Carbamazepine_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.187881
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.187171
AREG amphiregulin 0.15884
VIM vimentin 0.143465
ERRFI1 ERBB receptor feedback inhibitor 1 0.120011
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.116972
ANXA1 annexin A1 0.10285
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0924025
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0871227
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0813377
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0738745
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0725517
CALR calreticulin 0.0724584
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0707138
KDM3A lysine (K)-specific demethylase 3A 0.0672394
PABPC1 poly(A) binding protein, cytoplasmic 1 0.06596
ASPH aspartate beta-hydroxylase 0.0592815
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0573924
HSPA8 heat shock 70kDa protein 8 0.0559573
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.055468
XPO1 exportin 1 0.0536159
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0533517
EIF4B eukaryotic translation initiation factor 4B 0.0521192
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.051504
EEF2 eukaryotic translation elongation factor 2 0.0498357
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0480951
TPM3 tropomyosin 3 0.04775
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0472187
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0464613
CANX calnexin 0.0457454
NAP1L1 nucleosome assembly protein 1-like 1 0.0455241
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0454996
PGK1 phosphoglycerate kinase 1 0.0440123
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0430019
APP amyloid beta (A4) precursor protein 0.0413587
EIF4A2 eukaryotic translation initiation factor 4A2 0.041344
TPI1 triosephosphate isomerase 1 0.0412361
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0411696
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0402325
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0398765
KIF5B kinesin family member 5B 0.0394658
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0383193
RNF213 ring finger protein 213 0.0381524
H1-0 H1.0 linker histone 0.0374399
ENO1 enolase 1, (alpha) 0.0369614
RRM2 ribonucleotide reductase M2 0.036613
CSNK1A1 casein kinase 1, alpha 1 0.0360935
GCG glucagon 0.0355569
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0353638
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0353171
PCBP2 poly(rC) binding protein 2 0.0351128
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.034834
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0335575
MKI67 marker of proliferation Ki-67 0.0328162
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0327615
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0321638
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0317199
AHNAK AHNAK nucleoprotein 0.0310554
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0309836
UBC ubiquitin C 0.0307285
NCAPD2 non-SMC condensin I complex, subunit D2 0.0302177
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0292696
RSL1D1 ribosomal L1 domain containing 1 0.0292353
YEATS2 YEATS domain containing 2 0.028969
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.028576
SPATS2 spermatogenesis associated, serine-rich 2 0.0280426
GPR15 G protein-coupled receptor 15 0.0278655
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0271825
ARRDC3 arrestin domain containing 3 0.027054
TPX2 TPX2, microtubule-associated 0.0268878
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0267765
EIF4A1 eukaryotic translation initiation factor 4A1 0.0266229
FKBP4 FK506 binding protein 4, 59kDa 0.0265561
FXR1 fragile X mental retardation, autosomal homolog 1 0.0264993
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0264838
PLEC plectin 0.0264413
IL6ST interleukin 6 signal transducer 0.0261493
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0260586
ACLY ATP citrate lyase 0.0258339
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0258239
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0258194
CCDC47 coiled-coil domain containing 47 0.0257728
ZNF217 zinc finger protein 217 0.0253363
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0252263
SPAG9 sperm associated antigen 9 0.025149
XPOT exportin, tRNA 0.0251129
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0250669
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0247491
SERINC1 serine incorporator 1 0.0247391
PDIA4 protein disulfide isomerase family A, member 4 0.0246594
RERE arginine-glutamic acid dipeptide (RE) repeats 0.024603
UBQLN1 ubiquilin 1 0.0244425
HSPH1 heat shock 105kDa/110kDa protein 1 0.0242165
PDIA6 protein disulfide isomerase family A, member 6 0.0242119
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0240483
HMGB2 high mobility group box 2 0.0239616
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.023759
EZR ezrin 0.0237275
HDLBP high density lipoprotein binding protein 0.023665
FAT1 FAT atypical cadherin 1 0.0235649

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.182365
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.110325
TMSB10 thymosin beta 10 -0.0826633
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0766045
NLGN1 neuroligin 1 -0.0760172
PDE4D phosphodiesterase 4D, cAMP-specific -0.0729755
RPL23 ribosomal protein L23 -0.0699151
RPS6 ribosomal protein S6 -0.0691853
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0626778
FTL ferritin, light polypeptide -0.062386
ANKRD12 ankyrin repeat domain 12 -0.0618142
RPS12 ribosomal protein S12 -0.058343
RPLP2 ribosomal protein, large, P2 -0.0542818
RPL35A ribosomal protein L35a -0.0541682
EGR1 early growth response 1 -0.0537671
PFN1 profilin 1 -0.0529261
RPS8 ribosomal protein S8 -0.0479496
RPL37A ribosomal protein L37a -0.0465119
RPS19 ribosomal protein S19 -0.043222
TENM3 teneurin transmembrane protein 3 -0.0418659
PCDH7 protocadherin 7 -0.0413021
ZNF804A zinc finger protein 804A -0.0405533
CNRIP1 cannabinoid receptor interacting protein 1 -0.0400189
RPL9 ribosomal protein L9 -0.0388136
CELF2 CUGBP, Elav-like family member 2 -0.0385153
NCEH1 neutral cholesterol ester hydrolase 1 -0.0380172
ERBIN erbb2 interacting protein -0.0377815
HMGA2 high mobility group AT-hook 2 -0.0373103
RTN4 reticulon 4 -0.037249
RPL12 ribosomal protein L12 -0.0370269
EDARADD EDAR-associated death domain -0.0368473
TSC22D2 TSC22 domain family, member 2 -0.0361344
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0355744
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0355283
RPL36 ribosomal protein L36 -0.0342008
MARCHF4 membrane associated ring-CH-type finger 4 -0.0336525
RPL26 ribosomal protein L26 -0.0322197
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0317224
RPLP1 ribosomal protein, large, P1 -0.0316503
RPL34 ribosomal protein L34 -0.0305509
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0305365
BRD4 bromodomain containing 4 -0.0303139
MMP12 matrix metallopeptidase 12 -0.0301305
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0290552
RPL28 ribosomal protein L28 -0.0288969
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0283549
ANKRD28 ankyrin repeat domain 28 -0.0275967
RPL37 ribosomal protein L37 -0.0275962
CCDC88A coiled-coil domain containing 88A -0.0272654
JMJD1C jumonji domain containing 1C -0.0271757
RPS13 ribosomal protein S13 -0.0270071
MAP1B microtubule-associated protein 1B -0.0264465
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0264038
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0259739
RACK1 receptor for activated C kinase 1 -0.0258102
DTNA dystrobrevin, alpha -0.0254882
DPYD dihydropyrimidine dehydrogenase -0.0254218
RASAL2 RAS protein activator like 2 -0.0246082
NF1 neurofibromin 1 -0.0240963
RPL19 ribosomal protein L19 -0.0239924
MSRB3 methionine sulfoxide reductase B3 -0.0239352
RAB7A RAB7A, member RAS oncogene family -0.0238451
RAP1B RAP1B, member of RAS oncogene family -0.0238058
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0237516
RPS27 ribosomal protein S27 -0.0234001
RPL11 ribosomal protein L11 -0.0231262
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0227762
PRR16 proline rich 16 -0.0225286
SEC62 SEC62 homolog (S. cerevisiae) -0.022356
CCN2 cellular communication network factor 2 -0.0220679
GARS1 glycyl-tRNA synthetase 1 -0.021471
RPS20 ribosomal protein S20 -0.0214216
HSPB1 heat shock 27kDa protein 1 -0.0212753
RPS16 ribosomal protein S16 -0.0212016
THOC2 THO complex 2 -0.0211199
RPS29 ribosomal protein S29 -0.0210882
POTEF POTE ankyrin domain family, member F -0.0208897
CALD1 caldesmon 1 -0.0208268
CDH12 cadherin 12, type 2 (N-cadherin 2) -0.0208179
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0201525
LATS2 large tumor suppressor kinase 2 -0.0201028
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0198961
RPL10A ribosomal protein L10a -0.0198707
BCHE butyrylcholinesterase -0.0197367
PHF14 PHD finger protein 14 -0.0195508
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0193655
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0193185
RPL31 ribosomal protein L31 -0.0189631
SRSF11 serine/arginine-rich splicing factor 11 -0.0189315
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0187953
NABP1 nucleic acid binding protein 1 -0.0187854
DLC1 DLC1 Rho GTPase activating protein -0.0185394
RPS5 ribosomal protein S5 -0.0184685
RPS24 ribosomal protein S24 -0.018285
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0180167
EIF5B eukaryotic translation initiation factor 5B -0.0179956
RPS2 ribosomal protein S2 -0.0178654
GGNBP2 gametogenetin binding protein 2 -0.0177763
FBXL17 F-box and leucine-rich repeat protein 17 -0.0177219
PUM1 pumilio RNA-binding family member 1 -0.0177031