Carbamazepine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Carbamazepine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.323734
MCL1 myeloid cell leukemia 1 0.158551
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.108623
NAMPT nicotinamide phosphoribosyltransferase 0.0966605
MYOF myoferlin 0.0964162
EFNA5 ephrin-A5 0.0952265
GDA guanine deaminase 0.0862416
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0841996
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0840777
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0790129
PSD3 pleckstrin and Sec7 domain containing 3 0.0777458
ERRFI1 ERBB receptor feedback inhibitor 1 0.0771216
LIMCH1 LIM and calponin homology domains 1 0.0763268
ELL2 elongation factor, RNA polymerase II, 2 0.0749038
KYNU kynureninase 0.0725001
CANX calnexin 0.0705132
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0701807
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0699959
SOD2 superoxide dismutase 2, mitochondrial 0.0674733
TRIO trio Rho guanine nucleotide exchange factor 0.0666926
IGFBP3 insulin-like growth factor binding protein 3 0.0654048
PM20D1 peptidase M20 domain containing 1 0.0648101
FLNB filamin B, beta 0.0618151
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.059761
PDE10A phosphodiesterase 10A 0.059169
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0590389
EEF2 eukaryotic translation elongation factor 2 0.0575333
NPAS2 neuronal PAS domain protein 2 0.0573868
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.055918
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0553792
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0551874
SPAG9 sperm associated antigen 9 0.0550962
DGKD diacylglycerol kinase, delta 130kDa 0.0530983
ESYT2 extended synaptotagmin-like protein 2 0.0528508
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0527005
ITPRID2 ITPR interacting domain containing 2 0.0525077
CXCL8 chemokine (C-X-C motif) ligand 8 0.0501078
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0497322
ASPH aspartate beta-hydroxylase 0.0497069
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0496424
PDLIM5 PDZ and LIM domain 5 0.0491963
PCBP3 poly(rC) binding protein 3 0.0484832
SAMD4A sterile alpha motif domain containing 4A 0.0483153
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0483122
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0480568
PDGFA platelet-derived growth factor alpha polypeptide 0.0472388
DST dystonin 0.0470452
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0465226
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.045897
PYGL phosphorylase, glycogen, liver 0.0458
FNDC3B fibronectin type III domain containing 3B 0.0451577
ZEB2 zinc finger E-box binding homeobox 2 0.0439471
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.043821
SLC38A2 solute carrier family 38, member 2 0.0426308
DDIT4 DNA-damage-inducible transcript 4 0.0425317
DOCK4 dedicator of cytokinesis 4 0.0420083
LAMB1 laminin, beta 1 0.0418473
ZC3H11A zinc finger CCCH-type containing 11A 0.0412617
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0401834
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0396237
FLNA filamin A, alpha 0.0395201
PGK1 phosphoglycerate kinase 1 0.039305
OGA O-GlcNAcase 0.038192
TBXT T-box transcription factor T 0.0380127
INHBA inhibin, beta A 0.0373762
SMOC1 SPARC related modular calcium binding 1 0.0370829
TGFBI transforming growth factor, beta-induced, 68kDa 0.0364678
BASP1 brain abundant, membrane attached signal protein 1 0.0362744
STC2 stanniocalcin 2 0.0357371
IGF1R insulin-like growth factor 1 receptor 0.0354184
TGFBR1 transforming growth factor, beta receptor 1 0.035407
TMX4 thioredoxin-related transmembrane protein 4 0.0342581
CD109 CD109 molecule 0.0334536
LAMA1 laminin, alpha 1 0.0333641
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0333566
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0329633
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0326069
APLP2 amyloid beta (A4) precursor-like protein 2 0.0322606
DNER delta/notch-like EGF repeat containing 0.0320162
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0317035
EZR ezrin 0.031552
FNDC3A fibronectin type III domain containing 3A 0.0315209
FMNL2 formin-like 2 0.0315184
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0305465
ARRDC3 arrestin domain containing 3 0.0305439
MYH9 myosin, heavy chain 9, non-muscle 0.030389
NCOR2 nuclear receptor corepressor 2 0.0302499
KMT2C lysine (K)-specific methyltransferase 2C 0.0301967
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0299747
STC1 stanniocalcin 1 0.0295605
TM4SF1 transmembrane 4 L six family member 1 0.0295252
TNIP1 TNFAIP3 interacting protein 1 0.0294813
HDLBP high density lipoprotein binding protein 0.0292036
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0290706
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0289164
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0288641
MSN moesin 0.0282106
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0281049
CSNK1A1 casein kinase 1, alpha 1 0.0280449
IQGAP1 IQ motif containing GTPase activating protein 1 0.0275897

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.0937398
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0909884
RPLP1 ribosomal protein, large, P1 -0.0857617
TMSB10 thymosin beta 10 -0.0816235
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0802435
RPS8 ribosomal protein S8 -0.0755501
RPL37A ribosomal protein L37a -0.0748731
PTMA prothymosin, alpha -0.07257
TPT1 tumor protein, translationally-controlled 1 -0.0702592
RPL35A ribosomal protein L35a -0.0652466
FTL ferritin, light polypeptide -0.0644683
RPL23 ribosomal protein L23 -0.0605424
RPL31 ribosomal protein L31 -0.0591528
RPL26 ribosomal protein L26 -0.0550058
RPS24 ribosomal protein S24 -0.0534268
RPL12 ribosomal protein L12 -0.0525127
RPS12 ribosomal protein S12 -0.0521211
RPS19 ribosomal protein S19 -0.0498807
RPL9 ribosomal protein L9 -0.0481821
RPL34 ribosomal protein L34 -0.0477722
MT2A metallothionein 2A -0.0473006
PDE4D phosphodiesterase 4D, cAMP-specific -0.040148
RPL11 ribosomal protein L11 -0.0385991
RPS29 ribosomal protein S29 -0.0385927
RPL36 ribosomal protein L36 -0.0384912
RPS3 ribosomal protein S3 -0.0378502
RPL37 ribosomal protein L37 -0.0376166
RPL19 ribosomal protein L19 -0.037358
RPLP2 ribosomal protein, large, P2 -0.0365018
NALF1 NALCN channel auxiliary factor 1 -0.0357046
RPS25 ribosomal protein S25 -0.0356406
RPS27 ribosomal protein S27 -0.0323045
RPS27A ribosomal protein S27a -0.0318539
RPS14 ribosomal protein S14 -0.0316632
RPLP0 ribosomal protein, large, P0 -0.03076
ACTG1 actin gamma 1 -0.0305269
RPS13 ribosomal protein S13 -0.029981
RPS17 ribosomal protein S17 -0.0292659
RPL7A ribosomal protein L7a -0.0277245
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0276174
RPL35 ribosomal protein L35 -0.026563
RPL27 ribosomal protein L27 -0.0265082
RPS23 ribosomal protein S23 -0.0261422
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0254181
RPS16 ribosomal protein S16 -0.0250647
ATP5F1E ATP synthase F1 subunit epsilon -0.0250633
RPL36A ribosomal protein L36a -0.0241694
RPL38 ribosomal protein L38 -0.0239393
RPL28 ribosomal protein L28 -0.0235511
WSB1 WD repeat and SOCS box containing 1 -0.0229176
RPS20 ribosomal protein S20 -0.022818
HLA-B major histocompatibility complex, class I, B -0.0219319
RPS21 ribosomal protein S21 -0.0217508
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0217443
POTEF POTE ankyrin domain family, member F -0.0216684
RPL5 ribosomal protein L5 -0.0214975
RACK1 receptor for activated C kinase 1 -0.0212643
SMYD3 SET and MYND domain containing 3 -0.0209396
RPL13A ribosomal protein L13a -0.0208706
PRKN parkin RBR E3 ubiquitin protein ligase -0.0207662
RPL18 ribosomal protein L18 -0.0202687
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0200267
S100A10 S100 calcium binding protein A10 -0.0194881
VIM vimentin -0.0191767
EIF5B eukaryotic translation initiation factor 5B -0.0185633
HMGB1 high mobility group box 1 -0.0179694
RPL30 ribosomal protein L30 -0.0175289
PRDX1 peroxiredoxin 1 -0.0174505
RPL32 ribosomal protein L32 -0.0174218
RPS5 ribosomal protein S5 -0.0173578
RPS2 ribosomal protein S2 -0.0172973
SRGN serglycin -0.0171623
CADM2 cell adhesion molecule 2 -0.0170243
RPL8 ribosomal protein L8 -0.0163562
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0163335
RPS10 ribosomal protein S10 -0.0162111
ISG15 ISG15 ubiquitin-like modifier -0.0159568
RPS28 ribosomal protein S28 -0.0159471
LSAMP limbic system-associated membrane protein -0.0158157
ANTXR1 anthrax toxin receptor 1 -0.0157077
RPS11 ribosomal protein S11 -0.0155226
MGST1 microsomal glutathione S-transferase 1 -0.0153377
DNAH14 dynein, axonemal, heavy chain 14 -0.0152562
S100A6 S100 calcium binding protein A6 -0.0150556
RPS15 ribosomal protein S15 -0.0149699
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0146604
P3H2 prolyl 3-hydroxylase 2 -0.014576
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0142673
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0140652
SLF1 SMC5-SMC6 complex localization factor 1 -0.0140083
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0139983
PALLD palladin, cytoskeletal associated protein -0.0137841
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0135791
PFN1 profilin 1 -0.0135036
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0134822
KIAA0825 KIAA0825 -0.0133729
NAP1L1 nucleosome assembly protein 1-like 1 -0.0131396
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0127693
RPL27A ribosomal protein L27a -0.0125263
NT5C2 5'-nucleotidase, cytosolic II -0.0125103