Carbamazepine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.111271
PCBP2 poly(rC) binding protein 2 0.109867
SOD2 superoxide dismutase 2, mitochondrial 0.094673
SMAD3 SMAD family member 3 0.0910547
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0793506
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0777877
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0727784
MYH9 myosin, heavy chain 9, non-muscle 0.0652866
TRIO trio Rho guanine nucleotide exchange factor 0.0592782
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0588742
IGFBP3 insulin-like growth factor binding protein 3 0.0585052
OGA O-GlcNAcase 0.057411
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0538232
FAM13A family with sequence similarity 13, member A 0.0537881
GRB10 growth factor receptor-bound protein 10 0.0532583
MAP2K1 mitogen-activated protein kinase kinase 1 0.0506985
NAV2 neuron navigator 2 0.0495351
APLP2 amyloid beta (A4) precursor-like protein 2 0.0492479
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0483812
GOLGA4 golgin A4 0.0476616
CXCL8 chemokine (C-X-C motif) ligand 8 0.0469727
PFKP phosphofructokinase, platelet 0.0466702
FLNB filamin B, beta 0.045838
CTNND1 catenin (cadherin-associated protein), delta 1 0.0452708
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0451619
NAMPT nicotinamide phosphoribosyltransferase 0.0442275
VEGFA vascular endothelial growth factor A 0.0438479
LOXL2 lysyl oxidase-like 2 0.0411942
SETD5 SET domain containing 5 0.0404775
EEF2 eukaryotic translation elongation factor 2 0.0403166
TGM2 transglutaminase 2 0.0395757
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0387736
EIF3B eukaryotic translation initiation factor 3, subunit B 0.037469
EGFR epidermal growth factor receptor 0.037365
ARRDC3 arrestin domain containing 3 0.0371864
ESYT2 extended synaptotagmin-like protein 2 0.0371762
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0362368
CABIN1 calcineurin binding protein 1 0.0359094
DSCAM Down syndrome cell adhesion molecule 0.035389
UBA6 ubiquitin-like modifier activating enzyme 6 0.0350229
RAB8B RAB8B, member RAS oncogene family 0.0344876
CEP250 centrosomal protein 250kDa 0.0342903
FNDC3B fibronectin type III domain containing 3B 0.0338407
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0333271
SPAG9 sperm associated antigen 9 0.0332945
KMT2C lysine (K)-specific methyltransferase 2C 0.0325199
ATP13A3 ATPase type 13A3 0.0323036
PICALM phosphatidylinositol binding clathrin assembly protein 0.0322218
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0322063
PRELID2 PRELI domain containing 2 0.0318715
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0318217
TNIP1 TNFAIP3 interacting protein 1 0.0311507
NFE2L1 nuclear factor, erythroid 2-like 1 0.0305892
KDM3A lysine (K)-specific demethylase 3A 0.0302994
DOCK5 dedicator of cytokinesis 5 0.0301624
SRP54 signal recognition particle 54kDa 0.0295113
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0289142
BHLHE40 basic helix-loop-helix family, member e40 0.0288419
YEATS2 YEATS domain containing 2 0.0287468
NGLY1 N-glycanase 1 0.0277387
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0273333
AMPD3 adenosine monophosphate deaminase 3 0.027329
NBAS neuroblastoma amplified sequence 0.0273163
HELZ helicase with zinc finger 0.0272442
YTHDC1 YTH domain containing 1 0.0271974
RPL3 ribosomal protein L3 0.0271629
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0270298
HYOU1 hypoxia up-regulated 1 0.0267538
DDIT4 DNA-damage-inducible transcript 4 0.0267038
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0266321
KDM2A lysine (K)-specific demethylase 2A 0.0264456
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0263884
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0263241
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0262827
SEC23A Sec23 homolog A (S. cerevisiae) 0.0262679
JARID2 jumonji, AT rich interactive domain 2 0.0261211
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0260631
MSN moesin 0.0259561
COPA coatomer protein complex, subunit alpha 0.0259457
PELI1 pellino E3 ubiquitin protein ligase 1 0.0256125
SREBF2 sterol regulatory element binding transcription factor 2 0.0254372
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0252705
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0250664
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0249563
CSDE1 cold shock domain containing E1, RNA-binding 0.02494
PYGL phosphorylase, glycogen, liver 0.0247729
SUCO SUN domain containing ossification factor 0.0246917
APP amyloid beta (A4) precursor protein 0.0244307
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0242115
CANX calnexin 0.0239747
FMNL2 formin-like 2 0.023703
MCL1 myeloid cell leukemia 1 0.0235997
MYO1B myosin IB 0.0234851
ANO6 anoctamin 6 0.0234758
ZFC3H1 zinc finger, C3H1-type containing 0.0234641
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0234301
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0234031
ITCH itchy E3 ubiquitin protein ligase 0.0233607
HDLBP high density lipoprotein binding protein 0.0233209
MINDY2 MINDY lysine 48 deubiquitinase 2 0.023172

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.35895
TMSB10 thymosin beta 10 -0.191652
FTL ferritin, light polypeptide -0.112644
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.102307
CD44 CD44 molecule (Indian blood group) -0.0895053
GLCCI1 glucocorticoid induced 1 -0.0829752
LOX lysyl oxidase -0.0812288
DPYD dihydropyrimidine dehydrogenase -0.0740488
RPLP1 ribosomal protein, large, P1 -0.0731016
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0720756
PDE4D phosphodiesterase 4D, cAMP-specific -0.0692312
NRG1 neuregulin 1 -0.0688451
TPT1 tumor protein, translationally-controlled 1 -0.0672627
TFPI2 tissue factor pathway inhibitor 2 -0.0648777
IER3 immediate early response 3 -0.0647053
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0634824
RPL35A ribosomal protein L35a -0.0632177
RPS21 ribosomal protein S21 -0.0601269
RPL34 ribosomal protein L34 -0.0570533
ANKRD28 ankyrin repeat domain 28 -0.0569405
PTMA prothymosin, alpha -0.0564218
S100A6 S100 calcium binding protein A6 -0.0553695
EGR1 early growth response 1 -0.0519327
MT2A metallothionein 2A -0.0517419
VIM vimentin -0.0514328
NTN4 netrin 4 -0.0510206
RPS19 ribosomal protein S19 -0.0506397
S100A10 S100 calcium binding protein A10 -0.0502021
OSMR oncostatin M receptor -0.0488704
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0481992
RPS6 ribosomal protein S6 -0.0473372
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.046017
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0458799
CDH13 cadherin 13 -0.045539
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0454712
FTH1 ferritin, heavy polypeptide 1 -0.0451427
RPS24 ribosomal protein S24 -0.044016
WSB1 WD repeat and SOCS box containing 1 -0.0435908
LOC102724023 ES1 protein homolog, mitochondrial -0.0434856
RPS8 ribosomal protein S8 -0.043128
RPLP0 ribosomal protein, large, P0 -0.0422227
HMGA2 high mobility group AT-hook 2 -0.042178
FN1 fibronectin 1 -0.0417057
SYT1 synaptotagmin I -0.0415398
RPL32 ribosomal protein L32 -0.0402447
RPS29 ribosomal protein S29 -0.039789
MAP1B microtubule-associated protein 1B -0.0396652
RPL23 ribosomal protein L23 -0.0393708
RPLP2 ribosomal protein, large, P2 -0.0371186
AHNAK AHNAK nucleoprotein -0.0366696
ASPH aspartate beta-hydroxylase -0.0363862
B2M beta-2-microglobulin -0.0361179
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0349313
ANTXR2 anthrax toxin receptor 2 -0.0348578
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0348192
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0344559
RPL28 ribosomal protein L28 -0.0343353
GPC6 glypican 6 -0.0342508
CLMP CXADR-like membrane protein -0.0341697
GLIS3 GLIS family zinc finger 3 -0.0337454
RPL38 ribosomal protein L38 -0.0334325
RPL31 ribosomal protein L31 -0.0331229
NAP1L1 nucleosome assembly protein 1-like 1 -0.0328393
RPS13 ribosomal protein S13 -0.0323543
HLA-B major histocompatibility complex, class I, B -0.0319567
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0316718
TM4SF1 transmembrane 4 L six family member 1 -0.0313448
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0312959
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0312648
S100A9 S100 calcium binding protein A9 -0.0302765
SP100 SP100 nuclear antigen -0.0301062
RASAL2 RAS protein activator like 2 -0.0297991
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0292223
IFI6 interferon, alpha-inducible protein 6 -0.029145
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0287969
ACTG1 actin gamma 1 -0.0283052
NRP1 neuropilin 1 -0.0279512
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0277905
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0276639
EMP1 epithelial membrane protein 1 -0.0275866
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0275656
ZNF804A zinc finger protein 804A -0.0275483
EIF1 eukaryotic translation initiation factor 1 -0.0274709
RPL37A ribosomal protein L37a -0.0273751
ARHGAP5 Rho GTPase activating protein 5 -0.027118
RPL11 ribosomal protein L11 -0.0271077
C15ORF48 chromosome 15 open reading frame 48 -0.0270535
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0269994
RPL36 ribosomal protein L36 -0.0267988
NCOA7 nuclear receptor coactivator 7 -0.0265323
ENOSF1 enolase superfamily member 1 -0.0257824
RPS11 ribosomal protein S11 -0.0256496
RPS5 ribosomal protein S5 -0.0252855
CCNI cyclin I -0.0252029
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0251761
SLC38A1 solute carrier family 38, member 1 -0.0250416
VDAC1 voltage-dependent anion channel 1 -0.0249865
SOS1 son of sevenless homolog 1 (Drosophila) -0.0249265
RPS15 ribosomal protein S15 -0.0247122
CUX1 cut-like homeobox 1 -0.0244776