| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Carbidopa (monohydrate) perturbation in C-33 A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Carbidopa (monohydrate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TOX | thymocyte selection-associated high mobility group box | 0.0828298 |
| TENM3 | teneurin transmembrane protein 3 | 0.0609614 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0595704 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.0556678 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0538675 |
| SMYD3 | SET and MYND domain containing 3 | 0.0492058 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0481456 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0480085 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.040367 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0378181 |
| GRID2 | glutamate receptor, ionotropic, delta 2 | 0.0375151 |
| USP34 | ubiquitin specific peptidase 34 | 0.0374263 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0371982 |
| NEBL | nebulette | 0.0371299 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0370355 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0369368 |
| HHIP | hedgehog interacting protein | 0.0361289 |
| NGLY1 | N-glycanase 1 | 0.035796 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0354766 |
| NF1 | neurofibromin 1 | 0.0333942 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.03219 |
| ZFP64 | ZFP64 zinc finger protein | 0.0321013 |
| NFIA | nuclear factor I/A | 0.0317341 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0316202 |
| SEPTIN2 | septin 2 | 0.0312387 |
| RTN4 | reticulon 4 | 0.0308633 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0297137 |
| PRELID2 | PRELI domain containing 2 | 0.0297119 |
| YEATS2 | YEATS domain containing 2 | 0.0293156 |
| TBC1D32 | TBC1 domain family, member 32 | 0.0289032 |
| NKTR | natural killer cell triggering receptor | 0.0285879 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0283093 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0281917 |
| SBF2 | SET binding factor 2 | 0.0280723 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.027603 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0275778 |
| PRICKLE1 | prickle homolog 1 (Drosophila) | 0.0275607 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0273704 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0271944 |
| KIAA1328 | KIAA1328 | 0.0269304 |
| ZNF292 | zinc finger protein 292 | 0.0267419 |
| VMP1 | vacuole membrane protein 1 | 0.0263709 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0263174 |
| JMJD1C | jumonji domain containing 1C | 0.0261561 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0260305 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.02599 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0258797 |
| TMEM259 | transmembrane protein 259 | 0.0258666 |
| FOXO3 | forkhead box O3 | 0.025764 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0255764 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.0249908 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0249325 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.024911 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.024805 |
| WLS | wntless Wnt ligand secretion mediator | 0.0243846 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0243127 |
| DMTF1 | cyclin D binding myb-like transcription factor 1 | 0.0242627 |
| BBX | bobby sox homolog (Drosophila) | 0.024137 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0237224 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0235448 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0235099 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0234968 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0233054 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | 0.0231977 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.0227183 |
| WASF2 | WAS protein family, member 2 | 0.0226914 |
| SPRY1 | sprouty homolog 1, antagonist of FGF signaling (Drosophila) | 0.0226721 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0225666 |
| ENTREP2 | endosomal transmembrane epsin interactor 2 | 0.022507 |
| EPB41 | erythrocyte membrane protein band 4.1 | 0.0224757 |
| MED13L | mediator complex subunit 13-like | 0.022425 |
| KBTBD2 | kelch repeat and BTB (POZ) domain containing 2 | 0.0224238 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0223774 |
| NFIB | nuclear factor I/B | 0.0223515 |
| CLTC | clathrin, heavy chain (Hc) | 0.0222601 |
| TNPO3 | transportin 3 | 0.0217298 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.021532 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0214338 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.021299 |
| ZNF609 | zinc finger protein 609 | 0.0212044 |
| INVS | inversin | 0.0208995 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0208825 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0208403 |
| TLK1 | tousled-like kinase 1 | 0.020832 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0207937 |
| TPD52 | tumor protein D52 | 0.020696 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0206625 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0206467 |
| KIAA1958 | KIAA1958 | 0.0206159 |
| IREB2 | iron-responsive element binding protein 2 | 0.0205445 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0205303 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0205135 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0203188 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0202619 |
| RPS25 | ribosomal protein S25 | 0.0202485 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0199556 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0198608 |
| CNNM2 | cyclin and CBS domain divalent metal cation transport mediator 2 | 0.0198597 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | 0.0198566 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0197536 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.126457 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.124414 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0969428 |
| ACTG1 | actin gamma 1 | -0.080656 |
| PTMA | prothymosin, alpha | -0.07911 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0751718 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0689313 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0633878 |
| ENO1 | enolase 1, (alpha) | -0.0620971 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0532658 |
| ATP11A | ATPase, class VI, type 11A | -0.0524693 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0507059 |
| CANX | calnexin | -0.0506919 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0505668 |
| RPS2 | ribosomal protein S2 | -0.0503549 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0491625 |
| TMSB10 | thymosin beta 10 | -0.0488312 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0485561 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.048254 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0480649 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0479625 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.045698 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0455228 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0445268 |
| SET | SET nuclear proto-oncogene | -0.0434956 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0434289 |
| RPL13A | ribosomal protein L13a | -0.0430655 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0429073 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0426211 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.042553 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0424243 |
| HMGB2 | high mobility group box 2 | -0.0409069 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0405907 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.0404756 |
| FMNL2 | formin-like 2 | -0.0402484 |
| RPS6 | ribosomal protein S6 | -0.0399515 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | -0.039927 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0399049 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0386779 |
| RACK1 | receptor for activated C kinase 1 | -0.0385369 |
| RPLP1 | ribosomal protein, large, P1 | -0.0384395 |
| SYAP1 | synapse associated protein 1 | -0.0383777 |
| LDHA | lactate dehydrogenase A | -0.0382004 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0377414 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0376113 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0373301 |
| FBL | fibrillarin | -0.0364066 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0357343 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0356831 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0353006 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0346105 |
| YBX1 | Y box binding protein 1 | -0.0344536 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.034179 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0329845 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0328917 |
| CALR | calreticulin | -0.0325401 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0325392 |
| ILF3 | interleukin enhancer binding factor 3, 90kDa | -0.0323377 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0321256 |
| RPS4X | ribosomal protein S4, X-linked | -0.0315153 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | -0.0311353 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0310195 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0308058 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.029594 |
| RPL4 | ribosomal protein L4 | -0.0293742 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0288862 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.02876 |
| APP | amyloid beta (A4) precursor protein | -0.0287445 |
| ZNF217 | zinc finger protein 217 | -0.0286309 |
| RPS11 | ribosomal protein S11 | -0.0285512 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.0284254 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.028087 |
| FUS | FUS RNA binding protein | -0.0279886 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0279425 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0276397 |
| SIK3 | SIK family kinase 3 | -0.0274281 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0274174 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.027314 |
| RPL19 | ribosomal protein L19 | -0.0272463 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0272444 |
| CADM2 | cell adhesion molecule 2 | -0.0272156 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.026993 |
| RPS3 | ribosomal protein S3 | -0.0267301 |
| PAPOLA | poly(A) polymerase alpha | -0.0266643 |
| QKI | QKI, KH domain containing, RNA binding | -0.0263593 |
| KDM5C | lysine (K)-specific demethylase 5C | -0.0263516 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0261616 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0260832 |
| CAVIN1 | caveolae associated protein 1 | -0.0259425 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0259058 |
| RPS17 | ribosomal protein S17 | -0.0258855 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0258505 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0258208 |
| MKI67 | marker of proliferation Ki-67 | -0.0258176 |
| RPL38 | ribosomal protein L38 | -0.0257884 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | -0.025737 |
| NAA15 | N(alpha)-acetyltransferase 15, NatA auxiliary subunit | -0.0257132 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0256632 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0254214 |
| CCNY | cyclin Y | -0.0254034 |
