Carbamazepine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.16371
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0845809
VCL vinculin 0.0819214
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0780708
FAM13A family with sequence similarity 13, member A 0.0686866
FMN1 formin 1 0.0667516
MYH9 myosin, heavy chain 9, non-muscle 0.0657555
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0594312
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0534225
AKAP12 A kinase (PRKA) anchor protein 12 0.0523681
EXT1 exostosin glycosyltransferase 1 0.0480874
DST dystonin 0.0476808
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.045885
TRIB2 tribbles pseudokinase 2 0.0440327
DSCAM Down syndrome cell adhesion molecule 0.0415652
SEPTIN9 septin 9 0.0411119
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0401618
WAC WW domain containing adaptor with coiled-coil 0.0400439
ZMIZ1 zinc finger, MIZ-type containing 1 0.0393179
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0374523
DDIT4 DNA-damage-inducible transcript 4 0.0374149
NCOR2 nuclear receptor corepressor 2 0.0370714
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0357342
MSI2 musashi RNA-binding protein 2 0.0356542
TPM1 tropomyosin 1 (alpha) 0.035111
NFE2L1 nuclear factor, erythroid 2-like 1 0.0345544
PSD3 pleckstrin and Sec7 domain containing 3 0.0343778
HSPA8 heat shock 70kDa protein 8 0.0343177
ERRFI1 ERBB receptor feedback inhibitor 1 0.0341725
PDLIM5 PDZ and LIM domain 5 0.0337885
SOX9 SRY (sex determining region Y)-box 9 0.0330873
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0323867
SLITRK6 SLIT and NTRK-like family, member 6 0.0323387
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0320745
RNF213 ring finger protein 213 0.0317043
EIF3A eukaryotic translation initiation factor 3, subunit A 0.031538
SET SET nuclear proto-oncogene 0.0312935
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0307594
ITPRID2 ITPR interacting domain containing 2 0.0305781
ZSWIM6 zinc finger, SWIM-type containing 6 0.0303359
STK38L serine/threonine kinase 38 like 0.0301025
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0294425
SPAG9 sperm associated antigen 9 0.0293867
HELZ helicase with zinc finger 0.0286966
APLP2 amyloid beta (A4) precursor-like protein 2 0.0285207
MEIS2 Meis homeobox 2 0.0282776
ARRDC3 arrestin domain containing 3 0.0280864
GPBP1 GC-rich promoter binding protein 1 0.0279549
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.027668
KMT2C lysine (K)-specific methyltransferase 2C 0.0275432
NPAS2 neuronal PAS domain protein 2 0.0274573
PTPRM protein tyrosine phosphatase, receptor type, M 0.0271649
CADM1 cell adhesion molecule 1 0.0270246
VMP1 vacuole membrane protein 1 0.0264554
HMGB2 high mobility group box 2 0.0260842
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0257087
G3BP2 GTPase activating protein (SH3 domain) binding protein 2 0.0255866
KMT2E lysine (K)-specific methyltransferase 2E 0.0255284
RNF145 ring finger protein 145 0.0252235
FERMT2 fermitin family member 2 0.0246108
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0245494
TLE4 transducin-like enhancer of split 4 0.0245458
VGF VGF nerve growth factor inducible 0.0242285
FAM107B family with sequence similarity 107, member B 0.0241295
DTNA dystrobrevin, alpha 0.0239861
LRRC59 leucine rich repeat containing 59 0.0239016
STARD4 StAR-related lipid transfer (START) domain containing 4 0.023642
MED13 mediator complex subunit 13 0.0235975
VEGFA vascular endothelial growth factor A 0.0235071
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0233942
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0233408
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0232845
COL3A1 collagen, type III, alpha 1 0.0232641
IGSF9B immunoglobulin superfamily, member 9B 0.0231123
MKI67 marker of proliferation Ki-67 0.0230145
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0227666
MEMO1 mediator of cell motility 1 0.0225514
ARHGAP9 Rho GTPase activating protein 9 0.0225033
CDK14 cyclin-dependent kinase 14 0.0221019
BHLHE40 basic helix-loop-helix family, member e40 0.0218657
EEF2 eukaryotic translation elongation factor 2 0.0217251
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0216001
TNIP1 TNFAIP3 interacting protein 1 0.021343
YY1AP1 YY1 associated protein 1 0.0212451
TPM3 tropomyosin 3 0.021212
YTHDC1 YTH domain containing 1 0.0210939
RB1CC1 RB1-inducible coiled-coil 1 0.0210807
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0208748
HILPDA hypoxia inducible lipid droplet-associated 0.0207501
PPP1R9B protein phosphatase 1, regulatory subunit 9B 0.0207183
ADD1 adducin 1 (alpha) 0.0205902
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0205873
FRMD6 FERM domain containing 6 0.0203585
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0203133
SOD2 superoxide dismutase 2, mitochondrial 0.0198743
BRD2 bromodomain containing 2 0.0198637
SAFB scaffold attachment factor B 0.0197319
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0196641
COPA coatomer protein complex, subunit alpha 0.0194561
ACTN4 actinin, alpha 4 0.019446

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.333646
RPL23 ribosomal protein L23 -0.122209
IGF2 insulin-like growth factor 2 -0.119088
SYT1 synaptotagmin I -0.106968
RPLP1 ribosomal protein, large, P1 -0.100919
RPL35A ribosomal protein L35a -0.0982652
PTMA prothymosin, alpha -0.0960588
RPS6 ribosomal protein S6 -0.0951544
ACTG1 actin gamma 1 -0.086927
RPL38 ribosomal protein L38 -0.0837931
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0778121
RPS24 ribosomal protein S24 -0.0738387
RPL34 ribosomal protein L34 -0.0736946
TMSB10 thymosin beta 10 -0.0731555
RPL12 ribosomal protein L12 -0.0630629
FTL ferritin, light polypeptide -0.0626777
TPT1 tumor protein, translationally-controlled 1 -0.0611795
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0594797
EIF1 eukaryotic translation initiation factor 1 -0.0586706
MBD5 methyl-CpG binding domain protein 5 -0.0570424
BPTF bromodomain PHD finger transcription factor -0.0560311
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0493334
VIM vimentin -0.0479477
H3-3B H3.3 histone B -0.0478009
RPL31 ribosomal protein L31 -0.0464469
COL1A1 collagen, type I, alpha 1 -0.0452958
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.044705
GARS1 glycyl-tRNA synthetase 1 -0.044122
RPL32 ribosomal protein L32 -0.0440873
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0436002
RPL37A ribosomal protein L37a -0.0432182
MAP1B microtubule-associated protein 1B -0.0432029
RPS19 ribosomal protein S19 -0.0416363
RPL36 ribosomal protein L36 -0.0385875
RPS23 ribosomal protein S23 -0.0382053
DLC1 DLC1 Rho GTPase activating protein -0.0373897
RPLP2 ribosomal protein, large, P2 -0.0368471
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0366316
B2M beta-2-microglobulin -0.0362874
RPL27 ribosomal protein L27 -0.0362263
RPLP0 ribosomal protein, large, P0 -0.0360131
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0355679
KPNB1 karyopherin (importin) beta 1 -0.0352468
RPS3 ribosomal protein S3 -0.0346947
RPS27A ribosomal protein S27a -0.0342307
S100A9 S100 calcium binding protein A9 -0.0340824
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0330379
S100A6 S100 calcium binding protein A6 -0.0329921
RPS5 ribosomal protein S5 -0.0329025
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0328645
PCDH9 protocadherin 9 -0.0327463
RPS21 ribosomal protein S21 -0.0326237
IER3 immediate early response 3 -0.0323732
VDAC1 voltage-dependent anion channel 1 -0.0313533
RPL28 ribosomal protein L28 -0.0312777
RPL18 ribosomal protein L18 -0.0306477
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0305912
RPL9 ribosomal protein L9 -0.0302239
RPL11 ribosomal protein L11 -0.0301788
CEMIP cell migration inducing protein, hyaluronan binding -0.02986
ATRNL1 attractin-like 1 -0.0296038
RPS12 ribosomal protein S12 -0.029542
RPS11 ribosomal protein S11 -0.0292491
LSAMP limbic system-associated membrane protein -0.029175
RPS29 ribosomal protein S29 -0.0287744
RPL37 ribosomal protein L37 -0.0285297
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0285114
RPL26 ribosomal protein L26 -0.0282326
HAND2 heart and neural crest derivatives expressed 2 -0.0280437
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0277233
ADGRB3 adhesion G protein-coupled receptor B3 -0.027573
ANXA2 annexin A2 -0.0274185
RPL30 ribosomal protein L30 -0.0271644
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0271068
RPS8 ribosomal protein S8 -0.0267312
RPS4X ribosomal protein S4, X-linked -0.0267118
RPS14 ribosomal protein S14 -0.0266144
RPL7A ribosomal protein L7a -0.0265193
RPS13 ribosomal protein S13 -0.0263431
IFI16 interferon, gamma-inducible protein 16 -0.0261913
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0259722
BCAS3 breast carcinoma amplified sequence 3 -0.0259151
PTPRK protein tyrosine phosphatase, receptor type, K -0.0258472
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0256659
STC1 stanniocalcin 1 -0.0255374
RPS16 ribosomal protein S16 -0.0254686
ZBTB20 zinc finger and BTB domain containing 20 -0.0254665
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0251445
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0249737
SOS1 son of sevenless homolog 1 (Drosophila) -0.0249643
PHF14 PHD finger protein 14 -0.0249284
KLF6 Kruppel-like factor 6 -0.0244591
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0244326
PTPRD protein tyrosine phosphatase, receptor type, D -0.0243657
RPL5 ribosomal protein L5 -0.0241966
POU2F1 POU class 2 homeobox 1 -0.0241618
UBB ubiquitin B -0.0239922
RPS15 ribosomal protein S15 -0.0239866
TBX2 T-box 2 -0.023932
TENT5A terminal nucleotidyltransferase 5A -0.0235756