| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. (Chemical Entities of Biological Interest Ontology, CHEBI_3387) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2554 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Carbamazepine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MCOLN2 | mucolipin 2 | 2.37 |
| BBS9 | Bardet-Biedl syndrome 9 | 1.76 |
| ALPK3 | alpha-kinase 3 | 1.61 |
| ZNF12 | zinc finger protein 12 | 1.49 |
| KIAA1107 | KIAA1107 | 0.7 |
| KLHL9 | kelch-like family member 9 | 0.61 |
| MRPL50 | mitochondrial ribosomal protein L50 | 0.59 |
| TRIAP1 | TP53 regulated inhibitor of apoptosis 1 | 0.56 |
| PMF1 | polyamine-modulated factor 1 | 0.52 |
| TCEA2 | transcription elongation factor A (SII), 2 | 0.47 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | 0.46 |
| HSBP1 | heat shock factor binding protein 1 | 0.43 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.43 |
| CARD8 | caspase recruitment domain family, member 8 | 0.43 |
| ZNF451 | zinc finger protein 451 | 0.42 |
| HMGCL | 3-hydroxymethyl-3-methylglutaryl-CoA lyase | 0.4 |
| TRIR | telomerase RNA component interacting RNase | 0.4 |
| ZNF766 | zinc finger protein 766 | 0.39 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.38 |
| ATG4D | autophagy related 4D, cysteine peptidase | 0.38 |
| FRMD6 | FERM domain containing 6 | 0.37 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | 0.37 |
| ZNF888 | zinc finger protein 888 | 0.36 |
| ADCY9 | adenylate cyclase 9 | 0.35 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | 0.35 |
| PDLIM7 | PDZ and LIM domain 7 (enigma) | 0.34 |
| RPL31 | ribosomal protein L31 | 0.33 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | 0.33 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | 0.33 |
| FCHO1 | FCH domain only 1 | 0.33 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | 0.32 |
| FXN | frataxin | 0.32 |
| ATG10 | autophagy related 10 | 0.31 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.31 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.31 |
| MLPH | melanophilin | 0.31 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.31 |
| SPTBN4 | spectrin, beta, non-erythrocytic 4 | 0.3 |
| CTTN | cortactin | 0.3 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.3 |
| XTBD1 | XRN2 binding domain containing 1 | 0.29 |
| ZDHHC12 | zinc finger, DHHC-type containing 12 | 0.29 |
| FAM161A | family with sequence similarity 161, member A | 0.29 |
| MKRN4P | makorin ring finger protein 4, pseudogene | 0.29 |
| SP1 | Sp1 transcription factor | 0.29 |
| ARL16 | ADP-ribosylation factor-like 16 | 0.29 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.28 |
| B2M | beta-2-microglobulin | 0.28 |
| TOMM5 | translocase of outer mitochondrial membrane 5 homolog (yeast) | 0.28 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | 0.27 |
| CXXC5 | CXXC finger protein 5 | 0.27 |
| GRB7 | growth factor receptor-bound protein 7 | 0.27 |
| HEATR5A | HEAT repeat containing 5A | 0.26 |
| ZNF263 | zinc finger protein 263 | 0.26 |
| HFE | hemochromatosis | 0.26 |
| KCTD6 | potassium channel tetramerization domain containing 6 | 0.25 |
| ZNF627 | zinc finger protein 627 | 0.25 |
| DNASE2 | deoxyribonuclease II, lysosomal | 0.25 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.25 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.25 |
| TSPAN31 | tetraspanin 31 | 0.25 |
| CCDC18 | coiled-coil domain containing 18 | 0.25 |
| CASKIN2 | CASK interacting protein 2 | 0.25 |
| CALHM2 | calcium homeostasis modulator 2 | 0.25 |
| COP1 | COP1 E3 ubiquitin ligase | 0.24 |
| FDX1 | ferredoxin 1 | 0.24 |
| RPL10A | ribosomal protein L10a | 0.24 |
| PROSER3 | proline and serine rich 3 | 0.24 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.24 |
| MOCOS | molybdenum cofactor sulfurase | 0.24 |
| DUSP6 | dual specificity phosphatase 6 | 0.23 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.23 |
| LRFN3 | leucine rich repeat and fibronectin type III domain containing 3 | 0.23 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | 0.23 |
| TUFT1 | tuftelin 1 | 0.23 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | 0.23 |
| UFC1 | ubiquitin-fold modifier conjugating enzyme 1 | 0.23 |
| S100A2 | S100 calcium binding protein A2 | 0.23 |
| NCKAP5L | NCK-associated protein 5-like | 0.23 |
| TMEM102 | transmembrane protein 102 | 0.23 |
| ADIRF | adipogenesis regulatory factor | 0.22 |
| ITGA7 | integrin, alpha 7 | 0.22 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | 0.22 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.22 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.22 |
| PRICKLE3 | prickle homolog 3 (Drosophila) | 0.22 |
| DSC2 | desmocollin 2 | 0.22 |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 | 0.22 |
| RPL35A | ribosomal protein L35a | 0.22 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.22 |
| PPP2R5B | protein phosphatase 2, regulatory subunit B', beta | 0.22 |
| S100A6 | S100 calcium binding protein A6 | 0.22 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.22 |
| TMC4 | transmembrane channel-like 4 | 0.22 |
| SET | SET nuclear proto-oncogene | 0.22 |
| TMEM222 | transmembrane protein 222 | 0.22 |
| TMEM184A | transmembrane protein 184A | 0.22 |
| R3HDM2 | R3H domain containing 2 | 0.22 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | 0.22 |
| TRAPPC6A | trafficking protein particle complex 6A | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EMC10 | ER membrane protein complex subunit 10 | -0.96 |
| FBN3 | fibrillin 3 | -0.7 |
| FKTN | fukutin | -0.59 |
| MTFP1 | mitochondrial fission process 1 | -0.58 |
| MIIP | migration and invasion inhibitory protein | -0.56 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.55 |
| MAPKBP1 | mitogen-activated protein kinase binding protein 1 | -0.55 |
| MIDN | midnolin | -0.52 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.51 |
| ADCK1 | aarF domain containing kinase 1 | -0.51 |
| FAAP24 | FA core complex associated protein 24 | -0.47 |
| EIF5A2 | eukaryotic translation initiation factor 5A2 | -0.47 |
| TSPAN15 | tetraspanin 15 | -0.46 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.46 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | -0.45 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.42 |
| IFFO1 | intermediate filament family orphan 1 | -0.41 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | -0.39 |
| SNX13 | sorting nexin 13 | -0.39 |
| SPATA7 | spermatogenesis associated 7 | -0.38 |
| NPEPL1 | aminopeptidase-like 1 | -0.37 |
| CLIC6 | chloride intracellular channel 6 | -0.36 |
| LAMA3 | laminin, alpha 3 | -0.36 |
| MSRB2 | methionine sulfoxide reductase B2 | -0.36 |
| PRDM4 | PR domain containing 4 | -0.35 |
| RND3 | Rho family GTPase 3 | -0.35 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.34 |
| GSE1 | Gse1 coiled-coil protein | -0.34 |
| SGCE | sarcoglycan, epsilon | -0.33 |
| ZFP36 | ZFP36 ring finger protein | -0.33 |
| DCLRE1C | DNA cross-link repair 1C | -0.33 |
| KBTBD11 | kelch repeat and BTB (POZ) domain containing 11 | -0.33 |
| PITX2 | paired-like homeodomain 2 | -0.33 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | -0.32 |
| ABCB4 | ATP-binding cassette, sub-family B (MDR/TAP), member 4 | -0.32 |
| MYZAP | myocardial zonula adherens protein | -0.32 |
| RGN | regucalcin | -0.31 |
| DNAH9 | dynein, axonemal, heavy chain 9 | -0.31 |
| FGFR4 | fibroblast growth factor receptor 4 | -0.31 |
| SGK3 | serum/glucocorticoid regulated kinase family, member 3 | -0.31 |
| TMEM63B | transmembrane protein 63B | -0.31 |
| IGF1R | insulin-like growth factor 1 receptor | -0.31 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | -0.31 |
| LRP1 | low density lipoprotein receptor-related protein 1 | -0.31 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | -0.3 |
| C6ORF136 | chromosome 6 open reading frame 136 | -0.3 |
| PRG4 | proteoglycan 4 | -0.3 |
| VWA5A | von Willebrand factor A domain containing 5A | -0.3 |
| NLRP1 | NLR family, pyrin domain containing 1 | -0.3 |
| PIP | prolactin-induced protein | -0.3 |
| SLC22A23 | solute carrier family 22, member 23 | -0.3 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.3 |
| AXIN1 | axin 1 | -0.29 |
| SESN2 | sestrin 2 | -0.29 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.29 |
| PEX16 | peroxisomal biogenesis factor 16 | -0.29 |
| LRRC8B | leucine rich repeat containing 8 family, member B | -0.28 |
| LAMA2 | laminin, alpha 2 | -0.28 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | -0.28 |
| ZNF729 | zinc finger protein 729 | -0.28 |
| WTAP | Wilms tumor 1 associated protein | -0.28 |
| TBC1D14 | TBC1 domain family, member 14 | -0.27 |
| GEMIN7 | gem (nuclear organelle) associated protein 7 | -0.27 |
| ATXN7L3 | ataxin 7-like 3 | -0.27 |
| GLT8D2 | glycosyltransferase 8 domain containing 2 | -0.26 |
| GLMP | glycosylated lysosomal membrane protein | -0.26 |
| DNAJC24 | DnaJ (Hsp40) homolog, subfamily C, member 24 | -0.26 |
| ZNRD1 | zinc ribbon domain containing 1 | -0.25 |
| CMC2 | C-x(9)-C motif containing 2 | -0.25 |
| RNASEH2C | ribonuclease H2, subunit C | -0.25 |
| ABHD4 | abhydrolase domain containing 4 | -0.25 |
| IL6ST | interleukin 6 signal transducer | -0.25 |
| RGP1 | RGP1 retrograde golgi transport homolog (S. cerevisiae) | -0.25 |
| TPBG | trophoblast glycoprotein | -0.25 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.25 |
| USP43 | ubiquitin specific peptidase 43 | -0.25 |
| ENOX2 | ecto-NOX disulfide-thiol exchanger 2 | -0.25 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | -0.24 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.24 |
| ATP13A2 | ATPase type 13A2 | -0.24 |
| ZBTB5 | zinc finger and BTB domain containing 5 | -0.24 |
| HLA-B | major histocompatibility complex, class I, B | -0.24 |
| TTC39A | tetratricopeptide repeat domain 39A | -0.24 |
| TMPO | thymopoietin | -0.24 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.24 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.23 |
| CFAP410 | cilia and flagella associated protein 410 | -0.23 |
| NMNAT3 | nicotinamide nucleotide adenylyltransferase 3 | -0.23 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.23 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.23 |
| C1ORF122 | chromosome 1 open reading frame 122 | -0.23 |
| HGFAC | HGF activator | -0.23 |
| RNF6 | ring finger protein (C3H2C3 type) 6 | -0.23 |
| CYP1A1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | -0.23 |
| MIER3 | mesoderm induction early response 1, family member 3 | -0.23 |
| DNAH6 | dynein, axonemal, heavy chain 6 | -0.22 |
| LMBR1 | limb development membrane protein 1 | -0.22 |
| CBARP | CACN subunit beta associated regulatory protein | -0.22 |
| CCDC66 | coiled-coil domain containing 66 | -0.22 |
| RWDD3 | RWD domain containing 3 | -0.22 |
