Carbamazepine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

136 genes differentially expressed following the Carbamazepine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EIF1 eukaryotic translation initiation factor 1 0.124044
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.116547
NDRG1 N-myc downstream regulated 1 0.0971143
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.094391
EPS8 epidermal growth factor receptor pathway substrate 8 0.094241
ERBIN erbb2 interacting protein 0.084317
ZNF292 zinc finger protein 292 0.0839921
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.072912
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.071064
PTMA prothymosin, alpha 0.0710227
EXT1 exostosin glycosyltransferase 1 0.0666152
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.065946
PTK2 protein tyrosine kinase 2 0.0642726
DSCAM Down syndrome cell adhesion molecule 0.0612884
RLF rearranged L-myc fusion 0.0597886
KMT2C lysine (K)-specific methyltransferase 2C 0.0576476
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0574256
TPT1 tumor protein, translationally-controlled 1 0.056205
LMO7 LIM domain 7 0.0561044
RAB1A RAB1A, member RAS oncogene family 0.0544541
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0540639
SPAG9 sperm associated antigen 9 0.0529646
NAMPT nicotinamide phosphoribosyltransferase 0.0509485
CYRIB CYFIP related Rac1 interactor B 0.0508827
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0482056
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0445331
RPS3 ribosomal protein S3 0.0431367
FTL ferritin, light polypeptide 0.0428345
GOLGA4 golgin A4 0.0412778
SETD5 SET domain containing 5 0.040069
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0396057
RPL19 ribosomal protein L19 0.0395855
KDM2A lysine (K)-specific demethylase 2A 0.0371087
RPL23 ribosomal protein L23 0.0360284
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0350734
NUP58 nucleoporin 58 0.034223
PRRC2C proline-rich coiled-coil 2C 0.0321177
WAC WW domain containing adaptor with coiled-coil 0.0319072
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0307062
UBC ubiquitin C 0.030626
USP34 ubiquitin specific peptidase 34 0.0304797
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0297374
ACTN4 actinin, alpha 4 0.0269045
PDLIM5 PDZ and LIM domain 5 0.0260529
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.025282
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0250616
KMT2E lysine (K)-specific methyltransferase 2E 0.0238971
BIRC6 baculoviral IAP repeat containing 6 0.0208667
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.01958
PGK1 phosphoglycerate kinase 1 0.0195232
TRIO trio Rho guanine nucleotide exchange factor 0.0191925
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0170303
ADAM10 ADAM metallopeptidase domain 10 0.0170166
HELZ helicase with zinc finger 0.0144474
PARD3 par-3 family cell polarity regulator 0.013749
MT2A metallothionein 2A 0.0124253
TPI1 triosephosphate isomerase 1 0.012031
RPS27A ribosomal protein S27a 0.0114021
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00966429
ANXA2 annexin A2 0.00801188
RPL31 ribosomal protein L31 0.00732164
PKM pyruvate kinase, muscle 0.00700808
CCNI cyclin I 0.00671174
RSF1 remodeling and spacing factor 1 0.00647789
LDHA lactate dehydrogenase A 0.0064142
EEF2 eukaryotic translation elongation factor 2 0.00498893
PFN1 profilin 1 0.00390839
SRPK2 SRSF protein kinase 2 0.00340509
RPS12 ribosomal protein S12 0.00181485
FNDC3B fibronectin type III domain containing 3B 5.50001E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.191331
FN1 fibronectin 1 -0.180936
PDE4D phosphodiesterase 4D, cAMP-specific -0.151183
LIMS1 LIM and senescent cell antigen-like domains 1 -0.113136
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.112778
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.102607
PSD3 pleckstrin and Sec7 domain containing 3 -0.101854
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.100104
TMSB10 thymosin beta 10 -0.0992867
NALF1 NALCN channel auxiliary factor 1 -0.0862913
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0833003
PDE10A phosphodiesterase 10A -0.081499
INHBA inhibin, beta A -0.0734991
MAML3 mastermind-like 3 (Drosophila) -0.0695807
WSB1 WD repeat and SOCS box containing 1 -0.0583548
GPHN gephyrin -0.0570967
CDH13 cadherin 13 -0.0569761
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0525022
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0498825
VIM vimentin -0.0498347
GPC6 glypican 6 -0.049299
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0483845
EGFR epidermal growth factor receptor -0.0479933
ASPH aspartate beta-hydroxylase -0.0447922
ENO1 enolase 1, (alpha) -0.0433853
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0422331
MED13L mediator complex subunit 13-like -0.0368307
COL6A1 collagen, type VI, alpha 1 -0.0356779
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0329333
DLG1 discs, large homolog 1 (Drosophila) -0.0304113
SAMD4A sterile alpha motif domain containing 4A -0.0294527
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0273165
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0266266
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0263068
ESYT2 extended synaptotagmin-like protein 2 -0.0260151
CD44 CD44 molecule (Indian blood group) -0.0258633
ZBTB20 zinc finger and BTB domain containing 20 -0.0253042
MYH9 myosin, heavy chain 9, non-muscle -0.0228721
DOCK4 dedicator of cytokinesis 4 -0.0220731
SMYD3 SET and MYND domain containing 3 -0.0213281
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0189375
CUX1 cut-like homeobox 1 -0.0187024
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0180179
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.016289
AKAP12 A kinase (PRKA) anchor protein 12 -0.0158892
MYOF myoferlin -0.0152335
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0150636
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0144763
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0141263
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0137482
EFNA5 ephrin-A5 -0.00978966
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.00965804
DST dystonin -0.00951022
ANKRD12 ankyrin repeat domain 12 -0.00891571
DOCK5 dedicator of cytokinesis 5 -0.00887284
NAP1L1 nucleosome assembly protein 1-like 1 -0.00814222
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.00787499
WDFY3 WD repeat and FYVE domain containing 3 -0.00632412
RPS6 ribosomal protein S6 -0.0055421
MCL1 myeloid cell leukemia 1 -0.00508558
KTN1 kinectin 1 (kinesin receptor) -0.00392934
KDM3A lysine (K)-specific demethylase 3A -0.00390568
RTN4 reticulon 4 -0.00325171
RPL11 ribosomal protein L11 -0.00180149
THSD4 thrombospondin, type I, domain containing 4 -0.00152658
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.00131822