Carbidopa (monohydrate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.147898
PTMA prothymosin, alpha 0.111164
DTNA dystrobrevin, alpha 0.105056
GRB10 growth factor receptor-bound protein 10 0.104164
LAMB3 laminin, beta 3 0.101848
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0945542
UBC ubiquitin C 0.0874316
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0776199
EHBP1 EH domain binding protein 1 0.0754128
ELL2 elongation factor, RNA polymerase II, 2 0.0724702
F3 coagulation factor III (thromboplastin, tissue factor) 0.069942
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0694933
MMP7 matrix metallopeptidase 7 0.0653395
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0647101
AKAP12 A kinase (PRKA) anchor protein 12 0.064592
FNDC3B fibronectin type III domain containing 3B 0.0591813
AHNAK AHNAK nucleoprotein 0.0587441
PGK1 phosphoglycerate kinase 1 0.0586476
ENO1 enolase 1, (alpha) 0.0578705
TSC22D2 TSC22 domain family, member 2 0.0553069
KDM5B lysine (K)-specific demethylase 5B 0.0552574
CXCL8 chemokine (C-X-C motif) ligand 8 0.0547722
FAM13A family with sequence similarity 13, member A 0.0542772
CCNY cyclin Y 0.0517848
HILPDA hypoxia inducible lipid droplet-associated 0.0513706
KMT2C lysine (K)-specific methyltransferase 2C 0.0512312
HLA-A major histocompatibility complex, class I, A 0.0510855
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0508631
VIM vimentin 0.0489768
ANKRD11 ankyrin repeat domain 11 0.0489383
H1-0 H1.0 linker histone 0.0477059
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.047504
NT5C2 5'-nucleotidase, cytosolic II 0.0471798
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0467231
GSK3B glycogen synthase kinase 3 beta 0.046139
WSB1 WD repeat and SOCS box containing 1 0.0459705
RAB6A RAB6A, member RAS oncogene family 0.0459617
USP3 ubiquitin specific peptidase 3 0.0459413
RIOK3 RIO kinase 3 0.0458979
OGA O-GlcNAcase 0.0437089
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0435964
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0433513
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0423865
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0418794
CP ceruloplasmin (ferroxidase) 0.0415856
ASPH aspartate beta-hydroxylase 0.0412693
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0409674
NPEPPS aminopeptidase puromycin sensitive 0.0400022
BIRC3 baculoviral IAP repeat containing 3 0.0398471
MAML2 mastermind-like 2 (Drosophila) 0.0397339
UBA6 ubiquitin-like modifier activating enzyme 6 0.0388889
PICALM phosphatidylinositol binding clathrin assembly protein 0.0381648
MCU mitochondrial calcium uniporter 0.0378743
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0376564
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0373442
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0368033
PDIA6 protein disulfide isomerase family A, member 6 0.0364225
INSIG1 insulin induced gene 1 0.0348139
COPA coatomer protein complex, subunit alpha 0.034479
TMSB10 thymosin beta 10 0.0337294
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0334956
S100A6 S100 calcium binding protein A6 0.0332447
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0331316
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0329628
RASAL2 RAS protein activator like 2 0.0323311
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0320601
SRP54 signal recognition particle 54kDa 0.0317612
MEF2A myocyte enhancer factor 2A 0.0314754
SPDYA speedy/RINGO cell cycle regulator family member A 0.0311433
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0310046
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0305468
PDIA3 protein disulfide isomerase family A, member 3 0.0305417
SEC24A SEC24 family member A 0.0302075
NCKAP5 NCK-associated protein 5 0.029597
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0292201
TRA2A transformer 2 alpha homolog (Drosophila) 0.0289707
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0289145
FTH1 ferritin, heavy polypeptide 1 0.0283096
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0282829
FGFR1 fibroblast growth factor receptor 1 0.0282816
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0280617
ATP13A3 ATPase type 13A3 0.0278845
RAP1B RAP1B, member of RAS oncogene family 0.0277718
LPP LIM domain containing preferred translocation partner in lipoma 0.0276435
RAB1A RAB1A, member RAS oncogene family 0.027527
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0274417
FOSL1 FOS-like antigen 1 0.0273438
TFG TRK-fused gene 0.0270972
GARS1 glycyl-tRNA synthetase 1 0.0270031
SEC23A Sec23 homolog A (S. cerevisiae) 0.026296
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0261706
TNS4 tensin 4 0.0261704
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0261691
MT1X metallothionein 1X 0.0256587
ADAM9 ADAM metallopeptidase domain 9 0.025479
HSPG2 heparan sulfate proteoglycan 2 0.0253803
HLA-B major histocompatibility complex, class I, B 0.0252713
FNBP1L formin binding protein 1-like 0.0251308
ZMIZ1 zinc finger, MIZ-type containing 1 0.0246951
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.024675

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.195213
MT2A metallothionein 2A -0.185695
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.148061
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.116801
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.104562
RPS2 ribosomal protein S2 -0.0999826
EIF1 eukaryotic translation initiation factor 1 -0.0862674
KRT19 keratin 19, type I -0.0851063
NDRG1 N-myc downstream regulated 1 -0.0841079
SMAD3 SMAD family member 3 -0.0825329
RPL19 ribosomal protein L19 -0.0795812
LAMC2 laminin, gamma 2 -0.0765852
MACC1 metastasis associated in colon cancer 1 -0.0634323
RPL23 ribosomal protein L23 -0.0624664
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0622576
ACTG1 actin gamma 1 -0.0588096
CDCP1 CUB domain containing protein 1 -0.0582677
RPS6 ribosomal protein S6 -0.058159
MYO1E myosin IE -0.0569072
RPLP1 ribosomal protein, large, P1 -0.0567462
APOL1 apolipoprotein L, 1 -0.0562592
RPL11 ribosomal protein L11 -0.0557436
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0542877
BRD2 bromodomain containing 2 -0.0537897
ARHGAP5 Rho GTPase activating protein 5 -0.0532648
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0524765
ALCAM activated leukocyte cell adhesion molecule -0.0520672
LOC112694756 uncharaterized LOC112694756 -0.0516689
FTL ferritin, light polypeptide -0.0514428
EFNA5 ephrin-A5 -0.0510095
TPT1 tumor protein, translationally-controlled 1 -0.0496403
ANO6 anoctamin 6 -0.0490683
POTEF POTE ankyrin domain family, member F -0.0489589
LAMA4 laminin, alpha 4 -0.0485865
RPL37A ribosomal protein L37a -0.0477604
C15ORF48 chromosome 15 open reading frame 48 -0.0477044
CLTC clathrin, heavy chain (Hc) -0.0469707
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0466603
MYOF myoferlin -0.0445403
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0436476
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0434696
TMSB4X thymosin beta 4, X-linked -0.0433044
RPS8 ribosomal protein S8 -0.0429918
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.042437
RPL9 ribosomal protein L9 -0.0424186
DOCK5 dedicator of cytokinesis 5 -0.0422655
AREG amphiregulin -0.0404805
RPS19 ribosomal protein S19 -0.0389168
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0386164
HMGA1 high mobility group AT-hook 1 -0.0381508
DSG2 desmoglein 2 -0.0375364
RPLP0 ribosomal protein, large, P0 -0.0375011
DSCAM Down syndrome cell adhesion molecule -0.0373215
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0367682
BACE2 beta-site APP-cleaving enzyme 2 -0.0360562
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0355304
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0354424
RPS3 ribosomal protein S3 -0.0351138
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0349603
SYNRG synergin, gamma -0.0349504
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0348874
RPS29 ribosomal protein S29 -0.0346776
PNN pinin, desmosome associated protein -0.0344132
MYH9 myosin, heavy chain 9, non-muscle -0.034277
LAMB1 laminin, beta 1 -0.0339759
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0338857
WWTR1 WW domain containing transcription regulator 1 -0.0338292
RPL7 ribosomal protein L7 -0.0336265
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0334157
APP amyloid beta (A4) precursor protein -0.0333797
RPL37 ribosomal protein L37 -0.0333069
NRIP1 nuclear receptor interacting protein 1 -0.0327205
RPS24 ribosomal protein S24 -0.0318508
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0317981
MACF1 microtubule-actin crosslinking factor 1 -0.0314822
MBNL1 muscleblind-like splicing regulator 1 -0.0314513
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0310314
GOLGB1 golgin B1 -0.0306906
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0305539
CLMN calmin (calponin-like, transmembrane) -0.0303296
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0301984
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0301836
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0299967
NAMPT nicotinamide phosphoribosyltransferase -0.0293374
TGM2 transglutaminase 2 -0.0292757
DSPP dentin sialophosphoprotein -0.0289109
TAOK3 TAO kinase 3 -0.0286114
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0284304
AKAP13 A kinase (PRKA) anchor protein 13 -0.0283542
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0280823
LDHA lactate dehydrogenase A -0.0279987
RPL38 ribosomal protein L38 -0.027912
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0278814
USP53 ubiquitin specific peptidase 53 -0.0278713
S100A10 S100 calcium binding protein A10 -0.0277562
RPS12 ribosomal protein S12 -0.0273909
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0273839
RPS23 ribosomal protein S23 -0.0272367
RPS27 ribosomal protein S27 -0.0270394
JAK1 Janus kinase 1 -0.0269122