Carbamazepine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SYNE2 spectrin repeat containing, nuclear envelope 2 0.104387
MYH9 myosin, heavy chain 9, non-muscle 0.103555
SPTBN1 spectrin, beta, non-erythrocytic 1 0.102447
ARGLU1 arginine and glutamate rich 1 0.0921255
DSPP dentin sialophosphoprotein 0.0852236
ERRFI1 ERBB receptor feedback inhibitor 1 0.0838434
DSCAM Down syndrome cell adhesion molecule 0.0764302
MLPH melanophilin 0.0751336
EZR ezrin 0.0734777
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0709597
NDRG1 N-myc downstream regulated 1 0.0705812
STK24 serine/threonine kinase 24 0.0697254
MACC1 metastasis associated in colon cancer 1 0.0687523
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0647793
B2M beta-2-microglobulin 0.0627217
FAT1 FAT atypical cadherin 1 0.057219
APLP2 amyloid beta (A4) precursor-like protein 2 0.0558832
TXNIP thioredoxin interacting protein 0.0547494
SORBS1 sorbin and SH3 domain containing 1 0.054343
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0533289
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0520313
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0518479
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0506141
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0506127
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0502481
SMAD3 SMAD family member 3 0.0496161
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0492031
PGK1 phosphoglycerate kinase 1 0.0478863
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0473955
LMO7 LIM domain 7 0.047008
ACTN4 actinin, alpha 4 0.0458147
CTNND1 catenin (cadherin-associated protein), delta 1 0.0458065
ARRDC3 arrestin domain containing 3 0.0452284
VEGFA vascular endothelial growth factor A 0.0446258
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0444026
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.044266
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0441787
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0433719
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0433517
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0427389
STYXL2 serine/threonine/tyrosine interacting like 2 0.0408731
TRIO trio Rho guanine nucleotide exchange factor 0.0405202
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0403601
ABHD2 abhydrolase domain containing 2 0.0399821
PADI1 peptidyl arginine deiminase, type I 0.0397221
EFNB2 ephrin-B2 0.0395104
PFKP phosphofructokinase, platelet 0.0391355
LASP1 LIM and SH3 protein 1 0.038572
CD46 CD46 molecule, complement regulatory protein 0.0384019
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.038203
MYO10 myosin X 0.0377931
CCNL1 cyclin L1 0.0376772
KIF16B kinesin family member 16B 0.0376077
IGFBP3 insulin-like growth factor binding protein 3 0.0374537
TUFT1 tuftelin 1 0.0372929
AFF1 AF4/FMR2 family, member 1 0.0370787
AREG amphiregulin 0.0369555
NCOR2 nuclear receptor corepressor 2 0.0367861
ENO1 enolase 1, (alpha) 0.036734
DAND5 DAN domain family member 5, BMP antagonist 0.0365172
PLIN2 perilipin 2 0.0363267
SCARB1 scavenger receptor class B, member 1 0.0355507
JUN jun proto-oncogene 0.0350032
MYH14 myosin, heavy chain 14, non-muscle 0.0340951
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0338357
CMIP c-Maf inducing protein 0.0337469
TSC22D1 TSC22 domain family, member 1 0.033507
BHLHE40 basic helix-loop-helix family, member e40 0.0332901
SFTPA2 surfactant protein A2 0.0331094
FHL2 four and a half LIM domains 2 0.0330319
RNF149 ring finger protein 149 0.0326963
ZFP36L1 ZFP36 ring finger protein-like 1 0.0319778
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0318873
LIMA1 LIM domain and actin binding 1 0.0318263
STS steroid sulfatase (microsomal), isozyme S 0.0317548
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0314557
IFNGR1 interferon gamma receptor 1 0.0314081
ANXA11 annexin A11 0.0313592
SH3PXD2A SH3 and PX domains 2A 0.0295608
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0291616
KRT19 keratin 19, type I 0.0291486
CANX calnexin 0.0291079
TACSTD2 tumor-associated calcium signal transducer 2 0.0289608
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0288536
ZNF292 zinc finger protein 292 0.0283843
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0283664
HLA-E major histocompatibility complex, class I, E 0.028061
MCL1 myeloid cell leukemia 1 0.0280461
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0279948
TPM3 tropomyosin 3 0.0276678
KIF13B kinesin family member 13B 0.0275428
PHF3 PHD finger protein 3 0.0275272
TOP2A topoisomerase (DNA) II alpha 170kDa 0.027523
ERCC5 excision repair cross-complementation group 5 0.0275226
SLC22A23 solute carrier family 22, member 23 0.0274236
SEPTIN9 septin 9 0.0270454
DST dystonin 0.0269937
CHD3 chromodomain helicase DNA binding protein 3 0.0269006
CTSB cathepsin B 0.0268308
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.026555

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.159133
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105421
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0999251
RUNX1 runt-related transcription factor 1 -0.0932808
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0848647
RIGI RNA sensor RIG-I -0.0840241
TPT1 tumor protein, translationally-controlled 1 -0.0816776
XAF1 XIAP associated factor 1 -0.0698819
EPSTI1 epithelial stromal interaction 1 (breast) -0.0673891
GMDS GDP-mannose 4,6-dehydratase -0.0661172
FNDC3A fibronectin type III domain containing 3A -0.0652182
WSB1 WD repeat and SOCS box containing 1 -0.0634948
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0632407
MX2 MX dynamin-like GTPase 2 -0.0598721
RABGAP1L RAB GTPase activating protein 1-like -0.0589731
RRBP1 ribosome binding protein 1 -0.0577754
SP100 SP100 nuclear antigen -0.0565238
HLA-B major histocompatibility complex, class I, B -0.0553425
RPL35A ribosomal protein L35a -0.0521387
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0516711
MAP7 microtubule-associated protein 7 -0.0505928
RPS6 ribosomal protein S6 -0.0488762
AHI1 Abelson helper integration site 1 -0.0482683
ANKRD10 ankyrin repeat domain 10 -0.0472773
RPL34 ribosomal protein L34 -0.0472684
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0471704
NCOA7 nuclear receptor coactivator 7 -0.0419372
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0417563
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0411172
RPL23 ribosomal protein L23 -0.041053
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0408561
EPHB2 EPH receptor B2 -0.0403992
PLSCR1 phospholipid scramblase 1 -0.0397115
GNAS GNAS complex locus -0.0390023
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0379373
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0377974
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0377486
AGR2 anterior gradient 2 -0.0372051
PMP22 peripheral myelin protein 22 -0.0365533
TMSB10 thymosin beta 10 -0.0362672
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0361103
PDIA3 protein disulfide isomerase family A, member 3 -0.0357139
IFIH1 interferon induced with helicase C domain 1 -0.0356121
RPLP1 ribosomal protein, large, P1 -0.0337752
RPL26 ribosomal protein L26 -0.0326436
MECOM MDS1 and EVI1 complex locus -0.0326192
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0323804
ZC3H13 zinc finger CCCH-type containing 13 -0.0321611
PERP PERP, TP53 apoptosis effector -0.0318028
RPS24 ribosomal protein S24 -0.0317954
ZBTB20 zinc finger and BTB domain containing 20 -0.0315859
ATP11A ATPase, class VI, type 11A -0.0305245
NF1 neurofibromin 1 -0.0304677
INTS6 integrator complex subunit 6 -0.0300816
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0293161
IFI6 interferon, alpha-inducible protein 6 -0.0292732
MBNL2 muscleblind-like splicing regulator 2 -0.0291691
GCLC glutamate-cysteine ligase, catalytic subunit -0.0291522
PIBF1 progesterone immunomodulatory binding factor 1 -0.0289141
WWOX WW domain containing oxidoreductase -0.028818
KIAA1217 KIAA1217 -0.0285307
BTBD9 BTB (POZ) domain containing 9 -0.0280893
TAS2R14 taste receptor, type 2, member 14 -0.0279967
BRCA2 breast cancer 2, early onset -0.0279599
VWA8 von Willebrand factor A domain containing 8 -0.027715
RPL28 ribosomal protein L28 -0.0276565
SPIDR scaffolding protein involved in DNA repair -0.0276241
LAMA4 laminin, alpha 4 -0.0272243
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0266179
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0265314
SIL1 SIL1 nucleotide exchange factor -0.0264816
ZNFX1 zinc finger, NFX1-type containing 1 -0.0264722
TRIM56 tripartite motif containing 56 -0.0262736
ANKRD12 ankyrin repeat domain 12 -0.0262268
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.026182
SEC24D SEC24 family member D -0.0261053
FTL ferritin, light polypeptide -0.0259098
RPLP0 ribosomal protein, large, P0 -0.0257958
NUCB2 nucleobindin 2 -0.0255746
CDK6 cyclin-dependent kinase 6 -0.0254248
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0252735
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0252285
NT5C2 5'-nucleotidase, cytosolic II -0.0250286
SKAP1 src kinase associated phosphoprotein 1 -0.0249838
TTC3 tetratricopeptide repeat domain 3 -0.0248827
C6ORF132 chromosome 6 open reading frame 132 -0.0247382
NEBL nebulette -0.024544
HMGB1 high mobility group box 1 -0.0244806
RPL12 ribosomal protein L12 -0.0242993
MICU2 mitochondrial calcium uptake 2 -0.0242816
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0242214
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0239207
S100A10 S100 calcium binding protein A10 -0.0238731
NPAS2 neuronal PAS domain protein 2 -0.0238003
HM13 histocompatibility (minor) 13 -0.0237682
FAF1 Fas (TNFRSF6) associated factor 1 -0.023435
HBS1L HBS1-like translational GTPase -0.0229919
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0226245
SAMHD1 SAM domain and HD domain 1 -0.0226021
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0225895