Carbamazepine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.0977579
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0902172
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0789935
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0688125
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0668639
DSCAM Down syndrome cell adhesion molecule 0.0641139
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0568778
CANX calnexin 0.0558855
EEF2 eukaryotic translation elongation factor 2 0.0552628
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0547699
MYH9 myosin, heavy chain 9, non-muscle 0.0542869
NUP58 nucleoporin 58 0.0537732
TPX2 TPX2, microtubule-associated 0.0529665
APLP2 amyloid beta (A4) precursor-like protein 2 0.0513731
TXNRD1 thioredoxin reductase 1 0.048559
NAMPT nicotinamide phosphoribosyltransferase 0.0464476
KIAA1958 KIAA1958 0.046093
CKAP5 cytoskeleton associated protein 5 0.0453734
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0444554
ANLN anillin, actin binding protein 0.0441453
CEP250 centrosomal protein 250kDa 0.043523
ARRDC3 arrestin domain containing 3 0.0434698
MBNL2 muscleblind-like splicing regulator 2 0.0430111
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0428865
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0418629
NUMA1 nuclear mitotic apparatus protein 1 0.039017
ELL2 elongation factor, RNA polymerase II, 2 0.0389034
CENPF centromere protein F, 350/400kDa 0.0378898
YAP1 Yes-associated protein 1 0.0372136
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0366772
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0366573
PDGFA platelet-derived growth factor alpha polypeptide 0.036519
ANKRD28 ankyrin repeat domain 28 0.0363132
SETD5 SET domain containing 5 0.0356786
AHCTF1 AT hook containing transcription factor 1 0.0356093
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0352896
CALU calumenin 0.0351773
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0351606
PCBP2 poly(rC) binding protein 2 0.035046
RSRC2 arginine/serine-rich coiled-coil 2 0.0349963
YBX3 Y box binding protein 3 0.0349519
CAPRIN2 caprin family member 2 0.0347544
DGKD diacylglycerol kinase, delta 130kDa 0.033722
SPAG9 sperm associated antigen 9 0.0336643
TNIP1 TNFAIP3 interacting protein 1 0.0334925
CHD1 chromodomain helicase DNA binding protein 1 0.0332922
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0326757
FXR1 fragile X mental retardation, autosomal homolog 1 0.0322875
EIF1 eukaryotic translation initiation factor 1 0.0322564
ERRFI1 ERBB receptor feedback inhibitor 1 0.0313877
RPL4 ribosomal protein L4 0.0311513
FLNA filamin A, alpha 0.0307148
ZC3H11A zinc finger CCCH-type containing 11A 0.0306272
HSPA8 heat shock 70kDa protein 8 0.0304334
MAP2K1 mitogen-activated protein kinase kinase 1 0.0296352
RAD21 RAD21 homolog (S. pombe) 0.0293364
CUL3 cullin 3 0.0293292
BRD2 bromodomain containing 2 0.0293158
GOLGA2 golgin A2 0.0290836
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0288591
MKI67 marker of proliferation Ki-67 0.0285635
MIS18BP1 MIS18 binding protein 1 0.0284615
RBM39 RNA binding motif protein 39 0.028371
AURKA aurora kinase A 0.0282028
KIF4A kinesin family member 4A 0.028054
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0278206
UBQLN1 ubiquilin 1 0.0277809
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0275171
HDLBP high density lipoprotein binding protein 0.0273776
DAND5 DAN domain family member 5, BMP antagonist 0.0273045
ANKRD37 ankyrin repeat domain 37 0.0270333
WWTR1 WW domain containing transcription regulator 1 0.0269963
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0269896
RRBP1 ribosome binding protein 1 0.0268714
SET SET nuclear proto-oncogene 0.0268569
ACIN1 apoptotic chromatin condensation inducer 1 0.0266897
CREBRF CREB3 regulatory factor 0.026484
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0262161
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0259931
HJURP Holliday junction recognition protein 0.0259422
YY1AP1 YY1 associated protein 1 0.0258479
SMC4 structural maintenance of chromosomes 4 0.0258126
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0256101
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0255832
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0255658
WDR36 WD repeat domain 36 0.0251251
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0251086
TMEM123 transmembrane protein 123 0.0250896
CALR calreticulin 0.024656
UIMC1 ubiquitin interaction motif containing 1 0.0246247
LASP1 LIM and SH3 protein 1 0.0245409
KIAA1328 KIAA1328 0.0245142
FANCI Fanconi anemia, complementation group I 0.0244747
ANXA1 annexin A1 0.0244303
DIAPH3 diaphanous-related formin 3 0.0243387
ZNF292 zinc finger protein 292 0.0242248
ANKRD36 ankyrin repeat domain 36 0.0238508
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0236879
CEP295 centrosomal protein 295kDa 0.023529
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0234898

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.189049
FNDC3B fibronectin type III domain containing 3B -0.151344
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.121435
TMSB10 thymosin beta 10 -0.104561
TPT1 tumor protein, translationally-controlled 1 -0.0946163
PRKCA protein kinase C, alpha -0.085267
HMGA2 high mobility group AT-hook 2 -0.085237
CD44 CD44 molecule (Indian blood group) -0.084406
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.078933
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.075725
POTEF POTE ankyrin domain family, member F -0.0687545
ZBTB20 zinc finger and BTB domain containing 20 -0.0668384
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.066709
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0568766
NALCN sodium leak channel, non selective -0.0541836
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0523919
WSB1 WD repeat and SOCS box containing 1 -0.0510616
RIGI RNA sensor RIG-I -0.0508209
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0506587
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0503985
ATM ATM serine/threonine kinase -0.0493145
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0483672
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0475008
ANGPTL4 angiopoietin-like 4 -0.0467733
SVIL supervillin -0.0457613
DST dystonin -0.0455999
PCED1B PC-esterase domain containing 1B -0.0451571
PRSS23 protease, serine, 23 -0.0433875
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0430907
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0422604
PRR16 proline rich 16 -0.0419367
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0414991
THSD4 thrombospondin, type I, domain containing 4 -0.041356
AKAP13 A kinase (PRKA) anchor protein 13 -0.0409433
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0402255
ZFHX3 zinc finger homeobox 3 -0.0397397
FNDC3A fibronectin type III domain containing 3A -0.039621
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0385837
ACTG1 actin gamma 1 -0.0380456
FMN1 formin 1 -0.0379438
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0379157
EXT1 exostosin glycosyltransferase 1 -0.0373315
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0370361
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0369806
RAI14 retinoic acid induced 14 -0.036332
S100A6 S100 calcium binding protein A6 -0.03631
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0361867
FTH1 ferritin, heavy polypeptide 1 -0.035905
TIMP1 TIMP metallopeptidase inhibitor 1 -0.035687
PODXL podocalyxin-like -0.0356245
VCL vinculin -0.035312
MACF1 microtubule-actin crosslinking factor 1 -0.0351166
S100A10 S100 calcium binding protein A10 -0.0346282
PLEK2 pleckstrin 2 -0.0345765
DPYD dihydropyrimidine dehydrogenase -0.0342515
PTPRG protein tyrosine phosphatase, receptor type, G -0.0341521
LDHA lactate dehydrogenase A -0.0339575
BTG1 B-cell translocation gene 1, anti-proliferative -0.0337559
ENO2 enolase 2 (gamma, neuronal) -0.0334143
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0332983
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0331184
NPAS2 neuronal PAS domain protein 2 -0.033064
PKM pyruvate kinase, muscle -0.0323447
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0323165
B2M beta-2-microglobulin -0.0322233
PRH1 proline-rich protein HaeIII subfamily 1 -0.0319083
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0315204
EFNA5 ephrin-A5 -0.0312859
RPS13 ribosomal protein S13 -0.0312369
USP34 ubiquitin specific peptidase 34 -0.030991
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0309577
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0305348
BPTF bromodomain PHD finger transcription factor -0.0301537
PNISR PNN-interacting serine/arginine-rich protein -0.0300776
ACER3 alkaline ceramidase 3 -0.0300555
CDCP1 CUB domain containing protein 1 -0.0298634
WWOX WW domain containing oxidoreductase -0.0296128
DTNA dystrobrevin, alpha -0.0294203
NPEPPS aminopeptidase puromycin sensitive -0.0289754
RAD51B RAD51 paralog B -0.0289403
TBCA tubulin folding cofactor A -0.0286688
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0286087
EGR1 early growth response 1 -0.0280669
COL5A1 collagen, type V, alpha 1 -0.027977
SDC4 syndecan 4 -0.0279679
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0279386
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0278662
PARD3 par-3 family cell polarity regulator -0.0276848
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0274578
WARS1 tryptophanyl-tRNA synthetase 1 -0.0272552
NAV3 neuron navigator 3 -0.0270596
FBXL7 F-box and leucine-rich repeat protein 7 -0.0268059
CCNI cyclin I -0.0267574
OASL 2'-5'-oligoadenylate synthetase-like -0.0267541
PTK2 protein tyrosine kinase 2 -0.0267485
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0266736
MAP1B microtubule-associated protein 1B -0.0266438
S100A9 S100 calcium binding protein A9 -0.0266381
AHNAK AHNAK nucleoprotein -0.0266292
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0265028