Carbamazepine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MUC17 mucin 17, cell surface associated 0.0970358
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0922878
KRT18 keratin 18, type I 0.082889
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0716775
FAT1 FAT atypical cadherin 1 0.069877
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0669382
DSPP dentin sialophosphoprotein 0.0666662
PIGR polymeric immunoglobulin receptor 0.064841
EEF2 eukaryotic translation elongation factor 2 0.0615509
MYH9 myosin, heavy chain 9, non-muscle 0.0576095
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0521995
FAM13A family with sequence similarity 13, member A 0.0513997
TXNIP thioredoxin interacting protein 0.0511206
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0509061
EREG epiregulin 0.0476053
DDIT4 DNA-damage-inducible transcript 4 0.0469458
NDRG1 N-myc downstream regulated 1 0.0464018
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0459548
LMO7 LIM domain 7 0.0455724
ACTN4 actinin, alpha 4 0.0451073
ESYT2 extended synaptotagmin-like protein 2 0.0436476
VEGFA vascular endothelial growth factor A 0.0427988
FLNB filamin B, beta 0.0413323
ERRFI1 ERBB receptor feedback inhibitor 1 0.0397465
MACF1 microtubule-actin crosslinking factor 1 0.0391676
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0375859
EZR ezrin 0.0373734
ITPRID2 ITPR interacting domain containing 2 0.0373693
GOLGA4 golgin A4 0.0369713
OGA O-GlcNAcase 0.0363337
WAC WW domain containing adaptor with coiled-coil 0.0358259
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.035146
RNF145 ring finger protein 145 0.0349078
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0335651
FOS FBJ murine osteosarcoma viral oncogene homolog 0.032793
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0322765
YTHDC1 YTH domain containing 1 0.031553
TMSB4X thymosin beta 4, X-linked 0.0300021
INSIG1 insulin induced gene 1 0.0299899
KDM3A lysine (K)-specific demethylase 3A 0.0299682
DSCAM Down syndrome cell adhesion molecule 0.0298664
MCL1 myeloid cell leukemia 1 0.029653
SREBF2 sterol regulatory element binding transcription factor 2 0.0290091
AREG amphiregulin 0.0285165
UBA6 ubiquitin-like modifier activating enzyme 6 0.0283677
RPL3 ribosomal protein L3 0.0280419
CSNK1A1 casein kinase 1, alpha 1 0.0278185
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0276414
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0276407
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0267083
TPM3 tropomyosin 3 0.0263291
ANXA11 annexin A11 0.0262558
EPHA2 EPH receptor A2 0.025981
PLEC plectin 0.0259292
DNM2 dynamin 2 0.0257978
EEF1G eukaryotic translation elongation factor 1 gamma 0.0257348
BHLHE40 basic helix-loop-helix family, member e40 0.0256404
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0254584
APLP2 amyloid beta (A4) precursor-like protein 2 0.025397
FHL2 four and a half LIM domains 2 0.0252565
EIF4B eukaryotic translation initiation factor 4B 0.0251038
TNIP1 TNFAIP3 interacting protein 1 0.0242551
CTNND1 catenin (cadherin-associated protein), delta 1 0.0240253
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0228176
TM9SF2 transmembrane 9 superfamily member 2 0.0227407
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0224247
FTH1 ferritin, heavy polypeptide 1 0.0223737
NCOR2 nuclear receptor corepressor 2 0.0221991
TMF1 TATA element modulatory factor 1 0.021781
LIMA1 LIM domain and actin binding 1 0.0211705
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0211613
FDPS farnesyl diphosphate synthase 0.0206014
RPL7 ribosomal protein L7 0.0205778
PSAT1 phosphoserine aminotransferase 1 0.0200249
ARGLU1 arginine and glutamate rich 1 0.0199192
CCNL1 cyclin L1 0.0196266
DERA deoxyribose-phosphate aldolase (putative) 0.019618
ABHD2 abhydrolase domain containing 2 0.0193013
SUCO SUN domain containing ossification factor 0.0192743
COPA coatomer protein complex, subunit alpha 0.0192705
RSRC2 arginine/serine-rich coiled-coil 2 0.0192294
GOLGA2 golgin A2 0.0192211
RBM39 RNA binding motif protein 39 0.0191654
SEC31A SEC31 homolog A (S. cerevisiae) 0.0191443
KRT19 keratin 19, type I 0.0190865
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0190625
SETD5 SET domain containing 5 0.0189968
EHF ets homologous factor 0.0188987
ARL5B ADP-ribosylation factor-like 5B 0.0188205
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0188181
KDM2A lysine (K)-specific demethylase 2A 0.0187268
SRRM2 serine/arginine repetitive matrix 2 0.0186779
CSDE1 cold shock domain containing E1, RNA-binding 0.0185462
LOC102724023 ES1 protein homolog, mitochondrial 0.0185139
KIF5B kinesin family member 5B 0.0182254
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0182044
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0181957
RB1CC1 RB1-inducible coiled-coil 1 0.0181931
KDM6A lysine (K)-specific demethylase 6A 0.0179237
FNBP4 formin binding protein 4 0.0178901

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.196927
TMSB10 thymosin beta 10 -0.135516
PTMA prothymosin, alpha -0.113926
GMDS GDP-mannose 4,6-dehydratase -0.11296
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.11232
RPS6 ribosomal protein S6 -0.104475
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0988164
TPT1 tumor protein, translationally-controlled 1 -0.0965628
ALCAM activated leukocyte cell adhesion molecule -0.095662
NALF1 NALCN channel auxiliary factor 1 -0.0930433
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.08183
ACTG1 actin gamma 1 -0.0788053
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0726614
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0683913
RPL35A ribosomal protein L35a -0.05822
ONECUT3 one cut homeobox 3 -0.0578391
PDE4D phosphodiesterase 4D, cAMP-specific -0.0577694
AHNAK AHNAK nucleoprotein -0.0575607
RPLP1 ribosomal protein, large, P1 -0.0564851
GPHN gephyrin -0.0560307
SMYD3 SET and MYND domain containing 3 -0.0553037
GREB1L growth regulation by estrogen in breast cancer-like -0.0550902
FHIT fragile histidine triad -0.0543581
RPL34 ribosomal protein L34 -0.0535207
PTPRK protein tyrosine phosphatase, receptor type, K -0.0532524
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0528286
RPS8 ribosomal protein S8 -0.0516371
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0507612
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0473197
RPS19 ribosomal protein S19 -0.0470926
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0453822
RPL23 ribosomal protein L23 -0.0447618
SLC35F3 solute carrier family 35, member F3 -0.0447181
RPS24 ribosomal protein S24 -0.0443994
MAML3 mastermind-like 3 (Drosophila) -0.0427212
CCSER1 coiled-coil serine-rich protein 1 -0.0427204
RPLP2 ribosomal protein, large, P2 -0.0425163
RAD51B RAD51 paralog B -0.0416576
EHBP1 EH domain binding protein 1 -0.0414029
SAMD5 sterile alpha motif domain containing 5 -0.0388996
LPP LIM domain containing preferred translocation partner in lipoma -0.0382275
RPL37A ribosomal protein L37a -0.0377716
MT2A metallothionein 2A -0.0376569
PARD3 par-3 family cell polarity regulator -0.0356929
RPS21 ribosomal protein S21 -0.0354833
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0354007
NRXN3 neurexin 3 -0.0351464
FAF1 Fas (TNFRSF6) associated factor 1 -0.0347683
ZBTB20 zinc finger and BTB domain containing 20 -0.0346446
FOXP1 forkhead box P1 -0.0345006
HMGB1 high mobility group box 1 -0.0340283
FRMD5 FERM domain containing 5 -0.0331896
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0329268
DIAPH2 diaphanous-related formin 2 -0.0326724
CCND1 cyclin D1 -0.0326437
ANTXR2 anthrax toxin receptor 2 -0.0324018
RPS29 ribosomal protein S29 -0.0322363
RPL26 ribosomal protein L26 -0.0321732
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0316262
PARD3B par-3 family cell polarity regulator beta -0.0313074
RPL9 ribosomal protein L9 -0.0309912
RPL36 ribosomal protein L36 -0.0306155
EGFR epidermal growth factor receptor -0.0302356
PATJ PATJ crumbs cell polarity complex component -0.0296422
VCL vinculin -0.0293627
MGST1 microsomal glutathione S-transferase 1 -0.0291767
MECOM MDS1 and EVI1 complex locus -0.0288073
S100A10 S100 calcium binding protein A10 -0.0285066
FTL ferritin, light polypeptide -0.0278229
TAS2R14 taste receptor, type 2, member 14 -0.0277379
RPL12 ribosomal protein L12 -0.0274573
CADPS Ca++-dependent secretion activator -0.0264514
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0264453
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.026224
LSAMP limbic system-associated membrane protein -0.0262195
MAML2 mastermind-like 2 (Drosophila) -0.0260798
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0260408
EXOC4 exocyst complex component 4 -0.0259197
DEK DEK proto-oncogene -0.0259156
RABGAP1L RAB GTPase activating protein 1-like -0.0258005
TRAPPC9 trafficking protein particle complex 9 -0.0255608
RPS27A ribosomal protein S27a -0.0255131
POTEF POTE ankyrin domain family, member F -0.0253027
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0252824
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0252392
RPS3 ribosomal protein S3 -0.025143
COMMD10 COMM domain containing 10 -0.0248391
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.024607
SOX4 SRY (sex determining region Y)-box 4 -0.0245566
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.024129
DLG1 discs, large homolog 1 (Drosophila) -0.0240496
NFIA nuclear factor I/A -0.02377
S100A9 S100 calcium binding protein A9 -0.0237684
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0232975
RPL31 ribosomal protein L31 -0.0231372
AGR2 anterior gradient 2 -0.023067
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0230356
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0229552
SH3D19 SH3 domain containing 19 -0.022929
RPS13 ribosomal protein S13 -0.0227558