Carbamazepine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Carbamazepine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.173568
PABPC1 poly(A) binding protein, cytoplasmic 1 0.12317
AKAP12 A kinase (PRKA) anchor protein 12 0.111049
ERRFI1 ERBB receptor feedback inhibitor 1 0.100598
CSDE1 cold shock domain containing E1, RNA-binding 0.0795571
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0728918
MYH9 myosin, heavy chain 9, non-muscle 0.0664291
OGA O-GlcNAcase 0.0634079
MCL1 myeloid cell leukemia 1 0.0619805
TRIO trio Rho guanine nucleotide exchange factor 0.0611887
GRAMD1B GRAM domain containing 1B 0.0588492
TPM3 tropomyosin 3 0.0585207
TXNRD1 thioredoxin reductase 1 0.0575902
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0573084
EEF2 eukaryotic translation elongation factor 2 0.0551975
KRT18 keratin 18, type I 0.0543425
SMAD3 SMAD family member 3 0.0530336
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0516011
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0501929
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0488838
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0485683
KDM3A lysine (K)-specific demethylase 3A 0.0480886
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0467126
PLEC plectin 0.0448958
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0447692
CSNK1A1 casein kinase 1, alpha 1 0.0443277
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0416871
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0410174
ADAR adenosine deaminase, RNA-specific 0.0406696
XPO1 exportin 1 0.0397772
PYGL phosphorylase, glycogen, liver 0.0397386
CTTN cortactin 0.0395844
MACF1 microtubule-actin crosslinking factor 1 0.0366535
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0365785
CEP250 centrosomal protein 250kDa 0.0357643
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0357167
EIF4B eukaryotic translation initiation factor 4B 0.0354315
TLN1 talin 1 0.0349554
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0349083
FKBP4 FK506 binding protein 4, 59kDa 0.0336057
HSPA8 heat shock 70kDa protein 8 0.0318998
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0317214
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0314927
RPL3 ribosomal protein L3 0.0309623
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0305199
USP9X ubiquitin specific peptidase 9, X-linked 0.0302512
ANO6 anoctamin 6 0.0301923
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0301786
COPA coatomer protein complex, subunit alpha 0.0295604
CHD4 chromodomain helicase DNA binding protein 4 0.0295187
NCAPD2 non-SMC condensin I complex, subunit D2 0.0294124
RNF213 ring finger protein 213 0.029115
NUMA1 nuclear mitotic apparatus protein 1 0.0289761
STK4 serine/threonine kinase 4 0.0284319
SPAG9 sperm associated antigen 9 0.0281192
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0274556
PRPF8 pre-mRNA processing factor 8 0.0273088
USP34 ubiquitin specific peptidase 34 0.027204
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0269239
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0269234
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0269036
FLNA filamin A, alpha 0.0268023
MSH6 mutS homolog 6 0.0266402
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0261296
DIDO1 death inducer-obliterator 1 0.0261263
MARCHF4 membrane associated ring-CH-type finger 4 0.0258396
SFPQ splicing factor proline/glutamine-rich 0.0253538
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0250472
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0247508
EIF3A eukaryotic translation initiation factor 3, subunit A 0.02421
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.024174
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0239585
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0238751
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0238561
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0234751
KDM2A lysine (K)-specific demethylase 2A 0.0230986
NABP1 nucleic acid binding protein 1 0.0229831
RIMKLB ribosomal modification protein rimK-like family member B 0.0229111
IGF1R insulin-like growth factor 1 receptor 0.0228827
GIGYF2 GRB10 interacting GYF protein 2 0.0228617
ACTN1 actinin, alpha 1 0.0227577
APP amyloid beta (A4) precursor protein 0.022682
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0226252
PUM2 pumilio RNA-binding family member 2 0.0226178
RBM33 RNA binding motif protein 33 0.0221358
ANKRD36 ankyrin repeat domain 36 0.0220876
SET SET nuclear proto-oncogene 0.0220416
INCENP inner centromere protein antigens 135/155kDa 0.0220328
IQGAP1 IQ motif containing GTPase activating protein 1 0.021833
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0216749
CLTC clathrin, heavy chain (Hc) 0.0216197
ARL5B ADP-ribosylation factor-like 5B 0.0216185
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0215858
ACIN1 apoptotic chromatin condensation inducer 1 0.0214424
PFKP phosphofructokinase, platelet 0.0213332
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0212987
CTNNBL1 catenin, beta like 1 0.0212256
HDLBP high density lipoprotein binding protein 0.021141
ZFC3H1 zinc finger, C3H1-type containing 0.0208222
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0208024

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.379971
TMSB10 thymosin beta 10 -0.124933
EGR1 early growth response 1 -0.0792891
MT2A metallothionein 2A -0.0643496
RPL35A ribosomal protein L35a -0.0635048
RPLP1 ribosomal protein, large, P1 -0.0589738
RPS8 ribosomal protein S8 -0.0545609
RPS19 ribosomal protein S19 -0.0543449
RPL23 ribosomal protein L23 -0.0509205
POTEF POTE ankyrin domain family, member F -0.0507746
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0499714
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0496436
RPS21 ribosomal protein S21 -0.0492289
PFN1 profilin 1 -0.0487639
RPS15 ribosomal protein S15 -0.0482352
RPS6 ribosomal protein S6 -0.0477734
HLA-B major histocompatibility complex, class I, B -0.047618
RPL37 ribosomal protein L37 -0.0475226
RPL37A ribosomal protein L37a -0.0465663
RPL34 ribosomal protein L34 -0.0441361
ACTG1 actin gamma 1 -0.0421765
FTL ferritin, light polypeptide -0.0399736
RPL9 ribosomal protein L9 -0.0396476
RPL31 ribosomal protein L31 -0.039458
RPL12 ribosomal protein L12 -0.0381685
RPL8 ribosomal protein L8 -0.0371985
RPS3 ribosomal protein S3 -0.0371952
RPL5 ribosomal protein L5 -0.0368679
RPL38 ribosomal protein L38 -0.0368662
RPS29 ribosomal protein S29 -0.0362355
PTMA prothymosin, alpha -0.0359567
RPLP2 ribosomal protein, large, P2 -0.0358976
WSB1 WD repeat and SOCS box containing 1 -0.0356446
RPL36 ribosomal protein L36 -0.0329909
RPL26 ribosomal protein L26 -0.0325924
TPT1 tumor protein, translationally-controlled 1 -0.0323518
PDE4D phosphodiesterase 4D, cAMP-specific -0.0314022
RPS10 ribosomal protein S10 -0.0311174
YBX3 Y box binding protein 3 -0.0291288
RPS27 ribosomal protein S27 -0.0284982
ATP5F1E ATP synthase F1 subunit epsilon -0.0278886
RPL28 ribosomal protein L28 -0.0276518
EIF5B eukaryotic translation initiation factor 5B -0.0271178
IFI6 interferon, alpha-inducible protein 6 -0.0269951
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.026405
PRH1 proline-rich protein HaeIII subfamily 1 -0.0256051
IER3 immediate early response 3 -0.0249997
FTH1 ferritin, heavy polypeptide 1 -0.0247024
RIMS2 regulating synaptic membrane exocytosis 2 -0.0243306
OSMR oncostatin M receptor -0.024073
RPL27 ribosomal protein L27 -0.02399
RPL32 ribosomal protein L32 -0.0239113
BPTF bromodomain PHD finger transcription factor -0.0234149
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0228735
S100A10 S100 calcium binding protein A10 -0.0227902
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0226408
RPL35 ribosomal protein L35 -0.0224157
RPLP0 ribosomal protein, large, P0 -0.0223717
RPS17 ribosomal protein S17 -0.0221798
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0221332
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0219752
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0218996
RPS14 ribosomal protein S14 -0.0213994
AKAP9 A kinase (PRKA) anchor protein 9 -0.0212354
RPS23 ribosomal protein S23 -0.0211145
DEK DEK proto-oncogene -0.0209329
RPS13 ribosomal protein S13 -0.0206766
THOC2 THO complex 2 -0.0202715
S100A11 S100 calcium binding protein A11 -0.0202107
RPS24 ribosomal protein S24 -0.0195762
HMGB1 high mobility group box 1 -0.0195566
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0195254
MYL12B myosin, light chain 12B, regulatory -0.0193736
ASTN2 astrotactin 2 -0.0192688
VDAC1 voltage-dependent anion channel 1 -0.0188409
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0185182
AFF3 AF4/FMR2 family, member 3 -0.0182916
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0182501
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0181032
LOC102724023 ES1 protein homolog, mitochondrial -0.0180121
PDIA3 protein disulfide isomerase family A, member 3 -0.0178255
RSF1 remodeling and spacing factor 1 -0.0177236
GNAS GNAS complex locus -0.017629
B2M beta-2-microglobulin -0.0175079
RPS12 ribosomal protein S12 -0.017279
RPS27A ribosomal protein S27a -0.0172498
SEC61G Sec61 gamma subunit -0.0167708
RACK1 receptor for activated C kinase 1 -0.0165017
SEPTIN7 septin 7 -0.0159703
WWOX WW domain containing oxidoreductase -0.0159438
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0159431
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0157576
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0154924
RPS16 ribosomal protein S16 -0.0153728
ATP5F1B ATP synthase F1 subunit beta -0.0152473
RPL36A ribosomal protein L36a -0.0152031
RPS20 ribosomal protein S20 -0.0151911
LDHB lactate dehydrogenase B -0.0151208
TUBA1B tubulin, alpha 1b -0.015052
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0150227