Captopril_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Captopril perturbation in SW 1271 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Captopril_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITCH itchy E3 ubiquitin protein ligase 0.0982814
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0951576
SETD5 SET domain containing 5 0.0934381
WAC WW domain containing adaptor with coiled-coil 0.0736782
HILPDA hypoxia inducible lipid droplet-associated 0.0724878
SEPTIN2 septin 2 0.0622661
RAB7A RAB7A, member RAS oncogene family 0.056069
UBE2K ubiquitin-conjugating enzyme E2K 0.0547654
SEC24A SEC24 family member A 0.0546606
ATP13A3 ATPase type 13A3 0.0531424
ERRFI1 ERBB receptor feedback inhibitor 1 0.0529832
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0523487
PICALM phosphatidylinositol binding clathrin assembly protein 0.0481957
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0477654
SRP54 signal recognition particle 54kDa 0.047483
IGF2 insulin-like growth factor 2 0.0471837
GGNBP2 gametogenetin binding protein 2 0.047049
MBNL1 muscleblind-like splicing regulator 1 0.0466478
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0449917
RAP1B RAP1B, member of RAS oncogene family 0.0449671
HJURP Holliday junction recognition protein 0.0443494
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.044065
SPAG9 sperm associated antigen 9 0.0439908
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0439887
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0437573
GOLGA4 golgin A4 0.0433502
KMT2E lysine (K)-specific methyltransferase 2E 0.0433005
CCDC88A coiled-coil domain containing 88A 0.0428643
OSBPL8 oxysterol binding protein-like 8 0.0425224
RAB6A RAB6A, member RAS oncogene family 0.0424652
PNISR PNN-interacting serine/arginine-rich protein 0.0424324
UGCG UDP-glucose ceramide glucosyltransferase 0.042226
ELL2 elongation factor, RNA polymerase II, 2 0.0417415
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0403557
GPBP1 GC-rich promoter binding protein 1 0.0393474
TAS2R14 taste receptor, type 2, member 14 0.0388596
PTMA prothymosin, alpha 0.038094
SMAD5 SMAD family member 5 0.0375806
UBE2B ubiquitin-conjugating enzyme E2B 0.0375461
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0374198
RBM25 RNA binding motif protein 25 0.0373618
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0373502
PUM2 pumilio RNA-binding family member 2 0.0372646
AKAP9 A kinase (PRKA) anchor protein 9 0.0366074
RNASEH2A ribonuclease H2, subunit A 0.0364878
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0363831
RAB1A RAB1A, member RAS oncogene family 0.0362867
B2M beta-2-microglobulin 0.0362227
HMGA1 high mobility group AT-hook 1 0.0360903
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0359941
NKTR natural killer cell triggering receptor 0.0357534
TNRC6B trinucleotide repeat containing 6B 0.0346721
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0343154
ADM adrenomedullin 0.0342102
TOP2A topoisomerase (DNA) II alpha 170kDa 0.034102
TM9SF2 transmembrane 9 superfamily member 2 0.0338566
PIAS1 protein inhibitor of activated STAT, 1 0.0337851
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0336252
RAB2A RAB2A, member RAS oncogene family 0.0333521
ANXA5 annexin A5 0.0333326
FLNB filamin B, beta 0.0331325
CCNT2 cyclin T2 0.0328309
ANKRD12 ankyrin repeat domain 12 0.0326619
SCAF11 SR-related CTD-associated factor 11 0.0321672
CEP192 centrosomal protein 192kDa 0.0321661
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0321
RNF145 ring finger protein 145 0.03179
MTDH metadherin 0.0317314
CAPRIN2 caprin family member 2 0.0317287
CSNK1A1 casein kinase 1, alpha 1 0.0316488
PEAK1 pseudopodium-enriched atypical kinase 1 0.031646
TXNRD1 thioredoxin reductase 1 0.03156
COG6 component of oligomeric golgi complex 6 0.0314284
RASA2 RAS p21 protein activator 2 0.0312802
DTNA dystrobrevin, alpha 0.0309628
ACTN1 actinin, alpha 1 0.0309173
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0308984
COG5 component of oligomeric golgi complex 5 0.0306269
ZSWIM6 zinc finger, SWIM-type containing 6 0.0303202
DCAF7 DDB1 and CUL4 associated factor 7 0.0300737
RPS17 ribosomal protein S17 0.0300147
DGKD diacylglycerol kinase, delta 130kDa 0.0299474
FBXO11 F-box protein 11 0.0298245
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.0298015
ANKRD11 ankyrin repeat domain 11 0.0295191
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0294079
PRRC1 proline-rich coiled-coil 1 0.0291104
HM13 histocompatibility (minor) 13 0.0289562
HBS1L HBS1-like translational GTPase 0.0288311
SPPL3 signal peptide peptidase like 3 0.0287603
VDAC1 voltage-dependent anion channel 1 0.0286475
AXL AXL receptor tyrosine kinase 0.0286239
CIB1 calcium and integrin binding 1 (calmyrin) 0.0285848
CHD1 chromodomain helicase DNA binding protein 1 0.0284918
RCOR1 REST corepressor 1 0.0283751
IST1 increased sodium tolerance 1 homolog (yeast) 0.0282905
ZBTB10 zinc finger and BTB domain containing 10 0.0282622
RPL5 ribosomal protein L5 0.0281621
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0279351
NOP58 NOP58 ribonucleoprotein 0.0278439

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.150094
AHNAK AHNAK nucleoprotein -0.134614
CANX calnexin -0.107982
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0774083
UBC ubiquitin C -0.0737043
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0678139
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0675683
LOC112694756 uncharaterized LOC112694756 -0.0642124
BIRC3 baculoviral IAP repeat containing 3 -0.0625679
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0605019
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0594213
EFNA5 ephrin-A5 -0.0584459
MYH9 myosin, heavy chain 9, non-muscle -0.0568765
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0547263
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0529506
PRKCA protein kinase C, alpha -0.0529222
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0522382
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0521959
ENO1 enolase 1, (alpha) -0.0515227
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0499568
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0499533
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0494937
HMGA2 high mobility group AT-hook 2 -0.0488361
SUN1 Sad1 and UNC84 domain containing 1 -0.048685
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0468923
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0467345
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0454429
EEF2 eukaryotic translation elongation factor 2 -0.0453412
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0432531
SETX senataxin -0.0430256
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0429617
ATF7IP activating transcription factor 7 interacting protein -0.0421574
TNIP1 TNFAIP3 interacting protein 1 -0.0420059
LDHA lactate dehydrogenase A -0.0420051
CENPF centromere protein F, 350/400kDa -0.0416466
RPL27A ribosomal protein L27a -0.0405872
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0405861
ATG10 autophagy related 10 -0.040036
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0396058
PKM pyruvate kinase, muscle -0.0391945
MBD5 methyl-CpG binding domain protein 5 -0.0387652
DPYD dihydropyrimidine dehydrogenase -0.0382697
SMYD3 SET and MYND domain containing 3 -0.0376447
ATXN1 ataxin 1 -0.0375273
APOLD1 apolipoprotein L domain containing 1 -0.0374689
CEP250 centrosomal protein 250kDa -0.037432
SVIL supervillin -0.0370261
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0367055
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0365215
ZC3H12B zinc finger CCCH-type containing 12B -0.0365031
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.0362529
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0359775
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0359764
CDK6 cyclin-dependent kinase 6 -0.0359497
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0354254
CLIC1 chloride intracellular channel 1 -0.0351361
CD44 CD44 molecule (Indian blood group) -0.0349731
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0346123
ADAR adenosine deaminase, RNA-specific -0.0343804
CAV1 caveolin 1, caveolae protein, 22kDa -0.0342468
POTEF POTE ankyrin domain family, member F -0.0341833
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0341806
TRIM56 tripartite motif containing 56 -0.0341719
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0339821
USP22 ubiquitin specific peptidase 22 -0.0339303
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0339185
IER3 immediate early response 3 -0.0338324
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.033803
ARHGAP26 Rho GTPase activating protein 26 -0.0337534
CSDE1 cold shock domain containing E1, RNA-binding -0.0329744
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0326646
RPS19 ribosomal protein S19 -0.0326266
NUMA1 nuclear mitotic apparatus protein 1 -0.0323806
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0323034
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0320343
LMO7 LIM domain 7 -0.0318364
NSD2 nuclear receptor binding SET domain protein 2 -0.0318216
KMT2A lysine (K)-specific methyltransferase 2A -0.0313139
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0311037
BBX bobby sox homolog (Drosophila) -0.0307753
PGGT1B protein geranylgeranyltransferase type I, beta subunit -0.0305732
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0302625
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0299556
TCF12 transcription factor 12 -0.0299328
RORA RAR-related orphan receptor A -0.0298495
FMN1 formin 1 -0.0298022
ZMYND8 zinc finger, MYND-type containing 8 -0.0295828
MORF4L1 mortality factor 4 like 1 -0.0295762
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0293595
MYO9A myosin IXA -0.029313
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0292308
JUN jun proto-oncogene -0.0290144
SSB Sjogren syndrome antigen B (autoantigen La) -0.0289678
STAG2 stromal antigen 2 -0.0289275
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0288806
TRIP12 thyroid hormone receptor interactor 12 -0.0287796
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0287382
RIOK3 RIO kinase 3 -0.0285217
HELZ helicase with zinc finger -0.0284108
VCL vinculin -0.0283418