| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NLGN1 | neuroligin 1 | 0.156799 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0677158 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0629946 |
| VMP1 | vacuole membrane protein 1 | 0.0621263 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0602103 |
| USP34 | ubiquitin specific peptidase 34 | 0.0553423 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0553142 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0540296 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0529636 |
| BCHE | butyrylcholinesterase | 0.0524793 |
| PRR16 | proline rich 16 | 0.0492476 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0475326 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0452838 |
| HMGA2 | high mobility group AT-hook 2 | 0.0430154 |
| EDARADD | EDAR-associated death domain | 0.0421867 |
| NHSL1 | NHS-like 1 | 0.0412819 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0406619 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0405728 |
| NEBL | nebulette | 0.0390863 |
| TMEM123 | transmembrane protein 123 | 0.0377186 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0359487 |
| NF1 | neurofibromin 1 | 0.0347687 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0339986 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0334843 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0329113 |
| EPHA6 | EPH receptor A6 | 0.0323725 |
| MGAT4C | MGAT4 family, member C | 0.0313396 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0305702 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0303673 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0299902 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | 0.0291818 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0289548 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0288644 |
| TBC1D32 | TBC1 domain family, member 32 | 0.0284332 |
| TMEM41B | transmembrane protein 41B | 0.0280328 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 0.0274255 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0272537 |
| FNIP1 | folliculin interacting protein 1 | 0.0267262 |
| CUX1 | cut-like homeobox 1 | 0.0260179 |
| TENM3 | teneurin transmembrane protein 3 | 0.0252622 |
| R3HDM1 | R3H domain containing 1 | 0.0245825 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0244673 |
| PCDH9 | protocadherin 9 | 0.0241184 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0235586 |
| ZNF292 | zinc finger protein 292 | 0.0231689 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0231306 |
| SETD5 | SET domain containing 5 | 0.0230199 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0229174 |
| FUS | FUS RNA binding protein | 0.0226858 |
| TBK1 | TANK-binding kinase 1 | 0.0223223 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0222641 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | 0.0219234 |
| BPTF | bromodomain PHD finger transcription factor | 0.021815 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0212094 |
| MSI2 | musashi RNA-binding protein 2 | 0.0210284 |
| SYT1 | synaptotagmin I | 0.0206941 |
| TPM4 | tropomyosin 4 | 0.0204575 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.020451 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.020294 |
| DTNA | dystrobrevin, alpha | 0.019861 |
| DTNB | dystrobrevin, beta | 0.0196735 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0194637 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0194327 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0193948 |
| PARD3 | par-3 family cell polarity regulator | 0.0191621 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | 0.019139 |
| LARP1 | La ribonucleoprotein domain family, member 1 | 0.0190662 |
| SRPK2 | SRSF protein kinase 2 | 0.0187915 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0187236 |
| C2ORF42 | chromosome 2 open reading frame 42 | 0.0187115 |
| PARD6B | par-6 family cell polarity regulator beta | 0.0184462 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0184011 |
| PHF21A | PHD finger protein 21A | 0.018304 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0181639 |
| CCDC91 | coiled-coil domain containing 91 | 0.0180011 |
| TMEM144 | transmembrane protein 144 | 0.0178986 |
| ZFR | zinc finger RNA binding protein | 0.017776 |
| MICU3 | mitochondrial calcium uptake family, member 3 | 0.0176981 |
| CDK19 | cyclin-dependent kinase 19 | 0.0176638 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0174099 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0173555 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0172191 |
| FGF14 | fibroblast growth factor 14 | 0.0171823 |
| KLHL5 | kelch-like family member 5 | 0.0169032 |
| PAXBP1 | PAX3 and PAX7 binding protein 1 | 0.0167089 |
| CABIN1 | calcineurin binding protein 1 | 0.0166165 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0166018 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.016397 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0163927 |
| PCNP | PEST proteolytic signal containing nuclear protein | 0.0162202 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0161673 |
| KIF18B | kinesin family member 18B | 0.0161491 |
| PCNX1 | pecanex 1 | 0.0161094 |
| CFDP1 | craniofacial development protein 1 | 0.0161041 |
| PDGFC | platelet derived growth factor C | 0.0159728 |
| FSTL5 | follistatin-like 5 | 0.0159049 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0158912 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0157982 |
| MBTD1 | mbt domain containing 1 | 0.0157885 |
| WWOX | WW domain containing oxidoreductase | 0.0156578 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.163477 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.131993 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.117183 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.109927 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.102896 |
| RPS2 | ribosomal protein S2 | -0.102525 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0987819 |
| RPS12 | ribosomal protein S12 | -0.0754546 |
| ANXA1 | annexin A1 | -0.0702275 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0648198 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0573126 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0571934 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0567796 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0548316 |
| TMSB10 | thymosin beta 10 | -0.0536276 |
| IPO7 | importin 7 | -0.0521936 |
| RPL12 | ribosomal protein L12 | -0.0516149 |
| FTL | ferritin, light polypeptide | -0.0509194 |
| PCBP2 | poly(rC) binding protein 2 | -0.050242 |
| RPL11 | ribosomal protein L11 | -0.0489956 |
| RPLP0 | ribosomal protein, large, P0 | -0.0489764 |
| RPS3 | ribosomal protein S3 | -0.0486887 |
| LMO7 | LIM domain 7 | -0.0486816 |
| POTEF | POTE ankyrin domain family, member F | -0.0470913 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0467371 |
| RACK1 | receptor for activated C kinase 1 | -0.0461747 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.044642 |
| CLTC | clathrin, heavy chain (Hc) | -0.0446084 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.044307 |
| RPL23 | ribosomal protein L23 | -0.0439224 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0426743 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.041626 |
| KIF5B | kinesin family member 5B | -0.0414403 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0413056 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0408388 |
| RPL19 | ribosomal protein L19 | -0.0398781 |
| SET | SET nuclear proto-oncogene | -0.0395562 |
| RPL13A | ribosomal protein L13a | -0.0392288 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0384201 |
| RPS6 | ribosomal protein S6 | -0.037909 |
| ASPH | aspartate beta-hydroxylase | -0.0378691 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0374368 |
| GOLGA4 | golgin A4 | -0.0373109 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0368037 |
| RPL3 | ribosomal protein L3 | -0.0357225 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0356592 |
| YBX3 | Y box binding protein 3 | -0.0353524 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.0352913 |
| RAB10 | RAB10, member RAS oncogene family | -0.0351221 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0350815 |
| AFF4 | AF4/FMR2 family, member 4 | -0.034944 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0346081 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0345454 |
| RPL7 | ribosomal protein L7 | -0.0336494 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0335306 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0332743 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0332222 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0329401 |
| RRM2 | ribonucleotide reductase M2 | -0.0323401 |
| EZR | ezrin | -0.0323336 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0322451 |
| DSPP | dentin sialophosphoprotein | -0.0321103 |
| RPS19 | ribosomal protein S19 | -0.031927 |
| RPS8 | ribosomal protein S8 | -0.0311743 |
| SERINC1 | serine incorporator 1 | -0.0308294 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0306796 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0303528 |
| SQSTM1 | sequestosome 1 | -0.0299102 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0296973 |
| CALR | calreticulin | -0.0296265 |
| RPL26 | ribosomal protein L26 | -0.0296039 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0294053 |
| RPL38 | ribosomal protein L38 | -0.0291983 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0291568 |
| UBC | ubiquitin C | -0.0291338 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0291051 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.028932 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0284391 |
| CCN2 | cellular communication network factor 2 | -0.0283379 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.0282862 |
| ACTG1 | actin gamma 1 | -0.027914 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.027806 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0277535 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0277098 |
| TPM3 | tropomyosin 3 | -0.0273375 |
| ZNF804A | zinc finger protein 804A | -0.0268348 |
| BIRC2 | baculoviral IAP repeat containing 2 | -0.0267175 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0265632 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0264453 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0264338 |
| BRD2 | bromodomain containing 2 | -0.0263056 |
| CANX | calnexin | -0.0261908 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0261267 |
| RPLP1 | ribosomal protein, large, P1 | -0.0260404 |
| RPL8 | ribosomal protein L8 | -0.0254737 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0248697 |
| RPLP2 | ribosomal protein, large, P2 | -0.0246676 |
| PRKCI | protein kinase C, iota | -0.0246393 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0244875 |
| ICE1 | interactor of little elongation complex ELL subunit 1 | -0.024413 |
