Carbidopa (monohydrate)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.191661
DLG1 discs, large homolog 1 (Drosophila) 0.185407
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.18305
TRIO trio Rho guanine nucleotide exchange factor 0.177321
NDRG1 N-myc downstream regulated 1 0.165508
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.104565
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0997701
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0913575
NAV2 neuron navigator 2 0.089176
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0878918
FNDC3B fibronectin type III domain containing 3B 0.0862348
ELL2 elongation factor, RNA polymerase II, 2 0.0847023
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0810371
CD109 CD109 molecule 0.0726833
FLNB filamin B, beta 0.0711576
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0646864
MMP12 matrix metallopeptidase 12 0.0631489
BHLHE40 basic helix-loop-helix family, member e40 0.0623449
OGA O-GlcNAcase 0.0621762
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0582631
SLC39A11 solute carrier family 39, member 11 0.05717
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0552818
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0533616
FBXL7 F-box and leucine-rich repeat protein 7 0.0521521
ZEB1 zinc finger E-box binding homeobox 1 0.0507585
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0493673
DTNA dystrobrevin, alpha 0.0470875
PRELID2 PRELI domain containing 2 0.0470364
ZFP36L1 ZFP36 ring finger protein-like 1 0.0467417
RSAD2 radical S-adenosyl methionine domain containing 2 0.0458049
AUTS2 autism susceptibility candidate 2 0.0445364
CYLD cylindromatosis (turban tumor syndrome) 0.0442643
HELZ helicase with zinc finger 0.0442269
ESYT2 extended synaptotagmin-like protein 2 0.0437882
INSIG2 insulin induced gene 2 0.0433484
FNIP1 folliculin interacting protein 1 0.0426368
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0410466
PICALM phosphatidylinositol binding clathrin assembly protein 0.0402828
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0401509
PODXL podocalyxin-like 0.0390042
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0385262
ZNF292 zinc finger protein 292 0.0383521
SPAG9 sperm associated antigen 9 0.0381712
SETD5 SET domain containing 5 0.0380705
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0377452
MX2 MX dynamin-like GTPase 2 0.0376912
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0372938
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.0372298
YEATS2 YEATS domain containing 2 0.0371867
MYOF myoferlin 0.0364503
MSI2 musashi RNA-binding protein 2 0.0359759
ATP13A3 ATPase type 13A3 0.0357418
UBC ubiquitin C 0.0355644
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0352113
SSBP2 single-stranded DNA binding protein 2 0.0347976
COL8A1 collagen, type VIII, alpha 1 0.0346541
RHOBTB3 Rho-related BTB domain containing 3 0.0342508
SDK1 sidekick cell adhesion molecule 1 0.0341923
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0335646
NGLY1 N-glycanase 1 0.033431
CHD1L chromodomain helicase DNA binding protein 1-like 0.033274
FBXL2 F-box and leucine-rich repeat protein 2 0.0331365
SBF2 SET binding factor 2 0.0330015
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0327557
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0325918
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0323711
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0322818
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0318325
IFIH1 interferon induced with helicase C domain 1 0.0318018
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0317191
RUNX1 runt-related transcription factor 1 0.031509
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0313913
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0313371
ANKRD11 ankyrin repeat domain 11 0.0311594
DPYSL2 dihydropyrimidinase-like 2 0.031044
SOCS5 suppressor of cytokine signaling 5 0.0308687
HIP1 huntingtin interacting protein 1 0.0308431
KIF13A kinesin family member 13A 0.0307943
NT5C2 5'-nucleotidase, cytosolic II 0.0307204
INSIG1 insulin induced gene 1 0.0306232
RNF24 ring finger protein 24 0.0304178
DENND5A DENN/MADD domain containing 5A 0.0301688
ZNF207 zinc finger protein 207 0.0300054
NBEAL1 neurobeachin-like 1 0.0298753
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0297301
LRRC49 leucine rich repeat containing 49 0.0296621
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0295452
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0295025
ARHGAP12 Rho GTPase activating protein 12 0.0294452
ANKRD36 ankyrin repeat domain 36 0.0292403
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0291888
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0291711
KIAA1217 KIAA1217 0.0291247
USP3 ubiquitin specific peptidase 3 0.0288653
SLC38A1 solute carrier family 38, member 1 0.0287054
MXI1 MAX interactor 1, dimerization protein 0.0284435
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0275937
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0273867
NCOR2 nuclear receptor corepressor 2 0.0270369
BACE2 beta-site APP-cleaving enzyme 2 0.0270111

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.224026
MT2A metallothionein 2A -0.153281
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0829751
HLA-B major histocompatibility complex, class I, B -0.0675716
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0630296
COL3A1 collagen, type III, alpha 1 -0.0559157
FTL ferritin, light polypeptide -0.0558965
VIM vimentin -0.0558703
GLIS3 GLIS family zinc finger 3 -0.0547133
B2M beta-2-microglobulin -0.0527079
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0512829
PRRC2C proline-rich coiled-coil 2C -0.0510825
POTEF POTE ankyrin domain family, member F -0.0502889
EIF1 eukaryotic translation initiation factor 1 -0.0499622
VCL vinculin -0.0495454
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0461953
MAP1B microtubule-associated protein 1B -0.0459063
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0449555
RPL36 ribosomal protein L36 -0.0440177
IFITM1 interferon induced transmembrane protein 1 -0.0432927
CSTB cystatin B (stefin B) -0.0430036
JMJD1C jumonji domain containing 1C -0.0421878
RPL23 ribosomal protein L23 -0.039975
COL1A2 collagen, type I, alpha 2 -0.0396463
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0394205
HLA-A major histocompatibility complex, class I, A -0.0393562
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0392385
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0382139
RPS3 ribosomal protein S3 -0.0381845
RPLP1 ribosomal protein, large, P1 -0.0380958
S100A11 S100 calcium binding protein A11 -0.0376911
FBN1 fibrillin 1 -0.037412
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0374025
ENO1 enolase 1, (alpha) -0.0362111
RPL28 ribosomal protein L28 -0.0340149
EXT1 exostosin glycosyltransferase 1 -0.0338405
PTMA prothymosin, alpha -0.0336186
RPLP2 ribosomal protein, large, P2 -0.0333862
S100A4 S100 calcium binding protein A4 -0.0331517
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0331331
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0326489
RPL12 ribosomal protein L12 -0.0325987
HLA-C major histocompatibility complex, class I, C -0.0322714
RPS6 ribosomal protein S6 -0.0322261
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0321447
CTSB cathepsin B -0.0316046
LOC112694756 uncharaterized LOC112694756 -0.0315449
EEF2 eukaryotic translation elongation factor 2 -0.0312532
CAVIN1 caveolae associated protein 1 -0.0311416
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0311152
FBXO11 F-box protein 11 -0.0310761
PARD3 par-3 family cell polarity regulator -0.0310197
TPM4 tropomyosin 4 -0.0306107
DOCK5 dedicator of cytokinesis 5 -0.0304044
ACTG1 actin gamma 1 -0.0299786
ENAH enabled homolog (Drosophila) -0.0294997
S100A6 S100 calcium binding protein A6 -0.0293446
EGR1 early growth response 1 -0.0292822
IFITM3 interferon induced transmembrane protein 3 -0.0292611
RRBP1 ribosome binding protein 1 -0.0289307
RPS8 ribosomal protein S8 -0.0287101
RPS19 ribosomal protein S19 -0.0284734
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0282001
APP amyloid beta (A4) precursor protein -0.0281716
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0281515
RPL32 ribosomal protein L32 -0.0275992
TXNRD1 thioredoxin reductase 1 -0.0272761
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0262814
WWTR1 WW domain containing transcription regulator 1 -0.0261191
RPL35A ribosomal protein L35a -0.0260701
GNAS GNAS complex locus -0.0258573
CYTH3 cytohesin 3 -0.0256607
EIF5B eukaryotic translation initiation factor 5B -0.0255808
BSG basigin (Ok blood group) -0.0253426
HDLBP high density lipoprotein binding protein -0.0251517
SERF2 small EDRK-rich factor 2 -0.0248908
TM4SF1 transmembrane 4 L six family member 1 -0.0248477
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0244447
RPS14 ribosomal protein S14 -0.0243708
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0243465
ARHGAP5 Rho GTPase activating protein 5 -0.0243029
NPR2 natriuretic peptide receptor 2 -0.0242892
LMNA lamin A/C -0.0241202
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0240038
COL5A2 collagen, type V, alpha 2 -0.0239785
HSPB1 heat shock 27kDa protein 1 -0.0239499
STC1 stanniocalcin 1 -0.0236835
SRRM2 serine/arginine repetitive matrix 2 -0.0235809
CALU calumenin -0.0234091
RPS21 ribosomal protein S21 -0.0233895
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0233101
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0232636
AKAP13 A kinase (PRKA) anchor protein 13 -0.0232401
TXNIP thioredoxin interacting protein -0.0231326
SH3KBP1 SH3-domain kinase binding protein 1 -0.02303
GOLGA2 golgin A2 -0.0228758
CDK13 cyclin-dependent kinase 13 -0.0228267
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0227615
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0225579
ATP5F1E ATP synthase F1 subunit epsilon -0.0223918