| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CSF1 | colony stimulating factor 1 (macrophage) | 0.131948 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.110892 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.105339 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0801739 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.0788589 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0686307 |
| TXNRD1 | thioredoxin reductase 1 | 0.0659862 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.064432 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0617603 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0615453 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0597089 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0582955 |
| NRP2 | neuropilin 2 | 0.0563006 |
| MSN | moesin | 0.0518502 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0509717 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0497594 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0471035 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.045679 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0449638 |
| ASPH | aspartate beta-hydroxylase | 0.0449194 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.041926 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0418277 |
| POTEF | POTE ankyrin domain family, member F | 0.041437 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0412134 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.038533 |
| SMAD3 | SMAD family member 3 | 0.0374702 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.0372222 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.036274 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0353691 |
| IRS2 | insulin receptor substrate 2 | 0.0352548 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0343037 |
| MAP1B | microtubule-associated protein 1B | 0.0342645 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0342493 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0340966 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.03396 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0339426 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.0338763 |
| ARRDC3 | arrestin domain containing 3 | 0.0337199 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0333619 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0328806 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.031483 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0314653 |
| XPO1 | exportin 1 | 0.0314084 |
| PKM | pyruvate kinase, muscle | 0.0313653 |
| DENND2B | DENN domain containing 2B | 0.0310969 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0308677 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0306687 |
| PFN1 | profilin 1 | 0.0306333 |
| TFG | TRK-fused gene | 0.0305956 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0304361 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0303922 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0294342 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0290916 |
| CCNL1 | cyclin L1 | 0.0288445 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0284305 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0282743 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0282496 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0282316 |
| ITGAV | integrin, alpha V | 0.0279673 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.027961 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0279384 |
| USP3 | ubiquitin specific peptidase 3 | 0.0278191 |
| PTK2 | protein tyrosine kinase 2 | 0.027766 |
| NFIB | nuclear factor I/B | 0.0276768 |
| ECT2 | epithelial cell transforming 2 | 0.0269078 |
| SP3 | Sp3 transcription factor | 0.0268498 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0268261 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0267794 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0266516 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0262616 |
| MYO10 | myosin X | 0.0260387 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0254867 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0253933 |
| CENPF | centromere protein F, 350/400kDa | 0.0253914 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0252076 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0247086 |
| TNFAIP2 | tumor necrosis factor, alpha-induced protein 2 | 0.0246582 |
| G0S2 | G0/G1 switch 2 | 0.0245645 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0244655 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0244003 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0243222 |
| AZIN1 | antizyme inhibitor 1 | 0.0243208 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0241875 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0239521 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0239189 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0235689 |
| RUNX1 | runt-related transcription factor 1 | 0.0234281 |
| RNF145 | ring finger protein 145 | 0.0234031 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0233508 |
| PCBP2 | poly(rC) binding protein 2 | 0.0231333 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0230856 |
| NCKAP1 | NCK-associated protein 1 | 0.0230798 |
| TPM3 | tropomyosin 3 | 0.0229246 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0228695 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0226966 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0225893 |
| VCAN | versican | 0.0223098 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0222405 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0219768 |
| SRPK2 | SRSF protein kinase 2 | 0.0219699 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FRMD4A | FERM domain containing 4A | -0.319527 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.31301 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.142457 |
| VIM | vimentin | -0.115855 |
| CP | ceruloplasmin (ferroxidase) | -0.101809 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0995473 |
| HLA-B | major histocompatibility complex, class I, B | -0.0950212 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0879135 |
| TMSB10 | thymosin beta 10 | -0.0833586 |
| RRBP1 | ribosome binding protein 1 | -0.0711463 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0656672 |
| FTL | ferritin, light polypeptide | -0.0622871 |
| GPC6 | glypican 6 | -0.0605916 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0584197 |
| RND3 | Rho family GTPase 3 | -0.0566243 |
| CAVIN1 | caveolae associated protein 1 | -0.0527394 |
| HLA-E | major histocompatibility complex, class I, E | -0.0504236 |
| RPL35A | ribosomal protein L35a | -0.0487502 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.04769 |
| NDRG1 | N-myc downstream regulated 1 | -0.0471322 |
| APOL1 | apolipoprotein L, 1 | -0.0464452 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0433368 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0431889 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0428982 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0421945 |
| RPL34 | ribosomal protein L34 | -0.0414362 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.041304 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0404628 |
| HLA-C | major histocompatibility complex, class I, C | -0.0387666 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0381126 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0376031 |
| PRKCA | protein kinase C, alpha | -0.0373944 |
| S100A6 | S100 calcium binding protein A6 | -0.0371206 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0360146 |
| CD82 | CD82 molecule | -0.0347129 |
| LAMB3 | laminin, beta 3 | -0.0338356 |
| FAM107B | family with sequence similarity 107, member B | -0.0334337 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0333139 |
| MMP7 | matrix metallopeptidase 7 | -0.0323064 |
| CTSD | cathepsin D | -0.0319172 |
| BNC2 | basonuclin 2 | -0.0318169 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0317367 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0315642 |
| NAV2 | neuron navigator 2 | -0.0303012 |
| PLIN2 | perilipin 2 | -0.0301983 |
| GOLGB1 | golgin B1 | -0.0300879 |
| LOXL2 | lysyl oxidase-like 2 | -0.0296391 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0290612 |
| CALR | calreticulin | -0.0288412 |
| RPL31 | ribosomal protein L31 | -0.0287609 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0287174 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.028707 |
| FUS | FUS RNA binding protein | -0.0286866 |
| CLMP | CXADR-like membrane protein | -0.0286654 |
| CD63 | CD63 molecule | -0.0286394 |
| MT2A | metallothionein 2A | -0.0284195 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0283817 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0281012 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0279863 |
| SLC22A3 | solute carrier family 22 (organic cation transporter), member 3 | -0.0277038 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0273022 |
| RPL38 | ribosomal protein L38 | -0.0271999 |
| RAB2A | RAB2A, member RAS oncogene family | -0.027135 |
| EGFR | epidermal growth factor receptor | -0.0269337 |
| COL5A1 | collagen, type V, alpha 1 | -0.0269172 |
| ACTG1 | actin gamma 1 | -0.0267245 |
| RAI14 | retinoic acid induced 14 | -0.0266257 |
| SRP72 | signal recognition particle 72kDa | -0.0265783 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0264801 |
| LMNA | lamin A/C | -0.0262672 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0262076 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0261687 |
| FRMD5 | FERM domain containing 5 | -0.0261369 |
| MTDH | metadherin | -0.0256925 |
| GPC5 | glypican 5 | -0.0256319 |
| OXR1 | oxidation resistance 1 | -0.0251405 |
| ANXA4 | annexin A4 | -0.0250746 |
| HM13 | histocompatibility (minor) 13 | -0.0250727 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0246711 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0243332 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0242561 |
| VCL | vinculin | -0.0237719 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0237061 |
| ADGRG1 | adhesion G protein-coupled receptor G1 | -0.0232927 |
| RPL37A | ribosomal protein L37a | -0.0232617 |
| MYO1E | myosin IE | -0.0231537 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.023141 |
| SMYD3 | SET and MYND domain containing 3 | -0.0230657 |
| TPM4 | tropomyosin 4 | -0.0225757 |
| SP100 | SP100 nuclear antigen | -0.0223284 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0221618 |
| RPS8 | ribosomal protein S8 | -0.0220564 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0220381 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0219609 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0219213 |
| RPL12 | ribosomal protein L12 | -0.0219095 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0218975 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0218089 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0215335 |
| ARF1 | ADP-ribosylation factor 1 | -0.0214609 |
