| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VMP1 | vacuole membrane protein 1 | 0.107279 |
| NDRG1 | N-myc downstream regulated 1 | 0.106729 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0751816 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.074634 |
| TMEM165 | transmembrane protein 165 | 0.0726585 |
| DTNA | dystrobrevin, alpha | 0.0701151 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0573391 |
| USP53 | ubiquitin specific peptidase 53 | 0.0497267 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0492688 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0486235 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0462475 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0456624 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0447249 |
| FGB | fibrinogen beta chain | 0.0434778 |
| GRB7 | growth factor receptor-bound protein 7 | 0.043087 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0414416 |
| PRELID2 | PRELI domain containing 2 | 0.0408133 |
| CCNL1 | cyclin L1 | 0.0395702 |
| KIAA1217 | KIAA1217 | 0.0390316 |
| TPD52 | tumor protein D52 | 0.037502 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0370211 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0362277 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0351539 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0351406 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0345979 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | 0.0342145 |
| VEGFA | vascular endothelial growth factor A | 0.0328613 |
| FNDC3B | fibronectin type III domain containing 3B | 0.032063 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0319338 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0318316 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.031793 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0312347 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0311711 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0309752 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0309256 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0305719 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0297216 |
| OSMR | oncostatin M receptor | 0.0296609 |
| PLSCR1 | phospholipid scramblase 1 | 0.0295983 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0283363 |
| SLFN5 | schlafen family member 5 | 0.0278754 |
| PMP22 | peripheral myelin protein 22 | 0.0272179 |
| ZNF292 | zinc finger protein 292 | 0.0271772 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0266282 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0265626 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0265445 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0262892 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0260896 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0255254 |
| VCL | vinculin | 0.025518 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0251019 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0248453 |
| CDH15 | cadherin 15, type 1, M-cadherin (myotubule) | 0.02481 |
| PTEN | phosphatase and tensin homolog | 0.0247177 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0246965 |
| FBXO11 | F-box protein 11 | 0.0244296 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0243825 |
| TENM2 | teneurin transmembrane protein 2 | 0.0242883 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0234493 |
| RNF24 | ring finger protein 24 | 0.0232739 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0231755 |
| MCL1 | myeloid cell leukemia 1 | 0.0231541 |
| N4BP1 | NEDD4 binding protein 1 | 0.0228367 |
| ZNF148 | zinc finger protein 148 | 0.0226217 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0226044 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0225756 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0223913 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0217589 |
| UBAP1 | ubiquitin associated protein 1 | 0.0216217 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0214652 |
| EGR1 | early growth response 1 | 0.0213857 |
| ITGB6 | integrin, beta 6 | 0.0213566 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0213366 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0213254 |
| MYO1B | myosin IB | 0.0212494 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.0212279 |
| ZNF609 | zinc finger protein 609 | 0.0211768 |
| FAM13A | family with sequence similarity 13, member A | 0.0211127 |
| RAD51B | RAD51 paralog B | 0.0207737 |
| WASL | Wiskott-Aldrich syndrome-like | 0.020662 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0205648 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0201397 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0200684 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0199907 |
| AMPD3 | adenosine monophosphate deaminase 3 | 0.0197877 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.0197555 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0195904 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0195525 |
| INTS6 | integrator complex subunit 6 | 0.0195175 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0194899 |
| PKP4 | plakophilin 4 | 0.0194607 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0194003 |
| ADAR | adenosine deaminase, RNA-specific | 0.019185 |
| DHX40 | DEAH (Asp-Glu-Ala-His) box polypeptide 40 | 0.0191574 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0188905 |
| TBK1 | TANK-binding kinase 1 | 0.0188777 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0188697 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0187997 |
| GLCCI1 | glucocorticoid induced 1 | 0.018782 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0187307 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL23 | ribosomal protein L23 | -0.139762 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | -0.107747 |
| LASP1 | LIM and SH3 protein 1 | -0.0900919 |
| TMSB10 | thymosin beta 10 | -0.0854109 |
| ACTG1 | actin gamma 1 | -0.0788671 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.07839 |
| RPL19 | ribosomal protein L19 | -0.0761629 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0725932 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0702617 |
| MT2A | metallothionein 2A | -0.0677663 |
| TMSB4X | thymosin beta 4, X-linked | -0.0658636 |
| PTMA | prothymosin, alpha | -0.0651194 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0645229 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0639333 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0609738 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0569545 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.054855 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | -0.0526305 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0509917 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | -0.0487701 |
| ENO1 | enolase 1, (alpha) | -0.0486328 |
| LMNA | lamin A/C | -0.0479933 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0475406 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0459281 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0459145 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0458732 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0454978 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.044936 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0446266 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0439458 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0436084 |
| KRT18 | keratin 18, type I | -0.0418465 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0408827 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.040732 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0403141 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.040161 |
| KRT19 | keratin 19, type I | -0.0399527 |
| AHNAK | AHNAK nucleoprotein | -0.0399445 |
| FADS2 | fatty acid desaturase 2 | -0.0399003 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0396687 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0396325 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0392621 |
| RPL12 | ribosomal protein L12 | -0.0391508 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0389441 |
| DST | dystonin | -0.0388789 |
| CD164 | CD164 molecule, sialomucin | -0.0379712 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0375221 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0375087 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0361432 |
| RPS19 | ribosomal protein S19 | -0.0351219 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0348481 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.034277 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0337325 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0337052 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0335637 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.033201 |
| S100A8 | S100 calcium binding protein A8 | -0.0330697 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0318926 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0318681 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0316327 |
| TTC6 | tetratricopeptide repeat domain 6 | -0.0315956 |
| SERF2 | small EDRK-rich factor 2 | -0.0311662 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0308629 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0306979 |
| KRT7 | keratin 7, type II | -0.0306711 |
| KLF6 | Kruppel-like factor 6 | -0.0299811 |
| CLTC | clathrin, heavy chain (Hc) | -0.0299647 |
| MIPOL1 | mirror-image polydactyly 1 | -0.029711 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.029567 |
| KRT8 | keratin 8, type II | -0.0293927 |
| CLDN4 | claudin 4 | -0.0291071 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0290719 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0285398 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0283065 |
| RPS3 | ribosomal protein S3 | -0.028281 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.0281225 |
| SEPTIN9 | septin 9 | -0.0281118 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0280691 |
| KIF1A | kinesin family member 1A | -0.0280679 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0273017 |
| RPLP0 | ribosomal protein, large, P0 | -0.0272882 |
| PTK2 | protein tyrosine kinase 2 | -0.0272728 |
| PFDN4 | prefoldin subunit 4 | -0.0272206 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | -0.0271881 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0271767 |
| KAZN | kazrin, periplakin interacting protein | -0.0268829 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0268358 |
| RRBP1 | ribosome binding protein 1 | -0.0267236 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0265453 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.0262349 |
| CCND1 | cyclin D1 | -0.0259867 |
| VCP | valosin containing protein | -0.0258016 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0257435 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0256213 |
| S100A9 | S100 calcium binding protein A9 | -0.0255931 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0249854 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0246656 |
| ZFHX3 | zinc finger homeobox 3 | -0.0244247 |
| S100A6 | S100 calcium binding protein A6 | -0.024319 |
| S100A14 | S100 calcium binding protein A14 | -0.0243158 |
