Carbidopa (monohydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Carbidopa (monohydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Carbidopa (monohydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.155972
NREP neuronal regeneration related protein 0.0676884
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0657558
FNDC3B fibronectin type III domain containing 3B 0.0616662
NDRG1 N-myc downstream regulated 1 0.0612875
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0575537
LINGO2 leucine rich repeat and Ig domain containing 2 0.0570651
PTPRD protein tyrosine phosphatase, receptor type, D 0.0531096
DPH6 diphthamine biosynthesis 6 0.0506236
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0495644
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.049106
NCAM2 neural cell adhesion molecule 2 0.0457809
PDE4D phosphodiesterase 4D, cAMP-specific 0.0419318
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0416382
FAM13A family with sequence similarity 13, member A 0.0412712
SOS1 son of sevenless homolog 1 (Drosophila) 0.0400641
GPC5 glypican 5 0.0394411
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0384986
ZBTB20 zinc finger and BTB domain containing 20 0.0361977
ITPRID2 ITPR interacting domain containing 2 0.0359687
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0345858
RNF213 ring finger protein 213 0.0334607
RO60 Ro60, Y RNA binding protein 0.0329895
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0321529
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0316446
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0312335
AHR aryl hydrocarbon receptor 0.0302189
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0301835
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0301172
STC1 stanniocalcin 1 0.0297094
RNF150 ring finger protein 150 0.0295082
EPAS1 endothelial PAS domain protein 1 0.0292736
SLITRK6 SLIT and NTRK-like family, member 6 0.0286152
VEGFA vascular endothelial growth factor A 0.0281817
KCNT2 potassium channel, sodium activated subfamily T, member 2 0.0280896
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0279786
TRIM25 tripartite motif containing 25 0.0278019
DST dystonin 0.0275417
FRMD6 FERM domain containing 6 0.0271342
UNC5C unc-5 homolog C (C. elegans) 0.0271204
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0271157
PTEN phosphatase and tensin homolog 0.0271099
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0265785
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0262656
MEF2A myocyte enhancer factor 2A 0.0262507
KDM4C lysine (K)-specific demethylase 4C 0.0260569
INSIG2 insulin induced gene 2 0.0259971
MTSS2 MTSS I-BAR domain containing 2 0.0258163
ZCCHC7 zinc finger, CCHC domain containing 7 0.0256265
FN1 fibronectin 1 0.0254663
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0253343
LIMS1 LIM and senescent cell antigen-like domains 1 0.0250043
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0246821
NRIP1 nuclear receptor interacting protein 1 0.0245207
CD36 CD36 molecule (thrombospondin receptor) 0.0244376
SSH1 slingshot protein phosphatase 1 0.0242202
SENP6 SUMO1/sentrin specific peptidase 6 0.0236533
EPHA3 EPH receptor A3 0.0229236
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0226085
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0223105
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0221477
XRN1 5'-3' exoribonuclease 1 0.0220918
AEBP2 AE binding protein 2 0.0217119
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0217073
DLC1 DLC1 Rho GTPase activating protein 0.0216097
RPTOR regulatory associated protein of MTOR, complex 1 0.021091
GIGYF2 GRB10 interacting GYF protein 2 0.0209937
EXOC4 exocyst complex component 4 0.0207734
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.020669
CAB39 calcium binding protein 39 0.0206583
AKAP12 A kinase (PRKA) anchor protein 12 0.0202249
ZNF638 zinc finger protein 638 0.0202174
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0201741
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0198504
ZNF148 zinc finger protein 148 0.0197158
LIMCH1 LIM and calponin homology domains 1 0.0195334
SCARB1 scavenger receptor class B, member 1 0.0194994
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.019367
ATRNL1 attractin-like 1 0.0193408
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0183056
AUTS2 autism susceptibility candidate 2 0.0182267
SPRED1 sprouty-related, EVH1 domain containing 1 0.0180569
TCERG1 transcription elongation regulator 1 0.0180504
SNX5 sorting nexin 5 0.0179469
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0177932
ADGRB3 adhesion G protein-coupled receptor B3 0.0175994
GLI3 GLI family zinc finger 3 0.0175944
ZNF652 zinc finger protein 652 0.0175301
EPHA6 EPH receptor A6 0.0174816
SNX14 sorting nexin 14 0.0174609
MTUS1 microtubule associated tumor suppressor 1 0.0174245
ANKRD11 ankyrin repeat domain 11 0.0170401
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.0170372
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.0170163
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0169736
ZNF146 zinc finger protein 146 0.0168299
UBE3D ubiquitin protein ligase E3D 0.0167443
MDM4 MDM4, p53 regulator 0.0166379
MACROD2 MACRO domain containing 2 0.0165545
PGK1 phosphoglycerate kinase 1 0.0165129

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.222894
IGF2 insulin-like growth factor 2 -0.185037
PTMA prothymosin, alpha -0.149025
VIM vimentin -0.145519
COL1A1 collagen, type I, alpha 1 -0.125685
RPL23 ribosomal protein L23 -0.110911
RPS6 ribosomal protein S6 -0.10364
TMSB10 thymosin beta 10 -0.0976873
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.093427
RPL19 ribosomal protein L19 -0.0931236
EIF1 eukaryotic translation initiation factor 1 -0.089296
ACTG1 actin gamma 1 -0.0880076
TPT1 tumor protein, translationally-controlled 1 -0.0818423
RPL34 ribosomal protein L34 -0.0815877
RPL35A ribosomal protein L35a -0.0774115
RPLP1 ribosomal protein, large, P1 -0.0769272
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0749768
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0730689
EXT1 exostosin glycosyltransferase 1 -0.067746
LMNA lamin A/C -0.067224
FTL ferritin, light polypeptide -0.0662558
HMGB2 high mobility group box 2 -0.0637684
COL3A1 collagen, type III, alpha 1 -0.0628487
MED13 mediator complex subunit 13 -0.0554035
RPS19 ribosomal protein S19 -0.0553378
IER3 immediate early response 3 -0.0550561
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0525935
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0502439
RPL38 ribosomal protein L38 -0.0496962
TLE4 transducin-like enhancer of split 4 -0.0496776
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0496405
B2M beta-2-microglobulin -0.0480623
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0474185
TOP2A topoisomerase (DNA) II alpha 170kDa -0.045673
GNAS GNAS complex locus -0.0451815
RPL36 ribosomal protein L36 -0.0450773
THSD4 thrombospondin, type I, domain containing 4 -0.0447562
RPS3 ribosomal protein S3 -0.04452
VCL vinculin -0.0440017
ARID4B AT rich interactive domain 4B (RBP1-like) -0.043292
RPS27A ribosomal protein S27a -0.0424096
RACK1 receptor for activated C kinase 1 -0.0417774
S100A6 S100 calcium binding protein A6 -0.0417373
RPS14 ribosomal protein S14 -0.0415602
RPL26 ribosomal protein L26 -0.0412792
TPR translocated promoter region, nuclear basket protein -0.0410603
RPLP0 ribosomal protein, large, P0 -0.0410061
POTEF POTE ankyrin domain family, member F -0.0403268
WAC WW domain containing adaptor with coiled-coil -0.0401866
NAP1L1 nucleosome assembly protein 1-like 1 -0.0400909
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0398902
DSCAM Down syndrome cell adhesion molecule -0.0397373
CRH corticotropin releasing hormone -0.0393493
KDM3A lysine (K)-specific demethylase 3A -0.0390302
RPL31 ribosomal protein L31 -0.0388946
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0383884
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0383181
HIP1 huntingtin interacting protein 1 -0.0378882
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0376691
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0371657
EEF2 eukaryotic translation elongation factor 2 -0.0368328
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0366446
SPAG9 sperm associated antigen 9 -0.0363342
ANXA2 annexin A2 -0.0360988
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0358902
AFF4 AF4/FMR2 family, member 4 -0.0358175
HELZ helicase with zinc finger -0.0357883
H3-3B H3.3 histone B -0.0345887
CLTC clathrin, heavy chain (Hc) -0.0343652
RSL1D1 ribosomal L1 domain containing 1 -0.0340483
RPS29 ribosomal protein S29 -0.0340155
RPS8 ribosomal protein S8 -0.0339302
RPS11 ribosomal protein S11 -0.0338143
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0335665
CCND1 cyclin D1 -0.0334132
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0332007
CEP350 centrosomal protein 350kDa -0.0331824
RPS24 ribosomal protein S24 -0.0330258
ARF1 ADP-ribosylation factor 1 -0.0328702
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0327811
RAB1A RAB1A, member RAS oncogene family -0.0326494
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0325043
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0322583
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0321426
CALU calumenin -0.032
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0319562
MARCHF6 membrane associated ring-CH-type finger 6 -0.0315066
KLF6 Kruppel-like factor 6 -0.0313181
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0308501
RPL27 ribosomal protein L27 -0.0307848
RPL37 ribosomal protein L37 -0.0307546
QKI QKI, KH domain containing, RNA binding -0.0307523
SOX4 SRY (sex determining region Y)-box 4 -0.0307174
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0304753
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0301133
RPS21 ribosomal protein S21 -0.0299261
CADM1 cell adhesion molecule 1 -0.0298906
SQSTM1 sequestosome 1 -0.0295433
SIK3 SIK family kinase 3 -0.0295031
FUS FUS RNA binding protein -0.0292913