Carbamazepine_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.104603
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0652927
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0627585
MYH9 myosin, heavy chain 9, non-muscle 0.061215
THBS1 thrombospondin 1 0.0524193
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0501932
COL11A1 collagen, type XI, alpha 1 0.0490544
PEG10 paternally expressed 10 0.0483556
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0342782
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0278066
ACTN4 actinin, alpha 4 0.0275347
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0269781
IQGAP1 IQ motif containing GTPase activating protein 1 0.026858
ZEB2 zinc finger E-box binding homeobox 2 0.0260276
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0257317
ANXA5 annexin A5 0.0255433
COL5A2 collagen, type V, alpha 2 0.0254216
ADAM9 ADAM metallopeptidase domain 9 0.0252918
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0250877
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0242839
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.024169
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0238532
ZC3H11A zinc finger CCCH-type containing 11A 0.0238185
CSDE1 cold shock domain containing E1, RNA-binding 0.0236071
APLP2 amyloid beta (A4) precursor-like protein 2 0.0234138
NCKAP1 NCK-associated protein 1 0.0232562
CFL2 cofilin 2 (muscle) 0.0223913
TPR translocated promoter region, nuclear basket protein 0.0223912
IGF1R insulin-like growth factor 1 receptor 0.0215681
NTM neurotrimin 0.0214538
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0212515
SPAG9 sperm associated antigen 9 0.0206258
ADGRG6 adhesion G protein-coupled receptor G6 0.0203262
MKI67 marker of proliferation Ki-67 0.0202283
TTC28 tetratricopeptide repeat domain 28 0.0201638
PRPF8 pre-mRNA processing factor 8 0.0200527
CERT1 ceramide transporter 1 0.0200393
MARCHF6 membrane associated ring-CH-type finger 6 0.0197334
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0196275
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0195128
APP amyloid beta (A4) precursor protein 0.0193438
TPX2 TPX2, microtubule-associated 0.0191254
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0190175
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0190066
CABLES1 Cdk5 and Abl enzyme substrate 1 0.0186291
COLGALT2 collagen beta(1-O)galactosyltransferase 2 0.0184699
SRRM2 serine/arginine repetitive matrix 2 0.0183527
INCENP inner centromere protein antigens 135/155kDa 0.0181814
MACF1 microtubule-actin crosslinking factor 1 0.0181392
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0180534
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0179986
PICALM phosphatidylinositol binding clathrin assembly protein 0.0176726
RIMKLB ribosomal modification protein rimK-like family member B 0.017456
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0174363
NFE2L1 nuclear factor, erythroid 2-like 1 0.0173304
IVNS1ABP influenza virus NS1A binding protein 0.0173178
TMSB4X thymosin beta 4, X-linked 0.017288
LHFPL6 LHFPL tetraspan subfamily member 6 0.0172779
ARGLU1 arginine and glutamate rich 1 0.0171598
RAD51B RAD51 paralog B 0.0170737
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.016944
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0169373
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0166855
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0166226
LRRC59 leucine rich repeat containing 59 0.0166209
CANX calnexin 0.0166199
SRP54 signal recognition particle 54kDa 0.0164696
TP53BP2 tumor protein p53 binding protein 2 0.0163819
PCBP2 poly(rC) binding protein 2 0.0163099
ADGRL3 adhesion G protein-coupled receptor L3 0.016199
CORO1C coronin, actin binding protein, 1C 0.0161733
ITGAV integrin, alpha V 0.016116
RBM33 RNA binding motif protein 33 0.016023
HYOU1 hypoxia up-regulated 1 0.015971
MTMR3 myotubularin related protein 3 0.0159461
TIMELESS timeless circadian clock 0.0159253
CHMP4B charged multivesicular body protein 4B 0.0158731
ANXA1 annexin A1 0.0157032
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0156994
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0155754
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.015549
IPO7 importin 7 0.0154909
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0153458
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0152966
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0152443
HMGA1 high mobility group AT-hook 1 0.0151585
USP53 ubiquitin specific peptidase 53 0.0150961
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0150546
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0149134
MED14 mediator complex subunit 14 0.0148378
SFPQ splicing factor proline/glutamine-rich 0.0148064
RHOH ras homolog family member H 0.0147726
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0146932
NUP160 nucleoporin 160kDa 0.0146566
SUCO SUN domain containing ossification factor 0.0145845
ECT2 epithelial cell transforming 2 0.0145689
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0144004
KIF5B kinesin family member 5B 0.0143684
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0142478
USP22 ubiquitin specific peptidase 22 0.0140909

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.147422
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101408
VIM vimentin -0.094027
RPS6 ribosomal protein S6 -0.089193
PTMA prothymosin, alpha -0.0860243
RPS16 ribosomal protein S16 -0.0855574
RPLP1 ribosomal protein, large, P1 -0.0816032
RPS8 ribosomal protein S8 -0.0681642
RPL35A ribosomal protein L35a -0.0656228
RPS12 ribosomal protein S12 -0.0602371
RPL23 ribosomal protein L23 -0.0592701
RPS19 ribosomal protein S19 -0.0569601
TPT1 tumor protein, translationally-controlled 1 -0.0548422
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0533533
RPLP2 ribosomal protein, large, P2 -0.0464828
RPS27A ribosomal protein S27a -0.0456957
HMGB1 high mobility group box 1 -0.0454409
RPL36 ribosomal protein L36 -0.0422784
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0415967
RPS3 ribosomal protein S3 -0.0406987
RPL26 ribosomal protein L26 -0.0381528
FNDC3B fibronectin type III domain containing 3B -0.037927
LOC102724023 ES1 protein homolog, mitochondrial -0.0375761
PFN1 profilin 1 -0.0367753
RPL31 ribosomal protein L31 -0.0364165
RPL5 ribosomal protein L5 -0.0358602
RPL37 ribosomal protein L37 -0.0349263
WSB1 WD repeat and SOCS box containing 1 -0.0344803
RPS4X ribosomal protein S4, X-linked -0.0329294
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0327538
RPL11 ribosomal protein L11 -0.0326688
RBM25 RNA binding motif protein 25 -0.0326591
FTL ferritin, light polypeptide -0.0326527
NAP1L1 nucleosome assembly protein 1-like 1 -0.0316159
ATP5F1E ATP synthase F1 subunit epsilon -0.0315684
RPL9 ribosomal protein L9 -0.0312697
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0310259
MYL12B myosin, light chain 12B, regulatory -0.0302188
MDK midkine (neurite growth-promoting factor 2) -0.0299995
RPL34 ribosomal protein L34 -0.0298209
MARCKS myristoylated alanine-rich protein kinase C substrate -0.029429
RPLP0 ribosomal protein, large, P0 -0.0294199
CNRIP1 cannabinoid receptor interacting protein 1 -0.0293789
RPS21 ribosomal protein S21 -0.0292028
RPL37A ribosomal protein L37a -0.0289169
NACA nascent polypeptide-associated complex alpha subunit -0.0285017
RPS2 ribosomal protein S2 -0.0283212
RPL32 ribosomal protein L32 -0.0280565
RPL8 ribosomal protein L8 -0.0276523
GPC3 glypican 3 -0.0275528
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.027456
RPL19 ribosomal protein L19 -0.027345
SFRP4 secreted frizzled-related protein 4 -0.0272027
NPAS3 neuronal PAS domain protein 3 -0.0269182
RPS13 ribosomal protein S13 -0.026914
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.026795
HSPB1 heat shock 27kDa protein 1 -0.0267012
FAM177A1 family with sequence similarity 177, member A1 -0.0264131
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0263089
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0255829
PARD3B par-3 family cell polarity regulator beta -0.0254108
B2M beta-2-microglobulin -0.0253073
ISG15 ISG15 ubiquitin-like modifier -0.0249981
TSC22D2 TSC22 domain family, member 2 -0.0248716
RPL12 ribosomal protein L12 -0.0248111
RPS5 ribosomal protein S5 -0.0243669
MT2A metallothionein 2A -0.0243086
ACTG1 actin gamma 1 -0.0243016
PUM2 pumilio RNA-binding family member 2 -0.0242479
JMJD1C jumonji domain containing 1C -0.0242434
EIF1 eukaryotic translation initiation factor 1 -0.0239841
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0237157
RPL28 ribosomal protein L28 -0.0233161
RPS25 ribosomal protein S25 -0.0232067
RPL38 ribosomal protein L38 -0.0230604
RACK1 receptor for activated C kinase 1 -0.0227842
S100A9 S100 calcium binding protein A9 -0.022697
RPL30 ribosomal protein L30 -0.02266
NOP58 NOP58 ribonucleoprotein -0.0224782
RPS23 ribosomal protein S23 -0.022437
PDIA6 protein disulfide isomerase family A, member 6 -0.0224272
RPS29 ribosomal protein S29 -0.0222089
S100A10 S100 calcium binding protein A10 -0.0218533
HDAC9 histone deacetylase 9 -0.0217824
SEPTIN7 septin 7 -0.0217262
RPS20 ribosomal protein S20 -0.0216664
KDM5B lysine (K)-specific demethylase 5B -0.0215688
RPL18 ribosomal protein L18 -0.0213667
ARHGAP15 Rho GTPase activating protein 15 -0.0213517
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0213204
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0212916
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0210575
RPL36A ribosomal protein L36a -0.0207119
ATF4 activating transcription factor 4 -0.0205795
RBM39 RNA binding motif protein 39 -0.0203331
KIF13A kinesin family member 13A -0.0201818
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0201772
MEIS2 Meis homeobox 2 -0.0198142
RPS17 ribosomal protein S17 -0.0195669
KIF20B kinesin family member 20B -0.0194852