Carbamazepine_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.182424
GRB10 growth factor receptor-bound protein 10 0.167798
ERRFI1 ERBB receptor feedback inhibitor 1 0.163166
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.149478
VIM vimentin 0.135846
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.134688
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.133503
KRT17 keratin 17, type I 0.129197
ANXA1 annexin A1 0.129124
RIGI RNA sensor RIG-I 0.118632
FN1 fibronectin 1 0.110771
ESYT2 extended synaptotagmin-like protein 2 0.106394
PDE4D phosphodiesterase 4D, cAMP-specific 0.094696
SPAG9 sperm associated antigen 9 0.0924528
PELI1 pellino E3 ubiquitin protein ligase 1 0.0910192
BACE2 beta-site APP-cleaving enzyme 2 0.0884646
ANXA2 annexin A2 0.0869489
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0867747
NDRG1 N-myc downstream regulated 1 0.0863086
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0857213
MYO1E myosin IE 0.0852995
RORA RAR-related orphan receptor A 0.0834757
PDLIM5 PDZ and LIM domain 5 0.082775
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0737837
FAM13A family with sequence similarity 13, member A 0.0712361
RSAD2 radical S-adenosyl methionine domain containing 2 0.0703617
CXCL8 chemokine (C-X-C motif) ligand 8 0.0700617
MT2A metallothionein 2A 0.0678285
PSD3 pleckstrin and Sec7 domain containing 3 0.0669426
PICALM phosphatidylinositol binding clathrin assembly protein 0.0664271
CD109 CD109 molecule 0.0642111
USP34 ubiquitin specific peptidase 34 0.063771
ELL2 elongation factor, RNA polymerase II, 2 0.0625857
CEMIP cell migration inducing protein, hyaluronan binding 0.0615635
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0615392
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0598252
FNDC3B fibronectin type III domain containing 3B 0.0585585
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0567142
PLAUR plasminogen activator, urokinase receptor 0.0557591
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0553268
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.054963
COPA coatomer protein complex, subunit alpha 0.0549628
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0545758
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0536522
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0528273
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0514477
OGA O-GlcNAcase 0.0506741
KDM2A lysine (K)-specific demethylase 2A 0.0494004
EZR ezrin 0.0488309
DDIT4 DNA-damage-inducible transcript 4 0.0480918
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0478792
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0472255
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0471279
GPC6 glypican 6 0.0457296
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0456107
EFNA5 ephrin-A5 0.0450371
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0446412
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0446278
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0444442
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0434514
ZNF292 zinc finger protein 292 0.0427766
NGLY1 N-glycanase 1 0.0425527
DTNA dystrobrevin, alpha 0.0414851
MACC1 metastasis associated in colon cancer 1 0.0409545
ZNF148 zinc finger protein 148 0.0409109
APP amyloid beta (A4) precursor protein 0.0408256
ANKHD1 ankyrin repeat and KH domain containing 1 0.039586
RTN4 reticulon 4 0.0393815
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.039278
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.038871
F3 coagulation factor III (thromboplastin, tissue factor) 0.0387368
BASP1 brain abundant, membrane attached signal protein 1 0.038074
SCFD1 sec1 family domain containing 1 0.0380255
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0341692
KDM3A lysine (K)-specific demethylase 3A 0.0340709
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0339652
DST dystonin 0.0332652
MAP2K1 mitogen-activated protein kinase kinase 1 0.0329541
TTC3 tetratricopeptide repeat domain 3 0.0327047
PTPRG protein tyrosine phosphatase, receptor type, G 0.0326442
ABI1 abl-interactor 1 0.0326012
SMAD3 SMAD family member 3 0.03207
RNF145 ring finger protein 145 0.0300603
SDC4 syndecan 4 0.0300233
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0290551
KYNU kynureninase 0.0288688
SBF2 SET binding factor 2 0.02808
MCTP1 multiple C2 domains, transmembrane 1 0.028037
PUM2 pumilio RNA-binding family member 2 0.027779
KDM5B lysine (K)-specific demethylase 5B 0.0275204
AKAP12 A kinase (PRKA) anchor protein 12 0.0274211
AFF4 AF4/FMR2 family, member 4 0.0265505
KMT2C lysine (K)-specific methyltransferase 2C 0.0264485
SND1 staphylococcal nuclease and tudor domain containing 1 0.0263796
ZNF638 zinc finger protein 638 0.0261409
FBXO11 F-box protein 11 0.0255527
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0253516
BBX bobby sox homolog (Drosophila) 0.025135
TPM4 tropomyosin 4 0.0248288
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0245482

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.115519
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.10623
SLC38A1 solute carrier family 38, member 1 -0.0884091
TMSB10 thymosin beta 10 -0.0811414
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0800374
DLG1 discs, large homolog 1 (Drosophila) -0.076299
SUCO SUN domain containing ossification factor -0.0756151
TXNRD1 thioredoxin reductase 1 -0.0750006
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0742517
GOLGA4 golgin A4 -0.0731209
GCLC glutamate-cysteine ligase, catalytic subunit -0.0703232
DICER1 dicer 1, ribonuclease type III -0.0681188
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0655873
RBM39 RNA binding motif protein 39 -0.0636117
CLINT1 clathrin interactor 1 -0.0635322
H3-3B H3.3 histone B -0.0632071
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0631113
ASPH aspartate beta-hydroxylase -0.0623591
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0622426
S100A10 S100 calcium binding protein A10 -0.0622046
IGF2 insulin-like growth factor 2 -0.0615426
RPLP0 ribosomal protein, large, P0 -0.0602256
USP9X ubiquitin specific peptidase 9, X-linked -0.0596399
ACVR1 activin A receptor, type I -0.0581743
RPL12 ribosomal protein L12 -0.0581358
STC1 stanniocalcin 1 -0.05677
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0566202
LCORL ligand dependent nuclear receptor corepressor-like -0.055679
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0531121
RPL11 ribosomal protein L11 -0.0530095
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0521971
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0521417
MARCHF6 membrane associated ring-CH-type finger 6 -0.0521188
VCL vinculin -0.0514511
KTN1 kinectin 1 (kinesin receptor) -0.0513873
TPT1 tumor protein, translationally-controlled 1 -0.0510583
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0501625
S100A6 S100 calcium binding protein A6 -0.0497262
RPS24 ribosomal protein S24 -0.0496853
RPS19 ribosomal protein S19 -0.0492388
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0487041
CNKSR3 CNKSR family member 3 -0.0479476
RAI14 retinoic acid induced 14 -0.0476213
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0473797
RBM25 RNA binding motif protein 25 -0.0466603
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0462736
RPL35A ribosomal protein L35a -0.0458373
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0447569
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0445342
KDM6A lysine (K)-specific demethylase 6A -0.0443418
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0434949
NAV2 neuron navigator 2 -0.043019
ANKRD10 ankyrin repeat domain 10 -0.0427708
EXT1 exostosin glycosyltransferase 1 -0.0424882
GNAS GNAS complex locus -0.0424261
NKD1 naked cuticle homolog 1 (Drosophila) -0.0423124
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.042299
NPEPPS aminopeptidase puromycin sensitive -0.042089
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0418738
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0403067
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0396488
SEPTIN7 septin 7 -0.0395875
TRA2A transformer 2 alpha homolog (Drosophila) -0.0392086
RPS8 ribosomal protein S8 -0.0388333
PIBF1 progesterone immunomodulatory binding factor 1 -0.0386794
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0386629
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.038635
NUP98 nucleoporin 98kDa -0.0378704
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0376232
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0368394
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0366219
TBC1D5 TBC1 domain family, member 5 -0.0365496
TMSB4X thymosin beta 4, X-linked -0.0365146
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0362191
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0361787
ANKRD11 ankyrin repeat domain 11 -0.0355231
SETD5 SET domain containing 5 -0.0354133
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0343739
IRS2 insulin receptor substrate 2 -0.0339205
LPP LIM domain containing preferred translocation partner in lipoma -0.0335445
MAML2 mastermind-like 2 (Drosophila) -0.0331479
PERP PERP, TP53 apoptosis effector -0.0331207
BTBD9 BTB (POZ) domain containing 9 -0.0329958
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0329512
MEF2A myocyte enhancer factor 2A -0.0327294
RPS3 ribosomal protein S3 -0.0324534
RPS4X ribosomal protein S4, X-linked -0.0322014
RAD51B RAD51 paralog B -0.0321066
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0320835
RPS5 ribosomal protein S5 -0.0316602
SMAD2 SMAD family member 2 -0.0309152
TNIP1 TNFAIP3 interacting protein 1 -0.030727
EEF2 eukaryotic translation elongation factor 2 -0.0306932
FNDC3A fibronectin type III domain containing 3A -0.0306635
JMJD1C jumonji domain containing 1C -0.0297809
ZNFX1 zinc finger, NFX1-type containing 1 -0.0294131
CEMIP2 cell migration inducing hyaluronidase 2 -0.0292797
COPB1 coatomer protein complex, subunit beta 1 -0.0290812
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0290778
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0286482