0825 -0.02268
IGF1R insulin-like growth factor 1 receptor -0.0226284
PTPRM protein tyrosine phosphatase, receptor type, M -0.0225845
TTC28 tetratricopeptide repeat domain 28 -0.0224906
RHOA ras homolog family member A -0.0221449
NOCT nocturnin -0.0219435
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0217454
TUBA1B tubulin, alpha 1b -0.0217224
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 -0.021535
LSAMP limbic system-associated membrane protein -0.0214814
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0209482
VDAC1 voltage-dependent anion channel 1 -0.0205031
RPS11 ribosomal protein S11 -0.0204746
AHNAK AHNAK nucleoprotein -0.0204288
MEF2D myocyte enhancer factor 2D -0.0203434
RPL28 ribosomal protein L28 -0.0200074
SOD2 superoxide dismutase 2, mitochondrial -0.0199544
SLC38A2 solute carrier family 38, member 2 -0.0198807
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0198678
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0195341
IFRD1 interferon-related developmental regulator 1 -0.0195187
MCL1 myeloid cell leukemia 1 -0.0194401
EPHA5 EPH receptor A5 -0.0192903