Carbamazepine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in SNU-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Carbamazepine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked 0.157748
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.139183
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0985695
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.091013
EEF2 eukaryotic translation elongation factor 2 0.0765097
PDE4B phosphodiesterase 4B, cAMP-specific 0.0731724
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0705466
VCL vinculin 0.0581523
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0571452
BMP10 bone morphogenetic protein 10 0.0526755
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0517258
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0507298
EIF4A2 eukaryotic translation initiation factor 4A2 0.0499257
AHNAK AHNAK nucleoprotein 0.0490252
HDLBP high density lipoprotein binding protein 0.0474385
LDHA lactate dehydrogenase A 0.0467958
APP amyloid beta (A4) precursor protein 0.0463771
PTMA prothymosin, alpha 0.0462408
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0455321
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.045398
PGK1 phosphoglycerate kinase 1 0.0442502
MKI67 marker of proliferation Ki-67 0.0441406
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0440854
LPP LIM domain containing preferred translocation partner in lipoma 0.042842
KDM3A lysine (K)-specific demethylase 3A 0.0420549
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0417905
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0414221
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0405691
EZR ezrin 0.0403279
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0395199
CPED1 cadherin-like and PC-esterase domain containing 1 0.0393956
MYOF myoferlin 0.0393257
PICALM phosphatidylinositol binding clathrin assembly protein 0.0393118
TOP2A topoisomerase (DNA) II alpha 170kDa 0.037504
ANXA1 annexin A1 0.03745
CENPF centromere protein F, 350/400kDa 0.0371919
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0367398
HJURP Holliday junction recognition protein 0.0365122
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0360585
CALR calreticulin 0.0351444
LOC112694756 uncharaterized LOC112694756 0.034643
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0342478
HSPA8 heat shock 70kDa protein 8 0.0338967
ENO1 enolase 1, (alpha) 0.0335208
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0321804
SLC38A2 solute carrier family 38, member 2 0.0321112
CEP250 centrosomal protein 250kDa 0.0318116
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0317078
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0302813
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.0301971
RPL7 ribosomal protein L7 0.0293764
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0292893
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0291679
APLP2 amyloid beta (A4) precursor-like protein 2 0.0286881
FNBP4 formin binding protein 4 0.0286836
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0285026
ARGLU1 arginine and glutamate rich 1 0.0279151
FBLN2 fibulin 2 0.0273327
TAC4 tachykinin 4 (hemokinin) 0.0272961
TPI1 triosephosphate isomerase 1 0.0272776
NAV2 neuron navigator 2 0.0269928
CKAP5 cytoskeleton associated protein 5 0.0265307
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0265299
PLK2 polo-like kinase 2 0.0262509
SEC31A SEC31 homolog A (S. cerevisiae) 0.0259335
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0259103
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.025888
ADAM10 ADAM metallopeptidase domain 10 0.0257837
OGA O-GlcNAcase 0.0257656
IQGAP1 IQ motif containing GTPase activating protein 1 0.025484
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0246688
SET SET nuclear proto-oncogene 0.0245711
CCND1 cyclin D1 0.0244088
AMOTL2 angiomotin like 2 0.0242168
FLNB filamin B, beta 0.0240541
XPO1 exportin 1 0.0239478
TPX2 TPX2, microtubule-associated 0.0239342
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0237831
PHF3 PHD finger protein 3 0.0235832
DSCAM Down syndrome cell adhesion molecule 0.0234818
SQSTM1 sequestosome 1 0.0234522
ZMYM2 zinc finger, MYM-type 2 0.0233015
UBC ubiquitin C 0.0230835
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0230217
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0229744
ADAM9 ADAM metallopeptidase domain 9 0.0227214
KDM4B lysine (K)-specific demethylase 4B 0.0225477
TMF1 TATA element modulatory factor 1 0.0225361
KIF5B kinesin family member 5B 0.0223572
GOLGA3 golgin A3 0.0223297
CAMTA1 calmodulin binding transcription activator 1 0.0222743
RSL1D1 ribosomal L1 domain containing 1 0.0220911
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0220714
EIF4A1 eukaryotic translation initiation factor 4A1 0.0219019
ANKRD11 ankyrin repeat domain 11 0.0217087
ERBIN erbb2 interacting protein 0.0216465
GYS1 glycogen synthase 1 (muscle) 0.0216382
GOLGA2 golgin A2 0.0214562
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0214526
RAD21 RAD21 homolog (S. pombe) 0.02123

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0635882
RPS6 ribosomal protein S6 -0.0617814
RPS8 ribosomal protein S8 -0.0600972
RPL35A ribosomal protein L35a -0.0579808
RPLP1 ribosomal protein, large, P1 -0.0449001
RPS19 ribosomal protein S19 -0.0432598
S100A6 S100 calcium binding protein A6 -0.0387978
RPS12 ribosomal protein S12 -0.0375629
RPL23 ribosomal protein L23 -0.0372598
RPL34 ribosomal protein L34 -0.0356213
PFN1 profilin 1 -0.0353698
RPL9 ribosomal protein L9 -0.0334393
RPL26 ribosomal protein L26 -0.0326476
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0301653
ACTG1 actin gamma 1 -0.0300643
RPL36 ribosomal protein L36 -0.0296216
RPL37A ribosomal protein L37a -0.0289875
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0271311
RPL31 ribosomal protein L31 -0.0260929
POTEF POTE ankyrin domain family, member F -0.0260417
RPLP2 ribosomal protein, large, P2 -0.0251256
PDE4D phosphodiesterase 4D, cAMP-specific -0.0250266
COG5 component of oligomeric golgi complex 5 -0.0250119
PKM pyruvate kinase, muscle -0.0247233
EIF5B eukaryotic translation initiation factor 5B -0.02467
RPS16 ribosomal protein S16 -0.0244392
RTN4 reticulon 4 -0.0242521
RPL28 ribosomal protein L28 -0.0237646
RACK1 receptor for activated C kinase 1 -0.022829
TSC22D1 TSC22 domain family, member 1 -0.0218539
ARB2A ARB2 cotranscriptional regulator A -0.0214593
GPHN gephyrin -0.0211705
RBM25 RNA binding motif protein 25 -0.0209728
CCNL1 cyclin L1 -0.0208487
DPYD dihydropyrimidine dehydrogenase -0.0204853
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.020468
RPL12 ribosomal protein L12 -0.0204513
RPL35 ribosomal protein L35 -0.0200757
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0197725
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0197151
PTBP2 polypyrimidine tract binding protein 2 -0.0196581
SESN2 sestrin 2 -0.0193793
S100A10 S100 calcium binding protein A10 -0.0187947
RPS3 ribosomal protein S3 -0.0184915
NAMPT nicotinamide phosphoribosyltransferase -0.0182219
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0182079
UGCG UDP-glucose ceramide glucosyltransferase -0.0179997
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0177337
TFG TRK-fused gene -0.0173768
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0173075
RPL30 ribosomal protein L30 -0.0172309
RPL27 ribosomal protein L27 -0.0171786
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0171402
BRWD1 bromodomain and WD repeat domain containing 1 -0.0167709
QKI QKI, KH domain containing, RNA binding -0.0167369
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0166581
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0163626
MATR3 matrin 3 -0.0162417
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0162254
RPS14 ribosomal protein S14 -0.0161773
RPL11 ribosomal protein L11 -0.0161632
LDHB lactate dehydrogenase B -0.0158398
RPS21 ribosomal protein S21 -0.0158059
SGMS1 sphingomyelin synthase 1 -0.0155466
NUP58 nucleoporin 58 -0.0155433
KCMF1 potassium channel modulatory factor 1 -0.015332
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0153318
PIAS1 protein inhibitor of activated STAT, 1 -0.0152672
ZNF207 zinc finger protein 207 -0.0152499
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0152395
SF1 splicing factor 1 -0.015079
SSBP2 single-stranded DNA binding protein 2 -0.0148482
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0146091
SREK1IP1 SREK1-interacting protein 1 -0.0145734
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0144659
RPL5 ribosomal protein L5 -0.0144243
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0143394
S100A4 S100 calcium binding protein A4 -0.0142778
NUP153 nucleoporin 153kDa -0.0142317
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0139671
RPS5 ribosomal protein S5 -0.0138961
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0138942
ARL15 ADP-ribosylation factor-like 15 -0.0138129
ZNF644 zinc finger protein 644 -0.0136362
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0136212
UBE2K ubiquitin-conjugating enzyme E2K -0.0136062
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0134943
STAU2 staufen double-stranded RNA binding protein 2 -0.0133643
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0133438
ATP13A3 ATPase type 13A3 -0.013249
ADNP activity-dependent neuroprotector homeobox -0.0131688
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0131327
TTC3 tetratricopeptide repeat domain 3 -0.0129826
WDPCP WD repeat containing planar cell polarity effector -0.0129738
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0128735
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -0.0128701
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0128674
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0127733
CHD1 chromodomain helicase DNA binding protein 1 -0.0127541
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.012674