Carbamazepine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbamazepine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbamazepine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.126707
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.12233
MYH9 myosin, heavy chain 9, non-muscle 0.0828125
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0827748
AHR aryl hydrocarbon receptor 0.0592058
OGA O-GlcNAcase 0.0500632
TXNIP thioredoxin interacting protein 0.049439
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0488287
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.044748
TPR translocated promoter region, nuclear basket protein 0.0436851
PRRC2C proline-rich coiled-coil 2C 0.0435978
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0432682
SMAD3 SMAD family member 3 0.0422983
CD109 CD109 molecule 0.0409575
APLP2 amyloid beta (A4) precursor-like protein 2 0.0399111
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0366796
SMOX spermine oxidase 0.036665
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0366158
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0366105
ETNK1 ethanolamine kinase 1 0.0364103
ZC3H11A zinc finger CCCH-type containing 11A 0.036065
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0356866
RUNX2 runt-related transcription factor 2 0.0356846
FNDC3B fibronectin type III domain containing 3B 0.0356591
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.034951
CXCL8 chemokine (C-X-C motif) ligand 8 0.034315
SOD2 superoxide dismutase 2, mitochondrial 0.0340803
EREG epiregulin 0.0337835
CANX calnexin 0.0336841
RNF145 ring finger protein 145 0.0334896
TM9SF3 transmembrane 9 superfamily member 3 0.032714
SEC23A Sec23 homolog A (S. cerevisiae) 0.030778
AFDN afadin, adherens junction formation factor 0.0298973
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0297159
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0287941
VEGFA vascular endothelial growth factor A 0.0284957
MCTP2 multiple C2 domains, transmembrane 2 0.0283777
IL6ST interleukin 6 signal transducer 0.0283485
RICTOR RPTOR independent companion of MTOR, complex 2 0.0280288
ARRDC3 arrestin domain containing 3 0.0279005
PELO pelota homolog (Drosophila) 0.0278692
FAM13A family with sequence similarity 13, member A 0.0277394
YME1L1 YME1-like 1 ATPase 0.0275784
MKI67 marker of proliferation Ki-67 0.0270533
CAB39 calcium binding protein 39 0.0269531
BHLHE40 basic helix-loop-helix family, member e40 0.0265958
PRPF8 pre-mRNA processing factor 8 0.0264029
FNBP1 formin binding protein 1 0.0263612
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0262413
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0262403
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.026015
TENT2 terminal nucleotidyltransferase 2 0.025693
SUCO SUN domain containing ossification factor 0.0256348
CENPF centromere protein F, 350/400kDa 0.0255777
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0254582
DDIT4 DNA-damage-inducible transcript 4 0.0252941
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0252179
COPA coatomer protein complex, subunit alpha 0.0251651
ACTN4 actinin, alpha 4 0.0251322
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0250011
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0247458
KMT2E lysine (K)-specific methyltransferase 2E 0.0246731
RAB8B RAB8B, member RAS oncogene family 0.0245782
ZNF292 zinc finger protein 292 0.0244276
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0243938
NEK7 NIMA-related kinase 7 0.0241296
HELZ helicase with zinc finger 0.0238436
NUP58 nucleoporin 58 0.0238185
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0234988
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0234837
DUSP5 dual specificity phosphatase 5 0.0234383
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0233994
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0231865
RAD21 RAD21 homolog (S. pombe) 0.023142
CTNND1 catenin (cadherin-associated protein), delta 1 0.0231154
RB1CC1 RB1-inducible coiled-coil 1 0.022953
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0228238
CDC73 cell division cycle 73 0.0227579
ANLN anillin, actin binding protein 0.0226679
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0224798
ADD3 adducin 3 (gamma) 0.0222363
FLNA filamin A, alpha 0.0222344
CLTC clathrin, heavy chain (Hc) 0.0220773
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0220532
DST dystonin 0.0219584
FBXL5 F-box and leucine-rich repeat protein 5 0.0218204
TPM3 tropomyosin 3 0.021735
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0216944
NRP1 neuropilin 1 0.021467
CREBRF CREB3 regulatory factor 0.0212273
MIS18BP1 MIS18 binding protein 1 0.0211604
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0210522
PELI1 pellino E3 ubiquitin protein ligase 1 0.0208176
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0208051
KDM3A lysine (K)-specific demethylase 3A 0.0206316
OSMR oncostatin M receptor 0.0205233
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0204309
EMSY EMSY transcriptional repressor, BRCA2 interacting 0.0203932
TFG TRK-fused gene 0.0203456
RBM39 RNA binding motif protein 39 0.0200798

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.332683
NRG1 neuregulin 1 -0.203323
PTMA prothymosin, alpha -0.19193
FTL ferritin, light polypeptide -0.153796
TMSB10 thymosin beta 10 -0.148414
TPT1 tumor protein, translationally-controlled 1 -0.116668
HLA-B major histocompatibility complex, class I, B -0.116178
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.103584
RPL35A ribosomal protein L35a -0.0972214
RPS6 ribosomal protein S6 -0.0942189
IFI27 interferon, alpha-inducible protein 27 -0.0879762
SQSTM1 sequestosome 1 -0.0865476
ACTG1 actin gamma 1 -0.0832471
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0796278
MT2A metallothionein 2A -0.0779846
RPL31 ribosomal protein L31 -0.0749428
RPL37A ribosomal protein L37a -0.0687177
INTS6 integrator complex subunit 6 -0.0661739
RPS8 ribosomal protein S8 -0.0633408
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0621402
HMGA2 high mobility group AT-hook 2 -0.0618603
RPL9 ribosomal protein L9 -0.0618584
B2M beta-2-microglobulin -0.0593562
VIM vimentin -0.0590002
RPL37 ribosomal protein L37 -0.0582448
RPL38 ribosomal protein L38 -0.0576146
RPS29 ribosomal protein S29 -0.0574734
S100A6 S100 calcium binding protein A6 -0.0561068
RPLP1 ribosomal protein, large, P1 -0.0557151
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0554617
ENO2 enolase 2 (gamma, neuronal) -0.0553435
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0550605
RPS24 ribosomal protein S24 -0.0545022
RPL23 ribosomal protein L23 -0.0494671
S100A10 S100 calcium binding protein A10 -0.0490443
RPL34 ribosomal protein L34 -0.0483035
IER3 immediate early response 3 -0.0470718
RPS25 ribosomal protein S25 -0.0464942
RPS23 ribosomal protein S23 -0.0462139
RPS21 ribosomal protein S21 -0.0455867
RPS11 ribosomal protein S11 -0.0450073
RPS27A ribosomal protein S27a -0.0444894
POTEF POTE ankyrin domain family, member F -0.0440148
RPS16 ribosomal protein S16 -0.0424518
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0421325
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0420882
RPLP2 ribosomal protein, large, P2 -0.0418451
ENO1 enolase 1, (alpha) -0.0414646
EIF1 eukaryotic translation initiation factor 1 -0.0414426
RACK1 receptor for activated C kinase 1 -0.041147
RPL26 ribosomal protein L26 -0.0409646
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0403859
RPS19 ribosomal protein S19 -0.039518
WSB1 WD repeat and SOCS box containing 1 -0.0394931
CTSD cathepsin D -0.0390898
IFI6 interferon, alpha-inducible protein 6 -0.0390802
RPL28 ribosomal protein L28 -0.0389675
S100A9 S100 calcium binding protein A9 -0.0386254
LRRC23 leucine rich repeat containing 23 -0.0378215
HLA-A major histocompatibility complex, class I, A -0.0375229
RPS27 ribosomal protein S27 -0.0372781
RPS3 ribosomal protein S3 -0.0369168
EFNA5 ephrin-A5 -0.0367974
GNAS GNAS complex locus -0.0366692
RPL11 ribosomal protein L11 -0.03636
SOX4 SRY (sex determining region Y)-box 4 -0.0357529
RPS5 ribosomal protein S5 -0.0357498
RPL8 ribosomal protein L8 -0.0355994
RPS12 ribosomal protein S12 -0.0352934
TM4SF1 transmembrane 4 L six family member 1 -0.0349372
EGR1 early growth response 1 -0.0345652
RPLP0 ribosomal protein, large, P0 -0.0345178
FTH1 ferritin, heavy polypeptide 1 -0.0341125
RAB7A RAB7A, member RAS oncogene family -0.0338966
RPL12 ribosomal protein L12 -0.0336311
RPS13 ribosomal protein S13 -0.0325181
RPS14 ribosomal protein S14 -0.0320867
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0317863
ZBTB20 zinc finger and BTB domain containing 20 -0.0315166
MRPS6 mitochondrial ribosomal protein S6 -0.030861
RPS15 ribosomal protein S15 -0.0307861
LOC102724023 ES1 protein homolog, mitochondrial -0.0302527
SLC35F3 solute carrier family 35, member F3 -0.0302113
SLC38A2 solute carrier family 38, member 2 -0.0299554
PALLD palladin, cytoskeletal associated protein -0.029591
EIF5B eukaryotic translation initiation factor 5B -0.0295839
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0292764
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0289275
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0288925
ASPH aspartate beta-hydroxylase -0.0278677
NDRG1 N-myc downstream regulated 1 -0.0275542
RPS17 ribosomal protein S17 -0.0274663
NALF1 NALCN channel auxiliary factor 1 -0.0274219
LY6E lymphocyte antigen 6 complex, locus E -0.0273438
RPL36A ribosomal protein L36a -0.0271814
BPTF bromodomain PHD finger transcription factor -0.0266585
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0263524
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0263008
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0260269
IGFBP3 insulin-like growth factor binding protein 3 -0.0260064