Carbamazepine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.194538
MYOF myoferlin 0.112245
MYH9 myosin, heavy chain 9, non-muscle 0.109992
FN1 fibronectin 1 0.108457
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0974331
APLP2 amyloid beta (A4) precursor-like protein 2 0.0962845
CLU clusterin 0.0912638
ENO1 enolase 1, (alpha) 0.0785
PLEC plectin 0.0768351
MSN moesin 0.075596
FOXO1 forkhead box O1 0.0750248
CEMIP cell migration inducing protein, hyaluronan binding 0.0709407
FLNA filamin A, alpha 0.0691887
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0671207
CTNND1 catenin (cadherin-associated protein), delta 1 0.0661511
EMP1 epithelial membrane protein 1 0.0660224
LDHA lactate dehydrogenase A 0.0657831
TGM2 transglutaminase 2 0.0620414
VCL vinculin 0.0615137
CD44 CD44 molecule (Indian blood group) 0.0604221
PDLIM1 PDZ and LIM domain 1 0.0579382
STC1 stanniocalcin 1 0.0577599
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0577504
MBNL1 muscleblind-like splicing regulator 1 0.056514
ANKRD33B ankyrin repeat domain 33B 0.0554983
NRG1 neuregulin 1 0.0529247
KRT6A keratin 6A, type II 0.0526095
CUL4B cullin 4B 0.0523517
LOXL2 lysyl oxidase-like 2 0.0521424
TMSB4X thymosin beta 4, X-linked 0.0521332
ITGA6 integrin, alpha 6 0.0516242
AKAP9 A kinase (PRKA) anchor protein 9 0.0510259
PLAT plasminogen activator, tissue 0.0500752
OGA O-GlcNAcase 0.0496217
EZR ezrin 0.0492096
KTN1 kinectin 1 (kinesin receptor) 0.0475897
BCL2L1 BCL2-like 1 0.047207
TPM3 tropomyosin 3 0.0462333
DOCK5 dedicator of cytokinesis 5 0.0458175
SEC31A SEC31 homolog A (S. cerevisiae) 0.0448392
MYO10 myosin X 0.0446632
PGK1 phosphoglycerate kinase 1 0.0436916
MCL1 myeloid cell leukemia 1 0.0435838
NCOR2 nuclear receptor corepressor 2 0.0430969
ARRDC3 arrestin domain containing 3 0.0424614
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0424145
COPB1 coatomer protein complex, subunit beta 1 0.0420855
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0416381
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0401926
EPHA2 EPH receptor A2 0.0398001
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0382427
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.037736
SMAD3 SMAD family member 3 0.0376259
DSCAM Down syndrome cell adhesion molecule 0.0372512
KMT2E lysine (K)-specific methyltransferase 2E 0.0369267
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0368718
KRT17 keratin 17, type I 0.0360521
NCEH1 neutral cholesterol ester hydrolase 1 0.035957
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0358514
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0358332
LOC112694756 uncharaterized LOC112694756 0.0356801
GOLGB1 golgin B1 0.0350568
EEF2 eukaryotic translation elongation factor 2 0.0348659
CAPRIN2 caprin family member 2 0.0345588
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0345126
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0344436
DUSP6 dual specificity phosphatase 6 0.0342595
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0340872
LUZP1 leucine zipper protein 1 0.0337374
NDRG1 N-myc downstream regulated 1 0.0336316
PLK2 polo-like kinase 2 0.0333308
BHLHE40 basic helix-loop-helix family, member e40 0.0332926
EHF ets homologous factor 0.0330717
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0329876
SERINC3 serine incorporator 3 0.0326427
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0324368
RIN2 Ras and Rab interactor 2 0.0323755
TSC22D1 TSC22 domain family, member 1 0.0322307
ANXA1 annexin A1 0.0321757
ACBD3 acyl-CoA binding domain containing 3 0.0318905
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0317961
OPTN optineurin 0.0314322
HLA-E major histocompatibility complex, class I, E 0.0312459
DSTN destrin (actin depolymerizing factor) 0.0310258
TLN1 talin 1 0.0309023
JAG1 jagged 1 0.0307952
LIMA1 LIM domain and actin binding 1 0.0306774
TNIP1 TNFAIP3 interacting protein 1 0.0305889
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0303041
NAMPT nicotinamide phosphoribosyltransferase 0.0302756
BLCAP bladder cancer associated protein 0.0290829
ITSN1 intersectin 1 (SH3 domain protein) 0.0289888
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0287203
ACTN4 actinin, alpha 4 0.0286564
RSRP1 arginine/serine-rich protein 1 0.0281125
SLC38A2 solute carrier family 38, member 2 0.0279694
LNPEP leucyl/cystinyl aminopeptidase 0.0278278
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0271181
TMF1 TATA element modulatory factor 1 0.0268019
HDLBP high density lipoprotein binding protein 0.0267188

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.289345
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.15222
MTSS1 metastasis suppressor 1 -0.135725
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0992618
SLC35F3 solute carrier family 35, member F3 -0.0983972
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0983038
DPYD dihydropyrimidine dehydrogenase -0.0805826
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0787268
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.077178
PDE4D phosphodiesterase 4D, cAMP-specific -0.0755979
ANO1 anoctamin 1, calcium activated chloride channel -0.0682191
SULF2 sulfatase 2 -0.0661558
AHNAK AHNAK nucleoprotein -0.0618556
ABI3BP ABI family, member 3 (NESH) binding protein -0.0600921
INTS6 integrator complex subunit 6 -0.0595781
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0559956
NAV2 neuron navigator 2 -0.0536262
PTK2 protein tyrosine kinase 2 -0.052666
BCAR3 breast cancer anti-estrogen resistance 3 -0.0507779
HMGA2 high mobility group AT-hook 2 -0.0505843
RPS21 ribosomal protein S21 -0.0472504
LAMC2 laminin, gamma 2 -0.0467698
THSD4 thrombospondin, type I, domain containing 4 -0.0465743
RIGI RNA sensor RIG-I -0.0449691
TPT1 tumor protein, translationally-controlled 1 -0.044196
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0432298
RPLP1 ribosomal protein, large, P1 -0.0430321
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0424208
PTMA prothymosin, alpha -0.0400949
ALCAM activated leukocyte cell adhesion molecule -0.0393398
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0388372
SOX5 SRY (sex determining region Y)-box 5 -0.0385831
RPS24 ribosomal protein S24 -0.0380132
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0377184
WSB1 WD repeat and SOCS box containing 1 -0.0376402
ZMYND8 zinc finger, MYND-type containing 8 -0.0371991
ANKRD11 ankyrin repeat domain 11 -0.0364342
GNAS GNAS complex locus -0.0355635
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0355606
FAF1 Fas (TNFRSF6) associated factor 1 -0.0353549
PSD3 pleckstrin and Sec7 domain containing 3 -0.0347443
RABGAP1L RAB GTPase activating protein 1-like -0.0346461
IFI44L interferon-induced protein 44-like -0.0344161
FNDC3A fibronectin type III domain containing 3A -0.0337861
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0333828
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0328014
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0326371
PODXL podocalyxin-like -0.0315238
EXOC4 exocyst complex component 4 -0.031432
KLF12 Kruppel-like factor 12 -0.0312332
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0302033
ARHGAP26 Rho GTPase activating protein 26 -0.0300575
MECOM MDS1 and EVI1 complex locus -0.0296706
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0292769
RPS8 ribosomal protein S8 -0.028654
UTRN utrophin -0.0284396
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0277297
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0275766
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0267761
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0264368
DENND1A DENN/MADD domain containing 1A -0.0264358
TNS3 tensin 3 -0.0261708
WARS1 tryptophanyl-tRNA synthetase 1 -0.0261484
HSPG2 heparan sulfate proteoglycan 2 -0.02603
SMYD3 SET and MYND domain containing 3 -0.0259114
RPL34 ribosomal protein L34 -0.0257587
LAMA5 laminin, alpha 5 -0.0255325
CUX1 cut-like homeobox 1 -0.0254164
RPLP2 ribosomal protein, large, P2 -0.0253508
RASAL2 RAS protein activator like 2 -0.0249222
RPS6 ribosomal protein S6 -0.0248092
NT5C2 5'-nucleotidase, cytosolic II -0.0247873
LRP1B low density lipoprotein receptor-related protein 1B -0.0247404
KIAA1549L KIAA1549-like -0.0243056
GRB10 growth factor receptor-bound protein 10 -0.0242978
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0241482
SRPK2 SRSF protein kinase 2 -0.0240821
TMSB10 thymosin beta 10 -0.0240711
TRAPPC9 trafficking protein particle complex 9 -0.023658
WDFY2 WD repeat and FYVE domain containing 2 -0.0235921
RPL31 ribosomal protein L31 -0.0235221
RCOR1 REST corepressor 1 -0.0231547
CDK13 cyclin-dependent kinase 13 -0.0231307
SPIDR scaffolding protein involved in DNA repair -0.0228387
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0227778
RPL26 ribosomal protein L26 -0.022528
RPL35A ribosomal protein L35a -0.0223867
PRSS23 protease, serine, 23 -0.022333
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0222226
RPS19 ribosomal protein S19 -0.0221555
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0217282
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0216982
MCU mitochondrial calcium uniporter -0.0215732
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0214737
SYN3 synapsin III -0.0214205
CTBP2 C-terminal binding protein 2 -0.0212908
HDAC9 histone deacetylase 9 -0.0212457
SP100 SP100 nuclear antigen -0.0211718
EXT1 exostosin glycosyltransferase 1 -0.021114
CNTNAP3 contactin associated protein-like 3 -0.0210038